Michael T Lawton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Suppression of MMP-9 by doxycycline in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, San Francisco, California, USA
    BMC Neurol 5:1. 2005
  2. doi request reprint Radiation arteriopathy in the transgenic arteriovenous fistula model
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California at San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 62:1129-38; discussion 138-9. 2008
  3. doi request reprint Tentorial dural arteriovenous fistulae: operative strategies and microsurgical results for six types
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California CA 94143 0112, USA
    Neurosurgery 62:110-24; discussion 124-5. 2008
  4. ncbi request reprint Effect of the neurosurgeon's surgical experience on outcomes from intraoperative aneurysmal rupture
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 57:9-15; discussion 9-15. 2005
  5. ncbi request reprint The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, 94143 0012, USA
    Neurosurgery 54:1463-71; discussion 1471. 2004
  6. ncbi request reprint Spetzler-Martin Grade III arteriovenous malformations: surgical results and a modification of the grading scale
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
    Neurosurgery 52:740-8; discussion 748-9. 2003
  7. ncbi request reprint Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case report
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 55:979-80. 2004
  8. ncbi request reprint Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patients
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:441-54; discussion 441-54. 2005
  9. ncbi request reprint Combined microsurgical and endovascular management of complex intracranial aneurysms
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
    Neurosurgery 52:263-74; discussion 274-5. 2003
  10. ncbi request reprint Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:485-93; discussion 485-93. 2005

Research Grants

Detail Information

Publications104 found, 100 shown here

  1. pmc Suppression of MMP-9 by doxycycline in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, San Francisco, California, USA
    BMC Neurol 5:1. 2005
    ..The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs)...
  2. doi request reprint Radiation arteriopathy in the transgenic arteriovenous fistula model
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California at San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 62:1129-38; discussion 138-9. 2008
    ....
  3. doi request reprint Tentorial dural arteriovenous fistulae: operative strategies and microsurgical results for six types
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California CA 94143 0112, USA
    Neurosurgery 62:110-24; discussion 124-5. 2008
    ..We differentiated these fistulae into six types and developed specific operative strategies on the basis of these types...
  4. ncbi request reprint Effect of the neurosurgeon's surgical experience on outcomes from intraoperative aneurysmal rupture
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 57:9-15; discussion 9-15. 2005
    ..Therefore, this analysis was undertaken to evaluate the effect of the neurosurgeon's experience on the management of this catastrophe in a consecutive series of patients treated microsurgically...
  5. ncbi request reprint The transgenic arteriovenous fistula in the rat: an experimental model of gene therapy for brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, 94143 0012, USA
    Neurosurgery 54:1463-71; discussion 1471. 2004
    ....
  6. ncbi request reprint Spetzler-Martin Grade III arteriovenous malformations: surgical results and a modification of the grading scale
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco 94143 0112, USA
    Neurosurgery 52:740-8; discussion 748-9. 2003
    ....
  7. ncbi request reprint Giant infiltrative cavernous malformation: clinical presentation, intervention, and genetic analysis: case report
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 55:979-80. 2004
    ..We present the case of a young boy with a complex cavernous malformation that evolved during the course of a decade to encompass the majority of his right cerebral hemisphere...
  8. ncbi request reprint Thrombotic intracranial aneurysms: classification scheme and management strategies in 68 patients
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:441-54; discussion 441-54. 2005
    ..A classification scheme was devised on the basis of aneurysm, thrombus, and lumen morphology to relate these anatomic features to surgical therapy...
  9. ncbi request reprint Combined microsurgical and endovascular management of complex intracranial aneurysms
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0012, USA
    Neurosurgery 52:263-74; discussion 274-5. 2003
    ....
  10. ncbi request reprint Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:485-93; discussion 485-93. 2005
    ..We hypothesized that patients with unruptured arteriovenous malformations (AVMs) at presentation have an increased risk of deterioration compared with patients with ruptured AVMs...
  11. pmc A supplementary grading scale for selecting patients with brain arteriovenous malformations for surgery
    Michael T Lawton
    Department of Neurological Surgery, and Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 66:702-13; discussion 713. 2010
    ..Patient age, hemorrhagic presentation, nidal diffuseness, and deep perforating artery supply are important factors when selecting patients with brain arteriovenous malformations (AVMs) for surgery...
