Research Topics
Species | DIANNE FIGLEWICZ LATTEMANNSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Insulin, food intake, and rewardDianne P Figlewicz
VA Puget Sound Health Care System, Seattle Division, Seattle, WA, USA
Semin Clin Neuropsychiatry 8:82-93. 2003..These studies are reviewed in the context of current knowledge of insulin action in the brain, and we offer speculation regarding the relevance of this expanded role of insulin in mental disorders...
Moderate high fat diet increases sucrose self-administration in young ratsDianne P Figlewicz
Metabolism Endocrinology, VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA Dept of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
Appetite 61:19-29. 2013..Together, our studies suggest that background diet plays a strong modulatory role in motivation for sweet taste in adolescent animals...- Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in ratsDianne P Figlewicz
Metabolism Endocrinology 151, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Behav Neurosci 118:479-87. 2004..Food-restricted rats receiving cerebrospinal fluid, insulin, or leptin had comparable CPPs. Results indicate that the CNS roles of insulin and leptin may include processes involving memory and reward... - Dopamine transporter mRNA is increased in the CNS of Zucker fatty (fa/fa) ratsD P Figlewicz
Division of Endocrinology Metabolism, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Brain Res Bull 46:199-202. 1998..These findings suggest that increased DA clearance, and perhaps decreased DA signaling, may occur in the obese Zucker fa/fa rat... - Intraventricular insulin and leptin decrease sucrose self-administration in ratsDianne P Figlewicz
VA Puget Sound Health Care System 151, Seattle WA 98108, United States
Physiol Behav 89:611-6. 2006.... - Modulation of food reward by adiposity signalsDianne P Figlewicz
VA Puget Sound Health Care System 151, Seattle WA 98108, USA
Physiol Behav 91:473-8. 2007.... - Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in ratsDianne P Figlewicz
Metabolism Endocrinology, 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 295:R388-94. 2008..Further, they support the interpretation that adiposity signals, such as insulin, can decrease different aspects of ingestion of a palatable food, such as sucrose, in an anatomically specific manner... - Endocrine links between food reward and caloric homeostasisDIANNE FIGLEWICZ LATTEMANN
VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA
Appetite 51:452-5. 2008..Future studies should elucidate the neural and cellular mechanisms which underlie these endocrine actions in the CNS... - Insulin, leptin, and food reward: update 2008Dianne P Figlewicz
Metabolism Endocrinology 151 VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 296:R9-R19. 2009..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders... - Effect of moderate intake of sweeteners on metabolic health in the ratD P Figlewicz
R and D 151, VA Puget Sound Health Care System, Seattle, WA 98108, United States
Physiol Behav 98:618-24. 2009.... - Energy regulatory signals and food rewardDianne P Figlewicz
Metabolism Endocrinology, VA Puget Sound Health Care System, Seattle Division, Seattle, WA 98108, USA
Pharmacol Biochem Behav 97:15-24. 2010..The understanding of neuroendocrine modulation of food reward, as well as food reward modulation by diet and obesity, may point to new directions for therapeutic approaches to overeating or eating disorders... - Sucrose self-administration and CNS activation in the ratDianne P Figlewicz
Metabolism Endocrinology 151, VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 300:R876-84. 2011..Given the role of the medial hypothalamus in regulation of energy balance, our study suggests that this circuitry may contribute to reward regulation within the larger context of energy homeostasis... - Catabolic action of insulin in rat arcuate nucleus is not enhanced by exogenous "tub" expressionDianne P Figlewicz
Metabolism Endocrinology, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Physiol Endocrinol Metab 286:E1004-10. 2004..Thus an excess of tub at the ARC does not enhance the in vivo effectiveness of insulin and is not able to compensate for the "downstream" consequences of a high-fat diet to impair CNS body weight regulatory mechanisms... - Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the ratD P Figlewicz
Metabolism Endocrinology 151, VA Puget Sound Health Care System, 1660 So Columbian Way, Seattle, WA 98108, USA
Brain Res 964:107-15. 2003..These findings suggest that midbrain dopamine neurons are direct targets of insulin and leptin, and that they participate in mediating the effects of these hormones on reward-seeking behavior... - Neurotransmitter transporters: target for endocrine regulationD P Figlewicz
Dept of Psychology, University of Washington, Seattle, USA
Horm Metab Res 31:335-9. 1999..Future directions should permit evaluation of the role of endocrine regulation in neurotransmitter clearance, and thus in the maintenance of normal CNS aminergic signaling... - Endocrine regulation of neurotransmitter transportersD P Figlewicz
Department of Psychology, University of Washington, Seattle 98195, USA
Epilepsy Res 37:203-10. 1999..The potential relevance of transporter regulation for the ketogenic diet is discussed... - Adiposity signals and food reward: expanding the CNS roles of insulin and leptinDianne P Figlewicz
Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle 98108, USA
Am J Physiol Regul Integr Comp Physiol 284:R882-92. 2003.... - Effects of repetitive hypoglycemia on neuroendocrine response and brain tyrosine hydroxylase activity in the ratD P Figlewicz
Metabolism Endocrinology 151, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Stress 5:217-26. 2002..This alternate response pattern suggests that insulin-induced hypoglycemia and cerebral neuroglucopenia represent somewhat different metabolic stressors at the CNS... - Leptin reverses sucrose-conditioned place preference in food-restricted ratsD P Figlewicz
Department of Psychology, University of Washington, Seattle, WA 98195 1525, USA
