Ebbing Lautenbach

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Patients' request for and emergency physicians' prescription of antimicrobial prophylaxis for anthrax during the 2001 bioterrorism-related outbreak
    Nkuchia M M'ikanatha
    Division of Infectious Disease Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA
    BMC Public Health 5:2. 2005
  2. ncbi Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: the role of inadequate empirical antimicrobial therapy
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 41:923-9. 2005
  3. ncbi Analysis and presentation of cumulative antimicrobial susceptibility data (antibiograms): substantial variability across medical centers in the United States
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:409-12. 2006
  4. ncbi Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Infect Dis 194:79-85. 2006
  5. ncbi Test characteristics of perirectal and rectal swab compared to stool sample for detection of fluoroquinolone-resistant Escherichia coli in the gastrointestinal tract
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 49:798-800. 2005
  6. ncbi Imipenem resistance among pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomes
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Infect Control Hosp Epidemiol 27:893-900. 2006
  7. ncbi Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospital
    Ebbing Lautenbach
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 50:3939-43. 2006
  8. ncbi Emergence of resistance to chloramphenicol among vancomycin-resistant enterococcal (VRE) bloodstream isolates
    Ebbing Lautenbach
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Int J Antimicrob Agents 23:200-3. 2004
  9. ncbi Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporins
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 36:440-6. 2003
  10. ncbi Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organisms
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 38:655-62. 2004

Detail Information

Publications91

  1. ncbi Patients' request for and emergency physicians' prescription of antimicrobial prophylaxis for anthrax during the 2001 bioterrorism-related outbreak
    Nkuchia M M'ikanatha
    Division of Infectious Disease Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA
    BMC Public Health 5:2. 2005
    ..However, little is documented about the extent to which individuals with self-identified risk of anthrax exposure approached physicians for antimicrobial prophylaxis during the 2001 bioterrorism attacks in the United States...
  2. ncbi Association between fluoroquinolone resistance and mortality in Escherichia coli and Klebsiella pneumoniae infections: the role of inadequate empirical antimicrobial therapy
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 41:923-9. 2005
    ..The prevalence of fluoroquinolone (FQ) resistance among Escherichia coli and Klebsiella pneumoniae has increased markedly in recent years. However, the impact of FQ resistance on mortality remains unknown...
  3. ncbi Analysis and presentation of cumulative antimicrobial susceptibility data (antibiograms): substantial variability across medical centers in the United States
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:409-12. 2006
    ....
  4. ncbi Phenotypic and genotypic characterization of fecal Escherichia coli isolates with decreased susceptibility to fluoroquinolones: results from a large hospital-based surveillance initiative
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Infect Dis 194:79-85. 2006
    ..The prevalence of fecal colonization with Escherichia coli that has reduced susceptibility to fluoroquinolones is unknown. A detailed characterization of such isolates is limited...
  5. ncbi Test characteristics of perirectal and rectal swab compared to stool sample for detection of fluoroquinolone-resistant Escherichia coli in the gastrointestinal tract
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 49:798-800. 2005
    ..For rectal swab, the sensitivity was 90% (95% CI, 68 to 99%) and the specificity was 100% (95% CI, 91 to 100%)...
  6. ncbi Imipenem resistance among pseudomonas aeruginosa isolates: risk factors for infection and impact of resistance on clinical and economic outcomes
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104 6021, USA
    Infect Control Hosp Epidemiol 27:893-900. 2006
    ..To identify risk factors for infection with imipenem-resistant Pseudomonas aeruginosa and determine the impact of imipenem resistance on clinical and economic outcomes among patients infected with P. aeruginosa...
  7. ncbi Duration of outpatient fecal colonization due to Escherichia coli Isolates with decreased susceptibility to fluoroquinolones: longitudinal study of patients recently discharged from the hospital
    Ebbing Lautenbach
    University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Antimicrob Agents Chemother 50:3939-43. 2006
    ..07) but was not associated with other resistance mechanisms, demographics, or antibiotic use...
