Chap T Le

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint A solution for the most basic optimization problem associated with an ROC curve
    Chap T Le
    School of Public Health, Division of Biostatistics and Cancer Center, University of Minnesota, MMC 303, Minneapolis 55455, USA
    Stat Methods Med Res 15:571-84. 2006
  2. ncbi request reprint Quality control and the identification of vaccine responders using ELISA-derived antibody data
    Chap T Le
    School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Stat Med 22:2935-42. 2003
  3. ncbi request reprint Design and analysis of in vitro experiments for combination chemotherapy
    T Le Chap
    School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biopharm Stat 15:179-86. 2005
  4. ncbi request reprint Estimation of cancer drug potencies and relative potencies from in vitro data
    T Le Chap
    Division of Biostatistics, University of Minnesota, School of Public Health, Minneapolis, Minnesota 55455, USA
    J Biopharm Stat 15:903-12. 2005
  5. doi request reprint Cap-dependent translation blockade and fixed dose-rate gemcitabine: interaction in an in vitro bioreactor system
    Brent W Williams
    Department of Experimental and Clinical Pharmacology, College of Pharmacy and Comprehensive Cancer Center, University of Minnesota, 717 Delaware St SE, Minneapolis, MN 55414, USA
    Cancer Lett 284:37-46. 2009
  6. ncbi request reprint Relationships between cigarette consumption and biomarkers of tobacco toxin exposure
    Anne M Joseph
    Section of General Internal Medicine 111 0, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Cancer Epidemiol Biomarkers Prev 14:2963-8. 2005
  7. ncbi request reprint Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplants
    Navneet S Majhail
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:985-92. 2008
  8. pmc Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
    Sarah Cooley
    University of Minnesota, Minneapolis, USA
    Blood 113:726-32. 2009
  9. ncbi request reprint Toxicant exposure in cigarette reducers versus light smokers
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 15:2355-8. 2006
  10. ncbi request reprint Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation
    Jeffrey S Miller
    Divisions of Medical and Pediatric Hematology Oncology and Transplantation, The Blood and Marrow Transplant Program, Department of Biostatistics, and The University of Minnesota Cancer Center, MN 55455, USA
    Clin Immunol 117:144-51. 2005

