Loic Le Marchand

Summary

Affiliation: University of Hawaii
Country: USA

Publications

  1. pmc Reliability of KRAS mutation testing in metastatic colorectal cancer patients across five laboratories
    Heather Spencer Feigelson
    Institute for Health Research Legacy Highlands, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
    BMC Res Notes 5:196. 2012
  2. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  3. pmc Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES)
    Corina J Shtir
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Genet 10:71. 2009
  4. pmc Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    BMC Cancer 9:43. 2009
  5. ncbi request reprint The predominance of the environment over genes in cancer causation: implications for genetic epidemiology
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1037-9. 2005
  6. ncbi request reprint The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1198-203. 2005
  7. ncbi request reprint Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1319-21. 2005
  8. pmc Genome-wide association studies and colorectal cancer
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Surg Oncol Clin N Am 18:663-8. 2009
  9. ncbi request reprint Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
  10. pmc Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 19:1471-7. 2010

Research Grants

Detail Information

Publications82

  1. pmc Reliability of KRAS mutation testing in metastatic colorectal cancer patients across five laboratories
    Heather Spencer Feigelson
    Institute for Health Research Legacy Highlands, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
    BMC Res Notes 5:196. 2012
    ..We evaluated comparability and consistency of KRAS test results among five laboratories currently being used to determine KRAS mutation status of metastatic colorectal cancer specimens in a large, multi-center observational study...
  2. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  3. pmc Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES)
    Corina J Shtir
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Genet 10:71. 2009
    ..Sensitivity of ancestry estimates to relative sample size was considered...
  4. pmc Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA
    BMC Cancer 9:43. 2009
    ....
  5. ncbi request reprint The predominance of the environment over genes in cancer causation: implications for genetic epidemiology
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1037-9. 2005
  6. ncbi request reprint The MTHFR C677T polymorphism and colorectal cancer: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1198-203. 2005
    ..It also suggests that this effect may be specific to advanced colon cancer...
  7. ncbi request reprint Association of an exon 1 polymorphism in the IGFBP3 gene with circulating IGFBP-3 levels and colorectal cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1319-21. 2005
    ..95; 95% CI, 1.35-2.83) than the colon (OR, 1.16; 95% CI, 0.92-1.45). These data suggest that the exon 1 G2133C missense variant in IGFBP3 may be a susceptibility factor for colorectal cancer...
  8. pmc Genome-wide association studies and colorectal cancer
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Surg Oncol Clin N Am 18:663-8. 2009
    ..This may, in turn, have important implications for targeting high-risk individuals for colonoscopy screening...
  9. ncbi request reprint Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
    ..They also provide support for an inverse association between CYP1A2*1F and breast cancer, which is consistent with the observation of lower circulating estrogen levels in premenopausal women with the CC genotype in a previous study...
  10. pmc Associations of plasma C-peptide and IGFBP-1 levels with risk of colorectal adenoma in a multiethnic population
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 19:1471-7. 2010
    ..Circulating levels of insulin and insulin-like growth factor (IGF) hormones have been associated with colorectal cancer risk, but few studies have examined their associations with colorectal adenoma...
  11. ncbi request reprint Sun exposure, diet, and melanoma in Hawaii Caucasians
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, 96813, USA
    Am J Epidemiol 164:232-45. 2006
    ..These data provide additional evidence for the association of constitutional susceptibility factors, intense sun exposure (particularly before age 20 years), and alcohol consumption with melanoma risk...
  12. doi request reprint Association of plasma vitamin B6 with risk of colorectal adenoma in a multiethnic case-control study
    Loic Le Marchand
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA
    Cancer Causes Control 22:929-36. 2011
    ..This study expands previous findings and suggests that vitamin B6 may be protective against the early stages of colorectal carcinogenesis...
