LESTER LAU

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc CCN1 and CCN2: blood brothers in angiogenic action
    Lester F Lau
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL, 60607 7170, USA
    J Cell Commun Signal 6:121-3. 2012
  2. pmc Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines
    Chih Chiun Chen
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 USA
    J Cell Commun Signal 4:63-9. 2010
  3. pmc CCN1/CYR61: the very model of a modern matricellular protein
    Lester F Lau
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Cell Mol Life Sci 68:3149-63. 2011
  4. ncbi request reprint The CCN family of angiogenic regulators: the integrin connection
    L F Lau
    Department of Molecular Genetics, Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, 60607 7170, USA
    Exp Cell Res 248:44-57. 1999
  5. ncbi request reprint Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans
    N Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 275:24953-61. 2000
  6. ncbi request reprint The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
    C C Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Ave, Chicago, IL 60607 7170, USA
    J Biol Chem 276:47329-37. 2001
  7. ncbi request reprint CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
    T M Grzeszkiewicz
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 276:21943-50. 2001
  8. ncbi request reprint Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells
    M Wong
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607 7170, USA
    Dev Biol 192:492-508. 1997
  9. ncbi request reprint The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts
    C C Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 60607 7170, USA
    J Biol Chem 276:10443-52. 2001
  10. ncbi request reprint Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)
    A Jedsadayanmata
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 274:24321-7. 1999

Collaborators

  • Ching Chow Chen
  • B Perbal
  • David Brigstock
  • B V Latinkic
  • M L Kireeva
  • T V Kolesnikova
  • A M Babic
  • N Chen
  • T M Grzeszkiewicz
  • C H Charles
  • A Jedsadayanmata
  • S C Lam
  • M Wong
  • T J Mohun
  • S Mercurio
  • J C Smith
  • E M A Hirst
  • Q Xu
  • B Bennett
  • S R Ross
  • F E Mo
  • N G Copeland
  • N A Jenkins
  • D J Gilbert
  • J A Greenspan
  • D J Kirschling
  • A S Abler
  • H Sun
  • G P Yang
  • T P O'Brien
  • N K Tonks
  • J S Simske
  • K Ryder
  • J K Yoon
  • D Nathans
  • S Hartzell
  • B A Christy
  • T G Hazel
  • A Lanahan
  • D Nathan
  • L Sanders

