Research Topics
Genomes and Genes
| Michael T LawtonSummaryAffiliation: University of California Country: USA Publications
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Publications
Suppression of MMP-9 by doxycycline in brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, San Francisco, California, USA
BMC Neurol 5:1. 2005..The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs)...
Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patientsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:441-54; discussion 441-54. 2005..A classification scheme was devised on the basis of aneurysm, thrombus, and lumen morphology to relate these anatomic features to surgical therapy...
Tentorial dural arteriovenous fistulae: operative strategies and microsurgical results for six typesMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California CA 94143 0112, USA
Neurosurgery 62:110-24; discussion 124-5. 2008..We differentiated these fistulae into six types and developed specific operative strategies on the basis of these types...- Radiation arteriopathy in the transgenic arteriovenous fistula modelMichael T Lawton
Department of Neurological Surgery, Center for Cerebrovascular Research, University of California at San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 62:1129-38; discussion 138-9. 2008.... - The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformationsMichael T Lawton
Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, 94143 0012, USA
Neurosurgery 54:1463-71; discussion 1471. 2004.... 
A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgeryMichael T Lawton
Department of Neurological Surgery, and Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 66:702-13; discussion 713. 2010..Patient age, hemorrhagic presentation, nidal diffuseness, and deep perforating artery supply are important factors when selecting patients with brain arteriovenous malformations (AVMs) for surgery...- Double reimplantation technique to reconstruct arterial bifurcations with giant aneurysmsMichael T Lawton
Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 58:ONS-347-53; discussion ONS-353-4. 2006..To introduce the double implantation technique, a variation of standard radial artery or saphenous vein bypass that can be used to reconstruct arterial bifurcations in the management of giant aneurysms with complex branch arteries... - Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformationsMichael T Lawton
Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:485-93; discussion 485-93. 2005..We hypothesized that patients with unruptured arteriovenous malformations (AVMs) at presentation have an increased risk of deterioration compared with patients with ruptured AVMs... - Effect of the neurosurgeon's surgical experience on outcomes from intraoperative aneurysmal ruptureMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 57:9-15; discussion 9-15. 2005..Therefore, this analysis was undertaken to evaluate the effect of the neurosurgeon's experience on the management of this catastrophe in a consecutive series of patients treated microsurgically... - The supratonsillar approach to the inferior cerebellar peduncle: anatomy, surgical technique, and clinical application to cavernous malformationsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 59:ONS244-51; discussion ONS251-2. 2006.... - Spetzler-Martin Grade III arteriovenous malformations: surgical results and a modification of the grading scaleMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
Neurosurgery 52:740-8; discussion 748-9. 2003.... - Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case reportMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 55:979-80. 2004..We present the case of a young boy with a complex cavernous malformation that evolved during the course of a decade to encompass the majority of his right cerebral hemisphere... - Sylvian fissure arteriovenous malformations: an application of the Sugita classification to 28 surgical patientsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 61:29-36; discussion 36-8. 2007..This classification scheme is simple and appealing, but is rarely applied. We applied the Sugita classification to a consecutive, single-surgeon experience with 28 patients to better characterize the Sugita subtypes... - Combined microsurgical and endovascular management of complex intracranial aneurysmsMichael T Lawton
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
Neurosurgery 52:263-74; discussion 274-5. 2003.... - Basilar apex aneurysms: surgical results and perspectives from an initial experienceMichael T Lawton
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M 780C, San Francisco, CA 94143 0112, USA
Neurosurgery 50:1-8; discussion 8-10. 2002.... - Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformationsBahar Mikhak
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
Cerebrovasc Dis 31:338-45. 2011..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH... - Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAHLandis A Fisher