  13. ncbi request reprint MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 13:2071-7. 2004
    ..This is consistent with the role of MTHFR in facilitating the flow of folate for thymidylate and purine synthesis and with the increased nucleic acid need resulting from the hyperproliferative effect of HRT on mammary epithelial cells...
  14. pmc Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:2195-201. 2009
    ..An inverse association with plasma folate was also observed among individuals with a low level of alcohol intake. These data suggest an independent role for vitamin B6 in reducing colorectal cancer risk...
  15. ncbi request reprint Intake of flavonoids and lung cancer
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    J Natl Cancer Inst 92:154-60. 2000
    ..To investigate the possible relationship between intake of flavonoids-powerful dietary antioxidants that may also inhibit P450 enzymes-and lung cancer risk, we conducted a population-based, case-control study in Hawaii...
  16. ncbi request reprint Association of a common polymorphism in the human GH1 gene with colorectal neoplasia
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    J Natl Cancer Inst 94:454-60. 2002
    ..Because a T-to-A polymorphism in the human GH1 gene at position 1663 is putatively associated with lower levels of GH and IGF-I, we investigated the relationship of this polymorphism to the risk of colorectal neoplasia...
  17. ncbi request reprint Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens
    L Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Res 58:4858-63. 1998
    ....
  18. doi request reprint Design considerations for genomic association studies: importance of gene-environment interactions
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 17:263-7. 2008
  19. ncbi request reprint Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 14:339-46. 2003
    ....
  20. ncbi request reprint Association of the cyclin D1 A870G polymorphism with advanced colorectal cancer
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    JAMA 290:2843-8. 2003
    ..A common adenine-to-guanine substitution polymorphism (A870G) in the CCND1 gene results in an altered messenger RNA transcript and a longer-life protein, which are preferentially encoded by the A allele...
  21. ncbi request reprint T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA
    Cancer Epidemiol Biomarkers Prev 13:412-5. 2004
    ..Given the strong biological rationale and the scarce and divergent epidemiologic data to date, additional investigations of the relationship between breast cancer and genetic variants in the TGF-beta signaling pathway appear warranted...
  22. pmc Association of plasma micronutrient levels and urinary isoprostane with risk of lung cancer: the multiethnic cohort study
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:1962-70. 2009
    ..Future research examining the possible relationship between isoprostanes and lung cancer is warranted...
  23. ncbi request reprint Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population
    Simona Ognjanovic
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 21:1131-8. 2010
    ....
  24. pmc Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study
    Ute Nöthlings
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:2098-106. 2009
    ..We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer risk...
  25. pmc Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA
    Hum Genet 128:165-77. 2010
    ..The bias may be large in case-only analysis of gene by gene interactions but it can be corrected by top PCs derived from all SNPs...
  26. pmc Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer
    Kiersten S Derby
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 17:3526-35. 2008
    ..The particularly low nicotine metabolism of Japanese smokers may contribute to their previously described decreased lung cancer risk...
  27. doi request reprint Heterocyclic amine intake, smoking, cytochrome P450 1A2 and N-acetylation phenotypes, and risk of colorectal adenoma in a multiethnic population
    Jenna Voutsinas
    Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Gut 62:416-22. 2013
    ..This study tested the hypotheses that well-done meat and cigarette smoking increase the risk of adenoma, the precursor to most colorectal cancers, especially in individuals with rapid CYP1A2 and rapid NAT2 activities...
  28. ncbi request reprint Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street Suite 407, Honolulu, HI 96813, USA
    Mutat Res 506:205-14. 2002
    ..An attempt to examine the risk associated with specific HAAs suggested that the main HAAs increase risk of rectal cancer in men and that they do not appreciably affect risk of rectal cancer in women or of colon cancer in either sex...
  29. pmc Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R49. 2009
    ..This multiethnic nested case-control study sought to examine the association of plasma carotenoids, retinol, and tocopherols with postmenopausal breast cancer risk...
