E R Laws

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Vascular injury and transsphenoidal surgery
    Rod J Oskouian
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:256-78. 2006
  2. ncbi Gliadel for pituitary adenomas and craniopharyngiomas
    Edward R Laws
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0212, USA
    Neurosurgery 53:255-69; discussion 259-60. 2003
  3. ncbi A neurosurgical way of life. The 1998 presidential address
    E R Laws
    Department of Neurosurgery, University of Virginia Health Systems, Charlottesville 22908, USA
    J Neurosurg 89:901-10. 1998
  4. ncbi Neurosurgical approach to treating pituitary adenomas
    Edward R Laws
    Department of Neurosurgery, University of Virginia, UVA Medical Center, PO Box 800212, Charlottesville, VA 22908, USA
    Growth Horm IGF Res 15:S36-41. 2005
  5. ncbi From child to adult
    E R Laws
    Department of Neurosurgery, University of Virginia Health System, Box 212, Charlottesville, VA 22908, USA
    Childs Nerv Syst 15:620-3. 1999
  6. ncbi Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project
    Edward R Laws
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Neurosurg 99:467-73. 2003
  7. ncbi Cushing's disease resulting from pituitary corticotrophic microadenoma. Treatment results from transsphenoidal microsurgery and gamma knife radiosurgery
    E R Laws
    Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908 0212, USA
    Neurochirurgie 48:294-9. 2002
  8. ncbi Hypophysitis
    Edward R Laws
    School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Pituitary 9:331-3. 2006
  9. ncbi Pioneers in the development of transsphenoidal surgery: Theodor Kocher, Oskar Hirsch, and Norman Dott
    G Lanzino
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Neurosurg 95:1097-103. 2001
  10. ncbi Fluoroscopic frameless stereotaxy for transsphenoidal surgery
    J A Jane
    Department of Neurosurgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 48:1302-7; discussion 1307-8. 2001

Collaborators

Detail Information

Publications81

  1. ncbi Vascular injury and transsphenoidal surgery
    Rod J Oskouian
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:256-78. 2006
    ..The anatomic substrate for such complications is discussed, along with technical aspects of surgery and other methods for the avoidance of vascular complications...
  2. ncbi Gliadel for pituitary adenomas and craniopharyngiomas
    Edward R Laws
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0212, USA
    Neurosurgery 53:255-69; discussion 259-60. 2003
    ..We developed a protocol for a clinical trial of postresection implantation of Gliadel wafers in patients with aggressive, relentlessly recurring pituitary adenomas and craniopharyngiomas...
  3. ncbi A neurosurgical way of life. The 1998 presidential address
    E R Laws
    Department of Neurosurgery, University of Virginia Health Systems, Charlottesville 22908, USA
    J Neurosurg 89:901-10. 1998
    ..Dr. Osler's influence on Cushing's role as a leader in neurosurgery is examined. Some basic principles of a neurosurgical "Way of Life" are reviewed...
  4. ncbi Neurosurgical approach to treating pituitary adenomas
    Edward R Laws
    Department of Neurosurgery, University of Virginia, UVA Medical Center, PO Box 800212, Charlottesville, VA 22908, USA
    Growth Horm IGF Res 15:S36-41. 2005
    ..In our experience, transsphenoidal surgery for pituitary adenomas is associated with low rates of morbidity, mortality, and disease recurrence...
  5. ncbi From child to adult
    E R Laws
    Department of Neurosurgery, University of Virginia Health System, Box 212, Charlottesville, VA 22908, USA
    Childs Nerv Syst 15:620-3. 1999
    ..These include patients with shunts for hydrocephalus, patients with spinal deformities, and patients with secondary effects of adjunctive therapy...
  6. ncbi Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project
    Edward R Laws
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Neurosurg 99:467-73. 2003
    ..Attempts were made to reduce the impact of selection bias by repeating the data analysis after omitting patients with major negative prognostic factors...