Detail Information

Publications32

  1. pmc CCN1 and CCN2: blood brothers in angiogenic action
    Lester F Lau
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL, 60607 7170, USA
    J Cell Commun Signal 6:121-3. 2012
    ..Understanding the angiogenic actions of CCN1 and CCN2 may have implication in the development of therapeutic strategies targeting these proteins for the treatment of diseases such as cancer and fibrosis...
  2. pmc Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines
    Chih Chiun Chen
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 USA
    J Cell Commun Signal 4:63-9. 2010
    ..These findings implicate CCN proteins as contextual regulators of the inflammatory response by dictating or enhancing the cytotoxicity of TNFalpha and related cytokines...
  3. pmc CCN1/CYR61: the very model of a modern matricellular protein
    Lester F Lau
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 S Ashland Avenue, Chicago, IL 60607, USA
    Cell Mol Life Sci 68:3149-63. 2011
    ..Emerging studies suggest that CCN1 might be useful as a biomarker or therapeutic target in certain diseases...
  4. ncbi request reprint The CCN family of angiogenic regulators: the integrin connection
    L F Lau
    Department of Molecular Genetics, Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, 60607 7170, USA
    Exp Cell Res 248:44-57. 1999
  5. ncbi request reprint Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans
    N Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 275:24953-61. 2000
    ..In addition, these findings suggest that Cyr61 might elicit disparate biological effects in different cell types through interaction with distinct integrin receptors...
  6. ncbi request reprint The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts
    C C Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 900 South Ashland Ave, Chicago, IL 60607 7170, USA
    J Biol Chem 276:47329-37. 2001
    ..We propose a model in which Cyr61 integrates its activities on endothelial cells, fibroblasts, and macrophages to regulate the processes of angiogenesis, inflammation, and matrix remodeling in the context of cutaneous wound healing...
  7. ncbi request reprint CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain
    T M Grzeszkiewicz
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    J Biol Chem 276:21943-50. 2001
    ..Together, these findings establish CYR61 as a novel ligand for integrin alpha(v)beta(5) and show that CYR61 interacts with distinct integrins to mediate disparate activities in a cell type-specific manner...
  8. ncbi request reprint Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells
    M Wong
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607 7170, USA
    Dev Biol 192:492-508. 1997
    ..Taken together, these results identify Cyr61 as a novel player in chondrogenesis that contributes to the development of the mammalian embryonic skeleton...
  9. ncbi request reprint The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts
    C C Chen
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 60607 7170, USA
    J Biol Chem 276:10443-52. 2001
    ....
  10. ncbi request reprint Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)
    A Jedsadayanmata
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 274:24321-7. 1999
    ....
  11. ncbi request reprint Promoter function of the angiogenic inducer Cyr61gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element
    B V Latinkic
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, 60607-7170, USA
    Endocrinology 142:2549-57. 2001
    ....
  12. pmc CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth
    A M Babic
    Department of Molecular Genetics, M C 669, University of Illinois at Chicago College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607 7170, USA
    Proc Natl Acad Sci U S A 95:6355-60. 1998
    ..Taken together, these results identify CYR61 as an angiogenic inducer that can promote tumor growth and vascularization; the results also suggest potential roles for CYR61 in physiologic and pathologic neovascularization...
  13. ncbi request reprint Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells
    T V Kolesnikova
    Department of Molecular Genetics, The University of Illinois College of Medicine, Chicago 60607 7170, USA
    Oncogene 16:747-54. 1998
    ..We show that hCYR61 acts in this cell system in part by displacement of bFGF bound to the extracellular matrix, thus increasing the effective concentration of bFGF. Possible biological implications of these observations are discussed...
  14. ncbi request reprint Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3
    M L Kireeva
    Molecular Genetics, College of Medicine, University of Illinois, Chicago, Illinois 60607 7170, USA
    J Biol Chem 273:3090-6. 1998
    ..The possibility that integrin alphavbeta3 functions as a signaling receptor for Cyr61 accounts for most if not all activities that can be ascribed to Cyr61 to date and suggests a mechanism of action discussed herein...
  15. pmc Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo
    A M Babic
    Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
    Mol Cell Biol 19:2958-66. 1999
    ....
  16. ncbi request reprint Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development
    M L Kireeva
    Department of Genetics, The University of Illinois College of Medicine, Chicago 60607 7170, USA
    Exp Cell Res 233:63-77. 1997
    ....
  17. pmc Promoter function and structure of the growth factor-inducible immediate early gene cyr61
    B V Latinkic
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Nucleic Acids Res 19:3261-7. 1991
    ..We conclude that the cyr61 SRE functions as a serum response element and may account for the coordinate activation of cyr61 and c-fos...
  18. ncbi request reprint Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling
    B V Latinkic
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 130:2429-41. 2003
    ..These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation...
  19. pmc Report on the second international workshop on the CCN family of genes
    B Perbal
    Laboratoire d Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Mol Pathol 56:80-5. 2003
    ..fr) as an important medium for the exchange of scientific knowledge and resources in the CCN field. Once more, the high quality of scientific communications and individual interactions set the stage for an extremely fruitful meeting...
  20. pmc Expression of cyr61, a growth factor-inducible immediate-early gene
    T P O'Brien
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Mol Cell Biol 10:3569-77. 1990
    ..Cyr61 is synthesized maximally at 1 to 2 h after serum stimulation and has a short half-life within the cell...
  21. ncbi request reprint Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development
    T P O'Brien
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Cell Growth Differ 3:645-54. 1992
    ....
  22. ncbi request reprint Transcriptional activation of the immediate early gene pip92 by serum growth factors requires both Ets and CArG-like elements
    B V Latinkic
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    J Biol Chem 269:23163-70. 1994
    ..We propose that different mechanisms can lead to the formation of such ternary complexes...
  23. pmc A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily
    T G Hazel
    Department of Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Proc Natl Acad Sci U S A 85:8444-8. 1988
    ..These results suggest that the growth factor-inducible immediate early gene nur/77 encodes a ligand-binding protein that regulates the genomic response to growth factors...
  24. ncbi request reprint cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Oncogene 7:187-90. 1992
    ..Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life...
  25. ncbi request reprint Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Oncogene 8:797-801. 1993
    ..We have identified the Gly96 protein in Balb/c 3T3 cells using affinity-purified antibodies recognizing the Gly96 polypeptide. We show that Gly96 is glycosylated and has a short half-life in serum stimulated fibroblasts...
  26. pmc The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612 7309
    Proc Natl Acad Sci U S A 90:5292-6. 1993
    ..Since 3CH134 expression is controlled transcriptionally and posttranscriptionally, it may represent a class of PTPases whose activity is regulated at the level of protein synthesis and degradation...
  27. pmc Proposal for a unified CCN nomenclature
    D R Brigstock
    Department of Surgery, Ohio State University, Colombus, Ohio 43205, USA
    Mol Pathol 56:127-8. 2003
    ..This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules...
  28. ncbi request reprint MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    H Sun
    Cold Spring Harbor Laboratory, New York 11724 2208
    Cell 75:487-93. 1993
    ..The mutant 3CH134 protein also forms a physical complex with the phosphorylated form of p42MAPK. These findings suggest that 3CH134 is a physiological MAP kinase phosphatase; we propose the name MKP-1 for this phosphatase...
  29. pmc Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Mol Cell Biol 10:6769-74. 1990
    ..We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals...
  30. pmc A gene activated by growth factors is related to the oncogene v-jun
    K Ryder
    Howard Hughes Medical Institute Laboratory, Baltimore, MD
    Proc Natl Acad Sci U S A 85:1487-91. 1988
    ..The jun-B protein, and perhaps other members of the jun family, may play a role in regulating the genomic response to growth factors...
  31. pmc A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences
    B A Christy
    Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 85:7857-61. 1988
    ..The SRE-like sequences could be responsible for the coordinate activation of zif/268 and fos after serum stimulation of 3T3 cells...
  32. pmc A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor
    S Hartzell
    Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Mol Cell Biol 9:2567-73. 1989
    ..mTF mRNA is present in many murine tissues and cell lines. Our results raise the possibility that mTF may also play a role in cell growth...

