Julie C Lauterborn

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 4292, USA
    J Neurosci 27:10685-94. 2007
  2. ncbi Stress induced changes in cortical and hypothalamic c-fos expression are altered in fragile X mutant mice
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain Res Mol Brain Res 131:101-9. 2004
  3. ncbi Chronic elevation of brain-derived neurotrophic factor by ampakines
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 4292, UA
    J Pharmacol Exp Ther 307:297-305. 2003
  4. ncbi Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons
    J C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 4292, USA
    J Neurosci 20:8-21. 2000
  5. ncbi Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
    Lulu Y Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 30:10977-84. 2010
  6. ncbi BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats
    Eniko A Kramar
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 4291, USA
    Neurobiol Aging 33:708-19. 2012
  7. ncbi LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice
    Ronald R Seese
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1275, USA
    J Neurosci 32:7403-13. 2012
  8. ncbi Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation
    Alex H Babayan
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 32:12854-61. 2012
  9. ncbi Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression
    J C Lauterborn
    Department of Anatomy and Neurobiology, Gillespie Neuroscience Research Facility Room 3119, 837 Health Science Drive, University of California at Irvine, Irvine, CA 92697 4291, USA
    Neuroscience 159:283-95. 2009
  10. ncbi Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling
    Matiar Jafari
    Department of Anatomy and Neurobiology, 3226 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697 1275, USA
    Mol Neurobiol 46:304-15. 2012

Research Grants

  1. Altered hypothalamic-pituitary-adrenal function in the Fragile X mouse
    JULIE LAUTERBORN; Fiscal Year: 2007

Collaborators

Detail Information

Publications17

  1. ncbi Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 4292, USA
    J Neurosci 27:10685-94. 2007
    ..The possibility of a pharmacological therapy based on these results is discussed...
  2. ncbi Stress induced changes in cortical and hypothalamic c-fos expression are altered in fragile X mutant mice
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain Res Mol Brain Res 131:101-9. 2004
    ..These data indicate a greater response to stress in FraX mutants than in WTs, and further support the hypothesis of a dysregulated hypothalamic-pituitary-adrenal (HPA) axis in FraX syndrome...
  3. ncbi Chronic elevation of brain-derived neurotrophic factor by ampakines
    Julie C Lauterborn
    Department of Anatomy and Neurobiology, Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 4292, UA
    J Pharmacol Exp Ther 307:297-305. 2003
    ..These results suggest that spaced ampakine treatments can be used to sustain elevated neurotrophin levels and to test the utility of this manipulation for neuroprotection by endogenous neurotrophins...
  4. ncbi Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons
    J C Lauterborn
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 4292, USA
    J Neurosci 20:8-21. 2000
    ....
  5. ncbi Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
    Lulu Y Chen
    Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 30:10977-84. 2010
    ..We propose that a Rac>PAK signaling pathway needed for rapid stabilization of activity-induced actin filaments, and thus for normal spine morphology and lasting synaptic changes, is defective in FXS...
  6. ncbi BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats
    Eniko A Kramar
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 4291, USA
    Neurobiol Aging 33:708-19. 2012
    ..These results provide the first evidence that minimally invasive, mechanism-based drug treatments can ameliorate defects in spine plasticity caused by depressed estrogen levels...
  7. ncbi LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice
    Ronald R Seese
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1275, USA
    J Neurosci 32:7403-13. 2012
    ..These impairments are predicted to compromise the response of the subsynaptic cytoskeleton to learning-related afferent activity, both locally and at distant sites...
  8. ncbi Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation
    Alex H Babayan
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 32:12854-61. 2012
    ....
  9. ncbi Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression
    J C Lauterborn
    Department of Anatomy and Neurobiology, Gillespie Neuroscience Research Facility Room 3119, 837 Health Science Drive, University of California at Irvine, Irvine, CA 92697 4291, USA
    Neuroscience 159:283-95. 2009
    ..These findings are encouraging with regard to the feasibility of using ampakines to tonically enhance BDNF-dependent functions in adult brain...
  10. ncbi Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling
    Matiar Jafari
    Department of Anatomy and Neurobiology, 3226 Gillespie Neuroscience Research Facility, University of California at Irvine, Irvine, CA 92697 1275, USA
    Mol Neurobiol 46:304-15. 2012
    ..Through effects on these actin regulatory pathways, GRs are positioned to exert acute effects on synaptic plasticity...
  11. ncbi Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons
    R T Robertson
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, 92697 1275, USA
    Cereb Cortex 8:142-55. 1998
    ..These results indicate a developmental or maintenance role for cholinergic afferents to cerebral cortical neurons...
  12. ncbi Integrins regulate neuronal neurotrophin gene expression through effects on voltage-sensitive calcium channels
    C M Gall
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 4292, USA
    Neuroscience 118:925-40. 2003
    ....
  13. ncbi Kappa opioid control of seizures produced by a virus in an animal model
    Marylou V Solbrig
    Department of Neurology, University of California Irvine, Irvine, CA 92697 4292, USA
    Brain 129:642-54. 2006
    ....
  14. ncbi Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice
    Danielle A Simmons
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    Neurobiol Dis 41:436-44. 2011
    ..These findings describe a minimally invasive, pharmacologically plausible strategy for treatment of HD and, potentially, other neuropathological diseases...
  15. ncbi Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus
    R Makuch
    Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine, CA 92697-1280, USA
    Neuroscience 104:81-91. 2001
    ..These data support the hypothesis that target cell development is a prerequisite for attracting the ingrowth of septal afferent axons...
  16. ncbi Prolonged positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors induces calpain-mediated PSD-95/Dlg/ZO-1 protein degradation and AMPA receptor down-regulation in cultured hippocampal slices
    Hussam Jourdi
    Neuroscience Program and Department of Biology, University of Southern California, Los Angeles, CA 90089-2520, USA
    J Pharmacol Exp Ther 314:16-26. 2005
    ..CX614-induced suppression of AMPAr gene expression is, however, calpain-independent, and all these effects are not associated with cell damage...
  17. ncbi Restoration of long-term potentiation in middle-aged hippocampus after induction of brain-derived neurotrophic factor
    Christopher S Rex
    Department of Neurobiology and Behavior, University of California at Irvine, 92697-4292, USA
    J Neurophysiol 96:677-85. 2006
    ..Together these results indicate that increases in endogenous BDNF signaling can offset deficits in the postinduction processes that stabilize LTP...

Research Grants1

  1. Altered hypothalamic-pituitary-adrenal function in the Fragile X mouse
    JULIE LAUTERBORN; Fiscal Year: 2007
    ....