  7. ncbi Cushing's disease resulting from pituitary corticotrophic microadenoma. Treatment results from transsphenoidal microsurgery and gamma knife radiosurgery
    E R Laws
    Department of Neurosurgery, University of Virginia, Charlottesville, VA 22908 0212, USA
    Neurochirurgie 48:294-9. 2002
    ..Currently this goal is best achieved by transsphenoidal microsurgery. This paper reviews the clinical presentation, laboratory analysis, surgical management and outcome in patients with Cushing's disease...
  8. ncbi Hypophysitis
    Edward R Laws
    School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Pituitary 9:331-3. 2006
    ..Therapy is generally supportive in nature but may require surgery for pathological diagnosis and treatment of mass effect...
  9. ncbi Pioneers in the development of transsphenoidal surgery: Theodor Kocher, Oskar Hirsch, and Norman Dott
    G Lanzino
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Neurosurg 95:1097-103. 2001
    ..Several pioneers contributed to its development and its eventual and nearly unconditional acceptance. In this historical vignette, the contributions of three master surgeons. Theodor Kocher, Oskar Hirsch, and Norman Dott, are reviewed...
  10. ncbi Fluoroscopic frameless stereotaxy for transsphenoidal surgery
    J A Jane
    Department of Neurosurgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 48:1302-7; discussion 1307-8. 2001
    ..Although it is useful in first-time transseptal transsphenoidal surgery, its primary benefit is realized in recurrent surgery...
  11. ncbi Results of transsphenoidal surgery for Cushing's disease in patients with no histologically confirmed tumor
    J M Sheehan
    Department of Neurosurgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 47:33-6; discussion 37-9. 2000
    ..We reviewed our experience to determine the prognostic significance of this lack of confirmation regarding outcome, and we evaluate explanations for this situation...
  12. ncbi Selective expression of estrogen receptor alpha and beta isoforms in human pituitary tumors
    M A Shupnik
    Department of Internal Medicine, University of Virginia Health Science Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 83:3965-72. 1998
    ....
  13. ncbi Acromegaly: historical perspectives and current therapy
    J A Jane
    Department of Neurosurgery, University of Virginia, Charlottesville, USA
    J Neurooncol 54:129-37. 2001
    ..Although medical and radiation treatments offer useful adjuncts, surgery provides optimal results...
  14. ncbi The history and evolution of transsphenoidal surgery
    J K Liu
    Department of Neurosurgery, New York Medical College, Valhalla, New York 10595, USA
    J Neurosurg 95:1083-96. 2001
    ..The evolution of the transsphenoidal approaches and their current applications and modifications are discussed...
  15. ncbi Estrogen receptors in prolactinomas: a clinico-pathological study
    G J Kaptain
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Pituitary 1:91-8. 1999
    ..The use of antiestrogen therapy in pituitary adenomas, however, has not been explored. This study attempted to identify a population who may benefit from antiestrogen therapy...
  16. ncbi Surgical management of intracranial gliomas--does radical resection improve outcome?
    E R Laws
    Department of Neurosurgery, Health Science Centre, University of Charlottesville Virginia, USA
    Acta Neurochir Suppl 85:47-53. 2003
    ..This paper discusses the arguments for and against radical tumor resection as a strategy for treatment of cerebral gliomas...
  17. ncbi The management of non-functioning pituitary adenomas
    J A Jane
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Neurol India 51:461-5. 2003
    ..The multidisciplinary management of non-functioning adenomas, their diagnosis and therapeutic outcomes, is discussed...
  18. ncbi Transsphenoidal approaches for the extracapsular resection of midline suprasellar and anterior cranial base lesions
    G J Kaptain
    Department of Neurosurgery, Oregon Health Sciences University, Portland, USA
    Neurosurgery 49:94-100; discussion 100-1. 2001
    ....
  19. ncbi Conventional radiotherapy for pituitary tumors
    E R Laws
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
    Neurosurg Clin N Am 11:617-25. 2000
    ..It is our belief that improvements in radiosurgical technology can significantly enhance the outcome for patients with these lesions...
