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| Ebbing LautenbachSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Initial response of health care institutions to emergence of H1N1 influenza: experiences, obstacles, and perceived future needsEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Clin Infect Dis 50:523-7. 2010....
Risk factors for fecal colonization with multiple distinct strains of Escherichia coli among long-term care facility residentsEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 30:491-3. 2009..There were no significant risk factors for colonization with multiple strains of E. coli. These results suggest that future efforts to efficiently identify the diversity of colonizing strains will be challenging...
Epidemiology of antimicrobial resistance among gram-negative organisms recovered from patients in a multistate network of long-term care facilitiesEbbing Lautenbach
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Infect Control Hosp Epidemiol 30:790-3. 2009..The prevalence of resistance varied significantly by facility type, size, and geographic location...
Epidemiology and impact of imipenem resistance in Acinetobacter baumanniiEbbing Lautenbach
Divisions of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 30:1186-92. 2009..Acinetobacter baumannii is an emerging gram-negative pathogen that can cause healthcare-acquired infections among patients. Treatment is complicated for cases of healthcare-acquired infection with A. baumannii resistant to imipenem...
The impact of household transmission on duration of outpatient colonization with methicillin-resistant Staphylococcus aureusE Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Epidemiol Infect 138:683-5. 2010..There was a borderline significant association between having a concurrent colonized household member and a longer duration of colonization (mean 44 days vs. 26 days, P=0.08)...
Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistanceEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, the Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 30:18-24. 2009..The objective of this study was to identify the prevalence of and risk factors for FQREC colonization among hospitalized patients...
Impact of diversity of colonizing strains on strategies for sampling Escherichia coli from fecal specimensEbbing Lautenbach
Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Clin Microbiol 46:3094-6. 2008..The ability to accurately characterize E. coli strain diversity is directly related to the number of colonies sampled and the underlying prevalence of the strain...
Efficient recovery of fluoroquinolone-susceptible and fluoroquinolone-resistant Escherichia coli strains from frozen samplesEbbing Lautenbach
Division of Infectious Diseases of the Department of Medicine, the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 29:367-9. 2008..The strains that were not recovered were typically present only in low numbers in the initial sample. These findings emphasize the utility of frozen surveillance samples...
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomesE Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Clin Infect Dis 32:1162-71. 2001..coli and K. pneumoniae should emphasize judicious use of all antibiotics as well as barrier precautions to reduce spread...
Resistant gram-negative bacilli: A neglected healthcare crisis?Ebbing Lautenbach
University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Am J Health Syst Pharm 64:S3-21; quiz S22-4. 2007....
Surveillance cultures for detection of methicillin-resistant Staphylococcus aureus: diagnostic yield of anatomic sites and comparison of provider- and patient-collected samplesEbbing Lautenbach
Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 30:380-2. 2009..Groin and perineum samples yielded positive results significantly more often for community-onset MRSA than for hospital-onset MRSA. Agreement rates between provider- and patient-collected swab specimens were excellent...
The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patientsEbbing Lautenbach
Divisions of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Clin Infect Dis 51:280-5. 2010..Fluoroquinolones are the most commonly prescribed antimicrobials. The epidemiology of fecal colonization with Escherichia coli demonstrating reduced susceptibility to fluoroquinolones remains unclear...
Bloodstream infections after median sternotomy at a children's hospitalSamir S Shah
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 133:435-40. 2007..The objectives of this retrospective cohort study were to determine the incidence and to identify risk factors for postoperative bloodstream infections among children after median sternotomy in an urban tertiary care children's hospital...
Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiativeEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
J Infect Dis 194:79-85. 2006..The prevalence of fecal colonization with Escherichia coli that has reduced susceptibility to fluoroquinolones is unknown. A detailed characterization of such isolates is limited...
Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospitalEbbing Lautenbach
University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Antimicrob Agents Chemother 50:3939-43. 2006..07) but was not associated with other resistance mechanisms, demographics, or antibiotic use...
Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impactLeanne B Gasink
Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Penn 19104 6021, USA
Am J Med 119:526.e19-25. 2006..Pseudomonas aeruginosa infections have been associated with considerable morbidity and mortality. Fluoroquinolones (FQ) are the only oral therapy available for P. aeruginosa infections, but resistance is increasingly prevalent...
Risk factors for and impact of infection or colonization with aztreonam-resistant Pseudomonas aeruginosaLeanne B Gasink
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 28:1175-80. 2007..To identify risk factors for infection or colonization with aztreonam-resistant Pseudomonas aeruginosa and examine the impact of this organism on mortality...
Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in childrenTheoklis E Zaoutis
Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 115:942-9. 2005..The objective of this study was to define the risk factors and outcomes associated with ESBL-EK bloodstream infections in children...
Risk adjustment for surgical site infection after median sternotomy in childrenJessica Kagen
Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Infect Control Hosp Epidemiol 28:398-405. 2007....
Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organismsEbbing Lautenbach
Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Clin Infect Dis 38:655-62. 2004..Efforts to elucidate the epidemiology of FQ resistance and identify targets for intervention must recognize and account for the variability of FQ resistance across organisms and clinical settings...
Staphylococcus aureus as a risk factor for bloodstream infection in children with postoperative mediastinitisSamir S Shah
Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pediatr Infect Dis J 24:834-7. 2005..4; 95% confidence interval, 1.4-29.3). Postoperative mediastinitis caused by S. aureus has a higher intrinsic risk of being complicated by BSI than mediastinitis caused by other pathogens...
Imipenem resistance among pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomesEbbing Lautenbach
Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
Infect Control Hosp Epidemiol 27:893-900. 2006..To identify risk factors for infection with imipenem-resistant Pseudomonas aeruginosa and determine the impact of imipenem resistance on clinical and economic outcomes among patients infected with P. aeruginosa...
Risk factors for fluconazole-resistant Candida glabrata bloodstream infectionsIngi Lee
MSCE, Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Arch Intern Med 169:379-83. 2009..Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied...
Limiting the emergence of extended-spectrum Beta-lactamase-producing enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventionsAdam D Lipworth
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6021, USA
Infect Control Hosp Epidemiol 27:279-86. 2006..Variability in the epidemiological profiles of ESBL-EK isolates at different hospitals must be considered when designing interventions to respond to these pathogens...
Test characteristics of perirectal and rectal swab compared to stool sample for detection of fluoroquinolone-resistant Escherichia coli in the gastrointestinal tractEbbing Lautenbach
Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Antimicrob Agents Chemother 49:798-800. 2005..For rectal swab, the sensitivity was 90% (95% CI, 68 to 99%) and the specificity was 100% (95% CI, 91 to 100%)...
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalenceGregory Bisson
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Infect Control Hosp Epidemiol 23:254-60. 2002..The evidence for nosocomial spread and the high percentage of patients with ESbetaL-EK admitted from other sites suggest that greater emphasis must be placed on controlling the spread of such organisms within and between institutions...
Colonization with extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella species in long-term care facility residentsEbbing Lautenbach
Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 33:302-4. 2012..Colonization prevalence differed significantly across the 3 LTCFs evaluated in the study, with recent use of levofloxacin and fecal incontinence demonstrating borderline significant associations with ESBL-EB colonization...
Serotype emergence and genotype distribution among macrolide-resistant invasive Streptococcus pneumoniae isolates in the postconjugate vaccine (PCV-7) eraZhenying Liu
Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Antimicrob Agents Chemother 56:743-50. 2012..In contrast, erythromycin-resistant isolates within the 15A serotype consisted of clonally identical or closely related isolates...
Clinical and economic outcomes of decreased fluconazole susceptibility in patients with Candida glabrata bloodstream infectionsIngi Lee
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Am J Infect Control 38:740-5. 2010..The impact of reduced fluconazole susceptibility on clinical and economic outcomes in patients with Candida glabrata bloodstream infections (BSI) is unknown...
