Helen Lavretsky

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Practical geriatrics: clinically significant nonmajor geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, 90095, USA
    Psychiatr Serv 54:297-9. 2003
  2. pmc Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
    Gary W Small
    Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024, USA
    Arch Gen Psychiatry 66:81-7. 2009
  3. pmc Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 16:999-1009. 2008
  4. pmc Prediction of cognitive decline by positron emission tomography of brain amyloid and tau
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Arch Neurol 69:215-22. 2012
  5. pmc Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:493-502. 2009
  6. pmc Differential FDDNP PET patterns in nondemented middle-aged and older adults
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:397-406. 2009
  7. pmc Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
  8. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
  9. pmc Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    Int Psychogeriatr 24:1076-84. 2012
  10. ncbi request reprint PET of brain amyloid and tau in mild cognitive impairment
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, USA
    N Engl J Med 355:2652-63. 2006

Detail Information

Publications41

  1. ncbi request reprint Practical geriatrics: clinically significant nonmajor geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, 90095, USA
    Psychiatr Serv 54:297-9. 2003
  2. pmc Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia
    Gary W Small
    Semel Institute, 760 Westwood Plaza, Ste 88 201, Los Angeles, CA 90024, USA
    Arch Gen Psychiatry 66:81-7. 2009
    ..Here we investigated whether known risk factors for Alzheimer disease and dementia are associated with FDDNP-PET binding...
  3. pmc Cognitive and cerebral metabolic effects of celecoxib versus placebo in people with age-related memory loss: randomized controlled study
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 16:999-1009. 2008
    ....
  4. pmc Prediction of cognitive decline by positron emission tomography of brain amyloid and tau
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Arch Neurol 69:215-22. 2012
    ..To determine whether 2-(1-{6-[(2-fluorine 18-labeled fluoroethyl)methylamino]-2-napthyl}ethylidene) malononitrile ([(18)F]FDDNP) brain regional values in individuals without dementia predict and correlate with future cognitive change...
  5. pmc Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:493-502. 2009
    ....
  6. pmc Differential FDDNP PET patterns in nondemented middle-aged and older adults
    Linda M Ercoli
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:397-406. 2009
    ....
  7. pmc Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Psychiatry 167:589-97. 2010
    ....
  8. ncbi request reprint The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study
    Helen Lavretsky
    UCLA School of Medicine, Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:55-9. 2008
    ....
  9. pmc Self-reported memory impairment and brain PET of amyloid and tau in middle-aged and older adults without dementia
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    Int Psychogeriatr 24:1076-84. 2012
    ..Here we investigate whether degree of self-reported memory impairment is associated with FDDNP-PET binding levels in persons without dementia...
  10. ncbi request reprint PET of brain amyloid and tau in mild cognitive impairment
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at the University of California, Los Angeles, USA
    N Engl J Med 355:2652-63. 2006
    ..Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnostics...
  11. pmc Vascular risk and FDDNP-PET influence cognitive performance
    David A Merrill
    Division of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA, USA
    J Alzheimers Dis 35:147-57. 2013
    ..These findings suggest that even mild cerebrovascular risk may influence the extent of cognitive dysfunction in pre-dementia, along with amyloid-β and tau burden...
  12. pmc Improving depression and enhancing resilience in family dementia caregivers: a pilot randomized placebo-controlled trial of escitalopram
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Semel Institute for Neuroscience, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 18:154-62. 2010
    ..This study examined the potential of an antidepressant drug, escitalopram, to improve depression, resilience to stress, and quality of life in family dementia caregivers in a randomized placebo-controlled double-blinded trial...
  13. ncbi request reprint Antidepressant exposure may protect against decrement in frontal gray matter volumes in geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    J Clin Psychiatry 66:964-7. 2005
    ..Depressed elderly patients with and without antidepressant exposure were compared to normal controls to examine the effects of prior antidepressant exposure on regional brain gray matter volumes using magnetic resonance imaging (MRI)...
  14. ncbi request reprint Localizing gray matter deficits in late-onset depression using computational cortical pattern matching methods
    Martina Ballmaier
    Laboratory of Neuro Imaging, Department of Neurology, Rm 4238, Reed Neurological Research Center, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Am J Psychiatry 161:2091-9. 2004
    ..The authors used magnetic resonance imaging and an image analysis technique known as cortical pattern matching to map cortical gray matter deficits in elderly depressed patients with an illness onset after age 60 (late-onset depression)...