  20. ncbi Surgical management of GH-secreting pituitary adenomas: an outcome study using modern remission criteria
    J Kreutzer
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:4072-7. 2001
    ..These results provide a benchmark for the contemporary results of surgical management as assessed by modern outcome criteria...
  21. ncbi Skull base chordomas: overview of disease, management options, and outcome
    G Lanzino
    Division of Neuropathology, Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Neurosurg Focus 10:E12. 2001
    ..Recurrences are common, although in a subset of patients prolonged disease-free survival is demonstrated...
  22. ncbi Cranial base reconstruction after transsphenoidal surgery with bioabsorbable implants
    G J Kaptain
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville, USA
    Neurosurgery 48:232-3; discussion 233-4. 2001
    ..Low-molecular-weight polylactide implants may serve as an effective alternative because they are immunologically inert, magnetic resonance imaging-compatible, and easily contoured to custom-fit a defect...
  23. ncbi Surgical management of pituitary adenomas
    J A Jane
    Department of Neurosurgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Singapore Med J 43:318-23. 2002
    ..With the exception of the prolactinomas, transsphenoidal surgery remains the first-line therapy for most pituitary adenomas. The current diagnosis and surgical management of pituitary adenomas is discussed...
  24. ncbi Optimizing accuracy in magnetic resonance imaging-guided stereotaxis: a technique with validation based on the anterior commissure-posterior commissure line
    C G diPierro
    Department of Neurosurgery, University of Virginia, Charlottesville 22908, USA
    J Neurosurg 90:94-100. 1999
    ..The goal of the present article is to present the authors' technique...
  25. ncbi Pituitary pseudocapsule
    Edward R Laws
    J Neurosurg 104:1-2; discussison 2-3. 2006
  26. ncbi Gamma knife radiosurgery for medically and surgically refractory prolactinomas
    Nader Pouratian
    Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA
    Neurosurgery 59:255-66; discussion 255-66. 2006
    ..Patients with tumors smaller than 3.0 cm3 and who are not receiving dopamine agonist at the time of treatment will likely benefit most...
  27. ncbi Computer-assisted frameless stereotaxy in transsphenoidal surgery at a single institution: review of 176 cases
    Jay Jagannathan
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908-00212, USA
    Neurosurg Focus 20:E9. 2006
    ..The MR imaging, CT scanning, and fluoroscopic stereotaxy modalities all have unique advantages as well as specific limitations...
  28. ncbi Rathke's cleft cysts
    Adam S Kanter
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:127-57. 2006
    ..This chapter aims to review the pathogenesis, symptomatologic manifestations, radiographic, morphologic and histopathological characteristics, treatment strategies and outcomes in the cysts of Rathke's cleft...
  29. ncbi The craniopharyngioma
    Rod J Oskouian
    Department of Neuorological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:105-26. 2006
    ..This chapter reviews the embryology, neuroanatomy, current treatment strategies, clinical features and the several surgical approaches to its treatment...
  30. ncbi Image guidance in pituitary surgery
    Ashok R Asthagiri
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:46-63. 2006
    ..The utility and limitations of common intraoperative aides including video fluoroscopy, frameless stereotaxy, ultrasound, and magnetic resonance imaging are reviewed...
  31. ncbi Extended transsphenoidal approach
    Aaron S Dumont
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Front Horm Res 34:29-45. 2006
    ..Meticulous attention to detail, particularly with respect to reconstruction and closure of the sellar floor, is necessary for its effective application...
  32. ncbi Brief history of endoscopic transsphenoidal surgery--from Philipp Bozzini to the First World Congress of Endoscopic Skull Base Surgery
    Francesco Doglietto
    Department of Neurological Surgery, University of Virginia Health Systems, Charlottesville, Virginia, USA
    Neurosurg Focus 19:E3. 2005
    ..Specifically, in this review the history of endoscopy and its application in endonasal neurosurgery are presented...
