Orly Lazarov

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc All in the Family: How the APPs Regulate Neurogenesis
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago Chicago, IL, USA
    Front Neurosci 6:81. 2012
  2. pmc Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking fMRP
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Hippocampus 22:1220-4. 2012
  3. pmc When neurogenesis encounters aging and disease
    Orly Lazarov
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA
    Trends Neurosci 33:569-79. 2010
  4. pmc Neurogenesis and Alzheimer's disease: at the crossroads
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, 808 S Wood St M C 512, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Neurol 223:267-81. 2010
  5. pmc Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation
    Michael P Demars
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurobiol Aging 34:2431-40. 2013
  6. pmc Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling
    Yuan Shih Hu
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA
    PLoS ONE 8:e64460. 2013
  7. pmc Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice
    Yuan Shih Hu
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    FASEB J 24:1667-81. 2010
  8. pmc Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice
    Michael Demars
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neurosci Res 88:2103-17. 2010
  9. pmc Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation
    Se Hoon Choi
    Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Neuron 59:568-80. 2008
  10. pmc Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
    Orly Lazarov
    Department of Anatomy and Cell Biology, The University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 27:7011-20. 2007

Detail Information

Publications19

  1. pmc All in the Family: How the APPs Regulate Neurogenesis
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago Chicago, IL, USA
    Front Neurosci 6:81. 2012
    ..This review will discuss the implications of the role of the APP family in neurogenesis for neuronal development, cognitive function, and brain disorders that compromise learning and memory, such as AD...
  2. pmc Impaired survival of neural progenitor cells in dentate gyrus of adult mice lacking fMRP
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Hippocampus 22:1220-4. 2012
    ..Impaired adult neurogenesis may underlie, at least in part, the learning deficits that characterize fragile X syndrome...
  3. pmc When neurogenesis encounters aging and disease
    Orly Lazarov
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA
    Trends Neurosci 33:569-79. 2010
    ..In addition, manipulation of endogenous neural stem cells and stem cell transplantation, as stand-alone or adjunct treatments, seems promising...
  4. pmc Neurogenesis and Alzheimer's disease: at the crossroads
    Orly Lazarov
    Department of Anatomy and Cell Biology, College of Medicine, 808 S Wood St M C 512, University of Illinois at Chicago, Chicago, IL 60612, USA
    Exp Neurol 223:267-81. 2010
    ....
  5. pmc Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation
    Michael P Demars
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    Neurobiol Aging 34:2431-40. 2013
    ..These observations suggest that adulthood is an appropriate time window for an intervention that upregulates neurogenesis, such as enhancement of sAPPα levels, for the prevention of declining brain plasticity and cognitive function. ..
  6. pmc Molecular mechanisms of environmental enrichment: impairments in Akt/GSK3β, neurotrophin-3 and CREB signaling
    Yuan Shih Hu
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA
    PLoS ONE 8:e64460. 2013
    ..However, in FAD mice, some of these pathways are impaired and cannot be rescued by environmental enrichment...
  7. pmc Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 mice
    Yuan Shih Hu
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    FASEB J 24:1667-81. 2010
    ..This study suggests that environmental modulation can rescue the impaired phenotype of the Alzheimer's brain and that induction of brain plasticity may represent therapeutic and preventive avenues in AD...
  8. pmc Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice
    Michael Demars
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60612, USA
    J Neurosci Res 88:2103-17. 2010
    ..Finally, hyperphosphorylation of the microtubule-associated protein tau, a critical player in cell proliferation, neuronal maturation, and axonal transport, is a major contributor to impaired neurogenesis in Alzheimer's disease...
  9. pmc Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation
    Se Hoon Choi
    Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Neuron 59:568-80. 2008
    ....
  10. pmc Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1
    Orly Lazarov
    Department of Anatomy and Cell Biology, The University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 27:7011-20. 2007
    ..Together, our data suggests that defects in anterograde FAT may underlie FAD-linked PS1-mediated neurodegeneration through a mechanism involving impairments in neurotrophin signaling and synaptic dysfunction...
  11. ncbi request reprint Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice
    Sylvia E Perez
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosci 25:10220-9. 2005
    ..These findings show a close association between amyloid deposition and nigrostriatal pathology and suggest that altered FAD-linked amyloid metabolism impairs, at least in part, the function of dopaminergic neurons...
  12. ncbi request reprint Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA
    Cell 120:701-13. 2005
    ....
  13. ncbi request reprint Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex
    Orly Lazarov
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 26:429-34. 2006
    ..We conclude that expression of FAD-linked mutant PS1 variants enhances the vulnerability of neurons in the entorhinal cortex to PP lesion-induced cytotoxicity...
  14. pmc Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
    Michael P Demars
    Department of Anatomy and Cell Biology, The University of Illinois at Chicago, 808 S Wood St, RM, 572 Chicago, IL 60612, USA
    Stem Cell Res Ther 2:36. 2011
    ..While a previous study implicates sAPPα in the regulation of neural progenitor cell proliferation in the subventricular zone of adult mice, the ubiquitous expression of APP suggests that its role as a growth factor might be broader...
  15. pmc Presenilin-1 regulates neural progenitor cell differentiation in the adult brain
    Archana Gadadhar
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Neurosci 31:2615-23. 2011
    ..These findings suggest a physiological role for PS1 in adult neurogenesis, and a potential target for the manipulation of neural progenitor cell differentiation...
  16. pmc DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects
    Sylvia E Perez
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosci Res 88:1026-40. 2010
    ..Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in reducing brain insults in female AD patients...
  17. ncbi request reprint Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 22:9785-93. 2002
    ....
  18. ncbi request reprint Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:2386-95. 2005
    ....

Research Grants3

  1. The role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?s
    Orly Lazarov; Fiscal Year: 2010
    ..The results of these studies may provide strategies to treat or prevent the development of the human illness. ..
  2. The role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?s
    Orly Lazarov; Fiscal Year: 2009
    ..The results of these studies may provide strategies to treat or prevent the development of the human illness. ..
  3. The role of PS1 in regulation of adult neurogenesis in the intact and Alzheimer?s
    Orly Lazarov; Fiscal Year: 2010
    ..The results of these studies may provide strategies to treat or prevent the development of the human illness. ..