  12. ncbi request reprint Sylvian fissure arteriovenous malformations: an application of the Sugita classification to 28 surgical patients
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 61:29-36; discussion 36-8. 2007
    ..This classification scheme is simple and appealing, but is rarely applied. We applied the Sugita classification to a consecutive, single-surgeon experience with 28 patients to better characterize the Sugita subtypes...
  13. ncbi request reprint Double reimplantation technique to reconstruct arterial bifurcations with giant aneurysms
    Michael T Lawton
    Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 58:ONS-347-53; discussion ONS-353-4. 2006
    ..To introduce the double implantation technique, a variation of standard radial artery or saphenous vein bypass that can be used to reconstruct arterial bifurcations in the management of giant aneurysms with complex branch arteries...
  14. ncbi request reprint Basilar apex aneurysms: surgical results and perspectives from an initial experience
    Michael T Lawton
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, M 780C, San Francisco, CA 94143 0112, USA
    Neurosurgery 50:1-8; discussion 8-10. 2002
    ....
  15. ncbi request reprint The supratonsillar approach to the inferior cerebellar peduncle: anatomy, surgical technique, and clinical application to cavernous malformations
    Michael T Lawton
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 59:ONS244-51; discussion ONS251-2. 2006
    ....
  16. ncbi request reprint Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH
    Landis A Fisher
    Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
    Neurocrit Care 5:180-5. 2006
    ..This study analyzed whether abnormal serum sodium levels are associated with cardiac outcomes and mortality after subarachnoid hemorrhage (SAH)...
  17. pmc Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations
    Bahar Mikhak
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, 94110, USA
    Cerebrovasc Dis 31:338-45. 2011
    ..We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH...
  18. ncbi request reprint Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhage
    Jonathan G Zaroff
    Department of Medicine, University of California, San Francisco, USA
    Stroke 37:1680-5. 2006
    ..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury...
  19. ncbi request reprint Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment
    Achal S Achrol
    Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    Neurosurgery 61:731-9; discussion 740. 2007
    ..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
  20. pmc Soluble endoglin modulates aberrant cerebral vascular remodeling
    Yongmei Chen
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California San Francisco, San Francisco, CA, USA
    Ann Neurol 66:19-27. 2009
    ....
  21. ncbi request reprint Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging
    Bradley P Dispensa
    Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California 94110, USA
    J Magn Reson Imaging 26:177-83. 2007
    ..Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time...
  22. pmc Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis
    Hua Su
    Center of Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Pathol 176:1018-27. 2010
    ..These three lines of evidence from human studies and a mouse model suggest that reduced expression of integrin beta8 may be involved in the pathogenesis of sporadic BAVMs...
  23. pmc Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro
    Yongfeng Fan
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 28:90-8. 2008
    ..05). These results suggest that IL-6 plays a crucial role in the biologic behavior of blood-derived EPCs, which may help clarify the mechanism of IL-6 inflammatory-related diseases...
  24. ncbi request reprint Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
    Stroke 38:2430-7. 2007
    ..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally...
  25. ncbi request reprint MMP-9 expression is associated with leukocytic but not endothelial markers in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Front Biosci 11:3121-8. 2006
    ..MPO co-localized with majority of MMP-9 signal by immunohistochemistry. Our data suggest that inflammation is a prominent feature of BAVM lesional phenotype, and neutrophils appear to be a major source of MMP-9 in these lesions...
  26. doi request reprint Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT study
    Lucas Elijovich
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0114, USA
    Stroke 39:1501-6. 2008
    ..Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established...
  27. pmc Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Cerebrovasc Dis 27:176-82. 2009
    ..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients...
  28. pmc Evidence of inflammatory cell involvement in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 62:1340-9; discussion 1349-50. 2008
    ..In this study, we characterized the presence of inflammatory cells in AVM lesional tissue specimens...
  29. ncbi request reprint Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations
    Achal S Achrol
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
    Stroke 37:231-4. 2006
    ....
  30. doi request reprint Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    World Neurosurg 74:200-5. 2010
    ..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord...
  31. pmc Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    Nerissa U Ko
    Department of Neurology, University of California, San Francisco, USA
    Stroke 39:1103-8. 2008
    ..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients...