  33. ncbi Perspectives on endoscopic transsphenoidal surgery
    John A Jane
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Neurosurg Focus 19:E2. 2005
    ..The authors describe their current endoscopic technique and elucidate the advantages and disadvantages of the pure endoscopic adenomectomy compared with the standard microscopic approach...
  34. ncbi Harvey Cushing and Oskar Hirsch: early forefathers of modern transsphenoidal surgery
    James K Liu
    Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City 84132, USA
    J Neurosurg 103:1096-104. 2005
    ..In this comparative analysis, the authors compare the operative nuances of the approaches of Cushing and Hirsch and describe the contributions of these pioneers to modern transsphenoidal surgery...
  35. ncbi Surgical management of adrenocorticotropic hormone-secreting macroadenomas: outcome and challenges in patients with Cushing's disease or Nelson's syndrome
    Claudio De Tommasi
    University of Bari, Italy
    J Neurosurg 103:825-30. 2005
    ..The outcome of modern surgical treatment is unclear and thus was assessed in a series of 43 patients, with the goal of improving therapeutic results in patients with ACTH-secreting macroadenomas...
  36. ncbi Pathobiology of pituitary adenomas and carcinomas
    Bernd W Scheithauer
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 59:341-53; discussion 341-53. 2006
    ....
  37. ncbi Pituitary adenomas: is Gamma Knife radiosurgery safe?
    Jason Sheehan
    University of Virginia Health Sciences Center, VA, USA
    Nat Clin Pract Endocrinol Metab 1:2-3. 2005
  38. ncbi Applications of radiotherapy and radiosurgery in the management of pediatric Cushing's disease: a review of the literature and our experience
    Jay Jagannathan
    Department of Neurological Surgery, University of Virginia Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    J Neurooncol 90:117-24. 2008
    ..This paper reviews the effectiveness of radiation in the treatment of pediatric Cushing's disease...
  39. ncbi Surgery for acromegaly: evolution of the techniques and outcomes
    Edward R Laws
    Department of Neurosurgery, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Rev Endocr Metab Disord 9:67-70. 2008
    ....
  40. ncbi Clinical relevance of precipitating factors in pituitary apoplexy
    Patrick L Semple
    Division of Neurosurgery, University of Cape Town, Cape Town, South Africa
    Neurosurgery 61:956-61; discussion 961-2. 2007
    ..Most of the published cases are in the form of case reports. We assessed the presumed precipitating factors in a series of patients treated surgically for pituitary apoplexy and reviewed the contemporary published literature...
  41. ncbi Late recurrences of Cushing's disease after initial successful transsphenoidal surgery
    Chirag G Patil
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Clin Endocrinol Metab 93:358-62. 2008
    ..Few studies have systematically analyzed the long-term recurrence rates of Cushing's disease after initial successful transsphenoidal surgery...
  42. ncbi Reconstruction of the sellar dura in transsphenoidal surgery using an expanded polytetrafluoroethylene dural substitute
    Jonathan H Sherman
    Department of Neurological Surgery, University of Virginia, Health Sciences Center, Charlottesville, Box 800212, VA 22908, USA
    Surg Neurol 69:73-6; discussion 76. 2008
    ..We studied the use of an ePTFE dural substitute (GORE Preclude MVP, W.L. Gore & Associates, Flagstaff, Arizona, USA), as a method for obtaining reliable reconstruction of the sellar dura...
  43. ncbi Benign brain tumors: sellar/parasellar tumors
    Jay Jagannathan
    Department of Neurosurgery, University of Virginia Health System, PO Box 800212, Charlottesville, VA 22908 0711, USA
    Neurol Clin 25:1231-49, xi. 2007
    ..Less invasive modalities, such as endoscopic transsphenoidal surgery, specific chemotherapeutic drugs, and stereotactic radiosurgery, show promise as adjuvant treatment modalities...
  44. ncbi National trends, complications, and outcomes following transsphenoidal surgery for Cushing's disease from 1993 to 2002
    Chirag G Patil
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Neurosurg Focus 23:E7. 2007
    ..In this study the authors report on inpatient death, morbidity, and outcomes following TSS for Cushing's disease on a national level...