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 5:180-5. 2006..075). CONCLUSION: In the acute period after SAH, hypernatremia is associated with adverse cardiac outcomes and death. SAH patients with hypernatremia should be monitored for evidence of cardiac dysfunction... - Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhageJonathan G Zaroff
Department of Medicine, University of California, San Francisco, USA
Stroke 37:1680-5. 2006..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury... - Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatmentAchal S Achrol
Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
Neurosurgery 61:731-9; discussion 740. 2007..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes... - Soluble endoglin modulates aberrant cerebral vascular remodelingYongmei Chen
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
Ann Neurol 66:19-27. 2009.... - MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformationsYongmei Chen
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Front Biosci 11:3121-8. 2006..MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions... - Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitroYongfeng Fan
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94110, USA
J Cereb Blood Flow Metab 28:90-8. 2008..05). These results suggest that IL-6 plays a crucial role in the biologic behavior of blood-derived EPCs, which may help clarify the mechanism of IL-6 inflammatory-related diseases... - Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesisHua Su
Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
Am J Pathol 176:1018-27. 2010..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs... - Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patientsHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
Stroke 38:2430-7. 2007..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally... - Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformationHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82. 2009..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients... - Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomasAaron J Clark
Department of Neurological Surgery, University of California, San Francisco, California, USA
World Neurosurg 74:200-5. 2010..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord... - Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformationsAchal S Achrol
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
Stroke 37:231-4. 2006.... - Evidence of inflammatory cell involvement in brain arteriovenous malformationsYongmei Chen
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 62:1340-9; discussion 1349-50. 2008..In this study, we characterized the presence of inflammatory cells in AVM lesional tissue specimens... - Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhageSirisha Yarlagadda
Department of Medicine, University of California San Francisco, San Francisco, CA 94143-0124, USA
Neurocrit Care 5:102-7. 2006..Though these effects may be explained by a reduction in cerebral perfusion pressure or other mechanisms, further research is required to determine whether or not they are causal in nature... - Numerical simulations of flow in cerebral aneurysms: comparison of CFD results and in vivo MRI measurementsVitaliy L Rayz
Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Biomech Eng 130:051011. 2008..The results demonstrate the clinical relevance of computational models and suggest that realistic patient-specific flow conditions are required for numerical simulations of the flow in aneurysmal blood vessels... - Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. Clinical articleEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 114:814-27. 2011..We hypothesized that an organized system of approaches can guide operative planning and lead to acceptable neurological outcomes in surgical patients... - Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhageAvinash Kothavale
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 4:199-205. 2006..34 per 10 bpm increase, p = 0.024) were predictive of RWMA. CONCLUSIONS: RWMA were frequent after SAH. High-grade SAH, an elevation in cTi levels, a history of prior stimulant drug use, and tachycardia are independent predictors of RWMA... - Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT studyLucas Elijovich
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0114, USA
Stroke 39:1501-6. 2008..Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established... - The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformationsRose Du
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 60:638-46; discussion 646-8. 2007..Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associated with microsurgical AVM resection... - Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgeryHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
Stroke 43:2497-9. 2012.... - Multiple intracranial aneurysms and moyamoya disease associated with microcephalic osteodysplastic primordial dwarfism type II: surgical considerationsJames S Waldron
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg Pediatr 4:439-44. 2009.... - Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformationsLudmila Pawlikowska