Exposure to children as a risk factor for bacteremic pneumococcal disease: changes in the post-conjugate vaccine eraJoshua P Metlay
Department of Medicine, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA
Arch Intern Med 170:725-31. 2010..We examined recent trends in serotypes responsible for disease and current risk factors among adults...
Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistanceKeira A Cohen
Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Infect Control Hosp Epidemiol 29:975-7. 2008..Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone...
The categorization of prior antibiotic use: impact on the identification of risk factors for drug resistance in case control studiesLeanne B Gasink
Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Infect Control 35:638-42. 2007..aeruginosa as models (IRPA), we aimed to examine the effect of different approaches to classification of prior antibiotic use (i.e., class versus spectrum) on the identification of risk factors for antibiotic resistance...
Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: the role of inadequate empirical antimicrobial therapyEbbing Lautenbach
Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
Clin Infect Dis 41:923-9. 2005..The prevalence of fluoroquinolone (FQ) resistance among Escherichia coli and Klebsiella pneumoniae has increased markedly in recent years. However, the impact of FQ resistance on mortality remains unknown...
Is there cross-reactivity between penicillins and cephalosporins?Andrea J Apter
Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
Am J Med 119:354.e11-9. 2006..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
Emergence of resistance to chloramphenicol among vancomycin-resistant enterococcal (VRE) bloodstream isolatesEbbing Lautenbach
Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Int J Antimicrob Agents 23:200-3. 2004..The correlation between both chloramphenicol use and quinolone use and the prevalence of CR-VRE suggests that efforts to preserve the utility of chloramphenicol in VRE infections may depend on optimizing the use of these agents...
Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistanceRhonda D Quain
University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Int J Antimicrob Agents 26:327-30. 2005..Efforts should be directed at modifying hospital policies for dosing of levofloxacin and DTCCs to prevent coadministration...
Fluoroquinolone-resistant Escherichia coli carriage in long-term care facilityJoel N Maslow
Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
Emerg Infect Dis 11:889-94. 2005..coli was documented and was associated with de novo colonization with genetically distinct strains. Unlike the case in the hospital setting, FQ-resistant E. coli carriage in long-term care facilities is associated with clonal spread...
Imipenem resistance in Pseudomonas aeruginosa: emergence, epidemiology, and impact on clinical and economic outcomesEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Infect Control Hosp Epidemiol 31:47-53. 2010..Pseudomonas aeruginosa is one of the most common gram-negative hospital-acquired pathogens. Resistance of this organism to imipenem complicates treatment...
Risk factors for mediastinitis following median sternotomy in childrenJessica Kagen
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatr Infect Dis J 26:613-8. 2007..The objective of this study was to identify risk factors for mediastinitis in a cohort of children undergoing cardiothoracic surgery at a tertiary care children's hospital...
Prior vancomycin use is a risk factor for reduced vancomycin susceptibility in methicillin-susceptible but not methicillin-resistant Staphylococcus aureus bacteremiaKara B Mascitti
Division of Infectious Diseases, Department of Medicine, St Luke s Hospital and Health Network, Bethlehem, Pennsylvania, USA
Infect Control Hosp Epidemiol 33:160-6. 2012..aureus have increased, and reduced vancomycin susceptibility (RVS) may be associated with treatment failure. We aimed to identify clinical risk factors for RVS in S. aureus bacteremia...
Impact of antimicrobial stewardship programme changes on unnecessary double anaerobic coverage therapyPinyo Rattanaumpawan
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Antimicrob Chemother 66:2655-8. 2011..We anticipated that this change would increase both unnecessary DACT and target antibiotic consumption...
Outcome of Escherichia coli and/or Klebsiella bloodstream infection in children with central venous cathetersJessica Buckley
Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 28:1308-10. 2007..6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without catheter removal...
Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infectionsEbbing Lautenbach
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Arch Intern Med 162:2469-77. 2002..Risk factors for FQ resistance in these pathogens remain unknown. Although FQs are important components of the present antimicrobial arsenal, their continued usefulness is threatened by rising FQ resistance...
Evaluation of antimicrobial therapy orders circumventing an antimicrobial stewardship program: investigating the strategy of "stealth dosing"Lori Ann LaRosa
Department of Pharmacy, University of Pennsylvania, Philadelphia, PA, USA
Infect Control Hosp Epidemiol 28:551-6. 2007..We evaluated whether prescribers wait until after the prior-approval period to order restricted antimicrobial therapy that is in conflict with guidelines or unnecessary...
Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infectionEmily P Hyle
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Arch Intern Med 165:1375-80. 2005..32 [1.49-12.54]). CONCLUSIONS: Inadequate initial antimicrobial therapy is an independent risk factor for mortality in ESBL-EK infections, but only among nonurinary infections. Multidrug resistance was a strong risk factor for IIAT...
Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistanceIngi Lee
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Infect Control 38:456-60. 2010..Although Candida glabrata is an emerging infection, risk factors for fluconazole resistance in patients with C glabrata bloodstram infection (BSI) have not been well elucidated...
Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecyclineKara B Anthony
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Clin Infect Dis 46:567-70. 2008..Observed evolution of resistance during therapy raises concern about routine use of tigecycline in treatment of such infections when other therapies are available...
Adverse events associated with prolonged antibiotic useSharon B Meropol
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:523-32. 2008....
Use of different thresholds of prior antimicrobial use in defining exposure: impact on the association between antimicrobial use and antimicrobial resistanceEmily P Hyle
Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Infect 55:414-8. 2007..We conducted the current study to determine the impact of varying the minimum threshold of prior antimicrobial use to define exposure status in studies of antimicrobial resistance...
Fluoroquinolone-resistant Escherichia coli in the long-term care settingAlana E Cohen
Columbia University, Department of Medicine, New York, NY, USA
Am J Med 119:958-63. 2006..Further studies are needed to examine the effect of interventions to decrease fluoroquinolone-resistant infections in the long-term care setting, including studying the effect of decreasing fluoroquinolone use...
Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella speciesJason Y Kim
Division of Infectious Diseases, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Am J Infect Control 36:70-3. 2008..28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK)...
Impact of different methods for describing the extent of prior antibiotic exposure on the association between antibiotic use and antibiotic-resistant infectionEmily P Hyle
Center for Research and Education on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Infect Control Hosp Epidemiol 28:647-54. 2007....
Reemergence of gram-negative health care-associated bloodstream infectionsSvenja J Albrecht
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Arch Intern Med 166:1289-94. 2006..This finding does not seem to be related to changes in specific gram-negative organisms or to antimicrobial resistance. If this trend continues, it will have important implications for the management of bloodstream infections...
Postoperative mediastinitis in children: epidemiology, microbiology and risk factors for Gram-negative pathogensCaroline B Long
Divisions of General Pediatrics, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatr Infect Dis J 24:315-9. 2005..More than one-half of patients with mediastinitis had concurrent bacteremia. Delayed sternal closure was an independent risk factor for Gram-negative mediastinitis...
Risk factors for increasing multidrug resistance among extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella speciesEmily P Hyle
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA
Clin Infect Dis 40:1317-24. 2005..The strong association between the species of infecting organism and MDR suggests that the epidemiology in K. pneumoniae may be unique. PFGE results suggest that horizontal spread is important in the emergence of MDR ESBL-EK...
Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniaeLeanne B Gasink
Division of Infectious Diseases, Department of Medicine, and the Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Infect Control Hosp Epidemiol 30:1180-5. 2009..pneumoniae is an emerging pathogen with serious clinical and infection control implications. To our knowledge, no study has specifically examined risk factors for KPC-producing K. pneumoniae or its impact on mortality...