  45. ncbi The role of the endoscope in the transsphenoidal management of cystic lesions of the sellar region
    Luigi M Cavallo
    Department of Neurological Sciences, Division of Neurosurgery, Universita degli Studi di Napoli Federico II, Via Sergio Pansini, 5, 80131 Naples, Italy
    Neurosurg Rev 31:55-64; discussion 64. 2008
    ..Its routine use during transsphenoidal surgery for such lesions is recommended to achieve maximal and safe tumor removal...
  46. ncbi History of endoscopic skull base surgery: its evolution and current reality
    Daniel M Prevedello
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    J Neurosurg 107:206-13. 2007
    ..This article discusses the history of the endoscope, the pivotal technological advances, and the key figures in the burgeoning field of endoneurosurgery...
  47. ncbi Arachnoid diverticula associated with anterior cranial base tumors: technical case report
    Jay Jagannathan
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
    Neurosurgery 61:E172-3; discussion E173. 2007
    ..When they occur, they often complicate the surgical management of these tumors via a transsphenoidal approach. This report examines the effectiveness of transsphenoidal surgery in the treatment of these rare entities...
  48. ncbi Outcomes and management of patients with Cushing's disease without pathological confirmation of tumor resection after transsphenoidal surgery
    Nader Pouratian
    Department of Neurological Surgery, University of Virginia, Box 800212, Charlottesville, Virginia 22903, USA
    J Clin Endocrinol Metab 92:3383-8. 2007
    ..The clinical significance of lack of histological confirmation remains unclear...
  49. ncbi Gamma Knife surgery for adrenocorticotropic hormone-producing pituitary adenomas after bilateral adrenalectomy
    William J Mauermann
    Lars Leksell Gamma Knife Center, University of Virginia Health System, Charlottesville, Virginia, USA
    J Neurosurg 106:988-93. 2007
    ..These patients with Nelson's syndrome can be treated with Gamma Knife surgery (GKS)...
  50. ncbi Gamma Knife surgery for Cushing's disease
    Jay Jagannathan
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 00212, USA
    J Neurosurg 106:980-7. 2007
    ..In this study the authors address the efficacy and safety of Gamma Knife surgery (GKS) in patients with adrenocorticotropic hormone-secreting pituitary adenomas...
  51. ncbi Management of Cushing's disease: outcome in patients with microadenoma detected on pituitary magnetic resonance imaging
    Daniel M Prevedello
    Department of Neurological Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurosurg 109:751-9. 2008
    ..The authors designed this study to verify the remission rate and outcomes after transsphenoidal surgery (TSS) for patients with CD who had positive findings on MR imaging...
  52. ncbi Surgery for primary brain tumors at United States academic training centers: results from the Residency Review Committee for neurological surgery
    John A Jane
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 103:789-93. 2005
    ..Practice with transsphenoidal surgery, however, is less well represented and tends to be clustered at several active centers. The implications for neurosurgical education are significant...
  53. ncbi Stereotactic radiosurgery for pituitary adenomas: a review of the literature
    Edward R Laws
    University of Virginia, Charlottesville, VA 22908, USA
    J Neurooncol 69:257-72. 2004
    ..In rare instances, radiosurgery may be the best initial treatment for patients with pituitary adenomas. Refinements in the radiosurgical technique will likely lead to improved outcomes...
  54. ncbi Rathke cleft cysts
    Edward R Laws
    J Neurosurg 101:571-2; discussion 572. 2004
  55. ncbi Primary hypophysitis: a single-center experience in 16 cases
    Gilberto K K Leung
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 101:262-71. 2004
    ..A postoperative recurrence developed in two patients (15.4%) and the treatment modalities included steroid therapy, repeated surgery, and radiosurgery...
  56. ncbi Depression in patients with high-grade glioma: results of the Glioma Outcomes Project
    N Scott Litofsky
    Division of Neurosurgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neurosurgery 54:358-66; discussion 366-7. 2004
    ..To study the incidence of depression among patients undergoing surgery for high-grade glioma, document factors associated with the presence of depression, and examine the relationship between depression and patient outcome...
