Cato T Laurencin

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint HIV/AIDS and the African-American community: a state of emergency
    Cato T Laurencin
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA
    J Natl Med Assoc 100:35-43. 2008
  2. doi request reprint Fracture repair: challenges and opportunities
    Cato T Laurencin
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
    J Bone Joint Surg Am 90:1-2. 2008
  3. pmc Cato T. Laurencin, MD, PhD
    Cato T Laurencin
    University of Virginia, USA
    J Natl Med Assoc 99:1286-7. 2007
  4. doi request reprint The FDA and safety--beyond the heparin crisis
    Cato T Laurencin
    Orthopaedic Surgery, University of Connecticut, Connecticut, USA
    Nat Biotechnol 26:621-3. 2008
  5. pmc Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering
    Meng Deng
    Department of Orthopaedic Surgery, University of Connecticut, Farmington, CT 06030 3800, USA
    Biomaterials 31:4898-908. 2010
  6. doi request reprint Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering
    Meng Deng
    Department of Orthopaedic Surgery, University of Connecticut, Farmington, Connecticut 06030, USA
    J Biomed Mater Res A 92:114-25. 2010
  7. doi request reprint Functionalization of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds via surface heparinization for bone tissue engineering
    Tao Jiang
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA
    J Biomed Mater Res A 93:1193-208. 2010
  8. doi request reprint Polyphosphazene functionalized polyester fiber matrices for tendon tissue engineering: in vitro evaluation with human mesenchymal stem cells
    M Sean Peach
    Department of Physiology, University of Virginia, Virginia 22903, USA
    Biomed Mater 7:045016. 2012
  9. ncbi request reprint Design and optimization of polyphosphazene functionalized fiber matrices for soft tissue regeneration
    M Sean Peach
    Department of Physiology, University of Virginia, Virginia 22903, USA
    J Biomed Nanotechnol 8:107-24. 2012
  10. ncbi request reprint Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation
    James A Cooper
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
    Biomaterials 26:1523-32. 2005

Collaborators

Detail Information

Publications82

  1. ncbi request reprint HIV/AIDS and the African-American community: a state of emergency
    Cato T Laurencin
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA
    J Natl Med Assoc 100:35-43. 2008
    ..The present incidence and prevalence of HIV/AIDS in the black community in the United States is of crisis proportions. The situation as it stands today is tantamount to a state of emergency for African Americans...
  2. doi request reprint Fracture repair: challenges and opportunities
    Cato T Laurencin
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
    J Bone Joint Surg Am 90:1-2. 2008
  3. pmc Cato T. Laurencin, MD, PhD
    Cato T Laurencin
    University of Virginia, USA
    J Natl Med Assoc 99:1286-7. 2007
  4. doi request reprint The FDA and safety--beyond the heparin crisis
    Cato T Laurencin
    Orthopaedic Surgery, University of Connecticut, Connecticut, USA
    Nat Biotechnol 26:621-3. 2008
  5. pmc Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering
    Meng Deng
    Department of Orthopaedic Surgery, University of Connecticut, Farmington, CT 06030 3800, USA
    Biomaterials 31:4898-908. 2010
    ..Both blends demonstrated improved biocompatibility in a rat subcutaneous implantation model compared to PLAGA over 12 weeks...
  6. doi request reprint Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering
    Meng Deng
    Department of Orthopaedic Surgery, University of Connecticut, Farmington, Connecticut 06030, USA
    J Biomed Mater Res A 92:114-25. 2010
    ..These findings establish the suitability of PNEG(50)MEEP(50)-PLAGA biodegradable blends as promising bioactive materials for orthopedic applications...
  7. doi request reprint Functionalization of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds via surface heparinization for bone tissue engineering
    Tao Jiang
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904, USA
    J Biomed Mater Res A 93:1193-208. 2010
    ..1 microg/scaffold). This study demonstrated the potential of functionalizing chitosan/PLAGA scaffolds via heparinization with improved cell functions for bone tissue engineering applications...