  15. pmc Complementary use of tai chi chih augments escitalopram treatment of geriatric depression: a randomized controlled trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences and the Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA
    Am J Geriatr Psychiatry 19:839-50. 2011
    ....
  16. pmc Prior depression history and deterioration of physical health in community-dwelling older adults--a prospective cohort study
    Hyong Jin Cho
    Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Semel Institute for Neuroscience, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 18:442-51. 2010
    ..This study examined whether prior depression history predicts deterioration of physical health in community-dwelling older adults...
  17. ncbi request reprint Executive dysfunction and memory in older patients with major and minor depression
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute, Geriatric Division, Los Angeles, CA, USA
    Arch Clin Neuropsychol 22:261-70. 2007
    ..In conclusion, the verbal memory deficits typically attributed to late-life depression may result from impaired executive functioning during the learning phase of the recall task...
  18. pmc Neuroanatomical characteristics of geriatric apathy and depression: a magnetic resonance imaging study
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 15:386-94. 2007
    ..Apathy is one of the most common late-life neuropsychiatric syndromes. The objective of our study was to examine the neuroanatomical correlates of apathy in older subjects with and without geriatric major depression (MDD)...
  19. doi request reprint Daily functioning and prefrontal brain morphology in healthy and depressed community-dwelling elderly
    Virginia Elderkin-Thompson
    Semel Institute for Neuroscience and Human Behavior, Geriatric Division, UCLA, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 16:633-42. 2008
    ..This study examined relationships between self-reported levels of general functioning and the combined volume of three integrated prefrontal structures associated with self-perception and emotion...
  20. ncbi request reprint Sex differences in brain structure in geriatric depression
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 12:653-7. 2004
    ..In an exploratory study, authors compared patients with late-life major depression (MDD) and age-matched control subjects to examine sex differences in frontal and orbito-frontal (OFC) regional brain volumes...
  21. pmc The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia
    Helen Lavretsky
    Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Geriatr Psychiatry 23:1040-50. 2008
    ..We examined the magnetic resonance imaging (MRI) correlates of depressed mood, apathy, anhedonia, and anergia in older adults with and without cognitive impairment or dementia...
  22. ncbi request reprint Methylphenidate-enhanced antidepressant response to citalopram in the elderly: a double-blind, placebo-controlled pilot trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90095, USA
    Am J Geriatr Psychiatry 14:181-5. 2006
    ..The authors evaluated the potential of methylphenidate to accelerate and enhance antidepressant response to citalopram in elderly depressed patients...
  23. ncbi request reprint Effects of a 14-day healthy longevity lifestyle program on cognition and brain function
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Am J Geriatr Psychiatry 14:538-45. 2006
    ..The objective of this study was to determine the effects of a 14-day healthy longevity lifestyle program on cognition and cerebral metabolism in people with mild age-related memory complaints...
  24. pmc Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, the Alzheimer s Disease Center, The Center on Aging, University of California, Los Angeles, CA 90095, USA
    Am J Geriatr Psychiatry 11:667-73. 2003
    ....
  25. ncbi request reprint Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California School of Medicine, Los Angeles 90095, USA
    J Clin Psychiatry 64:1410-4. 2003
    ..We evaluated the potential of methylphenidate to accelerate antidepressant response to citalopram and the safety and tolerability of the combined treatment in patients with geriatric major depressive disorder...
  26. ncbi request reprint Executive dysfunction and memory in older patients with major and minor depression
    Virginia Elderkin-Thompson
    UCLA Neuropsychiatric Research Institute, Geriatric Division, CA 90024 1759, USA
    Arch Clin Neuropsychol 21:669-76. 2006
    ..In conclusion, the verbal memory deficits typically attributed to late-life depression may result from impaired executive functioning during the learning phase of the recall task...
  27. ncbi request reprint Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy
    Anand Kumar
    Department of Psychiatry, University of California, Los Angeles, School of Medicine, USA
    Am J Psychiatry 159:630-6. 2002
    ..This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy...