  57. ncbi Clinical characteristics of silent corticotrophic adenomas and creation of an internet-accessible database to facilitate their multi-institutional study
    K Michael Webb
    Department of Neurosurgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Neurosurgery 53:1076-84; discussion 1084-5. 2003
    ..hsc.virginia.edu/neuro/neurosurgery/pituitary.html) for collection of multi-institutional data on these lesions...
  58. ncbi Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project
    Susan M Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143 0372, USA
    J Neurosurg 98:1175-81. 2003
    ..Factors predicting neurological outcome would also be helpful for patient selection for surgically based clinical trials...
  59. ncbi Intrasellar schwannomas: report of two cases
    Nicholas F Maartens
    Department of Neurosurgery, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Neurosurgery 52:1200-5; discussion 1205-6. 2003
    ..New and existing hypotheses regarding the histopathogenesis of intrasellar and parasellar schwannomas are presented...
  60. ncbi Key personalities in the development and popularization of the transsphenoidal approach to pituitary tumors: an historical overview
    Giuseppe Lanzino
    Department of Neurosurgery, University of Illinois College of Medicine at Peoria, 530 Glen Oak Avenue, Peoria, IL 61637 0999, USA
    Neurosurg Clin N Am 14:1-10. 2003
    ..These pioneers were original thinkers and bold (albeit careful) surgeons. Their persistence in the face of incredible obstacles provides a source of continuous inspiration...
  61. ncbi Hemangiopericytoma in the setting of acromegaly
    W Jeffrey Elias
    Department of Neurosurgery, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    Endocr Pathol 13:251-61. 2002
    ..Paracrine mechanisms related to IGF-1 may have contributed to its pathogenesis and growth. The presence of IGF-1 receptors in hemangiopericytomas may have treatment implications for additional adjuvant therapies...
  62. ncbi The neurosurgical management of Cushing's disease
    Margaret Reitmeyer
    Department of Endocrinology and Neurosurgery, University of Virginia, Charlottesville, VA 22908-0212, USA
    Mol Cell Endocrinol 197:73-9. 2002
    ..Currently, this goal is best achieved by transsphenoidal microsurgery. This paper reviews the clinical presentation, laboratory analysis, surgical management and outcome in patients with Cushing's disease...
  63. ncbi Use of FloSeal hemostatic sealant in transsphenoidal pituitary surgery: technical note
    Dilantha B Ellegala
    Department of Neurosurgery, University of Virginia, Charlottesville 22908, USA
    Neurosurgery 51:513-5; discussion 515-6. 2002
    ..FloSeal has been demonstrated to be safe and biocompatible as compared with hemostatic agents currently in use...
  64. ncbi Pituitary surgery: transsphenoidal approach
    John A Jane
    Department of Neurosurgery, University of Virginia, Charlottesville, USA
    Neurosurgery 51:435-42; discussion 442-4. 2002
    ..The methods and preferences described herein embody the distillation of an experience gained from 3900 transsphenoidal operations...
  65. ncbi Cushing's case XLV: Minnie G
    Giuseppe Lanzino
    Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville, USA
    J Neurosurg 97:231-4. 2002
    ..Minnie G. was the first case that Cushing reported. The clinical course of that case is briefly reviewed in this article...
  66. ncbi Stereotactic radiosurgery for hypersecreting pituitary tumors: part of a multimodality approach
    John A Jane
    Department of Internal Medicine, University of Virginia, Health Sciences Center, Charlottesville, Virginia 22908, USA
    Neurosurg Focus 14:e12. 2003
    ..The authors report their experience with GKS in patients in whom surgical and medical therapies failed...
  67. ncbi Functional outcomes and survival in patients with high-grade gliomas in dominant and nondominant hemispheres
    Richard S Polin
    Department of Neurosurgery, School of Medicine, The George Washington University, Washington, DC 20037, USA
    J Neurosurg 102:276-83. 2005
    ....