  8. doi request reprint Polyphosphazene functionalized polyester fiber matrices for tendon tissue engineering: in vitro evaluation with human mesenchymal stem cells
    M Sean Peach
    Department of Physiology, University of Virginia, Virginia 22903, USA
    Biomed Mater 7:045016. 2012
    ..These findings indicate that PNEA-mPh functionalization is an efficient method for improving cell interactions with electrospun PCL matrices for the purpose of tendon repair...
  9. ncbi request reprint Design and optimization of polyphosphazene functionalized fiber matrices for soft tissue regeneration
    M Sean Peach
    Department of Physiology, University of Virginia, Virginia 22903, USA
    J Biomed Nanotechnol 8:107-24. 2012
    ..Improving PCL matrix hydrophilicity via proposed surface functionalization may be an efficient method to improve cell-PCL matrix interactions...
  10. ncbi request reprint Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation
    James A Cooper
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
    Biomaterials 26:1523-32. 2005
    ..The resultant micro-porous scaffold exhibited optimal pore diameters (175-233 microm) for ligament tissue ingrowth, and initial mechanical properties of the construct approximate those of the native ligament...
  11. doi request reprint Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors
    Qing Lv
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia, USA
    J Biomed Mater Res A 91:679-91. 2009
    ..Therefore, PLAGA/n-HA mixed scaffolds are promising candidates for HARV bioreactor-based bone tissue engineering applications...
  12. ncbi request reprint Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: in vitro degradation and in vivo bone regeneration studies
    Tao Jiang
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Acta Biomater 6:3457-70. 2010
    ..Furthermore, histological analysis suggested that chitosan/PLAGA-based scaffolds supported normal bone formation via intramembranous formation...
  13. ncbi request reprint Biodegradable polyphosphazene-nanohydroxyapatite composite nanofibers: scaffolds for bone tissue engineering
    Subhabrata Bhattacharyya
    Department of Chemistry, University of Virginia, Virginia 22903, USA
    J Biomed Nanotechnol 5:69-75. 2009
    ..Providing cells with a natural bone like environment with a fibrillar structure and natural hydroxyapatite can enhance bone tissue regeneration/repair...
  14. doi request reprint Electrospun nanofibrous scaffolds for engineering soft connective tissues
    Roshan James
    Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
    Methods Mol Biol 726:243-58. 2011
    ....
  15. pmc The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization
    Kevin W H Lo
    Department of Orthopaedic Surgery, Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
    J Tissue Eng Regen Med 6:40-8. 2012
    ..Therefore, based on these findings, we propose that the PKA-specific small molecule 6-Bnz-cAMP may serve as a novel bone-inducing growth factor for repairing and regenerating bone tissues during bone-regenerative engineering...
  16. doi request reprint Tissue-engineered matrices as functional delivery systems: adsorption and release of bioactive proteins from degradable composite scaffolds
    Emily K Cushnie
    Department of Chemical Engineering, The University of Virginia, Charlottesville, Virginia, USA
    J Biomed Mater Res A 94:568-75. 2010
    ..The ability to control protein loading and delivery simply via composition of the HA-PLAGA scaffold offers the potential of forming robust functionalized bone grafts...
  17. pmc Novel factor-loaded polyphosphazene matrices: potential for driving angiogenesis
    Olugbemisola Oredein-McCoy
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    J Microencapsul 26:544-55. 2009
    ....
  18. pmc Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach
    Ehsan Jabbarzadeh
    Departments of Orthopaedic Surgery and Chemical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 105:11099-104. 2008
    ..We demonstrated that the combination of VEGF releasing ADSCs and ECs results in marked vascular growth within PLAGA scaffolds. We thereby delineate the potential of ADSCs to promote vascular growth into biomaterials...
  19. pmc Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering
    Syam P Nukavarapu
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Biomacromolecules 9:1818-25. 2008
    ..The 3-D polyphosphazene-nHAp composite microsphere scaffolds showed good osteoblast cell adhesion, proliferation, and alkaline phosphatase expression and are potential suitors for bone tissue engineering applications...
  20. doi request reprint Improved bio-implant using ultrafast laser induced self-assembled nanotexture in titanium
    Joshua R Bush
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biomed Mater Res B Appl Biomater 97:299-305. 2011
    ....