The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
Neurosurgery 58:838-43; discussion 838-43. 2006..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention... - Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imagingBradley P Dispensa
Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California 94110, USA
J Magn Reson Imaging 26:177-83. 2007..Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time... - Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) studyS Claiborne Johnston
Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
Stroke 39:120-5. 2008..The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated... - EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformationsShantel Weinsheimer
Center for Cerebrovascular Research, University of California, San Francisco, Calif 94110, USA
Circ Cardiovasc Genet 2:476-82. 2009..We investigated the association of single-nucleotide polymorphisms (SNPs) and haplotypes in EPHB4 with risk of ICH at clinical presentation in patients with BAVM... - Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhageNerissa U Ko
Department of Neurology, University of California, San Francisco, USA
Stroke 39:1103-8. 2008..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients... - The azygos anterior cerebral artery bypass: double reimplantation technique for giant anterior communicating artery aneurysmsZaman Mirzadeh
Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
J Neurosurg 114:1154-8. 2011..The authors conclude that the azygos ACA bypass is a novel option for revascularizing PcaA and CmaA, as part of the overall treatment of giant ACoA aneurysms... - Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cellsJianhua S Yao
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
J Cereb Blood Flow Metab 27:510-20. 2007..A novel role of IL-6 during HCSMC proliferation is upregulating KDR expression and phosphorylation. The results may contribute to the angiogenic phenotype of human brain vascular diseases, such as brain AVM... - Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation ruptureYi Guo
University of California, San Francisco, CA 94110, USA
Stroke 43:1240-6. 2012.... - Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation ruptureHelen Kim
Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
Am J Epidemiol 171:1317-22. 2010..The data also suggest a biologic change around age 10 years influencing ICH rate... - Supracerebellar-supratrochlear and infratentorial-infratrochlear approaches: gravity-dependent variations of the lateral approach over the cerebellumNader Sanai
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
Neurosurgery 66:264-74; discussion 274. 2010.... - Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhageAlexander Kopelnik
Division of Cardiology, University of California San Francisco Medical Center, San Francisco, CA 94143-0124, USA
Neurocrit Care 3:132-8. 2005..CONCLUSION: Diastolic dysfunction is common after SAH. It is associated with history of hypertension and older age and may explain the development of pulmonary edema in many SAH patients... - Acute neurocardiogenic injury after subarachnoid hemorrhageNader M Banki
Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA
Circulation 112:3314-9. 2005..These findings may be explained by excessive release of norepinephrine from myocardial sympathetic nerves, which could damage both myocytes and nerve terminals... - Interleukin-6 involvement in brain arteriovenous malformationsYongmei Chen
Center for Cerebrovascular Research, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA, USA
Ann Neurol 59:72-80. 2006.... - Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centersAlexander X Halim
Departments of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Stroke 33:675-9. 2002..This heterogeneity between populations undermines the validity of inferences on the role of aneurysms from any single referral series, and emphasizes the complexity in creating BAVM risk-stratification models that incorporate aneurysms... - Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patientsDario J Englot
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 71:572-80; discussion 580. 2012..Potential risk factors for epilepsy in patients with AVMs are poorly understood, and the importance of achieving freedom from seizures in their surgical treatment remains underappreciated... - In situ bypass in the management of complex intracranial aneurysms: technique application in 13 patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, California 94143 0112, USA
Neurosurgery 57:140-5; discussion 140-5. 2005..An experience with in situ bypasses was retrospectively reviewed... - Transcranial motor evoked potentials during basilar artery aneurysm surgery: technique application for 30 consecutive patientsAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
Neurosurgery 54:916-24; discussion 924. 2004..Transcranial motor evoked potential (TcMEP) monitoring was added to determine whether this modality improved intraoperative monitoring... - Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysmVitaliy L Rayz
Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
J Biomech Eng 130:021004. 2008..The study demonstrates that computational models may provide hypotheses to test in future studies, and might offer guidance for the interventional treatment of cerebral aneurysms... - Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and toleranceTim Frenzel
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Cerebrovasc Dis 25:157-63. 2008..Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations... - Microsurgical management of incompletely coiled and recurrent aneurysms: trends, techniques, and observations on coil extrusionJames S Waldron
Department of Neurological Surgery, University of California, San Francisco, San Francisco, Californi 94143 0112, USA
Neurosurgery 64:301-15; discussion 315-7. 2009..We present a consecutive surgical experience with previously coiled aneurysms to examine clinical trends, the phenomenon of coil extrusion, microsurgical techniques, and morphological features affecting clippability... - Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidityRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 02114, USA
Neurosurgery 64:231-8; discussion 238-40. 2009..To better characterize these effects, we compared results of microsurgical resection of radiated (RS) and nonradiated (RS) AVMs to demonstrate that previous radiosurgery facilitates surgery and decreases operative morbidity... - Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformationsLudmila Pawlikowska
Cardiovascular Research Institute, University of California, San Francisco, CA 94110, USA
Stroke 36:2278-80. 2005..We investigated whether polymorphisms in these genes are also associated with sporadic BAVM... - Long-term hemorrhage risk in children versus adults with brain arteriovenous malformationsHeather J Fullerton
Department of Neurology, University of California, San Francisco, CA 94143 0137, USA
Stroke 36:2099-104. 2005..Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited... - Neurosurgery at the crossroads: integrated multidisciplinary management of 449 patients with brain arteriovenous malformationsRose Du
Department of Neurological Surgery, University of California, San Francisco, USA
Clin Neurosurg 52:177-91. 2005 - The supracarotid-infrafrontal approach: surgical technique and clinical application to cavernous malformations in the anteroinferior Basal GangliaJames S Waldron
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 64:ons86-95; discussion ons95. 2009..We present an approach to these lesions through the supracarotid triangle, between ascending perforators, and through the basomedial frontal lobe... - Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformationsPeng Gao
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 67:1029-35. 2010..Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings... - Regionalization of treatment for subarachnoid hemorrhage: a cost-utility analysisNaomi S Bardach
School of Medicine, University of California, San Francisco, CA 94143-01, USA
Circulation 109:2207-12. 2004..However, current estimates of the impact of hospital volume on outcome require confirmation in more detailed cohort studies... - Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhagePam R Taub
Department of Medicine, Cardiology Division, University of California, San Diego, CA 94114, USA
Neurocrit Care 15:13-8. 2011..We sought to determine whether elevated levels of BNP are independently associated with radiographic cerebral infarction after SAH... - Perfusion CT compared to H(2) (15)O/O (15)O PET in patients with chronic cervical carotid artery occlusionAmita Kamath
Department of Radiology, Neuroradiology Section, University of California, San Francisco, San Francisco, CA 94143 0628, USA
Neuroradiology 50:745-51. 2008..The purpose of this study was to compare the results of perfusion computed tomography (PCT) with those of (15)O(2)/H(2) (15)O positron emission tomography (PET) in a subset of Carotid Occlusion Surgery Study (COSS) patients... - Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case reportGabriel Acevedo-Bolton
Department of Radiology, Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
Neurosurgery 59:E429-30; author reply E429-30. 2006.... - Intraoperative motor mapping of the cerebral peduncle during resection of a midbrain cavernous malformation: technical case reportAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:E439; discussion E439. 2005..In addition, intermittent monitoring with transcranial motor evoked potentials (TcMEPs) helps to protect this vital pathway during resection of the lesion... - Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular managementNader Sanai
Department of Neurological Surgery, University of California at San Francisco, California 94143-0112, USA
J Neurosurg 104:82-9. 2006..Parental biases toward nonoperative therapy should be thoroughly addressed before ultimately selecting a treatment strategy... - Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhageNader Banki
Division of Cardiology, University of California, San Francisco Medical Center, San Francisco, California, USA