Research Grants41

  1. Regulation of TNF-alpha by Integrin-Mediated Matrix Signaling
    LESTER LAU; Fiscal Year: 2009
    ....
  2. FoxM1B Protein in Stimulating Proliferation during Aging
    LESTER LAU; Fiscal Year: 2007
    ..abstract_text> ..
  3. Ribosome Biogenesis and p53 Dependent Cell Cycle Control
    LESTER LAU; Fiscal Year: 2006
    ..Through these studies we hope to elucidate the mechanism by which nucleolar surveillance functions as a novel cell cycle checkpoint. ..
  4. FoxM1B Protein in Stimulating Proliferation during Aging
    LESTER LAU; Fiscal Year: 2006
    ..abstract_text> ..
  5. Integrin-Matrix Interaction in Cardiovascular Development
    LESTER LAU; Fiscal Year: 2007
    ..Together, these studies will provide novel insights into how CCN proteins regulate cardiovascular development through extracellular matrix signaling, and shed light on their roles in cardiovascular diseases. ..
  6. Structure and Function of the Matricellular Protein CCN1
    LESTER LAU; Fiscal Year: 2007
    ..Through these studies, we hope to gain insight into how CCN1 acts as a matricellular protein to control multiple cellular processes. ..
  7. Regulation of TNF-alpha by Integrin-Mediated Matrix Signaling
    Lester F Lau; Fiscal Year: 2010
    ....
  8. Integrin-Matrix Interaction in Cardiovascular Development
    Lester F Lau; Fiscal Year: 2010
    ..Together, these studies will provide novel insights into how CCN proteins regulate cardiovascular development through extracellular matrix signaling, and shed light on their roles in cardiovascular diseases. ..
  9. Regulation of TNF-alpha by Integrin-Mediated Matrix Signaling
    LESTER LAU; Fiscal Year: 2009
    ....
  10. GROWTH RELATED IMMEDIATE EARLY GENES
    LESTER LAU; Fiscal Year: 2003
    ..Through these studies, a better understanding of how Cyr61 can function in such diverse yet important biological processes may emerge. ..
  11. INDUCIBLE GENES IN ANGIOGENESIS AND TUMOR GROWTH
    LESTER LAU; Fiscal Year: 2003
    ..Third, the role of Cyr61 in tumor growth and metastasis will be evaluated, and intervention of Cyr61 activities will be explored as a means of restricting tumor growth. ..
  12. GROWTH-RELATED GENES REGULATED WITH C-FOS
    LESTER LAU; Fiscal Year: 1993
    ..The effects of constitutive expression of this gene, inactivation by anti-sense RNA, and expression during phases of the cell cycle when it is usually silent will be investigated using a number of recombinant constructs...
  13. CYR61-Mediated Angiogenesis in Rheumatoid Arthritis
    LESTER LAU; Fiscal Year: 2002
    ..Then we will explore Cyr61 as a potential therapeutic target. We will test whether blockade of Cyr6l function, using monoclonal antibodies or inhibitory peptides, can prevent or ameliorate arthritis and joint destruction. ..