Miriam K Laufer

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Prevalence and spectrum of illness among hospitalized adults with malaria in Blantyre, Malawi
    Dalitso Segula
    Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, P, O, Box 30096 Blantyre, Malawi
    Malar J 13:391. 2014
  2. pmc Submicroscopic malaria infection during pregnancy and the impact of intermittent preventive treatment
    Lauren M Cohee
    Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, Maryland, USA
    Malar J 13:274. 2014
  3. pmc Timing of malaria infection during pregnancy has characteristic maternal, infant and placental outcomes
    Linda Kalilani-Phiri
    Department of Community Heath, University of Malawi College of Medicine, Blantyre, Malawi
    PLoS ONE 8:e74643. 2013
  4. pmc Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi
    Blair J Wylie
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Malar J 12:183. 2013
  5. pmc A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria
    Miriam K Laufer
    Malaria Group, Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42284. 2012
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
  7. ncbi request reprint Malaria treatment efficacy among people living with HIV: the role of host and parasite factors
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 77:627-32. 2007
  8. ncbi request reprint Monitoring and deterring drug-resistant malaria in the era of combination therapy
    Miriam K Laufer
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    Am J Trop Med Hyg 77:160-9. 2007
  9. pmc Monitoring antimalarial drug efficacy: current challenges
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Curr Infect Dis Rep 11:59-65. 2009
  10. pmc Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Infect Dis 202:801-8. 2010