  21. ncbi request reprint Apatite nano-crystalline surface modification of poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering: implications for protein adsorption
    Ehsan Jabbarzadeh
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22908, USA
    J Biomater Sci Polym Ed 18:1141-52. 2007
    ..Mineralization of tissue-engineered surfaces provides a method for both imparting bioactivity and controlling levels of protein adsorption and release...
  22. pmc Studies of bone morphogenetic protein-based surgical repair
    Kevin W H Lo
    Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA
    Adv Drug Deliv Rev 64:1277-91. 2012
    ..The prospective future of rhBMPs delivered in combination with tissue engineered scaffolds is also reviewed...
  23. pmc Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering
    Sangamesh G Kumbar
    Department of Orthopedic Surgery, University of Virginia, Charlottesville, VA 22903, USA
    Biomaterials 29:4100-7. 2008
    ..Based on the need, the proposed fiber skin substitutes can be successfully fabricated and optimized for skin fibroblast attachment and growth...
  24. ncbi request reprint In vitro evaluation of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds for bone tissue engineering
    Tao Jiang
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Biomaterials 27:4894-903. 2006
    ....
  25. ncbi request reprint Human endothelial cell growth and phenotypic expression on three dimensional poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering
    Ehsan Jabbarzadeh
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, Virginia 22903, USA
    Biotechnol Bioeng 98:1094-102. 2007
    ..The insights from this study should aid future studies aimed at enhancing angiogenesis in three dimensional tissue engineered scaffolds...
  26. ncbi request reprint Human osteoblast cells: isolation, characterization, and growth on polymers for musculoskeletal tissue engineering
    Saadiq F El-Amin
    Department of Orthopaedic Surgery, University of Virginia, 400 Ray C Hunt Drive, Charlottesville, Virginia 22903, USA
    J Biomed Mater Res A 76:439-49. 2006
    ..05). We believe human cell adhesion among these polymeric materials may be dependent on differences in cellular integrin expression and extracellular matrix protein elaboration...
  27. doi request reprint A chitosan thermogel for delivery of ropivacaine in regional musculoskeletal anesthesia
    Patricia L Foley
    Office of Animal Welfare, University of Virginia, Virginia, USA
    Biomaterials 34:2539-46. 2013
    ..This approach utilized a low solubility drug, a drug action enhancer, nanoparticles, and a thermogel matrix together to yield a multi-faceted delivery system capable of providing moderate-term pain management...
  28. doi request reprint Activation of cyclic amp/protein kinase: a signaling pathway enhances osteoblast cell adhesion on biomaterials for regenerative engineering
    Kevin W H Lo
    Department of Orthopaedic Surgery, New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Orthop Res 29:602-8. 2011
    ..Thus, this report suggests a new method to enhance osteoblast cell adhesion on biodegradable biomaterials for bone regenerative engineering applications...
  29. ncbi request reprint Fabrication and optimization of methylphenoxy substituted polyphosphazene nanofibers for biomedical applications
    Lakshmi S Nair
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22903, USA
    Biomacromolecules 5:2212-20. 2004
    ..Further, the electrospun nanofiber mats supported the adhesion of bovine coronary artery endothelial cells (BCAEC) as well as promoted the adhesion and proliferation of osteoblast like MC3T3-E1 cells...
  30. ncbi request reprint Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration
    Yuqing Wan
    Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Macromol Biosci 7:1217-24. 2007
    ..This study suggests that elastic POM scaffold may be an ideal candidate for AF tissue engineering...
  31. ncbi request reprint Novel low temperature setting nanocrystalline calcium phosphate cements for bone repair: osteoblast cellular response and gene expression studies
    Swaminathan Sethuraman
    Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia, USA
    J Biomed Mater Res A 82:884-91. 2007
    ..Thus, novel calcium-deficient HAs, CDHA, and CDSHA formed at low temperature are promising candidates for orthopaedic applications based on their ability to promote osteoblast cell adhesion and gene expression in vitro...
  32. ncbi request reprint Synthesis, characterization, and osteocompatibility evaluation of novel alanine-based polyphosphazenes
    Lakshmi S Nair
    Department of Orthopedic Surgery, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biomed Mater Res A 76:206-13. 2006
    ..Thus, these biodegradable amino-acid-based polyphosphazenes are promising new materials for forming self-setting bone cements...