  8. ncbi Emergence of resistance to chloramphenicol among vancomycin-resistant enterococcal (VRE) bloodstream isolates
    Ebbing Lautenbach
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Int J Antimicrob Agents 23:200-3. 2004
    ..The correlation between both chloramphenicol use and quinolone use and the prevalence of CR-VRE suggests that efforts to preserve the utility of chloramphenicol in VRE infections may depend on optimizing the use of these agents...
  9. ncbi Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: impact of progressive restrictions on use of vancomycin and third-generation cephalosporins
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 36:440-6. 2003
    ..The association between clindamycin use and the prevalence of VRE suggests that restriction of this and perhaps other antianaerobic agents might be an important component of future antimicrobial interventions...
  10. ncbi Longitudinal trends in fluoroquinolone resistance among Enterobacteriaceae isolates from inpatients and outpatients, 1989-2000: differences in the emergence and epidemiology of resistance across organisms
    Ebbing Lautenbach
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 38:655-62. 2004
    ..Efforts to elucidate the epidemiology of FQ resistance and identify targets for intervention must recognize and account for the variability of FQ resistance across organisms and clinical settings...
  11. ncbi Fluoroquinolone utilization in the emergency departments of academic medical centers: prevalence of, and risk factors for, inappropriate use
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 825 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 163:601-5. 2003
    ..Designing strategies to limit FQ resistance by optimizing FQ use depends on identifying patterns of inappropriate FQ use. Use of FQs in emergency departments (EDs) has not been studied...
  12. ncbi The prevalence of fluoroquinolone resistance mechanisms in colonizing Escherichia coli isolates recovered from hospitalized patients
    Ebbing Lautenbach
    Divisions of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Infect Dis 51:280-5. 2010
    ..Fluoroquinolones are the most commonly prescribed antimicrobials. The epidemiology of fecal colonization with Escherichia coli demonstrating reduced susceptibility to fluoroquinolones remains unclear...
  13. ncbi Epidemiology of antimicrobial resistance among gram-negative organisms recovered from patients in a multistate network of long-term care facilities
    Ebbing Lautenbach
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Infect Control Hosp Epidemiol 30:790-3. 2009
    ..The prevalence of resistance varied significantly by facility type, size, and geographic location...
  14. ncbi Bloodstream infections after median sternotomy at a children's hospital
    Samir S Shah
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 133:435-40. 2007
    ..The objectives of this retrospective cohort study were to determine the incidence and to identify risk factors for postoperative bloodstream infections among children after median sternotomy in an urban tertiary care children's hospital...
  15. ncbi Fluoroquinolone-resistant Pseudomonas aeruginosa: assessment of risk factors and clinical impact
    Leanne B Gasink
    Division of Infectious Diseases, University of Pennsylvania School of Medicine, Philadelphia, Penn 19104 6021, USA
    Am J Med 119:526.e19-25. 2006
    ..Pseudomonas aeruginosa infections have been associated with considerable morbidity and mortality. Fluoroquinolones (FQ) are the only oral therapy available for P. aeruginosa infections, but resistance is increasingly prevalent...
  16. ncbi Epidemiology and impact of imipenem resistance in Acinetobacter baumannii
    Ebbing Lautenbach
    Divisions of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:1186-92. 2009
    ..Acinetobacter baumannii is an emerging gram-negative pathogen that can cause healthcare-acquired infections among patients. Treatment is complicated for cases of healthcare-acquired infection with A. baumannii resistant to imipenem...
  17. ncbi Risk adjustment for surgical site infection after median sternotomy in children
    Jessica Kagen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
    Infect Control Hosp Epidemiol 28:398-405. 2007
    ....
