Yun Fai Chris Lau

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein
    Hyun Ju Oh
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Biol Reprod 72:407-15. 2005
  2. ncbi A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    Genesis 42:263-75. 2005
  3. ncbi The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions
    Yunmin Li
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center 111C5, University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 257:35-46. 2006
  4. pmc Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer
    Tatsuo Kido
    Laboratory of Cell and Developmental Genetics, Department of Medicine, VA Medical Center and Institute for Human Genetics, University of California, 4150 Clement Street, San Francisco, CA, USA
    Cell Biosci 4:9. 2014
  5. doi Gonadoblastoma locus and the TSPY gene on the human Y chromosome
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Birth Defects Res C Embryo Today 87:114-22. 2009
  6. doi The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    J Genet Genomics 36:193-202. 2009
  7. doi Role of the Y-located putative gonadoblastoma gene in human spermatogenesis
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Syst Biol Reprod Med 57:27-34. 2011
  8. pmc The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Hum Pathol 38:1470-81. 2007
  9. pmc TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells
    Shane W Oram
    Department of Medicine, VA Medical Center, University of California, San Francisco, USA
    BMC Cancer 6:154. 2006
  10. ncbi KRAB: a partner for SRY action on chromatin
    Hyun Ju Oh
    Department of Medicine, VA Medical Center, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 247:47-52. 2006

Research Grants

  1. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
  2. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2000
  3. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2001
  4. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2002
  5. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2003

Collaborators

Detail Information

Publications19

  1. ncbi Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein
    Hyun Ju Oh
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Biol Reprod 72:407-15. 2005
    ....
  2. ncbi A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California 94121, USA
    Genesis 42:263-75. 2005
    ..The tissue-specific expression of the hTSPY-Cre transgene should also be useful in studies utilizing Cre-mediated gene activation/inactivation strategies in gamatogenesis and/or neurogenesis...
  3. ncbi The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions
    Yunmin Li
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center 111C5, University of California at San Francisco, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 257:35-46. 2006
    ..PARP-1 represses Sry-mediated transactivation of a reporter gene in cultured cells. Hence, PARP-1 could modulate the regulatory function(s) of Sry on its target genes in this developmental pathway...
  4. pmc Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer
    Tatsuo Kido
    Laboratory of Cell and Developmental Genetics, Department of Medicine, VA Medical Center and Institute for Human Genetics, University of California, 4150 Clement Street, San Francisco, CA, USA
    Cell Biosci 4:9. 2014
    ....
  5. doi Gonadoblastoma locus and the TSPY gene on the human Y chromosome
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Birth Defects Res C Embryo Today 87:114-22. 2009
    ....
  6. doi The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    J Genet Genomics 36:193-202. 2009
    ....
  7. doi Role of the Y-located putative gonadoblastoma gene in human spermatogenesis
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Syst Biol Reprod Med 57:27-34. 2011
    ....
  8. pmc The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Hum Pathol 38:1470-81. 2007
    ..Our results suggest that TSPY, in combination with other markers, could be an important marker for diagnosis and subclassification of TGCTs and support its role in the pathogenesis of both gonadoblastoma and TGCTs...
  9. pmc TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells
    Shane W Oram
    Department of Medicine, VA Medical Center, University of California, San Francisco, USA
    BMC Cancer 6:154. 2006
    ..TSPY contains a SET/NAP domain that is present in a family of cyclin B and/or histone binding proteins represented by the oncoprotein SET and the nucleosome assembly protein 1 (NAP1), involved in cell cycle regulation and replication...
  10. ncbi KRAB: a partner for SRY action on chromatin
    Hyun Ju Oh
    Department of Medicine, VA Medical Center, University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Mol Cell Endocrinol 247:47-52. 2006
    ....
  11. pmc The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 350:56-67. 2006
    ..Our results suggest that the rTspy may play critical roles as a histone chaperone during maturation of the elongating spermatids in the rat testis...
  12. doi The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Cancer 123:1573-85. 2008
    ..Our results suggest that TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription...
  13. pmc The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e22979. 2011
    ....
  14. ncbi The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, and Institute for Human Genetics, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 446:206-11. 2014
    ..These results suggest that TSPY could efficiently amplify its expression and oncogenic functions through a positive feedback loop, and contribute to the overall tumorigenic processes when it is expressed in various human cancers. ..
  15. ncbi Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Urol Oncol 25:141-6. 2007
    ..These findings support the candidacy of TSPY as the gene for the gonadoblastoma locus on Y chromosome and suggest that TSPY could be a significant marker for these types of germ cell tumors...
  16. doi Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies
    Ming Zheng
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, USA
    Methods Mol Biol 1067:185-202. 2013
    ..The various features of Mpeak will be illustrated with ChIP-chip datasets from a study designed to identify the target genes for the sex-determining factor, SRY, in mouse embryonic gonads at the time of sex determination...
  17. doi Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA, USA
    Methods Mol Biol 825:3-16. 2012
    ..As examples of applications, we describe the immunofluorescence detection of SOX9 expression in gonadal tissue sections and microRNAs profiling/expression in fetal gonads at a critical stage for sex determination...
  18. pmc Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours
    Yunmin Li
    Division of Cell and Developmental Genetics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Exp Pathol 89:342-9. 2008
    ....
  19. ncbi PIAS1 interacts with and represses SOX9 transactivation activity
    Hyun Ju Oh
    Department of Medicine, VA Medical Center, University of California, San Francisco, California, USA
    Mol Reprod Dev 74:1446-55. 2007
    ..Thus, PIAS1 appears to repress SOX9 activity by at least two SUMO-ligase dependent mechanisms: (1) the SUMOylation of SOX9 and (2) SUMOylation of unknown factors associated with SOX9 and/or PIAS1...

Research Grants5

  1. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  2. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2000
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  3. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2001
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  4. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2002
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  5. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2003
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..