  30. pmc Erythrocyte membrane fatty acid composition, serum lipids, and non-Hodgkin's lymphoma risk in a nested case-control study: the multiethnic cohort
    Yukiko Morimoto
    University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Causes Control 23:1693-703. 2012
    ..Composition of dietary fatty acid intake, which influences cytokine production, may contribute to the development of non-Hodgkin's lymphoma (NHL). Serum lipid levels may serve as biomarkers of inflammation associated with NHL risk...
  31. pmc Plasma matrix metalloproteinases and postmenopausal breast cancer risk: a nested case-control study in the Multiethnic Cohort study
    Yeonju Kim
    Epidemiology Program, University of Hawai i Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res Treat 136:837-45. 2012
    ..05). Few significant differences in risk by levels of the MMPs were found by any of the clinical variables. Circulating MMPs were not associated with postmenopausal breast cancer risk...
  32. pmc Susceptibility variants for waist size in relation to abdominal, visceral, and hepatic adiposity in postmenopausal women
    Unhee Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    J Acad Nutr Diet 112:1048-55. 2012
    ..If replicated, these genetic variants can be incorporated with other biomarkers to predict high-risk body fat distribution...
  33. pmc IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort
    Martijn Verheus
    Epidemiology Program, Cancer Research Center of Hawaii, Honolulu, HI
    Int J Cancer 127:1115-23. 2010
    ..Given the large number of SNPs tested and the few borderline significant results, we only found weak evidence that genetic variations in IGFBP1 or IGFBP3 may be related to mammographic density. Ethnicity may modify these relations...
  34. pmc Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Carcinogenesis 32:203-9. 2011
    ..This study suggests that the genomic region around ARNT rs12410394 may harbor variants associated with CRC...
  35. pmc Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies
    Unhee Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Int J Cancer 131:E1038-43. 2012
    ..No heterogeneity was observed across race/ethnic groups. Our findings suggest that the obesity risk variants are not likely to affect the risk of colorectal cancer substantially...
  36. pmc Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort Study
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:314-20. 2009
    ..The results suggest that further studies, with larger numbers, examining a possible interaction with the GSTP1 polymorphisms are warranted...
  37. ncbi request reprint B-vitamin intake, metabolic genes, and colorectal cancer risk (United States)
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Cancer Causes Control 13:239-48. 2002
    ....
  38. ncbi request reprint Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women
    Galina Lurie
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1521-7. 2005
    ..37 versus 1.76; P = 0.002). These data suggest that CYP1A2*1F is associated with lower circulating levels of E2, and that it may be a susceptibility locus for breast cancer...
  39. ncbi request reprint Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 11:409-12. 2002
    ..These data suggest that the presence of two hOGG1 326Cys alleles confers a 2-fold increased risk of lung cancer. Additional studies need to be conducted to confirm this association...
  40. pmc Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study
    Sungshim Lani Park
    Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Am J Epidemiol 178:780-90. 2013
    ..0823 kg/m(2), 95% confidence interval: 0.0559, 0.1128). Our data provide additional evidence that the association of FTO with obesity is partially mediated by dietary intake. ..
  41. pmc Dietary choline and betaine intakes vary in an adult multiethnic population
    Kim M Yonemori
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
    J Nutr 143:894-9. 2013
    ..0001), largely due to the variation in energy intake. Our findings demonstrate the feasibility of assessing choline and betaine intake and characterize the variation in intake that exists in a multiethnic population...
  42. pmc Risk factors for malignant melanoma in white and non-white/non-African American populations: the multiethnic cohort
    Sungshim Lani Park
    Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Prev Res (Phila) 5:423-34. 2012
    ..015). In conclusion, similar to whites, age at cohort entry, male sex, and susceptibility to sunburn phenotypes may be predictive of malignant melanoma risk in non-white populations excluding African Americans...