Detail Information

Publications26

  1. ncbi request reprint A solution for the most basic optimization problem associated with an ROC curve
    Chap T Le
    School of Public Health, Division of Biostatistics and Cancer Center, University of Minnesota, MMC 303, Minneapolis 55455, USA
    Stat Methods Med Res 15:571-84. 2006
    ..The difficulty lies in our failure to define and justify a criterion for optimality. In this paper, we will propose a solution by maximizing a well-known parameter--the Youden's Index--within the framework of the ROC curve...
  2. ncbi request reprint Quality control and the identification of vaccine responders using ELISA-derived antibody data
    Chap T Le
    School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Stat Med 22:2935-42. 2003
    ..The goal is to show that these two issues are inter-related, so that investigators could reduce misclassification which would interfere with the eventual comparison of immunogenicity results...
  3. ncbi request reprint Design and analysis of in vitro experiments for combination chemotherapy
    T Le Chap
    School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biopharm Stat 15:179-86. 2005
    ..We then propose a statistical framework, a simple experimental design, and a statistical test for use with this widely accepted methodology. The test we propose is a score test based on the linear logistic regression model...
  4. ncbi request reprint Estimation of cancer drug potencies and relative potencies from in vitro data
    T Le Chap
    Division of Biostatistics, University of Minnesota, School of Public Health, Minneapolis, Minnesota 55455, USA
    J Biopharm Stat 15:903-12. 2005
    ..A simulation study illustrates substantial gains in efficiency in the estimation of the median effective dose...
  5. doi request reprint Cap-dependent translation blockade and fixed dose-rate gemcitabine: interaction in an in vitro bioreactor system
    Brent W Williams
    Department of Experimental and Clinical Pharmacology, College of Pharmacy and Comprehensive Cancer Center, University of Minnesota, 717 Delaware St SE, Minneapolis, MN 55414, USA
    Cancer Lett 284:37-46. 2009
    ..We conclude that cap-dependent translation blockade and fixed dose rate infusion gemcitabine treatment results in a significant interaction affecting cell viability in vitro...
  6. ncbi request reprint Relationships between cigarette consumption and biomarkers of tobacco toxin exposure
    Anne M Joseph
    Section of General Internal Medicine 111 0, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Cancer Epidemiol Biomarkers Prev 14:2963-8. 2005
    ....
  7. ncbi request reprint Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplants
    Navneet S Majhail
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:985-92. 2008
    ..The HCT-CI, although a useful tool for capturing pretransplant comorbidity and risk-assessment, needs to be further validated prior to adopting it for routine clinical use...
  8. pmc Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia
    Sarah Cooley
    University of Minnesota, Minneapolis, USA
    Blood 113:726-32. 2009
    ..KIR genotyping of prospective donors, in addition to HLA typing, should be performed to identify HLA-matched donors with B KIR haplotypes...
  9. ncbi request reprint Toxicant exposure in cigarette reducers versus light smokers
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 15:2355-8. 2006
    ..The goal of this study is to investigate the occurrence of compensatory smoking in reducers compared with light smokers by measuring toxicant exposure...
  10. ncbi request reprint Diminished neo-antigen response to keyhole limpet hemocyanin (KLH) vaccines in patients after treatment with chemotherapy or hematopoietic cell transplantation
    Jeffrey S Miller
    Divisions of Medical and Pediatric Hematology Oncology and Transplantation, The Blood and Marrow Transplant Program, Department of Biostatistics, and The University of Minnesota Cancer Center, MN 55455, USA
    Clin Immunol 117:144-51. 2005
    ..KLH vaccines are safe and require only a single injection to test neo-antigen responses providing an optimal platform for definitive testing of strategies to improve diminished immune recovery after chemotherapy or post-HCT...
  11. pmc Model-based cluster analysis of microarray gene-expression data
    Wei Pan
    Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
    Genome Biol 3:RESEARCH0009. 2002
    ..Here, we introduce and illustrate its use in detecting differentially expressed genes. In particular, we do not cluster gene-expression patterns but a summary statistic, the t-statistic...
  12. ncbi request reprint A mixture model approach to detecting differentially expressed genes with microarray data
    Wei Pan
    Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo, MMC 303, 420 Delaware Street SE, Minneapolis, MN 55455 0378, USA
    Funct Integr Genomics 3:117-24. 2003
    ..Several methods are proposed to effectively control the false positives. The methodology is applied to a data set containing expression levels of 1,176 genes of rats with and without pneumococcal middle ear infection...
  13. ncbi request reprint Preliminary study on reducing oral moist snuff use
    Dorothy K Hatsukami
    University of Minnesota, Tobacco Use Research Center, 2701 University Ave SE, 210, Minneapolis 55414, USA
    Drug Alcohol Depend 70:215-20. 2003
    ..This pilot study examined whether reducing ST use using various methods can be achieved and whether this reduction results in lower exposure to carcinogens...
  14. pmc How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
    Wei Pan
    Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455 0378, USA
    Genome Biol 3:research0022. 2002
    ..Here, we discuss how to calculate the number of replicates in the context of applying a nonparametric statistical method, the normal mixture model approach, to detect changes in gene expression...
  15. ncbi request reprint Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial
    Anne M Joseph
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    Nicotine Tob Res 10:471-81. 2008
    ..These results emphasize the importance of abstinence for smokers with heart disease to minimize health risks from tobacco...
  16. ncbi request reprint Some statistical methods for investigating the date of birth as a disease indicator
    Chap T Le
    School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    Stat Med 22:2127-35. 2003
    ....
  17. pmc Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia
    Sarah Cooley
    Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 116:2411-9. 2010
    ..Adopting this practice could result in superior disease-free survival for patients with AML...
  18. pmc Effect of cigarette smoking on urinary 2-hydroxypropylmercapturic acid, a metabolite of propylene oxide
    Adam T Zarth
    Masonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN 55455, USA Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 953:126-31. 2014
    ..The method presented here can be used to rapidly quantify an individual's exposure to propylene oxide via tobacco smoke or other sources. ..
  19. ncbi request reprint Short versus continuous gemcitabine treatment of non-small cell lung cancer in an in vitro cell culture bioreactor system
    Mark N Kirstein
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Lung Cancer 58:196-204. 2007
    ..0085). In conclusion, gemcitabine infused by this novel method induced apoptosis after both the short and continuous infusions, and long-term survival was significantly diminished following continuous compared with the short infusion...
  20. pmc A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers
    Timothy R Church
    Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 18:260-6. 2009
    ..Its metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), have been studied as biomarkers of exposure to NNK. We studied the relation of prospectively measured NNK biomarkers to lung cancer risk...
  21. pmc Analysis of 4-Hydroxy-1-(3-pyridyl)-1-butanone (HPB)-Releasing DNA Adducts in Human Exfoliated Oral Mucosa Cells by Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
    Irina Stepanov
    Masonic Cancer Center and Division of Environmental Health Sciences, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 26:37-45. 2013
    ..73, p < 0.0001). Potentially, the method can be applied in studies of individual susceptibility to tobacco-induced cancers in humans. ..
  22. doi request reprint Analysis of cigarette purchase task instrument data with a left-censored mixed effects model
    Wenjie Liao
    Division of Biostatistics, School of Public Health and Department of Sociology, University of Minnesota, USA
    Exp Clin Psychopharmacol 21:124-32. 2013
    ..Theoretical implications of the findings, limitations of the proposed method, and future directions of research are also discussed...
  23. ncbi request reprint Efficacy of an osmotic pump delivered, GM-CSF-based tumor vaccine in the treatment of upper aerodigestive squamous cell carcinoma in rats
    Hamid R Djalilian
    Department of Otolaryngology, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Immunol Immunother 56:1207-14. 2007
    ..We presently tested the efficacy of granulocyte macrophage-colony stimulating factor (GM-CSF) delivered via 28-day continuous infusion pump, in combination with irradiated tumor cells, in a flank model of UADT cancer...
  24. ncbi request reprint Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen
    Daniel E Keyler
    Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Biochem Pharmacol 69:1385-95. 2005
    ..These data comment on the safety of vaccination against nicotine during pregnancy, and suggest that vaccination may reduce the distribution of nicotine to fetal brain under some nicotine dosing conditions...
  25. pmc Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions
    Ebbing P de Jong
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS ONE 5:e11148. 2010
    ..A test for proteins, ones found in non-invasively-collected whole saliva and whose abundances distinguish these lesion types, would meet this critical need...
  26. ncbi request reprint Purulent otitis media in children and adults
    Muhammet Tekin
    The Otitis Media Research Center, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, USA
    Eur Arch Otorhinolaryngol 259:67-72. 2002
    ..Our findings suggest the need to monitor children carefully under the age of 2 years who have POM...