  18. ncbi Risk factors for and impact of infection or colonization with aztreonam-resistant Pseudomonas aeruginosa
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:1175-80. 2007
    ..To identify risk factors for infection or colonization with aztreonam-resistant Pseudomonas aeruginosa and examine the impact of this organism on mortality...
  19. ncbi Risk factors for fluconazole-resistant Candida glabrata bloodstream infections
    Ingi Lee
    MSCE, Division of Infectious Diseases, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Arch Intern Med 169:379-83. 2009
    ..Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied...
  20. ncbi Staphylococcus aureus as a risk factor for bloodstream infection in children with postoperative mediastinitis
    Samir S Shah
    Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Infect Dis J 24:834-7. 2005
    ..4; 95% confidence interval, 1.4-29.3). Postoperative mediastinitis caused by S. aureus has a higher intrinsic risk of being complicated by BSI than mediastinitis caused by other pathogens...
  21. ncbi Colonization with extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella species in long-term care facility residents
    Ebbing Lautenbach
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 33:302-4. 2012
    ..Colonization prevalence differed significantly across the 3 LTCFs evaluated in the study, with recent use of levofloxacin and fecal incontinence demonstrating borderline significant associations with ESBL-EB colonization...
  22. ncbi Serotype emergence and genotype distribution among macrolide-resistant invasive Streptococcus pneumoniae isolates in the postconjugate vaccine (PCV-7) era
    Zhenying Liu
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 56:743-50. 2012
    ..In contrast, erythromycin-resistant isolates within the 15A serotype consisted of clonally identical or closely related isolates...
  23. ncbi Risk factors for fecal colonization with multiple distinct strains of Escherichia coli among long-term care facility residents
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:491-3. 2009
    ..There were no significant risk factors for colonization with multiple strains of E. coli. These results suggest that future efforts to efficiently identify the diversity of colonizing strains will be challenging...
  24. ncbi Risk factors for fluoroquinolone resistance in nosocomial Escherichia coli and Klebsiella pneumoniae infections
    Ebbing Lautenbach
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 162:2469-77. 2002
    ..Risk factors for FQ resistance in these pathogens remain unknown. Although FQs are important components of the present antimicrobial arsenal, their continued usefulness is threatened by rising FQ resistance...
  25. ncbi The categorization of prior antibiotic use: impact on the identification of risk factors for drug resistance in case control studies
    Leanne B Gasink
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Infect Control 35:638-42. 2007
    ..aeruginosa as models (IRPA), we aimed to examine the effect of different approaches to classification of prior antibiotic use (i.e., class versus spectrum) on the identification of risk factors for antibiotic resistance...
  26. ncbi Clinical and economic outcomes of decreased fluconazole susceptibility in patients with Candida glabrata bloodstream infections
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Am J Infect Control 38:740-5. 2010
    ..The impact of reduced fluconazole susceptibility on clinical and economic outcomes in patients with Candida glabrata bloodstream infections (BSI) is unknown...
  27. ncbi Exposure to children as a risk factor for bacteremic pneumococcal disease: changes in the post-conjugate vaccine era
    Joshua P Metlay
    Department of Medicine, University of Pennsylvania School of Medicine, 712 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104, USA
    Arch Intern Med 170:725-31. 2010
    ..We examined recent trends in serotypes responsible for disease and current risk factors among adults...
  28. ncbi Risk factors for mediastinitis following median sternotomy in children
    Jessica Kagen
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 26:613-8. 2007
    ..The objective of this study was to identify risk factors for mediastinitis in a cohort of children undergoing cardiothoracic surgery at a tertiary care children's hospital...
  29. ncbi Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in children
    Theoklis E Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 115:942-9. 2005
    ..The objective of this study was to define the risk factors and outcomes associated with ESBL-EK bloodstream infections in children...
  30. ncbi Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination Antibiogram
    Mari Mizuta
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:413-5. 2006
    ..Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam...
