Nathan D Lawson
Affiliation: University of Massachusetts Medical School
Lawson N. A New Conserved Player in Lymphatic Morphogenesis. Circ Res. 2017;120:1216-1218 pubmed publisher
Lawson N, Wolfe S. Forward and reverse genetic approaches for the analysis of vertebrate development in the zebrafish. Dev Cell. 2011;21:48-64 pubmed publisher
Lawson N. Reverse Genetics in Zebrafish: Mutants, Morphants, and Moving Forward. Trends Cell Biol. 2016;26:77-79 pubmed publisher
..These studies suggest that MOs should not be used as a standalone tool and underscore the need for guidelines that require defined mutants to assess gene function in zebrafish. ..
Zhu L, Gazin C, Lawson N, Pagès H, Lin S, Lapointe D, et al
. ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data. BMC Bioinformatics. 2010;11:237 pubmed publisher
..Tight integration to the biomaRt package enables up-to-date annotation retrieval from the BioMart database. ..
Lawson N, Mugford J, Diamond B, Weinstein B. phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes Dev. 2003;17:1346-51 pubmed
..Our results indicate that Plcg1 functions specifically downstream of the Vegf receptor during embryonic development to govern formation of the arterial system. ..
Shin M, Beane T, Quillien A, Male I, Zhu L, Lawson N. Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development. 2016;143:3796-3805 pubmed
..Together, these studies implicate ERK as a specific effector of Vegfa signaling in the induction of angiogenic genes during sprouting. ..
Shin M, Male I, Beane T, Villefranc J, Kok F, Zhu L, et al
. Vegfc acts through ERK to induce sprouting and differentiation of trunk lymphatic progenitors. Development. 2016;143:3785-3795 pubmed
..Moreover, distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations. ..
Quillien A, Abdalla M, Yu J, Ou J, Zhu L, Lawson N. Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Rep. 2017;20:709-720 pubmed publisher
..Thus, FANS-assisted ATAC-seq using transgenic zebrafish embryos provides a robust approach for genome-wide identification of active tissue-specific enhancer elements. ..