Research Topics
| B L LasleySummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Effects of soy consumption on gonadotropin secretion and acute pituitary responses to gonadotropin-releasing hormone in womenJill Nicholls
Department of Nutrition, University of California-Davis, CA 95616, USA
J Nutr 132:708-14. 2002..In one premenopausal woman, enhanced LH secretion was observed after soy treatment, suggesting there may be subpopulations of women who are highly sensitive to isoflavones...- The relationship of circulating dehydroepiandrosterone, testosterone, and estradiol to stages of the menopausal transition and ethnicityBill L Lasley
Department of Population Health and Reproduction, University of California, Davis, California 95616, USA
J Clin Endocrinol Metab 87:3760-7. 2002.... 
Biomarkers for assessing human female reproductive health, an interdisciplinary approachB L Lasley
Institute of Toxicology and Environmental Health, University of California, Davis 95616 8615, USA
Environ Health Perspect 106:955-60. 1998..This effort requires specific skills of toxicologists, epidemiologists, physicians, biochemists, and physiologists...- Adrenal androgens and the menopausal transitionBill L Lasley
Center for Population Health and the Environment, University of California at Davis, CA 95616, USA
Obstet Gynecol Clin North Am 38:467-75. 2011..Thus, adrenal steroid production may play a larger role in the occurrence of symptoms and the potential for healthier aging than previously recognized... - Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transitionBill L Lasley
Center for Health and the Environment, University of California at Davis, Davis, CA 95616, USA
Menopause 18:494-8. 2011..The objective of this study was to determine the source of the rise in circulating DHEAS... - Estrogen and progesterone metabolites and follicle-stimulating hormone in the aged macaque femaleS E Shideler
Institute of Toxicology and Environmental Health, University of California, Davis, California 95616, USA
Biol Reprod 65:1718-25. 2001..e., females were less likely to return to normal ovarian cycles the following breeding season and more likely to exhibit permanent ovarian quiescence)... - Molecular target of endocrine disruption in human luteinizing granulosa cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin: inhibition of estradiol secretion due to decreased 17alpha-hydroxylase/17,20-lyase cytochrome P450 expressionF M Moran
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Endocrinology 144:467-73. 2003.... - Effect of dioxin on ovarian function in the cynomolgus macaque (M. fascicularis)F M Moran
Institute of Toxicology and Environmental Health, University of California, Davis 95616, USA
Reprod Toxicol 15:377-83. 2001..These data demonstrate that a single exposure of 4 microg/kg BW TCDD leads to long-term adverse effects on ovarian function in primates... - Effects of two antiprogestins on early pregnancy in the long-tailed macaque (Macaca fascicularis)A F Tarantal
California Regional Primate Research Center, University of California, Davis 95616, USA
Contraception 54:107-15. 1996..m. and high dose oral dosing regimens, with little or no activity with the oral low dose; and (3) infants resulting from surviving pregnancies were not affected by early gestation exposure... - Effects of progesterone receptor blockers on human granulosa-luteal cell culture secretion of progesterone, estradiol, and relaxinC A VandeVoort
California Regional Primate Research Center, Division of Reproductive Biology, Department of Ob Gyn and Institute of Toxicology and Environmental Health, University of California, Davis, California 95616, USA
Biol Reprod 62:200-5. 2000..The data support the hypothesis that P(4) may be a required autocrine factor, not only for its own production but also for the maintenance of full endocrine function of the corpus luteum... - Differences in hormonal characteristics of conceptive versus nonconceptive menstrual cyclesH Li
Institute of Toxicology and Environmental Health and Department of Obstetrics and Gynecology, University of California, Davis, USA
Fertil Steril 75:549-53. 2001..Urinary FSH measurements may be useful in predicting less fecund ovulatory cycles and may identify some types of reduced female fertility... - Exposure to the dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces squamous metaplasia in the endocervix of cynomolgus macaquesM A Scott
Institute of Toxicology and Environmental Health, University of California, Davis 95616-8615, USA
J Med Primatol 30:156-60. 2001.... - Contribution of ovarian steroid production to urinary estrone conjugate concentrations in Macaca mulattaS E Shideler
Center for Health and the Environment, University of California Davis, Davis, California 95616 8615, USA
Am J Primatol 61:111-21. 2003..The results indicate that the use of E1C measurements is clearly a suitable method for monitoring ovarian function in intact, cycling animals, but urinary E2 measurements are required to verify loss of follicular activity... - Excretion and measurement of estradiol and progesterone metabolites in the feces and urine of female squirrel monkeys (Saimiri sciureus)E A Moorman