  32. ncbi request reprint Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhage
    Sirisha Yarlagadda
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0124, USA
    Neurocrit Care 5:102-7. 2006
    ..The objective of this study was to test the hypothesis that cardiovascular abnormalities are independently related to in-patient mortality after SAH...
  33. ncbi request reprint Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report
    Gabriel Acevedo-Bolton
    Department of Radiology, Veterans Affairs Medical Center San Francisco, San Francisco, California 94121, USA
    Neurosurgery 59:E429-30; author reply E429-30. 2006
    ....
  34. ncbi request reprint The effects of diffuseness and deep perforating artery supply on outcomes after microsurgical resection of brain arteriovenous malformations
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 60:638-46; discussion 646-8. 2007
    ..Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associated with microsurgical AVM resection...
  35. doi request reprint Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. Clinical article
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:814-27. 2011
    ..We hypothesized that an organized system of approaches can guide operative planning and lead to acceptable neurological outcomes in surgical patients...
  36. doi request reprint Numerical simulations of flow in cerebral aneurysms: comparison of CFD results and in vivo MRI measurements
    Vitaliy L Rayz
    Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Biomech Eng 130:051011. 2008
    ..The results demonstrate the clinical relevance of computational models and suggest that realistic patient-specific flow conditions are required for numerical simulations of the flow in aneurysmal blood vessels...
  37. ncbi request reprint Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhage
    Avinash Kothavale
    Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
    Neurocrit Care 4:199-205. 2006
    ..The aim of this study was to determine the prevalence of LV regional wall motion abnormalities (RWMA) after SAH and to quantify the independent effects of specific demographic and clinical variables in predicting the development of RWMA...
  38. pmc Evaluating performance of the spetzler-martin supplemented model in selecting patients with brain arteriovenous malformation for surgery
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA
    Stroke 43:2497-9. 2012
    ....
  39. ncbi request reprint Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    Stroke 39:120-5. 2008
    ..The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated...
  40. doi request reprint Multiple intracranial aneurysms and moyamoya disease associated with microcephalic osteodysplastic primordial dwarfism type II: surgical considerations
    James S Waldron
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 4:439-44. 2009
    ....
  41. pmc EPHB4 gene polymorphisms and risk of intracranial hemorrhage in patients with brain arteriovenous malformations
    Shantel Weinsheimer
    Center for Cerebrovascular Research, University of California, San Francisco, Calif 94110, USA
    Circ Cardiovasc Genet 2:476-82. 2009
    ..We investigated the association of single-nucleotide polymorphisms (SNPs) and haplotypes in EPHB4 with risk of ICH at clinical presentation in patients with BAVM...
  42. doi request reprint The azygos anterior cerebral artery bypass: double reimplantation technique for giant anterior communicating artery aneurysms
    Zaman Mirzadeh
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 114:1154-8. 2011
    ..The authors conclude that the azygos ACA bypass is a novel option for revascularizing PcaA and CmaA, as part of the overall treatment of giant ACoA aneurysms...
  43. ncbi request reprint Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations
    Ludmila Pawlikowska
    The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    Neurosurgery 58:838-43; discussion 838-43. 2006
    ..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention...
  44. ncbi request reprint Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells
    Jianhua S Yao
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, CA 94110, USA
    J Cereb Blood Flow Metab 27:510-20. 2007
    ..A novel role of IL-6 during HCSMC proliferation is upregulating KDR expression and phosphorylation. The results may contribute to the angiogenic phenotype of human brain vascular diseases, such as brain AVM...
  45. pmc Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture
    Yi Guo
    University of California, San Francisco, CA 94110, USA
    Stroke 43:1240-6. 2012
    ....
  46. doi request reprint Supracerebellar-supratrochlear and infratentorial-infratrochlear approaches: gravity-dependent variations of the lateral approach over the cerebellum
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143 0520, USA
    Neurosurgery 66:264-74; discussion 274. 2010
    ....
  47. ncbi request reprint Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centers
    Alexander X Halim
    Departments of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 33:675-9. 2002
    ..We studied the association between coexisting aneurysms and initial presentation with intracranial hemorrhage (ICH) in patients with BAVM evaluated at two tertiary-care centers...
