Christopher Lawrence

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc In vivo evidence for a recA-independent recombination process in Escherichia coli that permits completion of replication of DNA containing UV damage in both strands
    Ali I Ozgenc
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Bacteriol 187:1974-84. 2005
  2. pmc Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p
    C W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Philos Trans R Soc Lond B Biol Sci 356:41-6. 2001
  3. ncbi request reprint Following the RAD6 pathway
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 602 Elmwood Avenue, Rochester, NY 14642, United States
    DNA Repair (Amst) 6:676-86. 2007
  4. pmc The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination
    Hengshan Zhang
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:15954-9. 2005
  5. pmc The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen
    Hengshan Zhang
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genetics 173:1983-9. 2006
  6. ncbi request reprint Cellular roles of DNA polymerase zeta and Rev1 protein
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    DNA Repair (Amst) 1:425-35. 2002
  7. pmc The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genetics 169:575-82. 2005
  8. ncbi request reprint Classical mutagenesis techniques
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Methods Enzymol 350:189-99. 2002
  9. ncbi request reprint Cellular functions of DNA polymerase zeta and Rev1 protein
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Adv Protein Chem 69:167-203. 2004
  10. ncbi request reprint Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts
    Peter D Hoffman
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis Oregon 97331 7301, USA
    DNA Repair (Amst) 4:983-93. 2005

Research Grants

  1. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1993
  2. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1999
  3. DNA SEQUENCING OF UV INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 2003
  4. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1991
  5. MECHANISM OF TRANSLESION REPLICATION IN EUKARYOTES
    Christopher Lawrence; Fiscal Year: 2003

Collaborators

  • R Woodgate
  • J B Hays
  • Shigenori Iwai
  • Fumio Hanaoka
  • Hengshan Zhang
  • Peter E M Gibbs
  • Ali I Ozgenc
  • Peter D Hoffman
  • Ziqiang Li
  • Angela Borden
  • John McDonald
  • Huixian Wang
  • Edward S Szekeres
  • J Justin McCormick
  • Antonio R Fern├índez de Henestrosa
  • Veronica M Maher
  • Hong Zhang
  • Paul I O'Grady
  • Terrence P McManus
  • Dominique Vandewiele

Detail Information

Publications12

  1. pmc In vivo evidence for a recA-independent recombination process in Escherichia coli that permits completion of replication of DNA containing UV damage in both strands
    Ali I Ozgenc
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Bacteriol 187:1974-84. 2005
    ..The nature of the recA-independent recombination mechanism is not known but could perhaps result from a template-strand-switching, or copy choice, process...
  2. pmc Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p
    C W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Philos Trans R Soc Lond B Biol Sci 356:41-6. 2001
    ....
  3. ncbi request reprint Following the RAD6 pathway
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, 602 Elmwood Avenue, Rochester, NY 14642, United States
    DNA Repair (Amst) 6:676-86. 2007
    ..The following account highlights some of our work that contributed to an understanding of the mechanisms underlying these activities, carried out by the RAD6 pathway, my main preoccupation over this period...
  4. pmc The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination
    Hengshan Zhang
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 102:15954-9. 2005
    ....
  5. pmc The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen
    Hengshan Zhang
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genetics 173:1983-9. 2006
    ....
  6. ncbi request reprint Cellular roles of DNA polymerase zeta and Rev1 protein
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    DNA Repair (Amst) 1:425-35. 2002
    ..Finally, very little is known about the way these enzymes are regulated and brought into play when needed...
  7. pmc The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer
    Peter E M Gibbs
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genetics 169:575-82. 2005
    ..In contrast, bypass of the T-T dimer in the pol32delta strain occurs at the wild-type frequency...
  8. ncbi request reprint Classical mutagenesis techniques
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Methods Enzymol 350:189-99. 2002
  9. ncbi request reprint Cellular functions of DNA polymerase zeta and Rev1 protein
    Christopher W Lawrence
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Adv Protein Chem 69:167-203. 2004
  10. ncbi request reprint Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts
    Peter D Hoffman
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis Oregon 97331 7301, USA
    DNA Repair (Amst) 4:983-93. 2005
    ..Previous studies and the work here, taken together, suggest that in only about half of DNA sequence contexts could MutS (and presumably MutSalpha) selectively bind mismatched UV photoproducts and directly suppress UV mutagenesis...
  11. pmc Escherichia coli DNA polymerase III can replicate efficiently past a T-T cis-syn cyclobutane dimer if DNA polymerase V and the 3' to 5' exonuclease proofreading function encoded by dnaQ are inactivated
    Angela Borden
    Section on DNA Replication, Repair, and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2725, USA
    J Bacteriol 184:2674-81. 2002
    ..This mutant polymerase does not replicate past the much more distorted T-T (6-4) photoadduct, however, suggesting that it may only replicate past lesions, like the T-T dimer, that form base pairs normally...
  12. ncbi request reprint hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts
    Ziqiang Li
    Carcinogenesis Laboratory, Department of Microbiology and Molecular Genetics, Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824 1302, USA
    Mutat Res 510:71-80. 2002
    ..However, the conclusion is supported by the fact that in a similar study with a strain expressing a high level of antisense hREV1, a very similar result was obtained, i.e. UV or BPDE mutagenesis was virtually eliminated...

Research Grants24

  1. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1993
    ....
  2. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1999
    ..This work will lead to a better understanding of mutagenesis induced by UV, a serious environmental mutagen, and mutagenic processes in general, which are implicated in cancer induction. ..
  3. DNA SEQUENCING OF UV INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 2003
    ..abstract_text> ..
  4. DNA SEQUENCING OF UV-INDUCED CHROMOSOMAL MUTATIONS
    Christopher Lawrence; Fiscal Year: 1991
    ....
  5. MECHANISM OF TRANSLESION REPLICATION IN EUKARYOTES
    Christopher Lawrence; Fiscal Year: 2003
    ..These plasmids have proved useful in detecting different kinds of recombinant events, a likely mechanism for the pathway. ..