DIANNE FIGLEWICZ LATTEMANN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Insulin, food intake, and reward
    Dianne P Figlewicz
    VA Puget Sound Health Care System, Seattle Division, Seattle, WA, USA
    Semin Clin Neuropsychiatry 8:82-93. 2003
  2. doi request reprint Effect of recurrent yohimbine on immediate and post-hoc behaviors, stress hormones, and energy homeostatic parameters
    D P Figlewicz
    VA Puget Sound Health Care System 151, Seattle, WA 98108, USA Dept of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Physiol Behav 129:186-93. 2014
  3. pmc Moderate high fat diet increases sucrose self-administration in young rats
    Dianne P Figlewicz
    Metabolism Endocrinology, VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA
    Appetite 61:19-29. 2013
  4. ncbi request reprint Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats
    Dianne P Figlewicz
    Metabolism Endocrinology 151, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Behav Neurosci 118:479-87. 2004
  5. ncbi request reprint Intraventricular insulin and leptin decrease sucrose self-administration in rats
    Dianne P Figlewicz
    VA Puget Sound Health Care System 151, Seattle WA 98108, United States
    Physiol Behav 89:611-6. 2006
  6. pmc Modulation of food reward by adiposity signals
    Dianne P Figlewicz
    VA Puget Sound Health Care System 151, Seattle WA 98108, USA
    Physiol Behav 91:473-8. 2007
  7. pmc Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats
    Dianne P Figlewicz
    Metabolism Endocrinology, 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 295:R388-94. 2008
  8. pmc Endocrine links between food reward and caloric homeostasis
    DIANNE FIGLEWICZ LATTEMANN
    VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA
    Appetite 51:452-5. 2008
  9. pmc Insulin, leptin, and food reward: update 2008
    Dianne P Figlewicz
    Metabolism Endocrinology 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R9-R19. 2009
  10. pmc Effect of moderate intake of sweeteners on metabolic health in the rat
    D P Figlewicz
    R and D 151, VA Puget Sound Health Care System, Seattle, WA 98108, United States
    Physiol Behav 98:618-24. 2009

Research Grants

  1. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2003
  2. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
  3. ANTIDEPRESSANT THERAPY AND HYPOGLYCEMIA
    Dianne Lattemann; Fiscal Year: 2006
  4. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2007
  5. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2009
  6. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 1992
  7. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2010

Collaborators

  • Nicole M Sanders
  • Salwa al-Noori
  • P Szot
  • Francis Kim
  • S R Hill
  • Jon F Davis
  • S B Evans
  • G van Dijk
  • C L Roth
  • D G Baskin
  • C W Wilkinson
  • Gregory J Morton
  • Qi Mei
  • Diana L Williams
  • Dianne P Figlewicz
  • D P Figlewicz
  • Alfred J Sipols
  • Aryana Zavosh
  • Stephen C Benoit
  • Jennifer L Bennett
  • Sepideh Aliakbari
  • Amy M Naleid
  • Jeffrey W Grimm
  • Amy MacDonald Naleid
  • Aaron W Pardini
  • A Zavosh
  • Thomas O Mundinger
  • A S Zavosh
  • A J Sipols
  • Garret D Stuber
  • C H West
  • J L Jay
  • Molly A Acheson
  • Constance H West
  • Jennifer L Jay
  • Irwin J Magrisso
  • Sepideh Kittleson
  • Jennifer L Bennett-Jay
  • C Savard
  • G Ioannou
  • J Bennett Jay
  • S Kittleson
  • David A Kessler
  • Jason Wells
  • T A Patterson
  • Charles Davis
  • Michael W Schwartz
  • Hong T Nguyen
  • John F Neumaier
  • Karl Kaiyala
  • Jennifer Bennett
  • Timothy Sexton
  • M Hoen
  • Gerald J Taborsky
  • J Murphy
  • Ake Lernmark
  • Michael S Higgins
  • Yanping Pu
  • P Gronbeck
  • M Higgins
  • S B Ng-Evans
  • P J Havel
  • M S Higgins
  • M Roitman
  • M D Brot
  • L B Johnson
  • P A Israel

