Steven R Laviolette

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Canada, M5S 1A8
    Nat Rev Neurosci 5:55-65. 2004
  2. ncbi request reprint Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Canada
    Nat Neurosci 7:160-9. 2004
  3. ncbi request reprint GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
    Eur J Neurosci 20:2179-87. 2004
  4. ncbi request reprint A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input
    Steven R Laviolette
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 25:6066-75. 2005
  5. doi request reprint Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex
    Huibing Tan
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 31:5300-12. 2011
  6. doi request reprint Opiate exposure and withdrawal induces a molecular memory switch in the basolateral amygdala between ERK1/2 and CaMKIIα-dependent signaling substrates
    Danika Lyons
    Department of Anatomy and Cell Biology, Department of Psychiatry, Department of Psychology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 33:14693-704. 2013
  7. doi request reprint Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit
    Alessandra Lintas
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 31:11172-83. 2011
  8. doi request reprint Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission
    Alessandra Lintas
    Department of Anatomy and Cell Biology, 468 Medical Science Building, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Eur J Neurosci 35:279-90. 2012
  9. doi request reprint Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding
    Huibing Tan
    Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    Cereb Cortex 20:1486-96. 2010
  10. doi request reprint Inactivation of the basolateral amygdala during opiate reward learning disinhibits prelimbic cortical neurons and modulates associative memory extinction
    Ninglei Sun
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, 468 Medical Science Building, London, ON N6A 5C1, Canada
    Psychopharmacology (Berl) 222:645-61. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Canada, M5S 1A8
    Nat Rev Neurosci 5:55-65. 2004
  2. ncbi request reprint Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Canada
    Nat Neurosci 7:160-9. 2004
    ..After opiate exposure and subsequent withdrawal, the functional conductance properties of the rat VTA GABA(A) receptor switch from an inhibitory to an excitatory signaling mode...
  3. ncbi request reprint GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
    Eur J Neurosci 20:2179-87. 2004
    ..These findings suggest that GABAA receptors in the VTA can regulate differential reward signalling through separate neural systems during the transition from a drug-naive to a drug-dependent and withdrawn state...
  4. ncbi request reprint A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala input
    Steven R Laviolette
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 25:6066-75. 2005
    ..These results demonstrate that individual neurons in the mPFC that receive a functional input from the BLA actively encode emotional learning and that this process depends on DA D4 receptor stimulation in the mPFC...
  5. doi request reprint Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex
    Huibing Tan
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 31:5300-12. 2011
    ..Thus, cannabinoid transmission within the BLA strongly modulates the processing of associative fear memory via functional interactions with PLC neuronal populations...
  6. doi request reprint Opiate exposure and withdrawal induces a molecular memory switch in the basolateral amygdala between ERK1/2 and CaMKIIα-dependent signaling substrates
    Danika Lyons
    Department of Anatomy and Cell Biology, Department of Psychiatry, Department of Psychology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 33:14693-704. 2013
    ....
  7. doi request reprint Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuit
    Alessandra Lintas
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Neurosci 31:11172-83. 2011
    ....
  8. doi request reprint Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmission
    Alessandra Lintas
    Department of Anatomy and Cell Biology, 468 Medical Science Building, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Eur J Neurosci 35:279-90. 2012
    ..Our findings demonstrate a novel and functional DA D1/D2 receptor-mediated opiate reward memory switch within the BLA→NA shell circuit that controls opiate reward magnitude as a function of opiate exposure state...
  9. doi request reprint Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding
    Huibing Tan
    Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    Cereb Cortex 20:1486-96. 2010
    ....
  10. doi request reprint Inactivation of the basolateral amygdala during opiate reward learning disinhibits prelimbic cortical neurons and modulates associative memory extinction
    Ninglei Sun
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, 468 Medical Science Building, London, ON N6A 5C1, Canada
    Psychopharmacology (Berl) 222:645-61. 2012
    ..However, the nature by which the BLA regulates PLC neuronal encoding of associative opiate reward learning is not presently understood...