Department of Psychology, University of California-Davis, Davis, California 95616, USA
Am J Primatol 57:79-90. 2002..Examination of this profile confirmed that longitudinal fecal sampling and steroid hormone metabolite measurement in feces was not only feasible and practical, but accurately detected known reproductive events as well... - Use of porcine zona pellucida (PZP) vaccine as a contraceptive agent in free-ranging tule elk (Cervus elaphus nannodes)S E Shideler
Reprod Suppl 60:169-76. 2002.... - Effects of triclocarban on intact immature male rat: augmentation of androgen actionAntoni J Duleba
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, CA 95817, USA
Reprod Sci 18:119-27. 2011..In conclusion, TCC significantly affects intact male reproductive organs and potentiates androgen effects in prostate cancer cells... - Effect of estrogen and 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) on plasma fatty acids of immature male chickens (Gallus domesticus)Beckye J Stanton
Lasley Laboratory, Center for Health and the Environment, University of California, One Shields Ave, Davis, CA 95616, USA
Comp Biochem Physiol C Toxicol Pharmacol 132:129-42. 2002..Overall, TCDD treatment alone increased plasma lipids, possibly as a result of decreased clearance or utilization; whereas estrogen plus TCDD treatment antagonized estrogen-induced increases in 22:6n3 but did not cause hyperlipidemia... - Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in polycystic ovary syndromeSidika E Kasim-Karakas
Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of California, Davis, California 95616, USA
J Clin Endocrinol Metab 89:615-20. 2004..Urinary pregnanediol 3-glucuronide increased from 18.6 +/- 2.2 to 31.0 +/- 5.7 micro g/mg creatinine (P = 0.038). In conclusion, increased dietary PUFA intake can exert significant metabolic and endocrine effects in women with PCOS... - Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeysMari S Golub
Department of Internal Medicine, California National Primate Research Center, University of California, Davis 95616, USA
Toxicol Sci 74:103-13. 2003..Long-term consequences of this disruption of pubertal development are being studied in this cohort of monkeys as adults... - Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestroneSidika E Kasim-Karakas
Department of Internal Medicine, Division of Endocrinology, Clinical Nutrition, and Vascular Medicine, University of California, Davis, CA 95817, USA
Am J Clin Nutr 76:1422-7. 2002..High fiber intake is also associated with decreased breast cancer risk... - Sex steroid concentrations and localization of steroidogenic enzyme expression in free-ranging female northern fur seals (Callorhinus ursinus)Patience Browne
Population, Health and Reproduction, University of California, Davis, 1114 Tupper Hall, 95616, USA
Gen Comp Endocrinol 147:175-83. 2006..These data suggest androgens may play a substantial regulatory role in the embryonic delay of northern fur seals... - Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotropin secretion by human trophoblastsJiangang Chen
Center for Health and the Environment, School of Medicine, Tupper Hall, University of California, Davis, CA 95616, USA
Reprod Toxicol 17:87-93. 2003..These in vitro results support earlier in vivo studies in macaques suggesting that trophoblast is a target for TCCD and that TCDD-induced early pregnancy loss is accompanied by a decrease in the CG B/I ratio... - Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature male chickens (Gallus domesticus)B J Stanton
Lasley Laboratory, Institute of Toxicology and Environmental Health, University of California, One Shields Ave, 95616, Davis, CA, USA
Comp Biochem Physiol C Toxicol Pharmacol 129:35-47. 2001..These data show that TCDD antagonized several effects of exogenous estrogen in male chickens, while estrogen enhanced TCDD toxicity in a tissue-specific manner... - Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on fatty acid availability and neural tube formation in cynomolgus macaque, Macaca fascicularisF M Moran
Center for Health and the Environment, University of California, Davis, California 95616, USA
Birth Defects Res B Dev Reprod Toxicol 71:37-46. 2004..Since neural tube development is dependent, in part, on n-3 and n-6 fatty acids, it is possible that the limitation of these essential fatty acids in plasma resulted in the observed detrimental effects on early brain development... - Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogensKala Natarajan
Center for Health and the Environment, University of California, Davis, California 95616-8615, USA
Environ Health Perspect 110:791-5. 2002..However, when steroidal estrogens were removed by immunoprecipitation, we detected the estrogenic activity of NP in the bioassay. Thus, this approach is appropriate for detecting exogenous, nonsteroidal estrogens in serum samples... - Exogenous steroid substrate modifies the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estradiol production of human luteinized granulosa cells in vitroF M Moran