  48. ncbi request reprint Interleukin-6 involvement in brain arteriovenous malformations
    Yongmei Chen
    Center for Cerebrovascular Research, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA, USA
    Ann Neurol 59:72-80. 2006
    ....
  49. pmc Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
    Helen Kim
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 171:1317-22. 2010
    ..The data also suggest a biologic change around age 10 years influencing ICH rate...
  50. doi request reprint Distal aneurysms of intracranial arteries: application of numerical nomenclature, predilection for cerebellar arteries, and results of surgical management
    Ana Rodríguez-Hernández
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    World Neurosurg 80:103-12. 2013
    ..Distal intracranial aneurysms are rare, have unclear origins, and are frequently nonsaccular. Published clinical experience with these aneurysms is limited...
  51. ncbi request reprint Acute neurocardiogenic injury after subarachnoid hemorrhage
    Nader M Banki
    Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA
    Circulation 112:3314-9. 2005
    ..Possible mechanisms include myocardial ischemia versus excessive catecholamine release from sympathetic nerve terminals...
  52. ncbi request reprint Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhage
    Alexander Kopelnik
    Division of Cardiology, University of California San Francisco Medical Center, San Francisco, CA 94143 0124, USA
    Neurocrit Care 3:132-8. 2005
    ..Little is known about the occurrence of diastolic dysfunction in this setting. The purpose of this study was to determine the prevalence of diastolic dysfunction and its association with cardiac outcomes after SAH...
  53. doi request reprint Cerebellar arteriovenous malformations: anatomic subtypes, surgical results, and increased predictive accuracy of the supplementary grading system
    Ana Rodríguez-Hernández
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 71:1111-24. 2012
    ..Selection tools like the Spetzler-Martin grading system are designed to work best with cerebral AVMs but have shortcomings with cerebellar AVMs...
  54. doi request reprint Seizure predictors and control after microsurgical resection of supratentorial arteriovenous malformations in 440 patients
    Dario J Englot
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 71:572-80; discussion 580. 2012
    ..Potential risk factors for epilepsy in patients with AVMs are poorly understood, and the importance of achieving freedom from seizures in their surgical treatment remains underappreciated...
  55. ncbi request reprint Transcranial motor evoked potentials during basilar artery aneurysm surgery: technique application for 30 consecutive patients
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0112, USA
    Neurosurgery 54:916-24; discussion 924. 2004
    ..Transcranial motor evoked potential (TcMEP) monitoring was added to determine whether this modality improved intraoperative monitoring...
  56. ncbi request reprint In situ bypass in the management of complex intracranial aneurysms: technique application in 13 patients
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Center for Stroke and Cerebrovascular Disease, University of California, San Francisco, California 94143 0112, USA
    Neurosurgery 57:140-5; discussion 140-5. 2005
    ..An experience with in situ bypasses was retrospectively reviewed...
  57. pmc Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance
    Tim Frenzel
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Cerebrovasc Dis 25:157-63. 2008
    ..Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations...
  58. ncbi request reprint Neurosurgery at the crossroads: integrated multidisciplinary management of 449 patients with brain arteriovenous malformations
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, USA
    Clin Neurosurg 52:177-91. 2005
  59. doi request reprint Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysm
    Vitaliy L Rayz
    Radiology Service, VA Medical Center San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    J Biomech Eng 130:021004. 2008
    ..The study demonstrates that computational models may provide hypotheses to test in future studies, and might offer guidance for the interventional treatment of cerebral aneurysms...
  60. doi request reprint The supracarotid-infrafrontal approach: surgical technique and clinical application to cavernous malformations in the anteroinferior Basal Ganglia
    James S Waldron
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 64:ons86-95; discussion ons95. 2009
    ..We present an approach to these lesions through the supracarotid triangle, between ascending perforators, and through the basomedial frontal lobe...
  61. pmc Evidence of endothelial progenitor cells in the human brain and spinal cord arteriovenous malformations
    Peng Gao
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 67:1029-35. 2010
    ..Endothelial progenitor cells (EPCs) can be recruited by stromal cell-derived factor-1 (SDF-1), and participate in vascular remodeling in both physiological and pathological settings...
