William S Lawrence
Affiliation: University of Texas Medical Branch
- Hemodynamic effects of anthrax toxins in the rabbit model and the cardiac pathology induced by lethal toxinWilliam S Lawrence
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX 77555, USA
Toxins (Basel) 3:721-36. 2011..Our study demonstrates the hemodynamic effects of anthrax toxins, as well as the pathological effects of LeTx on the heart in the rabbit model, and it provides further evidence for the toxins' direct impact on the heart...
- The physiologic responses of Dutch belted rabbits infected with inhalational anthraxWilliam S Lawrence
Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, USA
Comp Med 59:257-65. 2009..Therefore, this rabbit model fulfills several of the criteria of a useful animal model for studying disease pathogenesis and evaluating therapeutics during inhalational anthrax...
- Telemetric left ventricular monitoring using wireless telemetry in the rabbit modelMallory K Tate
Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA
BMC Res Notes 4:320. 2011..abstract:..
- Transcriptional profiling of murine organ genes in response to infection with Bacillus anthracis Ames sporesScott T Moen
Department of Microbiology and Immunology, Medical Research Building, 301 University Boulevard, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
Microb Pathog 44:293-310. 2008..Additionally, the lung, spleen, and heart showed differential responses to the infection, further validating the demand for a better understanding of anthrax pathogenesis in order to design therapies against novel targets...
- Protection Afforded by Fluoroquinolones in Animal Models of Respiratory Infections with Bacillus anthracis, Yersinia pestis, and Francisella tularensisJohnny W Peterson
Department of Microbiology and Immunology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Blvd Galveston, Texas 77555 0610
Open Microbiol J 4:34-46. 2010..These results provide effective antibiotic dosages in mice, guinea pigs, and rabbits and lay the foundation for the development and evaluation of combinational treatment modalities...
- A replication-defective human type-5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and non-human primatesJian Sha
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA
Clin Vaccine Immunol . 2016..This is the first report showing the efficacy of an adenovirus-vectored trivalent vaccine against pneumonic plague in mouse and NHP models...