Population Health and Reproduction, University of California, Davis, Davis, California 95616, USA
Biol Reprod 68:244-51. 2003..Thus, these data suggest that the most likely target for the TCDD-induced inhibition of estrogen synthesis by hLGC is the 17,20-lyase activity of the P450(c17) enzyme complex... - Bayesian analysis of risk factors for anovulationYan Liu
Department of Epidemiology and Preventive Medicine, School of Medicine, University of California, Davis, CA 95616, USA
Stat Med 23:1901-19. 2004..Our results indicated that increasing physical activity was associated with a significantly increased risk of anovulation; and smokers had a potentially, but not statistically significant, increased occurrence of anovulation... - Hormonal characteristics in the early luteal phase of conceptive and nonconceptive menstrual cyclesJiangang Chen
Center for Health and the Environment, University of California, Davis, Davis, California, USA
J Soc Gynecol Investig 10:27-31. 2003..The differences in luteal phase hormones may reflect alterations in signaling in the hypothalamic-pituitary-ovarian axis that begin during the preovulatory period of nonconceptive cycles... - Effect of porcine zonae pellucidae immunisation on ovarian follicular development and endocrine function in domestic ewes (Ovis aries)M A Stoops
Department of Animal Science, University of California, Davis, CA 95616, USA
Reprod Fertil Dev 18:667-76. 2006..These data are the first generated in an ungulate species showing deleterious effects of pZP immunisation on folliculogenesis and oestrous cyclicity... - Circulating bioactive androgens in midlife womenJiangang Chen
Center for Health and the Environment, University of California, Davis, California 95616, USA
J Clin Endocrinol Metab 91:4387-94. 2006..Our data suggest that levels of circulating SHBG may have a significant impact on the levels of total circulating bioavailable androgens... - Urinary follicle-stimulating hormone peak as a biomarker for estimating the day of ovulationHongxia Li
Center for Health and the Environment, School of Medicine, University of California, Davis, Davis, California 95616 8739, USA
Fertil Steril 77:961-6. 2002..To evaluate urinary follicle-stimulating hormone (FSH) as a biomarker for the day of ovulation... - Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult cynomolgus monkeys (Macaca fascicularis)Yan-He Lue
Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, University of California, Davis 90509, USA
J Androl 23:799-805. 2002..We conclude that, similar to rodents, mild testicular hyperthermia results in azoospermia and oligozoospermia in monkeys through increased germ cell apoptosis with minimal effect on the hormonal milieu... - Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care productsJiangang Chen
Center for Health and the Environment, University of California, Davis, CA 95616, USA
Toxicol Appl Pharmacol 221:278-84. 2007..The data presented in this report demonstrate that some widely used antimicrobial compounds have antiandrogenic properties and warrant further investigation to fully understand their potential impact on human reproductive health... - Triclocarban enhances testosterone action: a new type of endocrine disruptor?Jiangang Chen
Center for Health and the Environment, University of California, Davis, California 95616, USA
Endocrinology 149:1173-9. 2008..The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC... - Hourly human chorionic gonadotropin secretion profiles during the peri-implantation period of successful pregnanciesPete N Lohstroh
Center for Health and the Environment, University of California, Davis, California 95616 8615, USA
Fertil Steril 87:1413-8. 2007..To characterize the hourly profiles of hCG secretion in blood during conceptive cycles that ended in successful pregnancy... - Secretion and excretion of human chorionic gonadotropin during early pregnancyPete N Lohstroh
Center for Health and the Environment, University of California-Davis, Davis, CA 95616, USA
Fertil Steril 83:1000-11. 2005..CONCLUSION(S): These data validate the use of urinary hCG as a biomarker for assessing peri-implantation pregnancy events... - The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on chorionic gonadotrophin activity in pregnant macaquesJiangang Chen
Center for Health and the Environment, University of California at Davis, One Shields Avenue, Davis, CA 95616-8739, USA
Toxicology 186:21-31. 2003..Because exposure of the conceptus to TCDD following differentiation of the trophoblast decreased the bioactivity of circulating mCG, we conclude that the action of TCDD in the placenta is directly on mCG synthesis... - Bone resorption is affected by follicular phase length in female rotating shift workersPete N Lohstroh
Center for Health and the Environment, University of California, Davis, California 95616, USA