  43. pmc Urinary phytoestrogen excretion and postmenopausal breast cancer risk: the multiethnic cohort study
    Marc T Goodman
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Prev Res (Phila) 2:887-94. 2009
    ..07). Our results provide some support to the hypothesis that a diet rich in isoflavones from soy products reduces the risk of postmenopausal breast cancer, particularly in populations with comparatively high excretion of phytoestrogens...
  44. pmc Prediagnostic leptin, adiponectin, C-reactive protein, and the risk of postmenopausal breast cancer
    Nicholas J Ollberding
    University of Hawaii Cancer Center, Epidemiology Program, 1236 Lauhala St, Honolulu, HI 96813, USA
    Cancer Prev Res (Phila) 6:188-95. 2013
    ..Further prospective studies examining the role of adipokines and inflammatory processes in the etiology of postmenopausal breast cancer are warranted. Cancer Prev Res; 6(3); 188-95. ©2013 AACR...
  45. pmc Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort
    Yumie Takata
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI, USA
    BMC Cancer 7:30. 2007
    ..This cross-sectional analysis examined the relation between mammographic density and the CYP1A2*1F and COMT Val58 Met polymorphisms among 332 breast cancer cases and 254 controls in the Hawaii component of the Multiethnic Cohort...
  46. pmc Plasma sex hormone concentrations and breast cancer risk in an ethnically diverse population of postmenopausal women: the Multiethnic Cohort Study
    Christy G Woolcott
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
    Endocr Relat Cancer 17:125-34. 2010
    ..This study provides the best evidence to date that the association between sex hormones and breast cancer risk is generalizable to an ethnically diverse population...
  47. doi request reprint Plasma coenzyme Q10 levels and prostate cancer risk: the multiethnic cohort study
    Weiwen Chai
    Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 20:708-10. 2011
    ..We examined the association of circulating CoQ10 levels with prostate cancer risk, using prediagnostic blood samples...
  48. pmc Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Res 68:9137-40. 2008
    ..Number of cigarettes per day, even if it could be accurately assessed, is not an adequate measure of smoking dose...
  49. doi request reprint Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies
    Iona Cheng
    Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96817, USA
    Gut 60:1703-11. 2011
    ..Diabetes has been positively associated with the risk of colorectal cancer. This study investigated whether recently established risk variants for diabetes also have effects on colorectal cancer...
  50. pmc Non-hodgkin lymphoma and circulating markers of inflammation and adiposity in a nested case-control study: the multiethnic cohort
    Shannon M Conroy
    Corresponding author Gertraud Maskarinec, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 22:337-47. 2013
    ..We examined the association of prediagnostic inflammatory markers and adipokines with NHL risk...
  51. pmc Predicting total, abdominal, visceral and hepatic adiposity with circulating biomarkers in Caucasian and Japanese American women
    Unhee Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
    PLoS ONE 7:e43502. 2012
    ..Characterization of abdominal and intra-abdominal fat requires imaging, and thus is not feasible in large epidemiologic studies...
  52. pmc Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort
    Christy G Woolcott
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Breast Cancer Res 11:R10. 2009
    ..Mammographic density is a strong risk factor for breast cancer. Our objective was to examine its association with polymorphisms identifying breast cancer susceptibility loci that were ascertained in recent genome-wide association studies...
  53. pmc Plasma 25-hydroxyvitamin D levels and the risk of colorectal cancer: the multiethnic cohort study
    Christy G Woolcott
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 19:130-4. 2010
    ..46). In summary, this study provides evidence of an association between vitamin D status and reduced risk of colorectal cancer in an ethnically diverse population...
  54. ncbi request reprint Trends of breast cancer incidence and risk factor prevalence over 25 years
    Gertraud Maskarinec
    Cancer Research Center, Honolulu, HI 96813, USA
    Breast Cancer Res Treat 98:45-55. 2006
    ..To examine the trends in the prevalence of breast cancer risk factors in relation to breast cancer incidence trends and to explore whether the changes in risk factors differed by ethnicity in Hawaii over a 25-year period...