Detail Information

Publications32

  1. ncbi request reprint Insulin, food intake, and reward
    Dianne P Figlewicz
    VA Puget Sound Health Care System, Seattle Division, Seattle, WA, USA
    Semin Clin Neuropsychiatry 8:82-93. 2003
    ..These studies are reviewed in the context of current knowledge of insulin action in the brain, and we offer speculation regarding the relevance of this expanded role of insulin in mental disorders...
  2. doi request reprint Effect of recurrent yohimbine on immediate and post-hoc behaviors, stress hormones, and energy homeostatic parameters
    D P Figlewicz
    VA Puget Sound Health Care System 151, Seattle, WA 98108, USA Dept of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Physiol Behav 129:186-93. 2014
    ....
  3. pmc Moderate high fat diet increases sucrose self-administration in young rats
    Dianne P Figlewicz
    Metabolism Endocrinology, VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA
    Appetite 61:19-29. 2013
    ..Together, our studies suggest that background diet plays a strong modulatory role in motivation for sweet taste in adolescent animals...
  4. ncbi request reprint Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats
    Dianne P Figlewicz
    Metabolism Endocrinology 151, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Behav Neurosci 118:479-87. 2004
    ..Food-restricted rats receiving cerebrospinal fluid, insulin, or leptin had comparable CPPs. Results indicate that the CNS roles of insulin and leptin may include processes involving memory and reward...
  5. ncbi request reprint Intraventricular insulin and leptin decrease sucrose self-administration in rats
    Dianne P Figlewicz
    VA Puget Sound Health Care System 151, Seattle WA 98108, United States
    Physiol Behav 89:611-6. 2006
    ....
  6. pmc Modulation of food reward by adiposity signals
    Dianne P Figlewicz
    VA Puget Sound Health Care System 151, Seattle WA 98108, USA
    Physiol Behav 91:473-8. 2007
    ....
  7. pmc Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats
    Dianne P Figlewicz
    Metabolism Endocrinology, 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 295:R388-94. 2008
    ..Further, they support the interpretation that adiposity signals, such as insulin, can decrease different aspects of ingestion of a palatable food, such as sucrose, in an anatomically specific manner...
  8. pmc Endocrine links between food reward and caloric homeostasis
    DIANNE FIGLEWICZ LATTEMANN
    VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA
    Appetite 51:452-5. 2008
    ..Future studies should elucidate the neural and cellular mechanisms which underlie these endocrine actions in the CNS...
  9. pmc Insulin, leptin, and food reward: update 2008
    Dianne P Figlewicz
    Metabolism Endocrinology 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R9-R19. 2009
    ..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders...
  10. pmc Effect of moderate intake of sweeteners on metabolic health in the rat
    D P Figlewicz
    R and D 151, VA Puget Sound Health Care System, Seattle, WA 98108, United States
    Physiol Behav 98:618-24. 2009
    ....
  11. pmc Energy regulatory signals and food reward
    Dianne P Figlewicz
    Metabolism Endocrinology, VA Puget Sound Health Care System, Seattle Division, Seattle, WA 98108, USA
    Pharmacol Biochem Behav 97:15-24. 2010
    ..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders...
  12. pmc Sucrose self-administration and CNS activation in the rat
    Dianne P Figlewicz
    Metabolism Endocrinology 151, VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 300:R876-84. 2011
    ..Given the role of the medial hypothalamus in regulation of energy balance, our study suggests that this circuitry may contribute to reward regulation within the larger context of energy homeostasis...
  13. ncbi request reprint Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expression
    Dianne P Figlewicz
    Metabolism Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 286:E1004-10. 2004
    ..Thus an excess of tub at the ARC does not enhance the in vivo effectiveness of insulin and is not able to compensate for the "downstream" consequences of a high-fat diet to impair CNS body weight regulatory mechanisms...
  14. ncbi request reprint Dopamine transporter mRNA is increased in the CNS of Zucker fatty (fa/fa) rats
    D P Figlewicz
    Division of Endocrinology Metabolism, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res Bull 46:199-202. 1998
    ..These findings suggest that increased DA clearance, and perhaps decreased DA signaling, may occur in the obese Zucker fa/fa rat...
  15. ncbi request reprint Neurotransmitter transporters: target for endocrine regulation
    D P Figlewicz
    Dept of Psychology, University of Washington, Seattle, USA
    Horm Metab Res 31:335-9. 1999
    ..Future directions should permit evaluation of the role of endocrine regulation in neurotransmitter clearance, and thus in the maintenance of normal CNS aminergic signaling...
  16. ncbi request reprint Endocrine regulation of neurotransmitter transporters
    D P Figlewicz
    Department of Psychology, University of Washington, Seattle 98195, USA
    Epilepsy Res 37:203-10. 1999
    ..The potential relevance of transporter regulation for the ketogenic diet is discussed...
  17. ncbi request reprint Leptin reverses sucrose-conditioned place preference in food-restricted rats
    D P Figlewicz
    Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
    Physiol Behav 73:229-34. 2001
    ..This finding suggests that in addition to metabolic adaptations, hypoleptinemia results in behavioral adaptations during states of energy deprivation...
  18. ncbi request reprint Effects of repetitive hypoglycemia on neuroendocrine response and brain tyrosine hydroxylase activity in the rat
    D P Figlewicz
    Metabolism Endocrinology 151, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Stress 5:217-26. 2002
    ..This alternate response pattern suggests that insulin-induced hypoglycemia and cerebral neuroglucopenia represent somewhat different metabolic stressors at the CNS...
  19. ncbi request reprint Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat
    D P Figlewicz
    Metabolism Endocrinology 151, VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