  62. doi request reprint Microsurgical management of incompletely coiled and recurrent aneurysms: trends, techniques, and observations on coil extrusion
    James S Waldron
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, Californi 94143 0112, USA
    Neurosurgery 64:301-15; discussion 315-7. 2009
    ..We present a consecutive surgical experience with previously coiled aneurysms to examine clinical trends, the phenomenon of coil extrusion, microsurgical techniques, and morphological features affecting clippability...
  63. ncbi request reprint Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations
    Ludmila Pawlikowska
    Cardiovascular Research Institute, University of California, San Francisco, CA 94110, USA
    Stroke 36:2278-80. 2005
    ..We investigated whether polymorphisms in these genes are also associated with sporadic BAVM...
  64. ncbi request reprint Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations
    Heather J Fullerton
    Department of Neurology, University of California, San Francisco, CA 94143 0137, USA
    Stroke 36:2099-104. 2005
    ..Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited...
  65. pmc Radiosurgery facilitates resection of brain arteriovenous malformations and reduces surgical morbidity
    Rene O Sanchez-Mejia
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 02114, USA
    Neurosurgery 64:231-8; discussion 238-40. 2009
    ..To better characterize these effects, we compared results of microsurgical resection of radiated (RS) and nonradiated (RS) AVMs to demonstrate that previous radiosurgery facilitates surgery and decreases operative morbidity...
  66. ncbi request reprint Regionalization of treatment for subarachnoid hemorrhage: a cost-utility analysis
    Naomi S Bardach
    School of Medicine, University of California, San Francisco, CA 94143 01, USA
    Circulation 109:2207-12. 2004
    ..Whether regionalization of care for SAH is cost-effective is unknown...
  67. pmc Elevated BNP is associated with vasospasm-independent cerebral infarction following aneurysmal subarachnoid hemorrhage
    Pam R Taub
    Department of Medicine, Cardiology Division, University of California, San Diego, CA 94114, USA
    Neurocrit Care 15:13-8. 2011
    ..We sought to determine whether elevated levels of BNP are independently associated with radiographic cerebral infarction after SAH...
  68. pmc Perfusion CT compared to H(2) (15)O/O (15)O PET in patients with chronic cervical carotid artery occlusion
    Amita Kamath
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Neuroradiology 50:745-51. 2008
    ..The purpose of this study was to compare the results of perfusion computed tomography (PCT) with those of (15)O(2)/H(2) (15)O positron emission tomography (PET) in a subset of Carotid Occlusion Surgery Study (COSS) patients...
  69. ncbi request reprint Intraoperative motor mapping of the cerebral peduncle during resection of a midbrain cavernous malformation: technical case report
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:E439; discussion E439. 2005
    ..In addition, intermittent monitoring with transcranial motor evoked potentials (TcMEPs) helps to protect this vital pathway during resection of the lesion...
  70. ncbi request reprint Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhage
    Nader Banki
    Division of Cardiology, University of California, San Francisco Medical Center, San Francisco, California, USA
    J Neurosurg 105:15-20. 2006
    ..The incidence and natural history of neurocardiogenic injury after SAH remains poorly understood. The objective of this study was to describe the incidence, time course, recovery rate, and segmental patterns of LV dysfunction after SAH...
  71. ncbi request reprint Pediatric intracranial aneurysms: durability of treatment following microsurgical and endovascular management
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 104:82-9. 2006
    ..The authors reviewed their experience at one institution regarding patients treated between 1977 and 2003, focusing on the issue of treatment durability...
  72. ncbi request reprint Association between subarachnoid hemorrhage outcomes and number of cases treated at California hospitals
    Naomi S Bardach
    School of Medicine, University of California, San Francisco, CA 94143 0114, USA
    Stroke 33:1851-6. 2002
    ..Studies of several complex medical conditions have shown that outcomes are better at hospitals that treat more cases. We tested the hypothesis that patients with subarachnoid hemorrhage treated at high-volume hospitals have better outcomes...
  73. ncbi request reprint "Tangential" resection of medial temporal lobe arteriovenous malformations with the orbitozygomatic approach
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 54:645-51; discussion 651-2. 2004
    ..The orbitozygomatic approach enhances exposure along this tangential trajectory and was used in a consecutive series of 10 patients to determine its advantages...