  33. ncbi request reprint Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications
    Lakshmi S Nair
    Department of Orthopaedic Surgery, University of Virginia, Virginia 22903, USA
    Biomacromolecules 8:3779-85. 2007
    ..The feasibility of using the gels as a stem cell carrier vehicle as well as a macromolecular delivery vehicle has been demonstrated...
  34. ncbi request reprint Mouse growth and differentiation factor-5 protein and DNA therapy potentiates intervertebral disc cell aggregation and chondrogenic gene expression
    Min Cui
    Department of Orthopaedic Surgery, University of Virginia, Hospital Drive, Cobb Hall, P O Box 800374, Charlottesville, VA 22908, USA
    Spine J 8:287-95. 2008
    ..Growth and differentiation factor-5 (GDF-5)-deficient mice showed abnormalities in intervertebral disc (IVD) structure and extracellular matrix. Adenovirus-mediated GDF-5 delivery can promote the growth of rabbit disc cells...
  35. ncbi request reprint Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters
    Dhirendra S Katti
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biomed Mater Res B Appl Biomater 70:286-96. 2004
    ..Therefore, PLAGA nanofibers show potential as antibiotic delivery systems for the treatment of wounds...
  36. pmc Tissue engineering of the anterior cruciate ligament using a braid-twist scaffold design
    Joseph W Freeman
    Department of Orthopaedic Surgery, The University of Virginia, 400 Ray C Hunt Drive, Ste 330, Charlottesville, VA 22903, USA
    J Biomech 40:2029-36. 2007
    ..Based on the findings of this study, the braid-twist scaffold studied was found to be a promising construct for tissue engineering of the ACL...
  37. ncbi request reprint Repair and restore with tissue engineering
    Cato T Laurencin
    University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, VA 22903, USA
    IEEE Eng Med Biol Mag 22:16-7. 2003
  38. ncbi request reprint Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix
    Francis H Shen
    Department of Orthopaedic Surgery, School of Medicine, P O Box 800159, University of Virginia, Charlottesville, VA 22908 0159, USA
    Spine J 6:615-23. 2006
    ....
  39. pmc Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)
    Meng Deng
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Biomaterials 29:337-49. 2008
    ..Blends of high strength PNEA(50)PhPh(50) and 85:15 PLAGA are promising biomaterials for a variety of musculoskeletal applications...
  40. ncbi request reprint Ligament tissue engineering: an evolutionary materials science approach
    Cato T Laurencin
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA
    Biomaterials 26:7530-6. 2005
    ....
  41. ncbi request reprint The ABJS Nicolas Andry Award: Tissue engineering of bone and ligament: a 15-year perspective
    Cato T Laurencin
    Laurencin Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Clin Orthop Relat Res 447:221-36. 2006
    ....
  42. ncbi request reprint Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineering
    Xudong Li
    Department of Orthopaedic Surgery, University of Virginia School of Medicine, P O Box 800374, Charlottesville, VA 22908, USA
    Biomaterials 27:2426-33. 2006
    ..We consider engineering cartilage tissue with chondrocytes cultured on allogenic demineralized BMG is a good approach for osteochondral tissue engineering...
  43. ncbi request reprint Biologically active chitosan systems for tissue engineering and regenerative medicine
    Tao Jiang
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904, USA
    Curr Top Med Chem 8:354-64. 2008
    ..This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems...
  44. pmc Solvent/non-solvent sintering: a novel route to create porous microsphere scaffolds for tissue regeneration
    Justin L Brown
    Department of Biomedical Engineering, University of Virginia, Virginia, USA
    J Biomed Mater Res B Appl Biomater 86:396-406. 2008
    ....
  45. ncbi request reprint In vivo biodegradability and biocompatibility evaluation of novel alanine ester based polyphosphazenes in a rat model
    Swaminathan Sethuraman
    Department of Chemical Engineering, University of Virginia, Charlottesville, 22903, USA
    J Biomed Mater Res A 77:679-87. 2006
    ..Thus, these polymers demonstrated excellent tissue compatibility and in vivo biodegradability and can be potential candidates for various biomedical applications...