  55. ncbi request reprint Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer
    Lenora W M Loo
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Genes Chromosomes Cancer 52:450-66. 2013
    ..The results from our integration analysis illustrate the complex relationship between genomic alterations and gene expression in colon cancer...
  56. pmc Meat consumption, heterocyclic amines and colorectal cancer risk: the Multiethnic Cohort Study
    Nicholas J Ollberding
    University of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI 96813, USA
    Int J Cancer 131:E1125-33. 2012
    ..Although our results do not support a role for meat or for HCAs from meat in the etiology of colorectal cancer, we cannot rule out the possibility of a modest effect...
  57. ncbi request reprint Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 11:1019-24. 2002
    ..These data provide additional support for the hypothesis that nitrosamines are carcinogenic to the rectum in humans and that RM and, in particular, PMs are significant sources of exposure for these compounds...
  58. pmc Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer
    Kiersten S Derby
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 125:2418-24. 2009
    ..Thus, exposure and detoxification of NNK are unlikely to explain, by themselves, the differences in LC risk among the 3 populations studied...
  59. pmc IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study
    Iona Cheng
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 18:1922-4. 2009
    ..None of these missense SNPs were significantly associated with breast cancer risk. Our findings provide no evidence that missense SNPs in IGF2R influence breast cancer susceptibility..
  60. ncbi request reprint Ethnic differences in trends and determinants of cigarette smoking in Hawaii
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, Hawaii 96813, USA
    Ethn Dis 15:316-23. 2005
    ..The goal of this project was to investigate the trends and predictors of cigarette smoking among a population of Caucasians, Japanese, Chinese, Filipino, and Native Hawaiians...
  61. ncbi request reprint Dietary fiber and colorectal cancer risk: the multiethnic cohort study
    Abraham M Y Nomura
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 18:753-64. 2007
    ..To investigate the association of dietary fiber with colorectal cancer..
  62. doi request reprint Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia
    Barbara S Saltzman
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Res 68:1236-44. 2008
    ..These results suggest that a haplotype containing SNP rs11466345 at the 3' end of TGFB1 is associated with genetic susceptibility to colorectal neoplasia...
  63. pmc Plasma coenzyme Q10 levels and postmenopausal breast cancer risk: the multiethnic cohort study
    Weiwen Chai
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 19:2351-6. 2010
    ..We examined the association of plasma CoQ10 levels with postmenopausal breast cancer risk using prospectively collected blood samples...
  64. pmc Circulating fatty acids and prostate cancer risk in a nested case-control study: the Multiethnic Cohort
    Song Yi Park
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Causes Control 20:211-23. 2009
    ..Dietary fat, including specific fatty acids, has been proposed to contribute to prostate cancer pathogenesis, but findings from the studies based on biomarkers have been conflicting...
  65. ncbi request reprint Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case-control study in the multiethnic cohort study
    Yeonju Kim
    Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    BMC Cancer 14:29. 2014
    ..The objective of this study was to examine the relation between plasma levels of vitamin D and the risk of postmenopausal breast cancer...
  66. pmc Evaluating genetic risk for prostate cancer among Japanese and Latinos
    Iona Cheng
    Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 21:2048-58. 2012
    ..In addition, we tested prostate cancer risk variants and developed genetic risk models of prostate cancer for Japanese and Latinos...
  67. ncbi request reprint Tobacco smoking increases risk of colorectal cancer
    Margreet Lüchtenborg
    Epidemiology Program, Cancer Research Center of Hawai i, USA
    Hawaii Med J 66:137, 139. 2007
  68. pmc Prediagnostic circulating carotenoid levels and the risk of non-Hodgkin lymphoma: the Multiethnic Cohort
    Nicholas J Ollberding
    University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Blood 119:5817-23. 2012
    ..These data provide support for a protective role of carotenoid-rich fruits and vegetables in the etiology of NHL...