  74. doi request reprint Aortocarotid bypass for hemispheric hypoperfusion in a child
    Nader Sanai
    Department of Neurological Surgery, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg Pediatr 1:343-7. 2008
    ..The bypass graft is amenable to angioplasty with or without stenting if delayed stenosis becomes an issue later in life...
  75. ncbi request reprint Posterior interhemispheric approach: surgical technique, application to vascular lesions, and benefits of gravity retraction
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 59:ONS41-9; discussion ONS41-9. 2006
    ....
  76. doi request reprint The current role of microsurgery for posterior circulation aneurysms: a selective approach in the endovascular era
    Nader Sanai
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Neurosurgery 62:1236-49; discussion 1249-53. 2008
    ..We present a large, multidisciplinary team experience with posterior circulation aneurysms in an institution that continues to use microsurgery as a primary treatment modality for selected aneurysms...
  77. ncbi request reprint Gene microarray analysis of human brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, and Center for Cerebrovascular Research, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Neurosurgery 54:410-23; discussion 423-5. 2004
    ..Human brain arteriovenous malformations (BAVMs) display abnormal expression of various angiogenesis-related genes and their products. We examined gene expression patterns in BAVMs by the gene microarray technique...
  78. ncbi request reprint Complications of lumboperitoneal shunts
    Vincent Y Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 60:1045-8; discussion 1049. 2007
    ..These shunts can be placed with or without valves. We sought to review the complications associated with the use of LP shunts with the increasing use of horizontal-vertical (HV) valve systems...
  79. ncbi request reprint Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
    Nader Sanai
    Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 427:740-4. 2004
    ..Unexpectedly, we find no evidence of chains of migrating neuroblasts in the SVZ or in the pathway to the olfactory bulb. Our work identifies SVZ astrocytes as neural stem cells in a niche of unique organization in the adult human brain...
  80. ncbi request reprint Unusual venous drainage of an arteriovenous malformation. Case illustration
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery University of California School of Medicine, San Francisco, California 94143 0112, USA
    J Neurosurg 98:642. 2003
  81. ncbi request reprint Spontaneous intracerebral hemorrhage due to coagulation disorders
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, University of California San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    Neurosurg Focus 15:E3. 2003
    ..The authors also discuss clinical features, diagnosis, and management of intracranial hemorrhage resulting from these bleeding disorders...
  82. ncbi request reprint Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Wade S Smith
    Department of Neurology, University of California, San Francisco, Calif 94134 0114, USA
    Stroke 35:2518-22. 2004
    ..Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans...
  83. doi request reprint Risk factors for hemorrhagic presentation in patients with dural arteriovenous fistulae
    Vineeta Singh
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neurosurgery 62:628-35; discussion 628-35. 2008
    ..The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs...
  84. ncbi request reprint Bow hunter stroke caused by cervical disc herniation. Case report
    G Edward Vates
    Department of Neurology, School of Medicine, University of California at San Francisco, 94143, USA
    J Neurosurg 96:90-3. 2002
    ..The use of TCD may be of value in the diagnosis and management of the disorder, and herniated cervical disc must be included in the roster of potential causes for this rare disease...
  85. doi request reprint Improvement in intensive care unit outcomes in patients with subarachnoid hemorrhage after initiation of neurointensivist co-management
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:626-30. 2010
    ..No study to date has examined the role of neurointensivists specifically in subarachnoid hemorrhage (SAH) management. This study examined the use of a team-based neurointensivist co-management approach...
  86. ncbi request reprint Coexpression of angiogenic factors in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Neurosurgery 56:1058-65; discussion 1058-65. 2005
    ..Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability...
  87. ncbi request reprint Anesthetic management of deep hypothermic circulatory arrest for cerebral aneurysm clipping
    William L Young
    Department of Anesthesia and Perioperative Care, and the Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94110, USA
    Anesthesiology 96:497-503. 2002
  88. ncbi request reprint Stereotactic radiosurgery for pediatric intracranial arteriovenous malformations: the University of California at San Francisco experience
    Matthew D Smyth
    Department of Neurological Surgery, University of California at San Francisco, 94143 0112, USA
    J Neurosurg 97:48-55. 2002
    ..In this study the authors describe a series of pediatric patients with a minimum follow-up duration of 36 months...
