Research Topics
Genomes and Genes | Steven R LavioletteSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate stateSteven R Laviolette
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
Eur J Neurosci 20:2179-87. 2004..These findings suggest that GABAA receptors in the VTA can regulate differential reward signalling through separate neural systems during the transition from a drug-naive to a drug-dependent and withdrawn state...- A subpopulation of neurons in the medial prefrontal cortex encodes emotional learning with burst and frequency codes through a dopamine D4 receptor-dependent basolateral amygdala inputSteven R Laviolette
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 25:6066-75. 2005..These results demonstrate that individual neurons in the mPFC that receive a functional input from the BLA actively encode emotional learning and that this process depends on DA D4 receptor stimulation in the mPFC... - Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental areaSteven R Laviolette
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Canada
Nat Neurosci 7:160-9. 2004..After opiate exposure and subsequent withdrawal, the functional conductance properties of the rat VTA GABA(A) receptor switch from an inhibitory to an excitatory signaling mode... - The neurobiology of nicotine addiction: bridging the gap from molecules to behaviourSteven R Laviolette
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Canada, M5S 1A8
Nat Rev Neurosci 5:55-65. 2004 
Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortexHuibing Tan
Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
J Neurosci 31:5300-12. 2011..Thus, cannabinoid transmission within the BLA strongly modulates the processing of associative fear memory via functional interactions with PLC neuronal populations...- Identification of a dopamine receptor-mediated opiate reward memory switch in the basolateral amygdala-nucleus accumbens circuitAlessandra Lintas
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
J Neurosci 31:11172-83. 2011.... - Inputs from the basolateral amygdala to the nucleus accumbens shell control opiate reward magnitude via differential dopamine D1 or D2 receptor transmissionAlessandra Lintas
Department of Anatomy and Cell Biology, 468 Medical Science Building, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
Eur J Neurosci 35:279-90. 2012..Our findings demonstrate a novel and functional DA D1/D2 receptor-mediated opiate reward memory switch within the BLA→NA shell circuit that controls opiate reward magnitude as a function of opiate exposure state... - Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encodingHuibing Tan
Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
Cereb Cortex 20:1486-96. 2010.... - The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptorSteven R Laviolette
Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, Ontario, Canada
Psychopharmacology (Berl) 166:306-13. 2003.... - DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphineHai Ying M Cheng
Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Eur J Neurosci 19:3033-41. 2004..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice... 
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawalTaryn E Grieder
Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 3E1
Proc Natl Acad Sci U S A 109:3101-6. 2012....- Concurrent exposure to methamphetamine and sexual behavior enhances subsequent drug reward and causes compulsive sexual behavior in male ratsKarla S Frohmader
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A5C1, Canada
J Neurosci 31:16473-82. 2011..Together, these data indicate that the association between drug use and mating may be required for expression of compulsive sexual behavior and is correlated with increased reward seeking for concurrent Meth exposure and mating... - Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental areaSteven R Laviolette
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
J Neurosci 22:8653-60. 2002..Our results suggest that the rewarding effects of nicotine in the VTA are dependent on a nondopaminergic, descending reward pathway to the brainstem TPP... - Dopamine D4-receptor modulation of cortical neuronal network activity and emotional processing: Implications for neuropsychiatric disordersNicole M Lauzon
Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
Behav Brain Res 208:12-22. 2010.... - NMDA receptor hypofunction in the prelimbic cortex increases sensitivity to the rewarding properties of opiates via dopaminergic and amygdalar substratesStephanie F Bishop
Department of Anatomy and Cell Biology, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
Cereb Cortex 21:68-80. 2011.... - Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala InputsSteven R Laviolette
Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 26:6458-68. 2006..These results are the first demonstration that cannabinoid signaling in the mPFC can modulate the magnitude of neuronal emotional learning plasticity and memory formation through functional inputs from the BLA... - Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processesSteven R Laviolette
Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, Medical Sciences Building, Toronto, Ont, Canada
Behav Brain Res 129:17-29. 2002..p.) before conditioning in a state of withdrawal, also blocks the aversive effects of opiate withdrawal. We propose that the aversive motivational effects of opiate withdrawal may be mediated by a specific dopaminergic neuronal signal... - Inactivation of the basolateral amygdala during opiate reward learning disinhibits prelimbic cortical neurons and modulates associative memory extinctionNinglei Sun
Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, University of Western Ontario, 468 Medical Science Building, London, ON N6A 5C1, Canada
Psychopharmacology (Berl) 222:645-61. 2012..However, the nature by which the BLA regulates PLC neuronal encoding of associative opiate reward learning is not presently understood... - DREAM is a critical transcriptional repressor for pain modulationHai Ying M Cheng
Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada
Cell 108:31-43. 2002..Thus, DREAM appears to be a critical transcriptional repressor in pain processing... - Dopamine signaling through D1-like versus D2-like receptors in the nucleus accumbens core versus shell differentially modulates nicotine reward sensitivitySteven R Laviolette
Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada N5Y 5T8
J Neurosci 28:8025-33. 2008..Thus, D(1)-like versus D(2)-like receptors in NAcore versus NAshell subdivisions play functionally dissociable roles in modulating systemic or intra-VTA nicotine motivational processing... - Dopamine modulation of emotional processing in cortical and subcortical neural circuits: evidence for a final common pathway in schizophrenia?Steven R Laviolette
Dept of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada N6A 5C1
Schizophr Bull 33:971-81. 2007....