  68. ncbi Development of pituitary surgery: the Chicago contributions
    James L Stone
    Department of Neurological Surgery, Center for the History of Neuroscience, University of Illinois, Chicago 60612, USA
    J Am Coll Surg 201:784-805. 2005
  69. ncbi Cushing's first case of transsphenoidal surgery: the launch of the pituitary surgery era
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55902, USA
    J Neurosurg 103:570-4. 2005
    ..In this article, the authors review the clinical details of Cushing's first case of transsphenoidal pituitary surgery...
  70. ncbi Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients
    Edward C Nemergut
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 103:448-54. 2005
    ..Diabetes insipidus (DI) is a common complication of transsphenoidal surgery. The purpose of this study was to elucidate patient- and surgery-specific risk factors for DI...
  71. ncbi Perioperative management of patients undergoing transsphenoidal pituitary surgery
    Edward C Nemergut
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, Virginia 22908 0710, USA
    Anesth Analg 101:1170-81. 2005
    ..Understanding preoperative assessment, intraoperative management, potential complications, their management, and strategies for avoidance are fundamental to successful perioperative patient care and avoidance of morbidity and mortality...
  72. ncbi The evolution of Harvey Cushing's surgical approach to pituitary tumors from transsphenoidal to transfrontal
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55902, USA
    J Neurosurg 103:372-7. 2005
    ....
  73. ncbi Biomechanical changes in gait following selective dorsal rhizotomy
    Mark F Abel
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Neurosurg 102:157-62. 2005
    ..The authors also expected that the changes from the SDR would be reflected in the electrical activities of the muscles...
  74. ncbi Pediatric sellar tumors: diagnostic procedures and management
    Jay Jagannathan
    Department of Neurological Surgery, University of Virginia Health Science Center, Charlottesville, Virginia, USA
    Neurosurg Focus 18:E6. 2005
    ..Less invasive methods, such as endoscopic transsphenoidal surgery and stereotactic radiosurgery, have shown promise as primary and adjuvant treatment modalities, respectively...
  75. ncbi Clinical review: the strategy of immediate reoperation for transsphenoidal surgery for Cushing's disease
    Marco Locatelli
    Department of Neuroscience, Ospedale Maggiore Policlinico, IRCCS, Milan, Italy
    J Clin Endocrinol Metab 90:5478-82. 2005
    ..A treatment algorithm is recommended, based on this study...
  76. ncbi Extended transsphenoidal approach
    Edward R Laws
    J Neurosurg 102:825-7; discussion 827-8. 2005
  77. ncbi Postoperative care following pituitary surgery
    Aaron S Dumont
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Intensive Care Med 20:127-40. 2005
    ..This review addresses the postoperative management of patients undergoing pituitary surgery with an emphasis on careful screening and recognition of complications...
  78. ncbi Battling blood loss in neurosurgery: Harvey Cushing's embrace of electrosurgery
    Jennifer R Voorhees
    Department of Neurological Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurosurg 102:745-52. 2005
    ..Nonetheless, he did know that by greatly reducing blood loss, electrosurgery allowed him to operate in patients whose tumors had been previously deemed inoperable and on the entire spectrum of neurosurgical patients more safely...
  79. ncbi Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium
    Jason P Sheehan
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg 102:678-91. 2005
    ..More recently, radiosurgery has emerged as a viable treatment option. The goal of this research was to define more fully the efficacy, safety, and role of radiosurgery in the treatment of pituitary adenomas...
  80. ncbi The transsphenoidal approach. A historical perspective
    Adam S Kanter
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Neurosurg Focus 18:e6. 2005
    ..This era's critical innovations and neurosurgical personalities are the topic of this historical overview...
  81. ncbi The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery
    Björn P Meij
    Department of Neurological Surgery, Health Sciences Center, University of Virginia, Charlottesville 22908 0214, USA
    J Neurosurg 96:195-208. 2002
    ....