    Brain Res 964:107-15. 2003
    ..These findings suggest that midbrain dopamine neurons are direct targets of insulin and leptin, and that they participate in mediating the effects of these hormones on reward-seeking behavior...
  20. ncbi request reprint Adiposity signals and food reward: expanding the CNS roles of insulin and leptin
    Dianne P Figlewicz
    Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle 98108, USA
    Am J Physiol Regul Integr Comp Physiol 284:R882-92. 2003
    ....
  21. ncbi request reprint Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia
    Scott B Evans
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195 6560, USA
    Am J Physiol Regul Integr Comp Physiol 286:R123-8. 2004
    ..The epinephrine, norepinephrine, and glucagon responses were not altered by DMH inactivation. Our finding suggests that DMH inactivation may play a specific role in decreasing the HPA axis response after repeated bouts of IIH...
  22. ncbi request reprint Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy
    Thomas O Mundinger
    Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 285:E1047-54. 2003
    ..We conclude that the early sympathetic islet neuropathy of BB D causes a functional defect of the sympathetic pathway to the alpha-cell that can, by itself, account for the impaired glucagon response to postganglionic SNS...
  23. ncbi request reprint Feeding and neuroendocrine responses after recurrent insulin-induced hypoglycemia
    Nicole M Sanders
    Division of Endocrinology Metabolism, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Physiol Behav 87:700-6. 2006
    ..Thus, neuroendocrine and behavioral (stimulation of food intake) CRR are differentially regulated by recurrent hypoglycemia experience...
  24. pmc The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling
    Gregory J Morton
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
    Am J Physiol Endocrinol Metab 297:E202-10. 2009
    ....
  25. pmc Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemia
    Nicole M Sanders
    Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Diabetes 56:217-23. 2007
    ..However, neural substrates surrounding the third ventricle are particularly sensitive to glucoprivic stimulation and may contribute importantly to the development of defective CRRs...
  26. pmc Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin
    Salwa al-Noori
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1446-54. 2008
    ..Collectively, these data suggest that RH stress triggers cellular changes that support synaptic plasticity, in specific neuroanatomical sites, which may contribute to the development of hypoglycemia-associated autonomic failure...
  27. ncbi request reprint Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failure
    Scott B Evans
    Departments of Psychology and of Medicine, University of Washington, Seattle 98195, USA
    Am J Physiol Regul Integr Comp Physiol 284:R57-65. 2003
    ..e., blunting the sympathoadrenal and hypothalamic-pituitary-adrenocortical axis response), but not in others (i.e., blunting the glucagon response)...
  28. pmc The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemia
    Nicole M Sanders
    Division of Endocrinology Metabolism, Veterans Affair Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 294:E853-60. 2008
    ..Instead, sertraline treatment resulted in an enhancement of hypoglycemia CRR and prevented the impaired adrenomedullary response normally observed in recurrent hypoglycemic rats...
  29. pmc Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemia
    Salwa al-Noori
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
    Brain Res 1194:65-72. 2008
    ....
  30. pmc Deconstructing the vanilla milkshake: the dominant effect of sucrose on self-administration of nutrient-flavor mixtures
    Amy M Naleid
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA
    Appetite 50:128-38. 2008
    ..4% oil solutions. These data suggest that, calorie-for-calorie, sucrose is the dominant reinforcing component of novel foods that contain a mixture of fat, sucrose, and flavor...
  31. ncbi request reprint Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis
    Aaron W Pardini
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Brain Res 1112:169-78. 2006
    ..An improved understanding of mechanisms underlying normal and abnormal energy homeostasis may be gained by analysis of the role played by signaling through IRS-2 in these brain areas...
  32. ncbi request reprint Food restriction modulates amphetamine-conditioned place preference and nucleus accumbens dopamine release in the rat
    Garret D Stuber
    Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
    Synapse 46:83-90. 2002
    ..In conclusion, altered DA release in the nucleus accumbens core is not a primary effect of moderate food restriction and cannot completely account for either the altered CPP behavior or enhanced locomotor activity observed in this study...

Research Grants24

  1. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2003
    ..abstract_text> ..
  2. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
    ..abstract_text> ..
  3. ANTIDEPRESSANT THERAPY AND HYPOGLYCEMIA
    Dianne Lattemann; Fiscal Year: 2006
    ..non-diabetic rats. The results of these studies will provide new knowledge that ultimately may assist primary physicians in determining the most advantageous treatment for their diabetic patients with depression. ..
  4. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2007
    ..abstract_text> ..
  5. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 2009
    ..abstract_text> ..
  6. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    Dianne Lattemann; Fiscal Year: 1992
    ..Together, these studies should determine whether the effectiveness of the candidate CNS adiposity signal, insulin, is regulated by changes in its uptake and/or action in the CNS...
  7. BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION
    DIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2010
    ..Our experiments thus model one aspect of the eating habits of people in 'Westernized'societies such as the U.S. and may provide translational insight into dealing with this excessive intake. ..