  31. ncbi Surveillance cultures for detection of methicillin-resistant Staphylococcus aureus: diagnostic yield of anatomic sites and comparison of provider- and patient-collected samples
    Ebbing Lautenbach
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:380-2. 2009
    ..Groin and perineum samples yielded positive results significantly more often for community-onset MRSA than for hospital-onset MRSA. Agreement rates between provider- and patient-collected swab specimens were excellent...
  32. ncbi Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  33. ncbi Limiting the emergence of extended-spectrum Beta-lactamase-producing enterobacteriaceae: influence of patient population characteristics on the response to antimicrobial formulary interventions
    Adam D Lipworth
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6021, USA
    Infect Control Hosp Epidemiol 27:279-86. 2006
    ..Variability in the epidemiological profiles of ESBL-EK isolates at different hospitals must be considered when designing interventions to respond to these pathogens...
  34. ncbi Coadministration of oral levofloxacin with agents that impair its absorption: potential impact on emergence of resistance
    Rhonda D Quain
    University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Int J Antimicrob Agents 26:327-30. 2005
    ..Efforts should be directed at modifying hospital policies for dosing of levofloxacin and DTCCs to prevent coadministration...
  35. ncbi Prior vancomycin use is a risk factor for reduced vancomycin susceptibility in methicillin-susceptible but not methicillin-resistant Staphylococcus aureus bacteremia
    Kara B Mascitti
    Division of Infectious Diseases, Department of Medicine, St Luke s Hospital and Health Network, Bethlehem, Pennsylvania, USA
    Infect Control Hosp Epidemiol 33:160-6. 2012
    ..aureus have increased, and reduced vancomycin susceptibility (RVS) may be associated with treatment failure. We aimed to identify clinical risk factors for RVS in S. aureus bacteremia...
  36. ncbi Impact of antimicrobial stewardship programme changes on unnecessary double anaerobic coverage therapy
    Pinyo Rattanaumpawan
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Antimicrob Chemother 66:2655-8. 2011
    ..We anticipated that this change would increase both unnecessary DACT and target antibiotic consumption...
  37. ncbi Fluoroquinolone-resistant Escherichia coli carriage in long-term care facility
    Joel N Maslow
    Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    Emerg Infect Dis 11:889-94. 2005
    ..coli was documented and was associated with de novo colonization with genetically distinct strains. Unlike the case in the hospital setting, FQ-resistant E. coli carriage in long-term care facilities is associated with clonal spread...
  38. ncbi Evaluation of antimicrobial therapy orders circumventing an antimicrobial stewardship program: investigating the strategy of "stealth dosing"
    Lori Ann LaRosa
    Department of Pharmacy, University of Pennsylvania, Philadelphia, PA, USA
    Infect Control Hosp Epidemiol 28:551-6. 2007
    ..We evaluated whether prescribers wait until after the prior-approval period to order restricted antimicrobial therapy that is in conflict with guidelines or unnecessary...
  39. ncbi Impact of inadequate initial antimicrobial therapy on mortality in infections due to extended-spectrum beta-lactamase-producing enterobacteriaceae: variability by site of infection
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
    Arch Intern Med 165:1375-80. 2005
    ..32 [1.49-12.54]). CONCLUSIONS: Inadequate initial antimicrobial therapy is an independent risk factor for mortality in ESBL-EK infections, but only among nonurinary infections. Multidrug resistance was a strong risk factor for IIAT...
  40. ncbi Adverse events associated with prolonged antibiotic use
    Sharon B Meropol
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:523-32. 2008
    ....
  41. ncbi Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistance
    Keira A Cohen
    Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 29:975-7. 2008
    ..Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone...
  42. ncbi Gastrointestinal tract colonization with fluoroquinolone-resistant Escherichia coli in hospitalized patients: changes over time in risk factors for resistance
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, the Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 30:18-24. 2009
    ..The objective of this study was to identify the prevalence of and risk factors for FQREC colonization among hospitalized patients...