  69. ncbi request reprint Trends and dietary determinants of overweight and obesity in a multiethnic population
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, 96813, USA
    Obesity (Silver Spring) 14:717-26. 2006
    ..To describe trends in BMI among different ethnic groups in Hawaii and to explore the relation of nutrient and food intake with excess weight...
  70. pmc Association of maternal and intrauterine characteristics with age at menarche in a multiethnic population in Hawaii
    Meira Epplein
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, HI, USA
    Cancer Causes Control 21:259-68. 2010
    ..18, 95% CI: 0.95-4.98); there was no association with second-degree family history. These findings support the hypothesis that maternal and intrauterine hormone-related exposures are associated with age at menarche...
  71. ncbi request reprint An investigation of mammographic density and gene variants in healthy women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 112:683-8. 2004
    ..Our data suggest lower mammographic density for women carrying the COMT and CYP1A2 variant alleles than for women carrying the common alleles, though this is the opposite of what is commonly hypothesized from the enzyme function...
  72. ncbi request reprint NAT2, meat consumption and colorectal cancer incidence: an ecological study among 27 countries
    Simona Ognjanovic
    Epidemiology Program, Cancer Research Center of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Causes Control 17:1175-82. 2006
    ..These data suggest that, in combination with meat intake, some proportion of the international variability in CRC incidence may be attributable to genetic susceptibility to heterocyclic amines, as determined by NAT2 genotype...
  73. doi request reprint Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study
    Nicholas J Ollberding
    University of Hawaii Cancer Center, Epidemiology Program, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 21:810-20. 2012
    ..Increased exposure of colonic and rectal epithelial cells to the promitotic and antiapoptotic effects of insulin and insulin-like growth factors (IGF) is hypothesized to increase colorectal cancer risk...
  74. pmc Association of selenium, tocopherols, carotenoids, retinol, and 15-isoprostane F(2t) in serum or urine with prostate cancer risk: the multiethnic cohort
    Jasmeet K Gill
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 20:1161-71. 2009
    ..We examine the association of antioxidants and 15-isoprostane F(2t) with risk of prostate cancer...
  75. pmc Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma
    Sungshim Lani Park
    Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Causes Control 22:1267-75. 2011
    ..6, 95% CI: 1.0-13; p (interaction) = 0.0035). Our findings observed here between serum IGF-I and malignant melanoma warrants replication in studies with a larger sample size and a prospective design...
  76. doi request reprint Development of a quantitative food frequency questionnaire for assessing food, nutrient, and heterocyclic aromatic amines intake in Japanese Brazilians for a colorectal adenoma case-control study
    Sangita Sharma
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, USA
    Int J Food Sci Nutr 60:128-39. 2009
    ..To develop of a quantitative food frequency questionnaire (QFFQ) to assess intake of specific foods, nutrients and heterocyclic aromatic amines (HAAs) in a case-control study of colorectal adenoma...
  77. ncbi request reprint Smoking and colorectal cancer: different effects by type of cigarettes?
    Margreet Lüchtenborg
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Suite 407, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 16:1341-7. 2007
    ..The data from this large study corroborate previous reports of a positive association between smoking and colorectal cancer and suggest that the association may vary by type of cigarette...
  78. pmc The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women
    Galina Lurie
    Cancer Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America
    PLoS ONE 6:e16756. 2011
    ....
  79. pmc cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue
    Lenora W M Loo
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
    PLoS ONE 7:e30477. 2012
    ....
  80. pmc Asian adolescents have a higher trunk:peripheral fat ratio than Whites
    Rachel Novotny
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, 96813, USA
    J Nutr 136:642-7. 2006
    ..In conclusion, Asian adolescents have a higher trunk:peripheral fat ratio than Whites. Adolescent bi-iliac breadth (positively) and birthweight (negatively) are associated with more body fat on the trunk vs. periphery during adolescence...
