Serrine Lau

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi Role of hydroquinone-thiol conjugates in benzene-mediated toxicity
    Serrine S Lau
    Department of Pharmacology and Toxicology, The University of Arizona Health Sciences Center, Southwest Environmental Health Sciences Center, Tucson, AZ 85721, United States
    Chem Biol Interact 184:212-7. 2010
  2. ncbi The fate of benzene-oxide
    Terrence J Monks
    Dept Pharmacology and Toxicology, College of Pharmacy, Southwest Environmental Health Sciences Center, University of Arizona, 1703 E Mabel Street, Tucson, AZ 85721 0207, USA
    Chem Biol Interact 184:201-6. 2010
  3. ncbi Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain
    Gladys V Erives
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, 1703 E Mabel Street, Tucson, AZ 85721 0207, USA
    J Pharmacol Exp Ther 324:284-91. 2008
  4. ncbi Ros-induced histone modifications and their role in cell survival and cell death
    Terrence J Monks
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721 0207, USA
    Drug Metab Rev 38:755-67. 2006
  5. ncbi The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity
    Terrence J Monks
    Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712 1074, USA
    Ther Drug Monit 26:132-6. 2004
  6. ncbi Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone
    Jing Dong
    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona Health Sciences Center, Tucson, Arizona 85721, USA
    Toxicol Sci 80:350-7. 2004
  7. ncbi EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death
    Jing Dong
    Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721, USA
    Am J Physiol Renal Physiol 287:F1049-58. 2004
  8. ncbi Serotonergic neurotoxic thioether metabolites of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): synthesis, isolation, and characterization of diastereoisomers
    Nieves Pizarro
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721, USA
    Chem Res Toxicol 21:2272-9. 2008
  9. ncbi Serotonergic neurotoxic metabolites of ecstasy identified in rat brain
    Douglas C Jones
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721-0207, USA
    J Pharmacol Exp Ther 313:422-31. 2005
  10. ncbi Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells
    Zhe Jia
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, 1703, E. Mabel St, Tucson, AZ 85721-0207, USA
    Am J Physiol Renal Physiol 287:F1113-22. 2004

Research Grants

  1. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
  2. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
  3. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2007
  4. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2007
  5. SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTER
    Serrine Lau; Fiscal Year: 2007
  6. METABOLISM AND TOXICITY OF HYDROQUINONE THIOETHERS
    Serrine Lau; Fiscal Year: 1993
  7. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2010

Collaborators

  • TERRENCE MONKS
  • R de la Torre
  • Kulbhushan Tikoo
  • D Li
  • Samy L Habib
  • Jing Dong
  • Douglas C Jones
  • Sampath Ramachandiran
  • Hae Seong Yoon
  • Zhe Jia
  • Maria D Person
  • Gladys V Erives
  • Nieves Pizarro
  • Mi Young Yang
  • Hae-Seong Yoon
  • Jeffrey I Everitt
  • Jesus Joglar
  • Ximena Perfetti
  • Noriko Okumura
  • Aiko Ikegami
  • Christopher M Olsen
  • Christine Duvauchelle
  • Mary Anne S Chacko
  • Jianjm Shen
  • Sean C Hensley
  • James L Stevens
  • Cheryl L Walker
  • Qihong Huang

