Donald K Layman

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint The role of leucine in weight loss diets and glucose homeostasis
    Donald K Layman
    Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois Urbana Champaign, 61801, USA
    J Nutr 133:261S-267S. 2003
  2. ncbi request reprint Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight loss
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 133:405-10. 2003
  3. ncbi request reprint A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 133:411-7. 2003
  4. doi request reprint Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats
    Gabriel J Wilson
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Am J Physiol Endocrinol Metab 301:E1236-42. 2011
  5. ncbi request reprint A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats
    Jamie I Baum
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:1855-61. 2006
  6. ncbi request reprint Dietary protein and exercise have additive effects on body composition during weight loss in adult women
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illnois, Urbana, 61801, USA
    J Nutr 135:1903-10. 2005
  7. doi request reprint The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 139:1103-9. 2009
  8. doi request reprint A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults
    Donald K Layman
    University of Illinois, Department of Food Science and Human Nutrition, Urbana, IL 61801, USA
    J Nutr 139:514-21. 2009
  9. ncbi request reprint Potential importance of leucine in treatment of obesity and the metabolic syndrome
    Donald K Layman
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 16801, USA
    J Nutr 136:319S-23S. 2006
  10. ncbi request reprint Dietary protein impact on glycemic control during weight loss
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 134:968S-73S. 2004

Detail Information

Publications21

  1. ncbi request reprint The role of leucine in weight loss diets and glucose homeostasis
    Donald K Layman
    Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois Urbana Champaign, 61801, USA
    J Nutr 133:261S-267S. 2003
    ..This review provides an overview of the current understanding of metabolic roles of leucine and proposes a metabolic framework to evaluate the merits of a higher protein diet for weight loss...
  2. ncbi request reprint Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight loss
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 133:405-10. 2003
    ..75 +/- 18 pmol/L). This study demonstrates that consumption of a diet with increased protein and a reduced CHO/protein ratio stabilizes blood glucose during nonabsorptive periods and reduces the postprandial insulin response...
  3. ncbi request reprint A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 133:411-7. 2003
    ..This study demonstrates that increasing the proportion of protein to carbohydrate in the diet of adult women has positive effects on body composition, blood lipids, glucose homeostasis and satiety during weight loss...
  4. doi request reprint Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats
    Gabriel J Wilson
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Am J Physiol Endocrinol Metab 301:E1236-42. 2011
    ..Administering Leu or CHO supplements ∼2 h after a meal maintains cellular energy status and extends the postprandial duration of MPS...
  5. ncbi request reprint A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in rats
    Jamie I Baum
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:1855-61. 2006
    ....
  6. ncbi request reprint Dietary protein and exercise have additive effects on body composition during weight loss in adult women
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illnois, Urbana, 61801, USA
    J Nutr 135:1903-10. 2005
    ..This study demonstrated that a diet with higher protein and reduced carbohydrates combined with exercise additively improved body composition during weight loss, whereas the effects on blood lipids differed between diet treatments...
  7. doi request reprint The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in rats
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 139:1103-9. 2009
    ..These studies demonstrate that peak activation but not duration of MPS is proportional to the Leu content of a meal...
  8. doi request reprint A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults
    Donald K Layman
    University of Illinois, Department of Food Science and Human Nutrition, Urbana, IL 61801, USA
    J Nutr 139:514-21. 2009
    ..01). The PRO diet was more effective for FM loss and body composition improvement during initial weight loss and long-term maintenance and produced sustained reductions in TAG and increases in HDL-C compared with the CHO diet...
  9. ncbi request reprint Potential importance of leucine in treatment of obesity and the metabolic syndrome
    Donald K Layman
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 16801, USA
    J Nutr 136:319S-23S. 2006
    ..These mechanisms produce protein sparing and provide a stable glucose environment with low insulin responses during energy-restricted periods...
  10. ncbi request reprint Dietary protein impact on glycemic control during weight loss
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 134:968S-73S. 2004
    ..This review focuses on the contributions of leucine and the BCAA to regulation of muscle protein synthesis and glycemic control...
  11. ncbi request reprint Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscle
    Jamie I Baum
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, Illinois, USA
    Am J Physiol Endocrinol Metab 288:E86-91. 2005
    ..These findings demonstrate that Leu reduces insulin-stimulated PI 3-kinase activity while increasing downstream translation initiation and with no effect on net glucose transport in skeletal muscle...
  12. pmc Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult rats
    Layne E Norton
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA
    Nutr Metab (Lond) 9:67. 2012
    ..abstract:..
  13. ncbi request reprint Protein quantity and quality at levels above the RDA improves adult weight loss
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 South Goodw, inUrbana, IL 61801, USA
    J Am Coll Nutr 23:631S-636S. 2004
    ..5 g/kg . d during weight loss. Further, our research suggests that increased use of high quality protein at breakfast maybe important for the metabolic advantage of a higher protein diet...
  14. ncbi request reprint Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise
    Layne E Norton
    Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 136:533S-537S. 2006
    ..Leucine's effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake...
  15. ncbi request reprint Protein in optimal health: heart disease and type 2 diabetes
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Am J Clin Nutr 87:1571S-1575S. 2008
    ..Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes...
  16. ncbi request reprint A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adults
    Matthew P Thorpe
    Division of Nutritional Sciences, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 138:1096-100. 2008
    ..4 g.kg(-1).d(-1) protein and 3 dairy servings increased urinary calcium excretion but provided improved calcium intake and attenuated bone loss over 4 mo of weight loss and 8 additional mo of weight maintenance...
  17. doi request reprint Breast tumors induced by N-methyl-N-nitrosourea are damaging to bone strength, structure, and mineralization in the absence of metastasis in rats
    Matthew P Thorpe
    Division of Nutritional Science, University of Illinois at Urbana Champaign, Urbana, IL, USA
    J Bone Miner Res 26:769-76. 2011
    ..05). Presence of MNU-induced tumors and total tumor burden showed a negative association with bone health of the femur in rats in the absence of metastasis. Further study is required to elucidate mechanisms for this association...
  18. ncbi request reprint Role of leucine in protein metabolism during exercise and recovery
    Donald K Layman
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, USA
    Can J Appl Physiol 27:646-63. 2002
    ..This review focuses on the unique roles of leucine in amino acid metabolism in skeletal muscle during and after exercise...
  19. pmc Moderate carbohydrate, moderate protein weight loss diet reduces cardiovascular disease risk compared to high carbohydrate, low protein diet in obese adults: A randomized clinical trial
    Denise A Walker Lasker
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Nutr Metab (Lond) 5:30. 2008
    ..To evaluate the metabolic effects of two weight loss diets differing in macronutrient composition on features of dyslipidemia and post-prandial insulin (INS) response to a meal challenge in overweight/obese individuals...
  20. ncbi request reprint Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal health
    D Joe Millward
    School of Biomedical and Molecular Sciences, University of Surrey, Surrey, UK
    Am J Clin Nutr 87:1576S-1581S. 2008
    ..As research continues to evolve in assessing protein's role in optimal health at higher intakes, there is also need to continue to explore implications for protein quality assessment...
  21. ncbi request reprint Amount and type of protein influences bone health
    Robert P Heaney
    Creighton University, Omaha, NE, USA
    Am J Clin Nutr 87:1567S-1570S. 2008
    ..The issue for public health professionals is whether recommended protein intakes should be increased, given the prevalence of osteoporosis and sarcopenia...