  46. ncbi request reprint Genetically modified mesodermal-derived cells for bone tissue engineering
    Michelle D Kofron
    University of Virginia, USA
    IEEE Eng Med Biol Mag 22:57-64. 2003
  47. pmc Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties
    Jonathan G Merrell
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    Clin Exp Pharmacol Physiol 36:1149-56. 2009
    ..7. These results demonstrate that the curcumin-loaded PCL nanofibre matrix is bioactive and has potential as a wound dressing with anti-oxidant and anti-inflammatory properties...
  48. doi request reprint An AAOS-NIH symposium. Fracture repair: challenges, opportunities, and directions for future research
    Thomas A Einhorn
    Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118, USA
    J Bone Joint Surg Am 90:438-42. 2008
  49. doi request reprint Fracture repair with ultrasound: clinical and cell-based evaluation
    Yusuf Khan
    Department of Orthopaedic Surgery, University of Virginia School of Medicine, Hospital Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:138-44. 2008
    ....
  50. ncbi request reprint Biphasic scaffold for annulus fibrosus tissue regeneration
    Yuqing Wan
    Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Biomaterials 29:643-52. 2008
    ..The excellent mechanical properties and biocompatibility of the BMG/PPCLM scaffold make it a promising candidate for AF repair...
  51. ncbi request reprint Polymers as biomaterials for tissue engineering and controlled drug delivery
    Lakshmi S Nair
    Department of Orthopaedic Surgery, College of Medicine, University of Virginia, Charlottesville 22903, USA
    Adv Biochem Eng Biotechnol 102:47-90. 2006
    ..This review highlights various biodegradable polymeric materials currently investigated for use in two key medical applications: drug delivery and tissue engineering...
  52. ncbi request reprint Development of novel tissue engineering scaffolds via electrospinning
    Lakshmi S Nair
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, 22903, USA
    Expert Opin Biol Ther 4:659-68. 2004
    ..This article reviews the recent advances in the development of synthetic biodegradable nanofibre-based matrices as scaffolds for tissue engineering...
  53. doi request reprint Tissue engineering of bone: material and matrix considerations
    Yusuf Khan
    University of Virginia School of Medicine, 400 Ray C Hunt Drive, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:36-42. 2008
    ....
  54. doi request reprint Nanofibers and nanoparticles for orthopaedic surgery applications
    Lakshmi S Nair
    Department of Orthopaedic Surgery, University of Virginia, 415 LaneRoad, Box 800759, Charlottesville, VA 22908, USA
    J Bone Joint Surg Am 90:128-31. 2008
    ..Apart from their unique wound-healing ability, silver nanoparticles also exhibit high antibacterial properties, making them potential candidates for use in the development of infection-resistant biomaterials...
  55. pmc Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization
    Xiaojun Yu
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 101:11203-8. 2004
    ....
  56. ncbi request reprint Bone tissue engineering by gene delivery
    Michelle D Kofron
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
    Adv Drug Deliv Rev 58:555-76. 2006
    ....
  57. ncbi request reprint Quantitative analysis of three-dimensional fluid flow in rotating bioreactors for tissue engineering
    Edward A Botchwey
    Department of Biomedical Engineering, The University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, Virginia 22903, USA
    J Biomed Mater Res A 69:205-15. 2004
    ..2 mm/s. Estimates of maximum interior shear stress ranged from 0.03 to 0.0007 N/m(2). These analytical methods provide an excellent vehicle for the study of bone tissue synthesis in three-dimensional culture with fluid flow...
  58. ncbi request reprint Tissue engineered bone: measurement of nutrient transport in three-dimensional matrices
    Edward A Botchwey
    Department of Biomedical Engineering, The University of Virginia, 400 Ray C Hunt Drive, Suite 330, Charlottesville, Virginia 22903, USA
    J Biomed Mater Res A 67:357-67. 2003
    ....