  28. pmc Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study
    Hyong Jin Cho
    Cousins Center for Psychoneuroimmunology, UCLA Semel Institute of Neuroscience, 300 Medical Plaza, Suite 3 109, Los Angeles, CA 90095 7057, USA
    Am J Psychiatry 165:1543-50. 2008
    ..A prior depressive episode is thought to increase the risk of depression. However, among older adults with prior depression, it is unclear whether sleep disturbance predicts depression recurrence independent of other depressive symptoms...
  29. ncbi request reprint Executive dysfunction and visuospatial ability among depressed elders in a community setting
    Virginia Elderkin-Thompson
    Neuropsychiatric Research Institute and Hospital, University of California, 760 Westwood Plaza, C8 688, Los Angeles, CA 90024 1759, USA
    Arch Clin Neuropsychol 19:597-611. 2004
    ..This result is consistent with the theory that dysfunction of the prefrontal cortex is a critical feature of late-life depression...
  30. ncbi request reprint Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex
    Martina Ballmaier
    Department of Neurology, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024, USA
    Am J Psychiatry 161:99-108. 2004
    ....
  31. doi request reprint Tai Chi and Qigong for the treatment and prevention of mental disorders
    Ryan Abbott
    Southwestern Law School, 3050 Wilshire Boulevard, Los Angeles, California, USA
    Psychiatr Clin North Am 36:109-19. 2013
    ..Evidence is promising that these treatments may be effective in reducing depressive symptoms, stress, anxiety, and mood disturbances...
  32. ncbi request reprint Mapping brain size and cortical gray matter changes in elderly depression
    Martina Ballmaier
    Laboratory of Neuro Imaging, Department of Neurology, David Geffen UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Biol Psychiatry 55:382-9. 2004
    ..Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression...
  33. pmc Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
    David S Black
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Psychoneuroendocrinology 38:348-55. 2013
    ..The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression...
  34. ncbi request reprint The significance of subsyndromal depression in geriatrics
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles School of Medicine, Room 37 425, 760 Westwood Place, Los Angeles, CA 90095, USA
    Curr Psychiatry Rep 6:25-31. 2004
    ..The authors draw conclusions from the published literature and present clinical criteria for the diagnosis of clinically significant non-major depression in the elderly...
  35. ncbi request reprint Innovations: geriatric psychiatry: diagnosis and treatment of neuropsychiatric symptoms in Alzheimer's disease
    Helen Lavretsky
    University of California, Los Angeles, CA 90095, USA
    Psychiatr Serv 57:617-9. 2006
    ..Such interventions include caregiver training and support, antipsychotics, antidepressants, and cholinesterase inhibitors, along with other drugs developed for the treatment of Alzheimer's disease...
  36. ncbi request reprint Clinically significant non-major depression: old concepts, new insights
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 10:239-55. 2002
    ..They draw conclusions from the published literature and propose clinical criteria for the diagnosis of clinically significant non-major depression in elderly persons...
  37. ncbi request reprint Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial
    Steven P Roose
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 161:2050-9. 2004
    ..This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old."..
  38. pmc Neuropsychiatric symptoms in Alzheimer disease and related disorders: why do treatments work in clinical practice but not in the randomized trials?
    Helen Lavretsky
    Am J Geriatr Psychiatry 16:523-7. 2008
  39. ncbi request reprint MRI subcortical hyperintensities in old and very old depressed outpatients: the important role of age in late-life depression
    Stephen Salloway
    Brown Medical School, Providence, RI, USA
    J Neurol Sci 203:227-33. 2002
    ..This study examined the severity of subcortical hyperintensities (SH) and the relationship between SH and depression characteristics in two samples of elderly depressed outpatients differing in age...
  40. ncbi request reprint Estrogen use and brain metabolic change in postmenopausal women
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Neurobiol Aging 26:229-35. 2005
    ..We used positron emission tomography to evaluate cerebral glucose metabolic change in postmenopausal women in a naturalistic observational study...
  41. ncbi request reprint Predictors of two-year mortality in a prospective "UPBEAT" study of elderly veterans with comorbid medical and psychiatric symptoms
    Helen Lavretsky
    Received August 9, 2000
    Am J Geriatr Psychiatry 10:458-68. 2002
    ..Lack of improvement in symptoms of depression and anxiety at 6 months was associated with higher rates of mortality...