Risk factors for efflux pump overexpression in fluoroquinolone-resistant Escherichia coliJennifer H Han
Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Infect Dis 206:1597-603. 2012....
Impact of automatic orders to discontinue vancomycin therapy on vancomycin use in an antimicrobial stewardship programDenise M Connor
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Infect Control Hosp Epidemiol 28:1408-10. 2007..Only one-third of patients had ASP stickers that warned of impending discontinuation of vancomycin therapy placed appropriately in the medical record...
Preferred treatment and prevention strategies for recurrent community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: a survey of adult and pediatric providersKara B Mascitti
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
Am J Infect Control 38:324-8. 2010..0001). For recurrent infections, 88% of providers employed at least 1 topical decolonization strategy...
Role of matching in case-control studies of antimicrobial resistanceElizabeth Cerceo
Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Infect Control Hosp Epidemiol 30:479-83. 2009..Analysis that accounted for matching was performed in only 52% of the case-control studies...
Longitudinal trends in antimicrobial susceptibilities across long-term-care facilities: emergence of fluoroquinolone resistanceMelissa Viray
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Infect Control Hosp Epidemiol 26:56-62. 2005....
Investigating the association between antibiotic use and antibiotic resistance: impact of different methods of categorising prior antibiotic useHeather MacAdam
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Int J Antimicrob Agents 28:325-32. 2006..Elucidating these issues is critical if effective strategies to curb resistance are to be designed...
Controlling for severity of illness in assessment of the association between antimicrobial-resistant infection and mortality: impact of calculation of Acute Physiology and Chronic Health Evaluation (APACHE) II scores at different time pointsKeith W Hamilton
Center for Research and Education on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 28:832-6. 2007..However, it is unclear when the severity of illness should be assessed. Controlling for severity of illness on the day the culture specimen is obtained may underestimate the true association between resistance and mortality...
Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination AntibiogramMari Mizuta
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 27:413-5. 2006..Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam...
Evaluation of mannitol salt agar, CHROMagar Staph aureus and CHROMagar MRSA for detection of meticillin-resistant Staphylococcus aureus from nasal swab specimensZhuolin Han
Department of Hospital Epidemiology and Infection Control, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Med Microbiol 56:43-6. 2007..7 versus 87.2 %) and at 48 h (94.9 versus 94.9 %). When combined with Staphaurex slide confirmation testing, both CSA and CSA-MRSA were highly specific (100 %) media for detecting MRSA from nasal swab specimens...
Contact isolation for infection control in hospitalized patients: is patient satisfaction affected?Leanne B Gasink
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Infect Control Hosp Epidemiol 29:275-8. 2008..In multivariable analysis, isolated patients were not less satisfied with inpatient care than were nonisolated patients...
Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measuresSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Epidemiol 60:911-8. 2007..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: impact of prior fluoroquinolone use?Carolyn V Gould
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Infect Control Hosp Epidemiol 25:138-45. 2004..The prevalence of vancomycin-resistant enterococci (VRE) has increased markedly during the past decade. Few data exist regarding the epidemiology of resistance of VRE to chloramphenicol, one of the few therapeutic options...
Colonization with extraintestinal pathogenic Escherichia coli among nursing home residents and its relationship to fluoroquinolone resistanceJoel N Maslow
Section of Infectious Diseases, Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104, USA
Antimicrob Agents Chemother 48:3618-20. 2004..coli, and 51% were colonized with fluoroquinolone-resistant E. coli. Among 80 unique isolates, adhesins correlated negatively and aerobactin correlated positively with fluoroquinolone resistance...
Patients' request for and emergency physicians' prescription of antimicrobial prophylaxis for anthrax during the 2001 bioterrorism-related outbreakNkuchia M M'ikanatha
Division of Infectious Disease Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA
BMC Public Health 5:2. 2005..However, little is documented about the extent to which individuals with self-identified risk of anthrax exposure approached physicians for antimicrobial prophylaxis during the 2001 bioterrorism attacks in the United States...
Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxisLeslie S Kersun
Department of Pediatrics, Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatr Blood Cancer 45:162-9. 2005..Our purpose was to determine the incidence of bacteremia and antimicrobial resistance post-HSCT in pediatric patients receiving GD, and to identify risk factors associated with infection...
Effect of accessibility of influenza vaccination on the rate of childcare staff vaccinationIngi Lee
Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 29:465-7. 2008..Staff vaccination prevalence was higher in each intervention season compared to the prior, nonintervention season. No baseline characteristics were associated with receipt of vaccination...
Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporinsEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Clin Infect Dis 36:440-6. 2003..The association between clindamycin use and the prevalence of VRE suggests that restriction of this and perhaps other antianaerobic agents might be an important component of future antimicrobial interventions...
Differences in the epidemiological characteristics and clinical outcomes of pandemic (H1N1) 2009 influenza, compared with seasonal influenzaKevin T Shiley
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Infect Control Hosp Epidemiol 31:676-82. 2010..There are limited data comparing the clinical presentations, comorbidities, and outcomes of patients with infections due to seasonal influenza with patients with infections due to pandemic (H1N1) 2009 influenza...
Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placementPaul C McGovern
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
Clin Infect Dis 36:759-65. 2003..Patients who received a Gliadel wafer had a higher incidence of infection than previously has been reported, and additional studies are required to better quantify this risk and describe the epidemiology of such infections...
Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibioticsBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
N Engl J Med 349:1628-35. 2003..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
Clinicians required very high sensitivity of a bacteremia prediction ruleEbbing Lautenbach
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 57:1104-6. 2004..However, no such models have been accepted into general clinical use. The goal of this study was to determine physicians' criteria for acceptability of a bacteremia clinical prediction rule...
The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: antibiotics or anxiolytics?Kevin T Shiley
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Infect Control Hosp Epidemiol 31:1177-83. 2010....
Analysis and presentation of cumulative antimicrobial susceptibility data (antibiograms): substantial variability across medical centers in the United StatesEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 27:409-12. 2006....
Inaccurate communications in telephone calls to an antimicrobial stewardship programDarren R Linkin
Department of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA
Infect Control Hosp Epidemiol 27:688-94. 2006....
Antibiotics, acne, and Staphylococcus aureus colonizationMatthew Fanelli
Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Arch Dermatol 147:917-21. 2011..To determine the frequency of Staphylococcus aureus colonization among patients with acne and to compare the susceptibility patterns between the patients who are using antibiotics and those who are not using antibiotics...
Agilent 2100 bioanalyzer for restriction fragment length polymorphism analysis of the Campylobacter jejuni flagellin geneI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
J Clin Microbiol 39:754-7. 2001..Overall, the bioanalyzer has the potential to replace conventional RFLP analysis by gel electrophoresis, but improvements in the chip separation are needed...
Performance of two rapid, single-use immunoassays for the detection of Clostridium difficile toxin AJ B Patel
Clinical Microbiology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Diagn Microbiol Infect Dis 39:21-4. 2001..difficile-associated disease...
Bacteremia caused by a novel isolate resembling leptotrichia species in a neutropenic patientJ B Patel
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Clin Microbiol 37:2064-7. 1999..However, it is more fastidious than previously reported isolates of Leptotrichia and may represent a novel species...
Sequence-based identification of Mycobacterium species using the MicroSeq 500 16S rDNA bacterial identification systemJ B Patel
Department of Pathology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Clin Microbiol 38:246-51. 2000..The MicroSeq identification system is an accurate and rapid method for the identification of Mycobacterium spp...
Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United StatesI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
J Infect Dis 179:1183-9. 1999....