Physiol Behav 73:229-34. 2001..This finding suggests that in addition to metabolic adaptations, hypoleptinemia results in behavioral adaptations during states of energy deprivation... - Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemiaScott B Evans
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle 98195-6560, USA
Am J Physiol Regul Integr Comp Physiol 286:R123-8. 2004..The epinephrine, norepinephrine, and glucagon responses were not altered by DMH inactivation. Our finding suggests that DMH inactivation may play a specific role in decreasing the HPA axis response after repeated bouts of IIH... - The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signalingGregory J Morton
Department of Medicine, University of Washington at South Lake Union, 815 Mercer St, Box 358055, Seattle, WA 98195, USA
Am J Physiol Endocrinol Metab 297:E202-10. 2009.... - Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysinSalwa al-Noori
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
Am J Physiol Regul Integr Comp Physiol 295:R1446-54. 2008..Collectively, these data suggest that RH stress triggers cellular changes that support synaptic plasticity, in specific neuroanatomical sites, which may contribute to the development of hypoglycemia-associated autonomic failure... - Inactivation of the PVN during hypoglycemia partially simulates hypoglycemia-associated autonomic failureScott B Evans
Departments of Psychology and of Medicine, University of Washington, Seattle 98195, USA
Am J Physiol Regul Integr Comp Physiol 284:R57-65. 2003..e., blunting the sympathoadrenal and hypothalamic-pituitary-adrenocortical axis response), but not in others (i.e., blunting the glucagon response)... - The selective serotonin reuptake inhibitor sertraline enhances counterregulatory responses to hypoglycemiaNicole M Sanders
Division of Endocrinology Metabolism, Veterans Affair Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Physiol Endocrinol Metab 294:E853-60. 2008..Instead, sertraline treatment resulted in an enhancement of hypoglycemia CRR and prevented the impaired adrenomedullary response normally observed in recurrent hypoglycemic rats... - Acute THPVP inactivation decreases the glucagon and sympathoadrenal responses to recurrent hypoglycemiaSalwa al-Noori
Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
Brain Res 1194:65-72. 2008.... - Antecedent hindbrain glucoprivation does not impair the counterregulatory response to hypoglycemiaNicole M Sanders
Division of Endocrinology Metabolism, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Diabetes 56:217-23. 2007..However, neural substrates surrounding the third ventricle are particularly sensitive to glucoprivic stimulation and may contribute importantly to the development of defective CRRs... - Feeding and neuroendocrine responses after recurrent insulin-induced hypoglycemiaNicole M Sanders
Division of Endocrinology Metabolism, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Physiol Behav 87:700-6. 2006..Thus, neuroendocrine and behavioral (stimulation of food intake) CRR are differentially regulated by recurrent hypoglycemia experience... - Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathyThomas O Mundinger
Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, USA
Am J Physiol Endocrinol Metab 285:E1047-54. 2003..We conclude that the early sympathetic islet neuropathy of BB D causes a functional defect of the sympathetic pathway to the alpha-cell that can, by itself, account for the impaired glucagon response to postganglionic SNS... - Deconstructing the vanilla milkshake: the dominant effect of sucrose on self-administration of nutrient-flavor mixturesAmy M Naleid
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA
Appetite 50:128-38. 2008..4% oil solutions. These data suggest that, calorie-for-calorie, sucrose is the dominant reinforcing component of novel foods that contain a mixture of fat, sucrose, and flavor... - Food restriction modulates amphetamine-conditioned place preference and nucleus accumbens dopamine release in the ratGarret D Stuber
Department of Psychology, University of Washington, Seattle, Washington 98195-1525, USA
Synapse 46:83-90. 2002..In conclusion, altered DA release in the nucleus accumbens core is not a primary effect of moderate food restriction and cannot completely account for either the altered CPP behavior or enhanced locomotor activity observed in this study... - Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasisAaron W Pardini
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
Brain Res 1112:169-78. 2006..An improved understanding of mechanisms underlying normal and abnormal energy homeostasis may be gained by analysis of the role played by signaling through IRS-2 in these brain areas...
Research Grants
- BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATIONDianne Lattemann; Fiscal Year: 2003..abstract_text> ..
- CNS Stress Pathways and the Development of Acute HAAFDianne Lattemann; Fiscal Year: 2003..abstract_text> ..
- ANTIDEPRESSANT THERAPY AND HYPOGLYCEMIADianne Lattemann; Fiscal Year: 2006..non-diabetic rats. The results of these studies will provide new knowledge that ultimately may assist primary physicians in determining the most advantageous treatment for their diabetic patients with depression. ..
- BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATIONDianne Lattemann; Fiscal Year: 2007..abstract_text> ..
- BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATIONDianne Lattemann; Fiscal Year: 2009..abstract_text> ..
- BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATIONDianne Lattemann; Fiscal Year: 1992..Together, these studies should determine whether the effectiveness of the candidate CNS adiposity signal, insulin, is regulated by changes in its uptake and/or action in the CNS...
- BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATIONDIANNE FIGLEWICZ LATTEMANN; Fiscal Year: 2010..Our experiments thus model one aspect of the eating habits of people in 'Westernized'societies such as the U.S. and may provide translational insight into dealing with this excessive intake. ..