  11. ncbi request reprint DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    Hai Ying M Cheng
    Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Neurosci 19:3033-41. 2004
    ..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice...
  12. ncbi request reprint The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor
    Steven R Laviolette
    Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 166:306-13. 2003
    ..However, the specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes responsible for these effects are not clearly understood...
  13. doi request reprint The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity
    Xavier De Jaeger
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Psychopharmacology (Berl) 225:687-95. 2013
    ..AMPA receptor transmission in the mPFC modulates opiate-related reward memory processing, and chronic opiate exposure is associated with alterations in intra-mPFC AMPA receptor function...
  14. pmc Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 3E1
    Proc Natl Acad Sci U S A 109:3101-6. 2012
    ....
  15. pmc Early versus late-phase consolidation of opiate reward memories requires distinct molecular and temporal mechanisms in the amygdala-prefrontal cortical pathway
    Shervin Gholizadeh
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e63612. 2013
    ..In addition, using in vivo multi-unit neuronal recordings in the mPFC, we report that protein synthesis within the BLA modulates the consolidation of opiate-reward memory in neuronal mPFC sub-populations, via the same temporal dynamic...
  16. ncbi request reprint Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:8653-60. 2002
    ..Our results suggest that the rewarding effects of nicotine in the VTA are dependent on a nondopaminergic, descending reward pathway to the brainstem TPP...
  17. doi request reprint Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male rats
    Karla S Frohmader
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A5C1, Canada
    J Neurosci 31:16473-82. 2011
    ..Together, these data indicate that the association between drug use and mating may be required for expression of compulsive sexual behavior and is correlated with increased reward seeking for concurrent Meth exposure and mating...
  18. doi request reprint Dopamine D4-receptor modulation of cortical neuronal network activity and emotional processing: Implications for neuropsychiatric disorders
    Nicole M Lauzon
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Behav Brain Res 208:12-22. 2010
    ....
  19. doi request reprint NMDA receptor hypofunction in the prelimbic cortex increases sensitivity to the rewarding properties of opiates via dopaminergic and amygdalar substrates
    Stephanie F Bishop
    Department of Anatomy and Cell Biology, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    Cereb Cortex 21:68-80. 2011
    ....
  20. pmc Natural and drug rewards act on common neural plasticity mechanisms with ΔFosB as a key mediator
    Kyle K Pitchers
    Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 3K7, Canada
    J Neurosci 33:3434-42. 2013
    ....
  21. ncbi request reprint Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes
    Steven R Laviolette
    Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Medical Sciences Building, Toronto, Ont, Canada
    Behav Brain Res 129:17-29. 2002
    ..p.) before conditioning in a state of withdrawal, also blocks the aversive effects of opiate withdrawal. We propose that the aversive motivational effects of opiate withdrawal may be mediated by a specific dopaminergic neuronal signal...
  22. ncbi request reprint Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs
    Steven R Laviolette
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:6458-68. 2006
    ..These results are the first demonstration that cannabinoid signaling in the mPFC can modulate the magnitude of neuronal emotional learning plasticity and memory formation through functional inputs from the BLA...
  23. ncbi request reprint DREAM is a critical transcriptional repressor for pain modulation
    Hai Ying M Cheng
    Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
    Cell 108:31-43. 2002
    ..Thus, DREAM appears to be a critical transcriptional repressor in pain processing...
  24. doi request reprint Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivity
    Steven R Laviolette
    Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada N5Y 5T8
    J Neurosci 28:8025-33. 2008
    ..Thus, D(1)-like versus D(2)-like receptors in NAcore versus NAshell subdivisions play functionally dissociable roles in modulating systemic or intra-VTA nicotine motivational processing...
  25. pmc Dopamine modulation of emotional processing in cortical and subcortical neural circuits: evidence for a final common pathway in schizophrenia?
    Steven R Laviolette
    Dept of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Schizophr Bull 33:971-81. 2007
    ....