  59. ncbi request reprint Xenotransplantation in orthopaedic surgery
    Cato T Laurencin
    Department of Orthopaedic Surgery, The University of Virginia, Charlottesville, VA, 22903, USA
    J Am Acad Orthop Surg 16:4-8. 2008
    ..Studies internationally have demonstrated a low relative risk of disease transmission, although there is concern regarding the potential for transmission into humans of agents not considered pathogenic or not detected in animals...
  60. ncbi request reprint Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules
    Sangamesh G Kumbar
    Department of Orthopaedic Surgery, University of Virginia, Virginia 22903, USA
    J Nanosci Nanotechnol 6:2591-607. 2006
    ..The nonwoven biodegradable polymeric nanofiber matrices are currently being reported as topical/local therapeutic agent delivery systems and as resorbable/biodegradable gauze for wound healing applications...
  61. ncbi request reprint Three-dimensional, bioactive, biodegradable, polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization of human osteoblast-like cells in vitro
    Helen H Lu
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
    J Biomed Mater Res A 64:465-74. 2003
    ..Future work will focus on the optimization of the composite scaffold for bone tissue-engineering applications and the evaluation of the 3-D composite in an in vivo model...
  62. ncbi request reprint Human osteoblast-like cells in three-dimensional culture with fluid flow
    Edward A Botchwey
    Department of Bioengineering, University of Pennsylvania, PA 19104, USA
    Biorheology 40:299-306. 2003
    ..In addition, flow cytometric analysis of the overall cell population showed that cells constitutively expressed integrin alpha3beta1 during 3D hydrodynamic culture...
  63. ncbi request reprint The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies
    Mark Borden
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 61:421-9. 2002
    ..These studies show that the sintered microsphere matrix has an osteoconductive structure capable of functioning as a cellular scaffold with a degradation profile suitable for bone regeneration...
  64. ncbi request reprint Cryopreservation of tissue engineered constructs for bone
    Michelle D Kofron
    Department of Biomedical Engineering, Drexel University, Philadelphia, PA 19104, USA
    J Orthop Res 21:1005-10. 2003
    ..The ability to successfully cryopreserve mineralized tissue engineered matrices for bone may offer an unlimited and readily available source of bone-like materials for orthopaedic applications...
  65. ncbi request reprint Electrospun nanofibrous structure: a novel scaffold for tissue engineering
    Wan Ju Li
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Biomed Mater Res 60:613-21. 2002
    ..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth...
  66. ncbi request reprint Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies
    Helen H Lu
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biomaterials 26:4805-16. 2005
    ..Therefore based on the overall cellular response and its temporal mechanical and degradation properties in vitro, the PLLA braided scaffold pre-coated with Fn was found to be the most suitable substrate for ACL tissue engineering...
  67. ncbi request reprint Novel polymer-synthesized ceramic composite-based system for bone repair: an in vitro evaluation
    Yusuf M Khan
    School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    J Biomed Mater Res A 69:728-37. 2004
    ..This composite scaffold represents a new and important vehicle for bone-tissue engineering...
  68. ncbi request reprint In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering using polymer-bone morphogenetic protein matrices
    Helen H Lu
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Biochem Biophys Res Commun 305:882-9. 2003
    ..These results demonstrate the efficacy of a BMP-polymer matrix in inducing the expression of the osteoblastic phenotype by muscle-derived cells and present a new paradigm for bone tissue engineering...
  69. ncbi request reprint Protein- and gene-based tissue engineering in bone repair
    Michelle D Kofron
    Curr Opin Biotechnol 15:399-405. 2004
    ....
  70. ncbi request reprint Integrin expression by human osteoblasts cultured on degradable polymeric materials applicable for tissue engineered bone
    Saadiq F El-Amin
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
    J Orthop Res 20:20-8. 2002
    ....
  71. pmc Biomimetic tissue-engineered anterior cruciate ligament replacement
    James A Cooper
    School of Biomedical, Engineering, Science, and Health Systems and Center for Advanced Biomaterials and Tissue Engineering, 3141 Chestnut Street, Drexel University, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:3049-54. 2007
    ..In this preliminary in vivo rabbit model study for ACL reconstruction, the histological and mechanical evaluation demonstrated excellent healing and regeneration with our cell-seeded, tissue-engineered ligament replacement...
