Y Lau

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
  2. ncbi Sry interactive proteins: implication for the mechanisms of sex determination
    Y F Lau
    Department of Medicine, VA Medical Center, University of California at San Francisco, 94121, USA
    Cytogenet Cell Genet 80:128-32. 1998
  3. pmc Gonadoblastoma, testicular and prostate cancers, and the TSPY gene
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VAMC 111C5, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Am J Hum Genet 64:921-7. 1999
  4. ncbi Expression analysis of thirty one Y chromosome genes in human prostate cancer
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, 111C5, University of California, San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 27:308-21. 2000
  5. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
  6. ncbi In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination
    J Zhang
    Department of Medicine, University of California, San Francisco 94121, USA
    Int J Dev Biol 43:219-27. 1999
  7. ncbi Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals
    M Xian
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, UCSF, San Francisco, California 94121, USA
    J Exp Zool 290:632-41. 2001
  8. ncbi Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997
    P H Vogt
    Institut fur Humangenetik, Universitat Heidelberg, Germany
    Cytogenet Cell Genet 79:1-20. 1997
  9. pmc Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach
    H Su
    Department of Medicine, VA Medical Center, University of California, San Francisco 94121
    Am J Hum Genet 52:24-38. 1993
  10. pmc A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids
    G Boissonneault
    Division of Cell and Developmental Genetics, University of California, San Francisco 94121
    Mol Cell Biol 13:4323-30. 1993

Collaborators

Detail Information

Publications21

  1. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
    ....
  2. ncbi Sry interactive proteins: implication for the mechanisms of sex determination
    Y F Lau
    Department of Medicine, VA Medical Center, University of California at San Francisco, 94121, USA
    Cytogenet Cell Genet 80:128-32. 1998
  3. pmc Gonadoblastoma, testicular and prostate cancers, and the TSPY gene
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VAMC 111C5, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Am J Hum Genet 64:921-7. 1999
  4. ncbi Expression analysis of thirty one Y chromosome genes in human prostate cancer
    Y F Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, 111C5, University of California, San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 27:308-21. 2000
    ..The up- and down-regulation of several Y chromosome genes by androgen suggest that they may play a role(s) in the hormonally stimulated proliferation of the responsive LNCaP cells...
  5. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
    ..The present observations suggest that TSPY may either be involved in the oncogenesis of or be a useful marker for both types of germ cell tumors...
  6. ncbi In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination
    J Zhang
    Department of Medicine, University of California, San Francisco 94121, USA
    Int J Dev Biol 43:219-27. 1999
    ..These observations support the hypothesis that the Q-rich domain may contribute to the biological function(s) of mouse Sry through a protein-protein interactive role(s)...
  7. ncbi Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals
    M Xian
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, UCSF, San Francisco, California 94121, USA
    J Exp Zool 290:632-41. 2001
    ..These results are discussed with reference to a second hypothesis invoking incompatible protein interaction(s) as a mechanism of aberrant sex determination in B6.Y(Dom) animals...
  8. ncbi Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997
    P H Vogt
    Institut fur Humangenetik, Universitat Heidelberg, Germany
    Cytogenet Cell Genet 79:1-20. 1997
  9. pmc Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach
    H Su
    Department of Medicine, VA Medical Center, University of California, San Francisco 94121
    Am J Hum Genet 52:24-38. 1993
    ..The results indicate that the human SRY gene is an intronless gene, produces transcripts of 1.1 kb, and possesses promoter activities in the transfected cells at approximately 310 bp of its upstream sequences...
  10. pmc A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids
    G Boissonneault
    Division of Cell and Developmental Genetics, University of California, San Francisco 94121
    Mol Cell Biol 13:4323-30. 1993
    ..These results suggest that this novel HMG box protein gene may be involved in the regulation of gene expression of the haploid male genome. The gene from which the cDNA was derived has been termed testis-specific HMG (tsHMG)...
  11. ncbi Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal
    P Coward
    Department of Medicine, VA Medical Center, University of California, San Francisco 94121
    Nat Genet 6:245-50. 1994
    ....
  12. ncbi The musculus-type Y chromosome of the laboratory mouse is of Asian origin
    C M Nagamine
    Vanderbilt University School of Medicine, Department of Cell Biology, Nashville, Tennessee 37232 2175
    Mamm Genome 3:84-91. 1992
    ....
  13. ncbi Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies
    H Su
    Department of Medicine, VA Medical Center, University of California, San Francisco
    Mol Reprod Dev 33:252-8. 1992
    ..Its location in the seminiferous tubules suggests a possible role in early germ cell development...
  14. ncbi Molecular isolation and characterization of an expressed gene from the human Y chromosome
    J S Zhang
    Division of Cell and Developmental Genetics, VA Medical Center, University of California, San Francisco 94121
    Hum Mol Genet 1:717-26. 1992
    ..The Y-231 (TSPY) gene is conserved in the male genome and expressed in the testis of the chimpanzee, suggesting that it may play an important role in the physiology of this organ in man and the great ape...
  15. pmc The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues
    Y F Lau
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Am J Hum Genet 45:942-52. 1989
    ..Significantly, the 3-kb ZFY transcript was also detected in other mammalian adult testes. The testis-specific transcription of the ZFY gene hence suggests that it serves a conserved function in this organ...
  16. ncbi Chromosome mapping and expression of a putative testis-determining gene in mouse
    C M Nagamine
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Science 243:80-3. 1989
    ..0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans...
  17. ncbi Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes
    W Y Leung
    Department of Human Genetics, Yale University School of Medicine, New Haven, CT 06510 8005
    Cytogenet Cell Genet 54:151-3. 1990
    ..These assignments of the ZFX gene in human and mouse add another marker to the conserved syntenic group for evaluating the evolutionary relationship of the human and mouse X chromosomes...
  18. ncbi Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen
    H Su
    Department of Medicine, University of California, San Francisco 94121
    J Reprod Immunol 21:275-91. 1992
    ..Analysis of an intersubspecies mouse backcross has assigned this gene to chromosome 5, between the loci Gus and Hnf-1...
  19. ncbi Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR
    V Kren
    Institute of Biology and Medical Genetics, First Medical Faculty, Charles University, Prague, Czech Republic
    Hypertension 37:1147-52. 2001
    ..Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease...
  20. pmc Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis
    Y F Lau
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Proc Natl Acad Sci U S A 86:8462-6. 1989
    ..3, close to the major histocompatibility complex locus. The genetic conservation and testis-specific expression of the MEA gene support the hypothesis that it plays an important role in mammalian spermatogenesis and/or testis development...
  21. ncbi The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues
    C M Nagamine
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 4:63-74. 1990
    ..However, because the Zfy genes are apparently also expressed during spermatogenesis and in fetal organs other than testes, they may serve additional functions besides their postulated role in testis determination...