Environ Health Perspect 111:618-22. 2003..In addition, these data indicate that there may be an association between accelerated bone resorption in menstrual cycles and changes of regularity in work schedule during the preceding LFPT... - Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN)Kim Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall 130 DeSoto St, Pittsburgh, PA 15261, USA
Circulation 111:1242-9. 2005..Recent clinical trials have shifted attention away from estrogens and toward androgens and sex hormone-binding globulin (SHBG) as potential mediators of increasing cardiovascular (CV) risk in women at midlife... - Luteal phase deficiency in recreational runners: evidence for a hypometabolic stateMary Jane De Souza
Women s Exercise and Bone Health Laboratory, Faculty of Physical Education and Health, University of Toronto, Toronto, Ontario, Canada M5S 2W6
J Clin Endocrinol Metab 88:337-46. 2003..These alterations may represent a metabolic adaptation to an intermittent short-term negative energy balance... - Factors affecting menstrual cycle characteristicsYan Liu
Center for Family Studies, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, FL 33136, USA
Am J Epidemiol 160:131-40. 2004..These results indicate that potentially modifiable risk factors, as well as immutable host factors, are associated with menstrual cycle characteristics that may in turn be related to subsequent disease risk... - Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortexJiandong Hao
Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY 10029, USA
Proc Natl Acad Sci U S A 104:11465-70. 2007..The results also suggest that the cognitive benefit of E treatment in aged monkeys is mediated by enabling synaptic plasticity through a cyclical increase in small, highly plastic dendritic spines in the primate dlPFC... - Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal statusJohn F Randolph
Clinical Centers: University of Michigan, Ann Arbor, Michigan 48109, USA
J Clin Endocrinol Metab 88:1516-22. 2003..All hormone concentrations were significantly correlated with body mass index. We conclude that serum sex steroid, FSH, and SHBG levels vary by ethnicity, but are highly confounded by ethnic disparities in body size... - Cigarette smoking and effects on hormone function in premenopausal womenGayle C Windham
Division of Environmental and Occupational Disease Control, California Department of Health Services, Oakland, California, USA
Environ Health Perspect 113:1285-90. 2005..This endocrine disruption likely contributes to the reported associations of smoking with adverse reproductive outcomes, including menstrual dysfunction, infertility, and earlier menopause... - A prospective study of serum DDT and progesterone and estrogen levels across the menstrual cycle in nulliparous women of reproductive ageMelissa J Perry
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 164:1056-64. 2006..03) in the luteal phase. These results support the potential for DDT to be associated with decrements in estrogen and progesterone levels at times during the menstrual cycle that are critical for ovulation and early pregnancy maintenance... - Urinary estrogen and progesterone metabolite concentrations in menstrual cycles of fertile women with non-conception, early pregnancy loss or clinical pregnancyScott A Venners
Division of Epidemiology and Biostatistics, University of Illinois at Chicago, School of Public Health, Chicago, IL, USA
Hum Reprod 21:2272-80. 2006..CONCLUSIONS: Estrogen concentrations varied from cycle to cycle, and higher estrogen was associated with achieving clinical pregnancy... - Urinary estrone conjugate and pregnanediol 3-glucuronide enzyme immunoassays for population researchKATHLEEN A O'CONNOR
Department of Anthropology and Center for Studies in Demography and Ecology, University of Washington, Seattle WA 98195, USA
Clin Chem 49:1139-48. 2003..We developed enzyme immunoassays for urinary pregnanediol 3-glucuronide (PDG) and estrone conjugates (E1Cs) that meet these criteria... - Alcohol consumption and serum hormone levels during pregnancyRichard G Stevens
Department of Community Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
Alcohol 36:47-53. 2005..Light alcohol intake during pregnancy is associated with lower maternal testosterone. The health implications are uncertain, but may include an increased breast density in the daughters of drinking mothers... - Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometriumAriane Germeyer
Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, California 94305 5317, USA
J Clin Endocrinol Metab 90:1783-90. 2005..The findings extend our understanding of VEGF action in the primate endometrium... - Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growthNihar R Nayak
Department of Gynecology and Obstetrics, Stanford University, Stanford, CA 94305 5317, USA
Mol Hum Reprod 11:791-9. 2005..These data suggest, for the first time, that Ang-1 may play a key role in the P-dependent growth of the unique spiral arteries in the primate endometrium...