J Neurosurg 105:15-20. 2006..CONCLUSIONS: Left ventricular systolic dysfunction occurs frequently after SAH and usually improves over time. The observed segmental patterns of LV dysfunction often do not correlate with coronary artery distributions... - Association between subarachnoid hemorrhage outcomes and number of cases treated at California hospitalsNaomi S Bardach
School of Medicine, University of California, San Francisco, CA 94143-0114, USA
Stroke 33:1851-6. 2002..Few patients with subarachnoid hemorrhage are being transferred to high-volume centers... - "Tangential" resection of medial temporal lobe arteriovenous malformations with the orbitozygomatic approachRose Du
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143-0112, USA
Neurosurgery 54:645-51; discussion 651-2. 2004..For these reasons, it may be the optimal approach for small- and medium-sized compact AVMs in the dominant medial temporal lobe... - Aortocarotid bypass for hemispheric hypoperfusion in a childNader Sanai
Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
J Neurosurg Pediatr 1:343-7. 2008..The bypass graft is amenable to angioplasty with or without stenting if delayed stenosis becomes an issue later in life... - Posterior interhemispheric approach: surgical technique, application to vascular lesions, and benefits of gravity retractionJohn H Chi
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143-0112, USA
Neurosurgery 59:ONS41-9; discussion ONS41-9. 2006.... - Gene microarray analysis of human brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Neurosurgery 54:410-23; discussion 423-5. 2004..Human brain arteriovenous malformations (BAVMs) display abnormal expression of various angiogenesis-related genes and their products. We examined gene expression patterns in BAVMs by the gene microarray technique... - Spontaneous intracerebral hemorrhage due to coagulation disordersAlfredo Quinones-Hinojosa
Department of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California 94143 0112, USA
Neurosurg Focus 15:E3. 2003..The authors also discuss clinical features, diagnosis, and management of intracranial hemorrhage resulting from these bleeding disorders... - Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhageWade S Smith
Department of Neurology, University of California, San Francisco, Calif 94134 0114, USA
Stroke 35:2518-22. 2004..Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans... - Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clippingWilliam L Young
Department of Anesthesia and Perioperative Care, and the Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
Anesthesiology 96:497-503. 2002 - Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNader Sanai
Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
Nature 427:740-4. 2004..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain... - Critical roles of macrophages in the formation of intracranial aneurysmYasuhisa Kanematsu
Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
Stroke 42:173-8. 2011..Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms... - Unusual venous drainage of an arteriovenous malformation. Case illustrationAlfredo Quinones-Hinojosa
Department of Neurological Surgery University of California School of Medicine, San Francisco, California 94143 0112, USA
J Neurosurg 98:642. 2003 - Magnetic source imaging demonstrates altered cortical distribution of function in patients with arteriovenous malformationsG Edward Vates
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 51:614-23; discussion 623-7. 2002..We used magnetic source imaging (MSI) to identify the central sulcus and to determine whether primary cortical function was shifted in a set of 30 patients. We correlated these findings with outcome after treatment... - Stereotactic radiosurgery for pediatric intracranial arteriovenous malformations: the University of California at San Francisco experienceMatthew D Smyth
Department of Neurological Surgery, University of California at San Francisco, 94143 0112, USA
J Neurosurg 97:48-55. 2002..In this study the authors describe a series of pediatric patients with a minimum follow-up duration of 36 months... - Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-managementS Andrew Josephson
Department of Neurology, University of California, San Francisco, California 94143, USA
J Neurosurg 112:626-30. 2010..No study to date has examined the role of neurointensivists specifically in subarachnoid hemorrhage (SAH) management. This study examined the use of a team-based neurointensivist co-management approach... - Bow hunter stroke caused by cervical disc herniation. Case reportG Edward Vates
Department of Neurology, School of Medicine, University of California at San Francisco, 94143, USA
J Neurosurg 96:90-3. 2002..The use of TCD may be of value in the diagnosis and management of the disorder, and herniated cervical disc must be included in the roster of potential causes for this rare disease... - Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformationsEdward F Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 65:31-7; discussion 37-8. 2009..The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures... - Risk factors for hemorrhagic presentation in patients with dural arteriovenous fistulaeVineeta Singh
Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA
Neurosurgery 62:628-35; discussion 628-35. 2008..The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs... - The current role of microsurgery for posterior circulation aneurysms: a selective approach in the endovascular eraNader Sanai
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 62:1236-49; discussion 1249-53. 2008..We present a large, multidisciplinary team experience with posterior circulation aneurysms in an institution that continues to use microsurgery as a primary treatment modality for selected aneurysms... - Continuous bleeding from a basilar terminus aneurysm imaged with CT angiography and conventional angiographyS Andrew Josephson
Department of Neurology, University of California, San Francisco, CA 94143-0114, USA
Neurocrit Care 1:103-6. 2004..Continued bleeding from an intracranial aneurysm is a rare event that can be recognized using computed tomography angiography and likely indicates a poor prognosis... - Complications of lumboperitoneal shuntsVincent Y Wang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 60:1045-8; discussion 1049. 2007..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems... - Coexpression of angiogenic factors in brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
Neurosurgery 56:1058-65; discussion 1058-65. 2005..Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability... - Microsurgical management of pediatric intracranial aneurysmsNader Sanai
Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, AZ, USA
Childs Nerv Syst 26:1319-27. 2010..Pediatric aneuryms are rare and have characteristics that distinguish them from their adult counterparts. There is a greater capacity for pediatric aneurysms to arise de novo and progress rapidly... - Arteriovenous malformationWilliam L Young
J Neurosurg 106:731-2; author reply 732-3. 2007 - Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformationsTomoki Hashimoto
Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
Stroke 34:925-31. 2003..CONCLUSIONS: We found increased levels of MMP-9 and TIMPs in BAVMs. Abnormal balance of MMP-9 and TIMPs may contribute to vascular instability of BAVMs... - Superior outcomes in children compared with adults after microsurgical resection of brain arteriovenous malformationsRene O Sanchez-Mejia
Department of Neurological Surgery, University of California, San Francisco, California, USA
J Neurosurg 105:82-7. 2006.... - The "yo-yo" technique to prevent cerebrospinal fluid rhinorrhea after anterior clinoidectomy for proximal internal carotid artery aneurysmsJohn H Chi
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143-0112, USA
Neurosurgery 59:ONS101-7; discussion ONS101-7. 2006.... - Predictors of neurocardiogenic injury after subarachnoid hemorrhagePoyee Tung
Division of Cardiology, UCSF Medical Center, USA
Stroke 35:548-51. 2004..This finding supports the hypothesis that cardiac injury after SAH is a neurally mediated process... - Clipping of complex aneurysms with fenestration tubes: application and assessment of three types of clip techniquesIsaac Yang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Neurosurgery 62:ONS371-8; discussion 378-9. 2008..Three variations of fenestration tubes were conceived and applied to a consecutive series of patients with aneurysms to determine their usefulness... - The relationship of coexisting extranidal aneurysms to intracranial hemorrhage in patients harboring brain arteriovenous malformationsEui Jong Kim
Center for Cerebrovascular Research, Department of Radiology, University of California, San Francisco, 94110, USA
Neurosurgery 54:1349-57; discussion 1357-8. 2004.... - Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformationsLudmila Pawlikowska
Cardiovascular Research Institute, University of California, San Francisco, Calif 94110, USA
Stroke 35:2294-300. 2004..Identification of genetic polymorphisms associated with ICH would facilitate risk stratification in BAVM patients... - Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhagePoyee P Tung
Division of Cardiology, University of California, San Francisco, CA, USA
Stroke 36:1567-9. 2005..The aim of this study was to prospectively quantify the relationship between BNP levels and cardiac outcomes after SAH... - Cardiac injury after subarachnoid hemorrhage is independent of the type of aneurysm therapyJacob C Miss
Department of Medicine, University of California, San Francisco, California 94143-0124, USA
Neurosurgery 55:1244-50; discussion 1250-1. 2004..CONCLUSION: Surgical and endovascular aneurysm therapies were associated with similar risks of cardiac injury and dysfunction after SAH. The presence of neurocardiogenic injury should not affect aneurysm treatment decisions...
Research Grants
- RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODELMichael Lawton; Fiscal Year: 2004..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..