Detail Information

Publications17

  1. ncbi Role of hydroquinone-thiol conjugates in benzene-mediated toxicity
    Serrine S Lau
    Department of Pharmacology and Toxicology, The University of Arizona Health Sciences Center, Southwest Environmental Health Sciences Center, Tucson, AZ 85721, United States
    Chem Biol Interact 184:212-7. 2010
    ..Identification of these adducts is required before the functional significance of such protein modifications can be determined...
  2. ncbi The fate of benzene-oxide
    Terrence J Monks
    Dept Pharmacology and Toxicology, College of Pharmacy, Southwest Environmental Health Sciences Center, University of Arizona, 1703 E Mabel Street, Tucson, AZ 85721 0207, USA
    Chem Biol Interact 184:201-6. 2010
    ..In summary, although the fate of benzene-oxide is known in remarkable detail, coupling this information to the site, and mechanism of action, remains to be established...
  3. ncbi Accumulation of neurotoxic thioether metabolites of 3,4-(+/-)-methylenedioxymethamphetamine in rat brain
    Gladys V Erives
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, 1703 E Mabel Street, Tucson, AZ 85721 0207, USA
    J Pharmacol Exp Ther 324:284-91. 2008
    ..The data indicate that neurotoxic metabolites of MDMA may accumulate in brain after multiple dosing...
  4. ncbi Ros-induced histone modifications and their role in cell survival and cell death
    Terrence J Monks
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721 0207, USA
    Drug Metab Rev 38:755-67. 2006
    ..Attempts to determine the precise site of histone H3 phosphorylation, putative histone H3 kinases, and histone H3 interacting proteins are underway...
  5. ncbi The role of metabolism in 3,4-(+)-methylenedioxyamphetamine and 3,4-(+)-methylenedioxymethamphetamine (ecstasy) toxicity
    Terrence J Monks
    Center for Cellular and Molecular Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712 1074, USA
    Ther Drug Monit 26:132-6. 2004
    ..The data are consistent with the view that thioether metabolites of alpha-MeDA and N-methyl-alpha-MeDA contribute to the neurotoxicity of the parent amphetamines...
  6. ncbi Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone
    Jing Dong
    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona Health Sciences Center, Tucson, Arizona 85721, USA
    Toxicol Sci 80:350-7. 2004
    ..These data indicate that activation of the ERK1/2 pathway precedes overt cytotoxicity and that the signaling pathways activated by TGHQ in vivo and in vitro differ...
  7. ncbi EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death
    Jing Dong
    Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721, USA
    Am J Physiol Renal Physiol 287:F1049-58. 2004
    ..e., histone H3 and Hsp27 phosphorylation, which have in common the potential ability to remodel chromatin...
  8. ncbi Serotonergic neurotoxic thioether metabolites of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"): synthesis, isolation, and characterization of diastereoisomers
    Nieves Pizarro
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, Arizona 85721, USA
    Chem Res Toxicol 21:2272-9. 2008
    ....
  9. ncbi Serotonergic neurotoxic metabolites of ecstasy identified in rat brain
    Douglas C Jones
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ 85721-0207, USA
    J Pharmacol Exp Ther 313:422-31. 2005
    ..The mechanisms by which such metabolites access the brain and produce selective serotonergic neurotoxicity remain to be determined...
  10. ncbi Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells
    Zhe Jia
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Health Sciences Center, 1703, E. Mabel St, Tucson, AZ 85721-0207, USA
    Am J Physiol Renal Physiol 287:F1113-22. 2004
    ..The findings suggest that additional proteins may act in concert with Grp78 during DDM-PGE(2)-mediated cytoprotection against oncotic cell death...
  11. ncbi Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells
    Douglas C Jones
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, USA
    J Pharmacol Exp Ther 311:298-306. 2004
    ....
  12. ncbi Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells
    Sampath Ramachandiran
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA
    Chem Res Toxicol 15:1635-42. 2002
    ..The data provide evidence that the activation of MAPKs by ROS in renal epithelial cells plays an important role in oncotic cell death, and NF-kB is involved in the cytoprotective effects of PD098059...
  13. ncbi 2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ)-mediated apoptosis of human promyelocytic leukemia cells is preceded by mitochondrial cytochrome c release in the absence of a decrease in the mitochondrial membrane potential
    Mi Young Yang
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA
    Toxicol Sci 86:92-100. 2005
    ..Taken together, we conclude that TGHQ facilitates ROS production, alters the post-translational modification of Bcl-2 and subcellular localization of Bax, culminating in the release of cytochrome c and caspase activation...
  14. ncbi Tuberous sclerosis-2 tumor suppressor modulates ERK and B-Raf activity in transformed renal epithelial cells
    Hae Seong Yoon
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Texas 78712, USA
    Am J Physiol Renal Physiol 286:F417-24. 2004
    ..The data indicate that loss of tuberin results in the upregulation of the ERK signaling pathway with subsequent increases in new DNA synthesis, and ultimately, tumor formation...
  15. ncbi An integrated approach to identifying chemically induced posttranslational modifications using comparative MALDI-MS and targeted HPLC-ESI-MS/MS
    Maria D Person
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, 78712, USA
    Chem Res Toxicol 16:598-608. 2003
    ..This unpredicted reaction product is characterized using our unbiased methods for detection and demonstrates the important influence of protein structure on chemical adduction...
  16. ncbi Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat
    Samy L Habib
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712-1074, USA
    Carcinogenesis 24:573-82. 2003
    ..In keeping with this view, acute TGHQ-induced cytotoxicity was greater in Tsc-2(EK/+) rats than in Tsc-2(+/+) rats. The mechanism(s) coupling tuberin expression to the regulation of OGG1 are not known and are under investigation...
  17. ncbi Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity
    Hae Seong Yoon
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712 1074, USA
    Am J Physiol Renal Physiol 283:F262-70. 2002
    ....

Research Grants22

  1. PROSTANOID MEDIATED CYOPROTECTION
    Serrine Lau; Fiscal Year: 2001
    ..Experiments detailed in the Preliminary Data and Experimental sections of this grant application directly address this deficiency in our knowledge. ..
  2. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
  3. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2007
    ..abstract_text> ..
  4. Identification and Significance of Protein Adducts
    Serrine Lau; Fiscal Year: 2007
    ..abstract_text> ..
  5. SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTER
    Serrine Lau; Fiscal Year: 2007
    ..This last goal is synergistic with the objective of extending basic research discoveries into the clinical and public health arenas. ..
  6. METABOLISM AND TOXICITY OF HYDROQUINONE THIOETHERS
    Serrine Lau; Fiscal Year: 1993
    ..Studies on factors regulating species susceptibility to these compounds will therefore be of toxicological significance...
  7. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2010
    ..Assessment of the beneficial effects of retinoids in animal model and human renal disease warrants further investigation. ..