  43. ncbi Risk factors for fluconazole resistance in patients with Candida glabrata bloodstream infection: potential impact of control group selection on characterizing the association between previous fluconazole use and fluconazole resistance
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Infect Control 38:456-60. 2010
    ..Although Candida glabrata is an emerging infection, risk factors for fluconazole resistance in patients with C glabrata bloodstram infection (BSI) have not been well elucidated...
  44. ncbi Resistant gram-negative bacilli: A neglected healthcare crisis?
    Ebbing Lautenbach
    University of Pennsylvania School of Medicine, 825 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Am J Health Syst Pharm 64:S3-21; quiz S22-4. 2007
    ....
  45. ncbi Outcome of Escherichia coli and/or Klebsiella bloodstream infection in children with central venous catheters
    Jessica Buckley
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:1308-10. 2007
    ..6 [95% confidence interval {CI}, 1.39-16.30]) and receipt of total parenteral nutrition (aOR, 3.5 [95% CI, 1.1-10.8]). A significant proportion of children with catheter-associated BSI were treated successfully without catheter removal...
  46. ncbi Use of different thresholds of prior antimicrobial use in defining exposure: impact on the association between antimicrobial use and antimicrobial resistance
    Emily P Hyle
    Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Infect 55:414-8. 2007
    ..We conducted the current study to determine the impact of varying the minimum threshold of prior antimicrobial use to define exposure status in studies of antimicrobial resistance...
  47. ncbi Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, and the Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Control Hosp Epidemiol 30:1180-5. 2009
    ..pneumoniae is an emerging pathogen with serious clinical and infection control implications. To our knowledge, no study has specifically examined risk factors for KPC-producing K. pneumoniae or its impact on mortality...
  48. ncbi Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species
    Jason Y Kim
    Division of Infectious Diseases, Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Infect Control 36:70-3. 2008
    ..28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK)...
  49. ncbi Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline
    Kara B Anthony
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Clin Infect Dis 46:567-70. 2008
    ..Observed evolution of resistance during therapy raises concern about routine use of tigecycline in treatment of such infections when other therapies are available...
  50. ncbi Reemergence of gram-negative health care-associated bloodstream infections
    Svenja J Albrecht
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Arch Intern Med 166:1289-94. 2006
    ..This finding does not seem to be related to changes in specific gram-negative organisms or to antimicrobial resistance. If this trend continues, it will have important implications for the management of bloodstream infections...
  51. ncbi Impact of different methods for describing the extent of prior antibiotic exposure on the association between antibiotic use and antibiotic-resistant infection
    Emily P Hyle
    Center for Research and Education on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Infect Control Hosp Epidemiol 28:647-54. 2007
    ....
  52. ncbi Risk factors for increasing multidrug resistance among extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species
    Emily P Hyle
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA
    Clin Infect Dis 40:1317-24. 2005
    ..The strong association between the species of infecting organism and MDR suggests that the epidemiology in K. pneumoniae may be unique. PFGE results suggest that horizontal spread is important in the emergence of MDR ESBL-EK...
  53. ncbi Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species: risk factors for colonization and impact of antimicrobial formulary interventions on colonization prevalence
    Gregory Bisson
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
    Infect Control Hosp Epidemiol 23:254-60. 2002
    ..The evidence for nosocomial spread and the high percentage of patients with ESbetaL-EK admitted from other sites suggest that greater emphasis must be placed on controlling the spread of such organisms within and between institutions...
  54. ncbi Fluoroquinolone-resistant Escherichia coli in the long-term care setting
    Alana E Cohen
    Columbia University, Department of Medicine, New York, NY, USA
    Am J Med 119:958-63. 2006
    ..Further studies are needed to examine the effect of interventions to decrease fluoroquinolone-resistant infections in the long-term care setting, including studying the effect of decreasing fluoroquinolone use...
