Research Topics
Species | Donald K LaymanSummaryAffiliation: University of Illinois Country: USA Publications
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Publications
The role of leucine in weight loss diets and glucose homeostasisDonald K Layman
Department of Food Science and Human Nutrition, Division of Nutritional Sciences, University of Illinois Urbana Champaign, 61801, USA
J Nutr 133:261S-267S. 2003..This review provides an overview of the current understanding of metabolic roles of leucine and proposes a metabolic framework to evaluate the merits of a higher protein diet for weight loss...- Increased dietary protein modifies glucose and insulin homeostasis in adult women during weight lossDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Nutr 133:405-10. 2003..75 +/- 18 pmol/L). This study demonstrates that consumption of a diet with increased protein and a reduced CHO/protein ratio stabilizes blood glucose during nonabsorptive periods and reduces the postprandial insulin response... - A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult womenDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Nutr 133:411-7. 2003..This study demonstrates that increasing the proportion of protein to carbohydrate in the diet of adult women has positive effects on body composition, blood lipids, glucose homeostasis and satiety during weight loss... 
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in ratsGabriel J Wilson
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
Am J Physiol Endocrinol Metab 301:E1236-42. 2011..Administering Leu or CHO supplements ∼2 h after a meal maintains cellular energy status and extends the postprandial duration of MPS...- A reduced carbohydrate, increased protein diet stabilizes glycemic control and minimizes adipose tissue glucose disposal in ratsJamie I Baum
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
J Nutr 136:1855-61. 2006.... - Dietary protein and exercise have additive effects on body composition during weight loss in adult womenDonald K Layman
Department of Food Science and Human Nutrition, University of Illnois, Urbana, 61801, USA
J Nutr 135:1903-10. 2005..This study demonstrated that a diet with higher protein and reduced carbohydrates combined with exercise additively improved body composition during weight loss, whereas the effects on blood lipids differed between diet treatments... - The leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of rapamycin signaling in ratsLayne E Norton
Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Nutr 139:1103-9. 2009..These studies demonstrate that peak activation but not duration of MPS is proportional to the Leu content of a meal... - A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adultsDonald K Layman
University of Illinois, Department of Food Science and Human Nutrition, Urbana, IL 61801, USA
J Nutr 139:514-21. 2009..01). The PRO diet was more effective for FM loss and body composition improvement during initial weight loss and long-term maintenance and produced sustained reductions in TAG and increases in HDL-C compared with the CHO diet... - Potential importance of leucine in treatment of obesity and the metabolic syndromeDonald K Layman
Division of Nutritional Sciences, University of Illinois, Urbana, IL 16801, USA
J Nutr 136:319S-23S. 2006..These mechanisms produce protein sparing and provide a stable glucose environment with low insulin responses during energy-restricted periods... - Dietary protein impact on glycemic control during weight lossDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
J Nutr 134:968S-73S. 2004..This review focuses on the contributions of leucine and the BCAA to regulation of muscle protein synthesis and glycemic control... - Leucine reduces the duration of insulin-induced PI 3-kinase activity in rat skeletal muscleJamie I Baum
Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois Urbana-Champaign, Urbana, Illinois, USA
Am J Physiol Endocrinol Metab 288:E86-91. 2005..These findings demonstrate that Leu reduces insulin-stimulated PI 3-kinase activity while increasing downstream translation initiation and with no effect on net glucose transport in skeletal muscle... 
Leucine content of dietary proteins is a determinant of postprandial skeletal muscle protein synthesis in adult ratsLayne E Norton
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA
Nutr Metab (Lond) 9:67. 2012..abstract:..- Protein quantity and quality at levels above the RDA improves adult weight lossDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, 905 South Goodw, inUrbana, IL 61801, USA
J Am Coll Nutr 23:631S-636S. 2004..5 g/kg . d during weight loss. Further, our research suggests that increased use of high quality protein at breakfast maybe important for the metabolic advantage of a higher protein diet... - Leucine regulates translation initiation of protein synthesis in skeletal muscle after exerciseLayne E Norton
Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
J Nutr 136:533S-537S. 2006..Leucine's effect on mTOR is synergistic with insulin via the phosphoinositol 3-kinase signaling pathway. Together, insulin and leucine allow skeletal muscle to coordinate protein synthesis with physiological state and dietary intake... - Protein in optimal health: heart disease and type 2 diabetesDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
Am J Clin Nutr 87:1571S-1575S. 2008..Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes... - A diet high in protein, dairy, and calcium attenuates bone loss over twelve months of weight loss and maintenance relative to a conventional high-carbohydrate diet in adultsMatthew P Thorpe
Division of Nutritional Sciences, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA
J Nutr 138:1096-100. 2008..4 g.kg(-1).d(-1) protein and 3 dairy servings increased urinary calcium excretion but provided improved calcium intake and attenuated bone loss over 4 mo of weight loss and 8 additional mo of weight maintenance... - Breast tumors induced by N-methyl-N-nitrosourea are damaging to bone strength, structure, and mineralization in the absence of metastasis in ratsMatthew P Thorpe
Division of Nutritional Science, University of Illinois at Urbana Champaign, Urbana, IL, USA
J Bone Miner Res 26:769-76. 2011..05). Presence of MNU-induced tumors and total tumor burden showed a negative association with bone health of the femur in rats in the absence of metastasis. Further study is required to elucidate mechanisms for this association... - Role of leucine in protein metabolism during exercise and recoveryDonald K Layman
Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, USA
Can J Appl Physiol 27:646-63. 2002..This review focuses on the unique roles of leucine in amino acid metabolism in skeletal muscle during and after exercise... - Moderate carbohydrate, moderate protein weight loss diet reduces cardiovascular disease risk compared to high carbohydrate, low protein diet in obese adults: A randomized clinical trialDenise A Walker Lasker
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA
Nutr Metab (Lond) 5:30. 2008..To evaluate the metabolic effects of two weight loss diets differing in macronutrient composition on features of dyslipidemia and post-prandial insulin (INS) response to a meal challenge in overweight/obese individuals... - Protein quality assessment: impact of expanding understanding of protein and amino acid needs for optimal healthD Joe Millward
School of Biomedical and Molecular Sciences, University of Surrey, Surrey, UK
Am J Clin Nutr 87:1576S-1581S. 2008..As research continues to evolve in assessing protein's role in optimal health at higher intakes, there is also need to continue to explore implications for protein quality assessment... - Amount and type of protein influences bone healthRobert P Heaney
Creighton University, Omaha, NE, USA
Am J Clin Nutr 87:1567S-1570S. 2008..The issue for public health professionals is whether recommended protein intakes should be increased, given the prevalence of osteoporosis and sarcopenia...