Christopher LawrenceSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
In vivo evidence for a recA-independent recombination process in Escherichia coli that permits completion of replication of DNA containing UV damage in both strandsAli I Ozgenc
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Bacteriol 187:1974-84. 2005..The nature of the recA-independent recombination mechanism is not known but could perhaps result from a template-strand-switching, or copy choice, process...- Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1pC W Lawrence
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Philos Trans R Soc Lond B Biol Sci 356:41-6. 2001.... 
Following the RAD6 pathwayChristopher W Lawrence
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 602 Elmwood Avenue, Rochester, NY 14642, United States
DNA Repair (Amst) 6:676-86. 2007..The following account highlights some of our work that contributed to an understanding of the mechanisms underlying these activities, carried out by the RAD6 pathway, my main preoccupation over this period...- The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombinationHengshan Zhang
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 102:15954-9. 2005.... - The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigenHengshan Zhang
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Genetics 173:1983-9. 2006.... - Cellular roles of DNA polymerase zeta and Rev1 proteinChristopher W Lawrence
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
DNA Repair (Amst) 1:425-35. 2002..Finally, very little is known about the way these enzymes are regulated and brought into play when needed... - The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimerPeter E M Gibbs
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Genetics 169:575-82. 2005..In contrast, bypass of the T-T dimer in the pol32delta strain occurs at the wild-type frequency... - Classical mutagenesis techniquesChristopher W Lawrence
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Methods Enzymol 350:189-99. 2002 - Cellular functions of DNA polymerase zeta and Rev1 proteinChristopher W Lawrence
Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Adv Protein Chem 69:167-203. 2004 - Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contextsPeter D Hoffman
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis Oregon 97331 7301, USA
DNA Repair (Amst) 4:983-93. 2005..Previous studies and the work here, taken together, suggest that in only about half of DNA sequence contexts could MutS (and presumably MutSalpha) selectively bind mismatched UV photoproducts and directly suppress UV mutagenesis... - Escherichia coli DNA polymerase III can replicate efficiently past a T-T cis-syn cyclobutane dimer if DNA polymerase V and the 3' to 5' exonuclease proofreading function encoded by dnaQ are inactivatedAngela Borden
Section on DNA Replication, Repair, and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2725, USA
J Bacteriol 184:2674-81. 2002..This mutant polymerase does not replicate past the much more distorted T-T (6-4) photoadduct, however, suggesting that it may only replicate past lesions, like the T-T dimer, that form base pairs normally... - hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblastsZiqiang Li
Carcinogenesis Laboratory, Department of Microbiology and Molecular Genetics, Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824 1302, USA
Mutat Res 510:71-80. 2002..However, the conclusion is supported by the fact that in a similar study with a strain expressing a high level of antisense hREV1, a very similar result was obtained, i.e. UV or BPDE mutagenesis was virtually eliminated...
Research Grants
- DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONSChristopher Lawrence; Fiscal Year: 1993....
- DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONSChristopher Lawrence; Fiscal Year: 1999..This work will lead to a better understanding of mutagenesis induced by UV, a serious environmental mutagen, and mutagenic processes in general, which are implicated in cancer induction. ..
- DNA SEQUENCING OF UV INDUCED CHROMOSOMAL MUTATIONSChristopher Lawrence; Fiscal Year: 2003..abstract_text> ..
- DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONSChristopher Lawrence; Fiscal Year: 1991....
- MECHANISM OF TRANSLESION REPLICATION IN EUKARYOTESChristopher Lawrence; Fiscal Year: 2003..These plasmids have proved useful in detecting different kinds of recombinant events, a likely mechanism for the pathway. ..