  89. ncbi request reprint Magnetic source imaging demonstrates altered cortical distribution of function in patients with arteriovenous malformations
    G Edward Vates
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 51:614-23; discussion 623-7. 2002
    ..We used magnetic source imaging (MSI) to identify the central sulcus and to determine whether primary cortical function was shifted in a set of 30 patients. We correlated these findings with outcome after treatment...
  90. ncbi request reprint Continuous bleeding from a basilar terminus aneurysm imaged with CT angiography and conventional angiography
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurocrit Care 1:103-6. 2004
    ..Continued bleeding from an intracranial aneurysm is a rare event that can be recognized using computed tomography angiography and likely indicates a poor prognosis...
  91. doi request reprint Seizure characteristics and control after microsurgical resection of supratentorial cerebral cavernous malformations
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neurosurgery 65:31-7; discussion 37-8. 2009
    ..The optimal management of seizures associated with cerebral cavernous malformations (CCMs) is unclear. The aim of this study was to determine the efficacy of surgery in the management of CCM-associated seizures...
  92. pmc Critical roles of macrophages in the formation of intracranial aneurysm
    Yasuhisa Kanematsu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA
    Stroke 42:173-8. 2011
    ..Using a mouse model of intracranial aneurysms, we tested whether macrophages play critical roles in the formation of intracranial aneurysms...
  93. doi request reprint Microsurgical management of pediatric intracranial aneurysms
    Nader Sanai
    Department of Neurological Surgery, Barrow Neurological Institute, Phoenix, AZ, USA
    Childs Nerv Syst 26:1319-27. 2010
    ..Pediatric aneuryms are rare and have characteristics that distinguish them from their adult counterparts. There is a greater capacity for pediatric aneurysms to arise de novo and progress rapidly...
  94. ncbi request reprint Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations
    Tomoki Hashimoto
    Department of Anesthesia and Perioperative Care, University of California, San Francisco 94110, USA
    Stroke 34:925-31. 2003
    ..In this study we examined the expression of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in brain arteriovenous malformations (BAVMs)...
  95. ncbi request reprint Predictors of neurocardiogenic injury after subarachnoid hemorrhage
    Poyee Tung
    Division of Cardiology, UCSF Medical Center, USA
    Stroke 35:548-51. 2004
    ..We hypothesized that myocardial necrosis after SAH is a neurally mediated process that is dependent on the severity of neurological injury...
  96. doi request reprint Spinal dural arteriovenous fistulae: clinical features and long-term results
    Jared Narvid
    School of Medicine, University of California, San Francisco, California, USA
    Neurosurgery 62:159-66; discussion 166-7. 2008
    ....
  97. ncbi request reprint The relationship of coexisting extranidal aneurysms to intracranial hemorrhage in patients harboring brain arteriovenous malformations
    Eui Jong Kim
    Center for Cerebrovascular Research, Department of Radiology, University of California, San Francisco, 94110, USA
    Neurosurgery 54:1349-57; discussion 1357-8. 2004
    ..We hypothesized that coexisting extranidal arterial aneurysms (EAs) would be associated with an increased risk of incident intracranial hemorrhage (ICH) from brain arteriovenous malformation (BAVM) rupture...
  98. ncbi request reprint Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformations
    Ludmila Pawlikowska
    Cardiovascular Research Institute, University of California, San Francisco, Calif 94110, USA
    Stroke 35:2294-300. 2004
    ..Identification of genetic polymorphisms associated with ICH would facilitate risk stratification in BAVM patients...
  99. ncbi request reprint Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhage
    Poyee P Tung
    Division of Cardiology, University of California, San Francisco, CA, USA
    Stroke 36:1567-9. 2005
    ..The aim of this study was to prospectively quantify the relationship between BNP levels and cardiac outcomes after SAH...
  100. ncbi request reprint Arteriovenous malformation
    William L Young
    J Neurosurg 106:731-2; author reply 732-3. 2007
  101. ncbi request reprint The "yo-yo" technique to prevent cerebrospinal fluid rhinorrhea after anterior clinoidectomy for proximal internal carotid artery aneurysms
    John H Chi
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 59:ONS101-7; discussion ONS101-7. 2006
    ..We present a technique for repairing this defect and preventing CSF rhinorrhea...

Research Grants1

  1. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..