  72. ncbi request reprint Amorphous hydroxyapatite-sintered polymeric scaffolds for bone tissue regeneration: physical characterization studies
    Emily K Cushnie
    Department of Chemical Engineering, The University of Virginia, Charlottesville, Virginia
    J Biomed Mater Res A 84:54-62. 2008
    ..These results suggest that the addition of amorphous HA to PLAGA microspheres resulted in porous, bioactive scaffolds that offer potential as alternative bone grafting materials for the field of regenerative medicine...
  73. ncbi request reprint Synthesis, characterization of chitosans and fabrication of sintered chitosan microsphere matrices for bone tissue engineering
    Wafa I Abdel-Fattah
    Department of Biomaterials, National Research Centre, Cairo, Egypt
    Acta Biomater 3:503-14. 2007
    ..62microm of the fabricated 3-D matrix. The compressive modulus of the sintered microsphere matrix (662.26+/-54.53MPa) was in the range of human cancellous bone (10-2000MPa), making it suitable for bone tissue engineering applications...
  74. ncbi request reprint Nanobiomaterial applications in orthopedics
    Elizabeth M Christenson
    Department of Bioengineering MS142, Rice University, PO Box 1892, Houston, Texas 77251 1892, USA
    J Orthop Res 25:11-22. 2007
    ..Overall, current trends in nanobiotechnology foreshadow a bright future through the use of nanobiomaterials in the orthopedic domain...
  75. pmc Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells
    Gang Feng
    Department of Orthopaedic Surgery, The Second Clinical Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, People s Republic of China
    Growth Factors 26:132-42. 2008
    ....
  76. pmc Fibroblast growth factor 2 induced proliferation in osteoblasts and bone marrow stromal cells: a whole cell model
    Melissa A Dupree
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biophys J 91:3097-112. 2006
    ....
  77. ncbi request reprint Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes
    Anurima Singh
    Department of Chemistry and Intercollege Materials Research Laboratory, The Pennsylvania State University, University Park, 16802 6300, USA
    Biomacromolecules 7:914-8. 2006
    ..4-7.6 MPa and the modulus of elasticity was in the range of 31.4-455.9 MPa. Thus, in this study we have demonstrated the tunability of biodegradable polyphosphazenes to suit a range of biomedical applications...
  78. ncbi request reprint Structural and nanoindentation studies of stem cell-based tissue-engineered bone
    Gadi Pelled
    Skeletal Biotech Laboratory, Hebrew University, Hadassah Medical Center, Ein Kerem, Jerusalem 91120, Israel
    J Biomech 40:399-411. 2007
    ....
  79. ncbi request reprint Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament
    James A Cooper
    Polymers Division, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8543, Gaithersburg, MD 20899, USA
    Biomaterials 27:2747-54. 2006
    ..This study would suggest that ACL differentiated matrix producing cells are the most suitable cells for further study and development of a tissue-engineered ligament...
  80. ncbi request reprint Miscibility of bioerodible polyphosphazene/poly(lactide-co-glycolide) blends
    Nicholas R Krogman
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biomacromolecules 8:1306-12. 2007
    ..This is attributed to the buffering capacity of the polyphosphazene hydrolysis products, which increases the pH of the degradation media from 2.5 to 4, thereby slowing the degradation rate of PLGA...
  81. ncbi request reprint Degradable polyphosphazene/poly(alpha-hydroxyester) blends: degradation studies
    Archel M A Ambrosio
    Department of Chemical Engineering, Center for Advanced Biomaterials and Tissue Engineering, Drexel University, Philadelphia, PA 19104, USA
    Biomaterials 23:1667-72. 2002
    ..Thus, results from these in vitro degradation studies suggest that the PLAGA-PPHOS-EG50 blend may provide a viable improvement to biomaterials based on acid-releasing organic polymers...
  82. ncbi request reprint Tissue engineered microsphere-based matrices for bone repair: design and evaluation
    Mark Borden
    Center for Advanced Biomaterials and Tissue Engineering, Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
    Biomaterials 23:551-9. 2002
    ..The microsphere-based matrices show promise as polymeric substitutes for bone repair...