JONATHAN KENT LEACH

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Alginate hydrogels containing cell-interactive beads for bone formation
    Archana Bhat
    1Department of Biomedical Engineering, University of California Davis, 451 Health Sciences Drive, GBSF 3321, Davis, CA 95616, USA
    FASEB J 27:4844-52. 2013
  2. pmc A reproducible, high throughput method for fabricating fibrin gels
    Kaitlin C Murphy
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    BMC Res Notes 5:423. 2012
  3. pmc Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF
    Damian C Genetos
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Mol Neurosci 40:360-6. 2010
  4. pmc Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation
    Martin L Decaris
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, CA 95616, USA
    Ann Biomed Eng 39:1174-85. 2011
  5. pmc Designing bioactive delivery systems for tissue regeneration
    Hillary E Davis
    Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive, 2303 Genome and Biomedical Sciences Facility, Davis, CA, 95616, USA
    Ann Biomed Eng 39:1-13. 2011
  6. pmc Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells
    Martin L Decaris
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Angiogenesis 12:303-11. 2009
  7. ncbi Multifunctional cell-instructive materials for tissue regeneration
    J Kent Leach
    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Regen Med 1:447-55. 2006
  8. doi Neurite outgrowth in fibrin gels is regulated by substrate stiffness
    Alan J Man
    Department of Biomedical Engineering, UC Davis, Davis, CA 95616, USA
    Tissue Eng Part A 17:2931-42. 2011
  9. ncbi Bone engineering by controlled delivery of osteoinductive molecules and cells
    J Kent Leach
    Department of Biomedical Engineering, University of Michigan, 5213 Dental Building, 1011 N University Ave, Ann Arbor, MI 48109 1078, USA
    Expert Opin Biol Ther 4:1015-27. 2004
  10. pmc Angiogenic response to bioactive glass promotes bone healing in an irradiated calvarial defect
    Ann Leu
    Department of Biomedical Engineering, University of California at Davis, Davis, California, USA
    Tissue Eng Part A 15:877-85. 2009

Research Grants

Collaborators

  • Damian C Genetos
  • DAVID J contact MOONEY
  • Martin L Decaris
  • Hillary E Davis
  • Rameshwar R Rao
  • Archana Bhat
  • Kaitlin C Murphy
  • Alan J Man
  • Jiawei He
  • Ann Leu
  • Allison I Hoch
  • Peter Bannerman
  • Aki Itoh
  • Alice F Tarantal
  • Chang I Lee
  • Susanne M Stieger
  • Paul Dayton
  • Mervin C Yoder
  • Katherine W Ferrara

Detail Information

Publications12

  1. doi Alginate hydrogels containing cell-interactive beads for bone formation
    Archana Bhat
    1Department of Biomedical Engineering, University of California Davis, 451 Health Sciences Drive, GBSF 3321, Davis, CA 95616, USA
    FASEB J 27:4844-52. 2013
    ..This strategy may provide an alternative to the engraftment of proteins or peptides onto the polymer backbone of hydrogels for directing cellular behavior...
  2. pmc A reproducible, high throughput method for fabricating fibrin gels
    Kaitlin C Murphy
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    BMC Res Notes 5:423. 2012
    ..However, current fabrication methods are time intensive with inherent variation. There is a pressing need to develop new and consistent approaches for producing fibrin-based hydrogels for examination...
  3. pmc Oxygen tension modulates neurite outgrowth in PC12 cells through a mechanism involving HIF and VEGF
    Damian C Genetos
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Mol Neurosci 40:360-6. 2010
    ..These findings demonstrate that behavior of neural-like cells is driven by the oxygen microenvironment via VEGF function, and suggest promising approaches for future applications in neural repair...
  4. pmc Design of experiments approach to engineer cell-secreted matrices for directing osteogenic differentiation
    Martin L Decaris
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, CA 95616, USA
    Ann Biomed Eng 39:1174-85. 2011
    ..This study demonstrates that DOE-based analysis is a powerful tool for optimizing engineered systems by identifying significant variables that have the greatest contribution to the target output...
  5. pmc Designing bioactive delivery systems for tissue regeneration
    Hillary E Davis
    Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive, 2303 Genome and Biomedical Sciences Facility, Davis, CA, 95616, USA
    Ann Biomed Eng 39:1-13. 2011
    ....
  6. pmc Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells
    Martin L Decaris
    Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA
    Angiogenesis 12:303-11. 2009
    ....
  7. ncbi Multifunctional cell-instructive materials for tissue regeneration
    J Kent Leach
    Department of Biomedical Engineering, University of California, Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Regen Med 1:447-55. 2006
    ..Specifically, the potential of various materials is described as it pertains to the control of cellular behavior, integration of engineered materials with host or transplanted tissue, and inductive factor presentation...
  8. doi Neurite outgrowth in fibrin gels is regulated by substrate stiffness
    Alan J Man
    Department of Biomedical Engineering, UC Davis, Davis, CA 95616, USA
    Tissue Eng Part A 17:2931-42. 2011
    ....
  9. ncbi Bone engineering by controlled delivery of osteoinductive molecules and cells
    J Kent Leach
    Department of Biomedical Engineering, University of Michigan, 5213 Dental Building, 1011 N University Ave, Ann Arbor, MI 48109 1078, USA
    Expert Opin Biol Ther 4:1015-27. 2004
    ..This review examines some of the recent developments in delivery systems used to manage the presentation of these factors at the desired site. Moreover, the authors provide suggestions for continued progress in bone regeneration...
  10. pmc Angiogenic response to bioactive glass promotes bone healing in an irradiated calvarial defect
    Ann Leu
    Department of Biomedical Engineering, University of California at Davis, Davis, California, USA
    Tissue Eng Part A 15:877-85. 2009
    ....
  11. doi Biomimetic scaffolds fabricated from apatite-coated polymer microspheres
    Hillary E Davis
    Department of Biomedical Engineering, University of California, 451 Health Sciences Drive, Davis, California 95616, USA
    J Biomed Mater Res A 90:1021-31. 2009
    ....
  12. doi Biomineralized composite substrates increase gene expression with nonviral delivery
    Rameshwar R Rao
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    J Biomed Mater Res A 94:344-54. 2010
    ..We observed increased uptake of both PEI and DNA by cells on mineralized films. The results of these studies offer an approach to modulate gene delivery and improve the potential benefit of nonviral gene delivery approaches...

Research Grants1

  1. Sequential Release of Growth Factors for Bone Formation
    Jonathan Leach; Fiscal Year: 2004
    ..Vascularization and bone formation will be compared to several control groups. ..