  55. ncbi Risk Factors for Efflux Pump Overexpression in Fluoroquinolone-Resistant Escherichia coli
    Jennifer H Han
    Division of Infectious Diseases, Department of Medicine
    J Infect Dis 206:1597-603. 2012
    ..Further studies are needed to elucidate the relationship between antimicrobial use and specific resistance mechanisms...
  56. ncbi Efficient recovery of fluoroquinolone-susceptible and fluoroquinolone-resistant Escherichia coli strains from frozen samples
    Ebbing Lautenbach
    Division of Infectious Diseases of the Department of Medicine, the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 29:367-9. 2008
    ..The strains that were not recovered were typically present only in low numbers in the initial sample. These findings emphasize the utility of frozen surveillance samples...
  57. ncbi Role of matching in case-control studies of antimicrobial resistance
    Elizabeth Cerceo
    Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 30:479-83. 2009
    ..Analysis that accounted for matching was performed in only 52% of the case-control studies...
  58. ncbi Imipenem resistance in Pseudomonas aeruginosa: emergence, epidemiology, and impact on clinical and economic outcomes
    Ebbing Lautenbach
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 31:47-53. 2010
    ..Pseudomonas aeruginosa is one of the most common gram-negative hospital-acquired pathogens. Resistance of this organism to imipenem complicates treatment...
  59. ncbi Investigating the association between antibiotic use and antibiotic resistance: impact of different methods of categorising prior antibiotic use
    Heather MacAdam
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
    Int J Antimicrob Agents 28:325-32. 2006
    ..Elucidating these issues is critical if effective strategies to curb resistance are to be designed...
  60. ncbi Impact of automatic orders to discontinue vancomycin therapy on vancomycin use in an antimicrobial stewardship program
    Denise M Connor
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Infect Control Hosp Epidemiol 28:1408-10. 2007
    ..Only one-third of patients had ASP stickers that warned of impending discontinuation of vancomycin therapy placed appropriately in the medical record...
  61. ncbi Controlling for severity of illness in assessment of the association between antimicrobial-resistant infection and mortality: impact of calculation of Acute Physiology and Chronic Health Evaluation (APACHE) II scores at different time points
    Keith W Hamilton
    Center for Research and Education on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 28:832-6. 2007
    ..However, it is unclear when the severity of illness should be assessed. Controlling for severity of illness on the day the culture specimen is obtained may underestimate the true association between resistance and mortality...
  62. ncbi Risk Factors for Gastrointestinal Tract Colonization with Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Species in Hospitalized Patients
    Jennifer H Han
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Infect Control Hosp Epidemiol 33:1242-5. 2012
    ..The prevalence of colonization with ESBL-EK was 2.6%. Colonization was associated with cirrhosis, longer duration of hospital stay prior to surveillance, and prior exposure to clindamycin or meropenem...
  63. ncbi Chloramphenicol resistance in vancomycin-resistant enterococcal bacteremia: impact of prior fluoroquinolone use?
    Carolyn V Gould
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Control Hosp Epidemiol 25:138-45. 2004
    ..The prevalence of vancomycin-resistant enterococci (VRE) has increased markedly during the past decade. Few data exist regarding the epidemiology of resistance of VRE to chloramphenicol, one of the few therapeutic options...
  64. ncbi Longitudinal trends in antimicrobial susceptibilities across long-term-care facilities: emergence of fluoroquinolone resistance
    Melissa Viray
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
    Infect Control Hosp Epidemiol 26:56-62. 2005
    ....
  65. ncbi Contact isolation for infection control in hospitalized patients: is patient satisfaction affected?
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Infect Control Hosp Epidemiol 29:275-8. 2008
    ..In multivariable analysis, isolated patients were not less satisfied with inpatient care than were nonisolated patients...
