Wei C Lau

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Clopidogrel-drug interactions
    Eric R Bates
    Division of Cardiovascular Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Am Coll Cardiol 57:1251-63. 2011
  2. ncbi request reprint Intraoperative transesophageal echocardiographic assessment of the effect of protamine on paraprosthetic aortic insufficiency immediately after stentless tissue aortic valve replacement
    Wei C Lau
    Department of Anesthesiology, University of Michigan, Ann Arbor 48109, USA
    J Am Soc Echocardiogr 15:1175-80. 2002
  3. ncbi request reprint Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction
    Wei C Lau
    Department of Anesthesiology, University of Michigan, Ann Arbor, USA
    Circulation 107:32-7. 2003
  4. doi request reprint The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activity
    Wei C Lau
    Cardiovascular Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 5861, USA
    J Cardiovasc Pharmacol 57:86-93. 2011
  5. ncbi request reprint Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    Wei C Lau
    Department of Anesthesiology, University of Michigan Health System, 1G323 University Hospital, Box 0048, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0048, USA
    Circulation 109:166-71. 2004
  6. ncbi request reprint Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4
    Wei C Lau
    Medical Director Cardiovascular Center Operating Rooms, Cardiovascular Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Pharm Res 23:2691-708. 2006
  7. ncbi request reprint Controversies in antiplatelet therapy for patients with cardiovascular disease
    Eric R Bates
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich, USA
    Circulation 111:e267-71. 2005
  8. doi request reprint Impact of adding aspirin to beta-blocker and statin in high-risk patients undergoing major vascular surgery
    Wei C Lau
    Department of Anesthesiology, University of Michigan Cardiovascular Center, Ann Arbor, MI 48109, USA
    Ann Vasc Surg 27:537-45. 2013
  9. pmc Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes
    Haoming Zhang
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5632, USA
    Mol Pharmacol 82:302-9. 2012
  10. doi request reprint Perioperative practice: time to throttle back
    Vineet Chopra
    University of Michigan Health System, Ann Arbor, Michigan 48109 5853, USA
    Ann Intern Med 152:47-51. 2010

Detail Information

Publications15

  1. doi request reprint Clopidogrel-drug interactions
    Eric R Bates
    Division of Cardiovascular Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Am Coll Cardiol 57:1251-63. 2011
    ....
  2. ncbi request reprint Intraoperative transesophageal echocardiographic assessment of the effect of protamine on paraprosthetic aortic insufficiency immediately after stentless tissue aortic valve replacement
    Wei C Lau
    Department of Anesthesiology, University of Michigan, Ann Arbor 48109, USA
    J Am Soc Echocardiogr 15:1175-80. 2002
    ..Protamine administration is associated with resolution of small AI jets immediately after implantation of a stentless aortic bioprosthesis, with a jet width 0.3 cm or less strongly predictive of resolution...
  3. ncbi request reprint Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction
    Wei C Lau
    Department of Anesthesiology, University of Michigan, Ann Arbor, USA
    Circulation 107:32-7. 2003
    ..Because atorvastatin is metabolized by cytochrome P450 (CYP) 3A4, we hypothesized that clopidogrel might be activated by CYP3A4...
  4. doi request reprint The effect of St John's Wort on the pharmacodynamic response of clopidogrel in hyporesponsive volunteers and patients: increased platelet inhibition by enhancement of CYP3A4 metabolic activity
    Wei C Lau
    Cardiovascular Center, Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 5861, USA
    J Cardiovasc Pharmacol 57:86-93. 2011
    ..0002) and increased platelet inhibition (23% ± 11% vs. 41% ± 16%, P = 0.002). SJW may be a future therapeutic option to increase CYP metabolic activity and antiplatelet effect of clopidogrel in hyporesponders...
  5. ncbi request reprint Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    Wei C Lau
    Department of Anesthesiology, University of Michigan Health System, 1G323 University Hospital, Box 0048, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0048, USA
    Circulation 109:166-71. 2004
    ..Because the prodrug clopidogrel is activated by hepatic cytochrome P450 (CYP) 3A4, we hypothesized that interindividual variability in clopidogrel efficacy might be related to interindividual differences in CYP3A4 metabolic activity...
  6. ncbi request reprint Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4
    Wei C Lau
    Medical Director Cardiovascular Center Operating Rooms, Cardiovascular Anesthesiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Pharm Res 23:2691-708. 2006
    ..Further investigation or guidelines are needed to optimize antiplatelet treatment strategies to identify and treat patients resistant to aspirin and/or clopidogrel...
  7. ncbi request reprint Controversies in antiplatelet therapy for patients with cardiovascular disease
    Eric R Bates
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Mich, USA
    Circulation 111:e267-71. 2005
  8. doi request reprint Impact of adding aspirin to beta-blocker and statin in high-risk patients undergoing major vascular surgery
    Wei C Lau
    Department of Anesthesiology, University of Michigan Cardiovascular Center, Ann Arbor, MI 48109, USA
    Ann Vasc Surg 27:537-45. 2013
    ..In this study we evaluated the benefits of adding aspirin (A) to BB and S (ABBS), with/without angiotensin-converting enzyme inhibitor (ACE-I) on postoperative outcome in high-risk patients undergoing major vascular surgery...
  9. pmc Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes
    Haoming Zhang
    Department of Pharmacology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5632, USA
    Mol Pharmacol 82:302-9. 2012
    ..These factors may affect the effective concentrations of the AM in vivo...
  10. doi request reprint Perioperative practice: time to throttle back
    Vineet Chopra
    University of Michigan Health System, Ann Arbor, Michigan 48109 5853, USA
    Ann Intern Med 152:47-51. 2010
    ..Our society demands better care at lower cost; in perioperative medicine, it is time for us to throttle back...
  11. ncbi request reprint Loading, pretreatment, and interindividual variability issues with clopidogrel dosing
    Eric R Bates
    Circulation 111:2557-9. 2005
  12. ncbi request reprint Clinical significance of the atorvastatin-clopidogrel drug-drug interaction
    Wei C Lau
    Circulation 110:e66-7; author reply e66-7. 2004
  13. doi request reprint Omeprazole: a possible new candidate influencing the antiplatelet effect of clopidogrel
    Paul A Gurbel
    J Am Coll Cardiol 51:261-3. 2008
  14. ncbi request reprint Drug-drug interactions involving antiplatelet agents
    Eric R Bates
    Eur Heart J 24:1707-9. 2003
  15. ncbi request reprint Clopidogrel resistance: implications for coronary stenting
    Paul A Gurbel
    Sinai Center for Thrombosis Research, Baltimore, Maryland 21215, USA
    Curr Pharm Des 12:1261-9. 2006
    ..The mechanisms of the response variability to clopidogrel remain incompletely defined. The contribution of intra- and extracellular pathways are under investigation...