Campylobacter species and Guillain-Barré syndromeI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
Clin Microbiol Rev 11:555-67. 1998..The purpose of this review is to summarize our current knowledge about the clinical, epidemiological, pathogenetic, and laboratory aspects of campylobacter-associated GBS...
Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritisI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
J Infect Dis 184:221-6. 2001..The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE...
Patterns of Guillain-Barre syndrome in children: results from a Mexican populationI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 4th Floor Gates Building, Philadelphia, PA 19104 4283, USA
Neurology 69:1665-71. 2007..Previous clinical studies suggested that AMAN also occurs in Mexican children. The purpose of this study was to describe the subtypes of GBS in children from Mexico City...
Utilization of tests for Lyme disease antibody at a university hospitalI Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
Clin Diagn Lab Immunol 3:287-9. 1996..Inappropriate testing of patients without indications of Lyme disease is frequently performed, and the ordering practices of physicians should be reassessed...
Trends in antimicrobial susceptibility patterns among inpatient enterococcal isolates (1990 to 1999): implications for therapeutic optionsEbbing Lautenbach
Infect Control Hosp Epidemiol 23:416-8. 2002
Low prevalence of prior streptococcus pneumoniae vaccination among potential lung transplant candidatesLeanne B Gasink
Division of Infectious Diseases, Department of Medicine, 502 Johnson Pavillion, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chest 130:218-21. 2006..Appropriate vaccination status in the pre-solid organ transplant period is critically important...
Recommendations for metrics for multidrug-resistant organisms in healthcare settings: SHEA/HICPAC Position paper Adam L Cohen
Divisions of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Infect Control Hosp Epidemiol 29:901-13. 2008
Applicability of Healthcare Failure Mode and Effects Analysis to healthcare epidemiology: evaluation of the sterilization and use of surgical instrumentsDarren R Linkin
Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA
Clin Infect Dis 41:1014-9. 2005..The HFMEA methodology facilitated the detection of previously unrecognized system errors, demonstrating its potential utility in addressing healthcare epidemiology-related adverse events...
Expanding the universe of methicillin-resistant Staphylococcus aureus preventionEbbing Lautenbach
Ann Intern Med 148:474-6. 2008
Prevention and treatment of health care-acquired infectionsLeanne B Gasink
Department of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Med Clin North Am 92:295-313, viii. 2008..This chapter aims to provide current data and strategies relating to the prevention of HAIs among hospitalized patients...
Hepatitis C virus seropositivity in organ donors and survival in heart transplant recipientsLeanne B Gasink
Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
JAMA 296:1843-50. 2006..Little is known about the effect of donor HCV positivity on survival in cardiac transplantation...
Impact of freezing on the future utility of archived surveillance culture specimensHeather P Green
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Infect Control Hosp Epidemiol 28:886-8. 2007..Results demonstrate that 98% of 250 bacterial isolates identified on initial culture were subsequently recovered by culture of frozen specimens after a median storage period of 564 days...
Fluoroquinolone utilization in the emergency departments of academic medical centers: prevalence of, and risk factors for, inappropriate useEbbing Lautenbach
Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Arch Intern Med 163:601-5. 2003..Designing strategies to limit FQ resistance by optimizing FQ use depends on identifying patterns of inappropriate FQ use. Use of FQs in emergency departments (EDs) has not been studied...
Research Grants
- Novel Application of Infection Control Strategies to Limit Transmission of ESBL'SEbbing Lautenbach; Fiscal Year: 2007....
- Clinical Impact of Quinolone-Resistant E.coli carriageEbbing Lautenbach; Fiscal Year: 2007....
- QUINOLONE RESISTANCE IN NOSOCOMIAL URINARY INFECTIONSEbbing Lautenbach; Fiscal Year: 2004DESCRIPTION (adapted from the application) This award will prepare Ebbing Lautenbach M.D., M.P.H...
- Quinolone resistant E coli in long term care facilitiesEbbing Lautenbach; Fiscal Year: 2009..abstract_text> ..