  81. ncbi request reprint Do Japanese have an increased susceptibility to colorectal cancer?
    Loic Le Marchand
    Epidemiology Program, Cancer Research Center of Hawai i, University of Hawai i, USA
    Hawaii Med J 65:296-7. 2006
  82. ncbi request reprint Cancer preventive effects of flavonoids--a review
    Loic Le Marchand
    Epidemiology Section, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Biomed Pharmacother 56:296-301. 2002
    ..This review focuses on the biological effects of the main flavonoids, as well as the epidemiologic evidence that support their potential cancer protective properties...

Research Grants33

  1. Whole Genome Scan for Modifier Genes in Colorectal Cancer
    Loic Le Marchand; Fiscal Year: 2009
    ..The study will generate a better biological understanding of the disease on which to base new prevention and therapeutic approaches. ..
  2. The TGFbeta Pathway, Gene Variants and Colorectal Neopl*
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  3. Case-Control Study of Adenoma in Sao Paulo Japanese
    Loic Le Marchand; Fiscal Year: 2007
    ....
  4. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2007
    ..abstract_text> ..
  5. Hawaii Colorectal Cancer Family Registry
    Loic Le Marchand; Fiscal Year: 2007
    ..par \par } ..
  6. Whole Genome Scan for Modifier Genes in Colorectal Cancer
    Loic Le Marchand; Fiscal Year: 2009
    ..The study will generate a better biological understanding of the disease on which to base new prevention and therapeutic approaches. ..
  7. Inflammation and Innate Immunity Genes and Colorectal Cancer Risk
    Loic Le Marchand; Fiscal Year: 2009
    ..It may also provide a means to identify susceptible sub-groups which may particularly benefit from intensive screening and/or primary prevention with non-steroidal inflammatory drugs. ..
  8. Whole Genome Scan for Modifier Genes in Colorectal Cancer
    Loic Le Marchand; Fiscal Year: 2010
    ..The study will generate a better biological understanding of the disease on which to base new prevention and therapeutic approaches. ..
  9. Inflammation and Innate Immunity Genes and Colorectal Cancer Risk
    Loic Le Marchand; Fiscal Year: 2010
    ..It may also provide a means to identify susceptible sub-groups which may particularly benefit from intensive screening and/or primary prevention with non-steroidal inflammatory drugs. ..
  10. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2006
    ..abstract_text> ..
  11. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2006
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  12. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2005
    ..abstract_text> ..
  13. DIET, GENETIC SUSCEPTIBILITY AND COLORECTAL ADENOMAS
    Loic Le Marchand; Fiscal Year: 1999
    ..Allele-specific PCR amplification will also be used to identify mutations at codons 12 and 13 of the K-ras gene in tumor tissue from the cases. DNA will also be stored for future examination of other germline and somatic mutations. ..
  14. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2000
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  15. DIET, GENETIC SUSCEPTIBILITY AND COLORECTAL ADENOMAS
    Loic Le Marchand; Fiscal Year: 2000
    ..Allele-specific PCR amplification will also be used to identify mutations at codons 12 and 13 of the K-ras gene in tumor tissue from the cases. DNA will also be stored for future examination of other germline and somatic mutations. ..
  16. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2001
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  17. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2002
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  18. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2002
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  19. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2003
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  20. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2003
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  21. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2004
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..
  22. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..The elucidation of the main enzymes responsible for carcinogen activation and of the impact of dietary factors on these enzymes would have important implications for cancer prevention. ..
  23. Ethnic/Racial Minorities in the Colon CFR
    Loic Le Marchand; Fiscal Year: 2004
    ..abstract_text> ..
  24. Diet, Genetic Susceptibility and Colorectal Neoplasia
    Loic Le Marchand; Fiscal Year: 2005
    ..Genotyping for random markers will permit to exclude residual confounding by ethnicity. ..