  66. ncbi A clinical prediction rule for fluoroquinolone resistance in healthcare-acquired gram-negative urinary tract infection
    Pinyo Rattanaumpawan
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Infect Control Hosp Epidemiol 32:1124-6. 2011
    ..This prediction rule has an excellent sensitivity and specificity (C-statistic, 0.816). External validation is necessary before implementing this rule to optimize empirical antibiotic use in clinical practice...
  67. ncbi Represcription of penicillin after allergic-like events
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 113:764-70. 2004
    ..72%). Represcription of penicillin to such patients is more frequent than anticipated...
  68. ncbi Comparison of unit-specific and hospital-wide antibiograms: potential implications for selection of empirical antimicrobial therapy
    Shawn Binkley
    Division of Infectious Diseases, Department of Pharmacy, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Infect Control Hosp Epidemiol 27:682-7. 2006
    ..These differences may have important implications for selecting the optimal empirical antimicrobial therapy...
  69. ncbi Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
    ..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
  70. ncbi Preferred treatment and prevention strategies for recurrent community-associated methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: a survey of adult and pediatric providers
    Kara B Mascitti
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA
    Am J Infect Control 38:324-8. 2010
    ..0001). For recurrent infections, 88% of providers employed at least 1 topical decolonization strategy...
  71. ncbi Postoperative mediastinitis in children: epidemiology, microbiology and risk factors for Gram-negative pathogens
    Caroline B Long
    Divisions of General Pediatrics, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 24:315-9. 2005
    ..More than one-half of patients with mediastinitis had concurrent bacteremia. Delayed sternal closure was an independent risk factor for Gram-negative mediastinitis...
  72. ncbi Colonization with extraintestinal pathogenic Escherichia coli among nursing home residents and its relationship to fluoroquinolone resistance
    Joel N Maslow
    Section of Infectious Diseases, Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104, USA
    Antimicrob Agents Chemother 48:3618-20. 2004
    ..coli, and 51% were colonized with fluoroquinolone-resistant E. coli. Among 80 unique isolates, adhesins correlated negatively and aerobactin correlated positively with fluoroquinolone resistance...
  73. ncbi Early bacteremia in pediatric hematopoietic stem cell transplant patients on oral antibiotic prophylaxis
    Leslie S Kersun
    Department of Pediatrics, Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 45:162-9. 2005
    ..Our purpose was to determine the incidence of bacteremia and antimicrobial resistance post-HSCT in pediatric patients receiving GD, and to identify risk factors associated with infection...
  74. ncbi Evaluation of mannitol salt agar, CHROMagar Staph aureus and CHROMagar MRSA for detection of meticillin-resistant Staphylococcus aureus from nasal swab specimens
    Zhuolin Han
    Department of Hospital Epidemiology and Infection Control, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Med Microbiol 56:43-6. 2007
    ..7 versus 87.2 %) and at 48 h (94.9 versus 94.9 %). When combined with Staphaurex slide confirmation testing, both CSA and CSA-MRSA were highly specific (100 %) media for detecting MRSA from nasal swab specimens...
  75. ncbi Antibiotics, acne, and Staphylococcus aureus colonization
    Matthew Fanelli
    Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Dermatol 147:917-21. 2011
    ..To determine the frequency of Staphylococcus aureus colonization among patients with acne and to compare the susceptibility patterns between the patients who are using antibiotics and those who are not using antibiotics...
  76. ncbi The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: antibiotics or anxiolytics?
    Kevin T Shiley
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Infect Control Hosp Epidemiol 31:1177-83. 2010
    ....
  77. ncbi Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    N Engl J Med 349:1628-35. 2003
    ..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
  78. ncbi Risk factors for postcraniotomy surgical site infection after 1,3-bis (2-chloroethyl)-1-nitrosourea (Gliadel) wafer placement
    Paul C McGovern
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Infect Dis 36:759-65. 2003
    ..Patients who received a Gliadel wafer had a higher incidence of infection than previously has been reported, and additional studies are required to better quantify this risk and describe the epidemiology of such infections...