Collaborators

Detail Information

Publications31

  1. pmc Prevalence and spectrum of illness among hospitalized adults with malaria in Blantyre, Malawi
    Dalitso Segula
    Malawi Liverpool Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, P, O, Box 30096 Blantyre, Malawi
    Malar J 13:391. 2014
    ..Regular surveys of adult admissions to a hospital in Malawi were conducted to characterize the clinical spectrum of malaria and to establish a baseline to monitor changes that occur in future...
  2. pmc Submicroscopic malaria infection during pregnancy and the impact of intermittent preventive treatment
    Lauren M Cohee
    Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, Maryland, USA
    Malar J 13:274. 2014
    ..Although submicroscopic infection is common during pregnancy and at delivery, its impact throughout pregnancy on the development of placental malaria and adverse pregnancy outcomes has not been clearly established...
  3. pmc Timing of malaria infection during pregnancy has characteristic maternal, infant and placental outcomes
    Linda Kalilani-Phiri
    Department of Community Heath, University of Malawi College of Medicine, Blantyre, Malawi
    PLoS ONE 8:e74643. 2013
    ..Interventions to control malaria early and aggressive case detection are required to limit the detrimental effects of pregnancy-associated malaria. ..
  4. pmc Gestational age assessment in malaria pregnancy cohorts: a prospective ultrasound demonstration project in Malawi
    Blair J Wylie
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Malar J 12:183. 2013
    ..Where ultrasound is accessible, sonographic confirmation of gestational age is more accurate than menstrual dating. The goal was to pilot the feasibility and utility of adding ultrasound to an observational pregnancy malaria cohort...
  5. pmc A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria
    Miriam K Laufer
    Malaria Group, Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42284. 2012
    ..We aimed to compare the ability of different partner drugs to preserve chloroquine efficacy and prevent the re-emergence of resistance...
  6. pmc World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs
    Ric N Price
    International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
    Malar J 6:119. 2007
    ..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed...
  7. ncbi request reprint Malaria treatment efficacy among people living with HIV: the role of host and parasite factors
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Trop Med Hyg 77:627-32. 2007
    ....
  8. ncbi request reprint Monitoring and deterring drug-resistant malaria in the era of combination therapy
    Miriam K Laufer
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    Am J Trop Med Hyg 77:160-9. 2007
    ..The malaria research and control community should not fail to exploit this opportunity to apply the lessons of the last 50 years to extend the useful therapeutic lives of ACTs...
  9. pmc Monitoring antimalarial drug efficacy: current challenges
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA
    Curr Infect Dis Rep 11:59-65. 2009
    ..This review discusses the challenges to various methods to monitor antimalarial drug resistance and proposes an integrated approach to the rapid detection and characterization of resistance to ACTs should it arise...
  10. pmc Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, Baltimore, MD 21201, USA
    J Infect Dis 202:801-8. 2010
    ..Chloroquine-susceptible parasites that predominate in Malawi likely represent a reexpansion of the susceptible parasites that survived in the population despite widespread drug pressure in the region...
  11. ncbi request reprint Return of chloroquine antimalarial efficacy in Malawi
    Miriam K Laufer
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    N Engl J Med 355:1959-66. 2006
    ..The molecular marker of chloroquine-resistant falciparum malaria subsequently declined in prevalence and was undetectable by 2001, suggesting that chloroquine might once again be effective in Malawi...
  12. pmc Pneumocystis pneumonia in HIV-positive adults, Malawi
    Joep J G van Oosterhout
    University of Malawi College of Medicine, Blantyre, Malawi
    Emerg Infect Dis 13:325-8. 2007
    ..PcP incidence was highest in patients with the lowest CD4 counts, but PcP is uncommon compared with incidences of pulmonary tuberculosis and bacterial pneumonia...
  13. ncbi request reprint Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA
    J Infect Dis 193:872-8. 2006
    ..Human immunodeficiency virus (HIV) infection and malaria coexist in much of Africa. Previous studies differ in their findings on the interactions between the 2 infections...
  14. pmc Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment
    Ayesha M Shaukat
    Malaria Group, Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Malar J 11:207. 2012
    ..The clinical benefit of preventing new infections has never been compared to that of curing the initial infection...
  15. ncbi request reprint Observational cohort study of HIV-infected African children
    Miriam K Laufer
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA
    Pediatr Infect Dis J 25:623-7. 2006
    ..Children identified through voluntary counseling and testing (VCT) represent a unique cohort that has not been previously described in the literature...
  16. pmc Bed net use among school-aged children after a universal bed net campaign in Malawi
    Andrea G Buchwald
    Institute for Global Health, University of Maryland School of Medicine, 685 W Baltimore St HSF 1 Room 480, Baltimore, MD, 21201, USA
    Malar J 15:127. 2016
    ..This study examined the effects of a universal ITN distribution campaign, and their durability over time in SAC in Malawi. This study identified factors that influence net usage among SAC and how these factors changed over time...
  17. ncbi request reprint Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies
    Miriam K Laufer
    Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, 685 W Baltimore Street, HSF 1 480, Baltimore, MD 21201, USA
    Drug Resist Updat 7:279-88. 2004
    ..The finding that drug resistance decreases with the removal of drug pressure could provide a new paradigm for malaria treatment policies in Africa...
  18. pmc The effect of local variation in malaria transmission on the prevalence of sulfadoxine-pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi
    Elena Artimovich
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 480, Baltimore, MD, 21201, USA
    Malar J 14:387. 2015
    ....
  19. doi request reprint Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi
    Anne E P Frosch
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore Department of Medicine, University of Minnesota, Minneapolis
    J Infect Dis 210:1110-4. 2014
    ..The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies...
  20. pmc Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory- and gastrointestinal-tract infections in Malawian children
    Elizabeth A Gilliams
    Department of Epidemiology and Public Health, University of Maryland School of Medicine Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
    J Infect Dis 210:585-92. 2014
    ..Chloroquine-azithromycin is being evaluated as combination therapy for malaria. It may provide added benefit in treating or preventing bacterial infections that occur in children with malaria...
  21. ncbi request reprint A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV
    Joep J G van Oosterhout
    Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
    J Acquir Immune Defic Syndr 39:626-31. 2005
    ..These should also assess benefit in patients receiving antiretroviral therapy...
  22. pmc Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi
    Elena Artimovich
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore
    J Infect Dis 212:694-701. 2015
    ..Here we estimate the effect of reduced SP pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci...
  23. pmc Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data
    Anne E P Frosch
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD, USA
    Malar J 10:116. 2011
    ..This observation suggests that there is continuing use of ineffective anti-malarials in Africa and that persistent chloroquine-resistant malaria is due to ongoing drug pressure despite national policy changes...
  24. pmc Resistance to antimalarial drugs: molecular, pharmacologic, and clinical considerations
    Mark A Travassos
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 65:64R-70R. 2009
    ..The emergence and spread of resistance also results from an interplay of these factors. Current efforts to characterize and deter resistance to new combination therapy are also discussed...
  25. pmc The prevalence of malaria at first antenatal visit in Blantyre, Malawi declined following a universal bed net campaign
    Sarah Boudová
    Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA
    Malar J 14:422. 2015
    ..This study tested the hypothesis that a universal bed net campaign would decrease the prevalence of malaria among pregnant women at their first antenatal visit...
  26. pmc Malaria control in Malawi: current status and directions for the future
    Don P Mathanga
    Department of Community Health, University of Malawi College of Medicine, Blantyre, Malawi
    Acta Trop 121:212-7. 2012
    ....
  27. pmc Pregnant women are a reservoir of malaria transmission in Blantyre, Malawi
    Sarah Boudová
    Center for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD, USA
    Malar J 13:506. 2014
    ..This would suggest that pregnant women may be important reservoirs of malaria transmission...
  28. pmc School-Age Children Are a Reservoir of Malaria Infection in Malawi
    Jenny A Walldorf
    Center for Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 10:e0134061. 2015
    ..School-age children used bednets less frequently than other age groups. Compared to young children, school-age children were brought less often for treatment and more often to unreliable treatment sources...
  29. pmc Antimalarial drug resistance in Africa: key lessons for the future
    Shannon Takala-Harrison
    Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland
    Ann N Y Acad Sci 1342:62-7. 2015
    ..We will review the most recent genomic and clinical data to help predict the behavior of resistance to new antimalarial medications and inform strategies to prevent the spread of drug-resistant malaria in Africa in the future. ..
  30. pmc Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravid, malaria-exposed Malian women
    Mark A Travassos
    Howard Hughes Medical Institute Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland Malaria Research and Training Center, University of Sciences, Techniques and Technology, Bamako, Mali Division of Infectious Diseases, Department of Medicine, University of California, Irvine, California Centre for Immunity, Infection and Evolution, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    Am J Trop Med Hyg 92:1190-4. 2015
    ..With carefully chosen sera from longitudinal studies of pregnant women, this approach has the potential to identify seroreactive VAR2CSA domains associated with protective immunity against pregnancy-associated malaria. ..
  31. ncbi request reprint Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions been answered?
    Miriam K Laufer
    Am J Trop Med Hyg 75:373-4. 2006

Research Grants2

  1. Molecular epidemiology of drug resistant malaria
    MIRIAM LAUFER; Fiscal Year: 2008
    ..abstract_text> ..
  2. A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versus
    MIRIAM LAUFER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..