  79. ncbi Differences in the epidemiological characteristics and clinical outcomes of pandemic (H1N1) 2009 influenza, compared with seasonal influenza
    Kevin T Shiley
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:676-82. 2010
    ..There are limited data comparing the clinical presentations, comorbidities, and outcomes of patients with infections due to seasonal influenza with patients with infections due to pandemic (H1N1) 2009 influenza...
  80. ncbi Inaccurate communications in telephone calls to an antimicrobial stewardship program
    Darren R Linkin
    Department of Medicine, Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 27:688-94. 2006
    ....
  81. ncbi Clinicians required very high sensitivity of a bacteremia prediction rule
    Ebbing Lautenbach
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 57:1104-6. 2004
    ..However, no such models have been accepted into general clinical use. The goal of this study was to determine physicians' criteria for acceptability of a bacteremia clinical prediction rule...
  82. ncbi Effect of accessibility of influenza vaccination on the rate of childcare staff vaccination
    Ingi Lee
    Division of Infectious Diseases, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Infect Control Hosp Epidemiol 29:465-7. 2008
    ..Staff vaccination prevalence was higher in each intervention season compared to the prior, nonintervention season. No baseline characteristics were associated with receipt of vaccination...
  83. ncbi Impact of diversity of colonizing strains on strategies for sampling Escherichia coli from fecal specimens
    Ebbing Lautenbach
    Department of Medicine, Division of Infectious Diseases, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    J Clin Microbiol 46:3094-6. 2008
    ..The ability to accurately characterize E. coli strain diversity is directly related to the number of colonies sampled and the underlying prevalence of the strain...
  84. ncbi Trends in antimicrobial susceptibility patterns among inpatient enterococcal isolates (1990 to 1999): implications for therapeutic options
    Ebbing Lautenbach
    Infect Control Hosp Epidemiol 23:416-8. 2002
  85. ncbi Expanding the universe of methicillin-resistant Staphylococcus aureus prevention
    Ebbing Lautenbach
    Ann Intern Med 148:474-6. 2008
  86. ncbi Prevention and treatment of health care-acquired infections
    Leanne B Gasink
    Department of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Med Clin North Am 92:295-313, viii. 2008
    ..This chapter aims to provide current data and strategies relating to the prevention of HAIs among hospitalized patients...
  87. ncbi Hepatitis C virus seropositivity in organ donors and survival in heart transplant recipients
    Leanne B Gasink
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    JAMA 296:1843-50. 2006
    ..Little is known about the effect of donor HCV positivity on survival in cardiac transplantation...
  88. ncbi Low prevalence of prior streptococcus pneumoniae vaccination among potential lung transplant candidates
    Leanne B Gasink
    Division of Infectious Diseases, Department of Medicine, 502 Johnson Pavillion, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 130:218-21. 2006
    ..Appropriate vaccination status in the pre-solid organ transplant period is critically important...
  89. ncbi Applicability of Healthcare Failure Mode and Effects Analysis to healthcare epidemiology: evaluation of the sterilization and use of surgical instruments
    Darren R Linkin
    Division of Infectious Diseases, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, USA
    Clin Infect Dis 41:1014-9. 2005
    ..The HFMEA methodology facilitated the detection of previously unrecognized system errors, demonstrating its potential utility in addressing healthcare epidemiology-related adverse events...
  90. ncbi Impact of freezing on the future utility of archived surveillance culture specimens
    Heather P Green
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Control Hosp Epidemiol 28:886-8. 2007
    ..Results demonstrate that 98% of 250 bacterial isolates identified on initial culture were subsequently recovered by culture of frozen specimens after a median storage period of 564 days...
  91. ncbi Recommendations for metrics for multidrug-resistant organisms in healthcare settings: SHEA/HICPAC Position paper
    Adam L Cohen
    Divisions of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Infect Control Hosp Epidemiol 29:901-13. 2008