Keren Lasker

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Macromolecular assembly structures by comparative modeling and electron microscopy
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA
    Methods Mol Biol 857:331-50. 2012
  2. pmc Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010
  3. pmc UCSF Chimera, MODELLER, and IMP: an integrated modeling system
    Zheng Yang
    Resource for Biocomputing, Visualization, and Informatics, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    J Struct Biol 179:269-78. 2012
  4. pmc Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies
    Daniel Russel
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 10:e1001244. 2012
  5. doi request reprint Modeling of proteins and their assemblies with the integrative modeling platform
    Benjamin Webb
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, CA, USA
    Methods Mol Biol 781:377-97. 2011
  6. pmc Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images
    Javier Velázquez-Muriel
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158 2552, USA
    Proc Natl Acad Sci U S A 109:18821-6. 2012
  7. doi request reprint Modeling of proteins and their assemblies with the Integrative Modeling Platform
    Benjamin Webb
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quanstitative Biosciences QB3, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 1091:277-95. 2014
  8. pmc The structural dynamics of macromolecular processes
    Daniel Russel
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, 1700 4th Street, San Francisco, CA 94158 2330, USA
    Curr Opin Cell Biol 21:97-108. 2009
  9. pmc MultiFit: a web server for fitting multiple protein structures into their electron microscopy density map
    Elina Tjioe
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA
    Nucleic Acids Res 39:W167-70. 2011
  10. pmc Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, California Institute of Quantitative Biosciences, 1700 4th Street, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:1380-7. 2012

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Macromolecular assembly structures by comparative modeling and electron microscopy
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA
    Methods Mol Biol 857:331-50. 2012
    ..In particular, we provide detailed instructions for density map-guided modeling using the Integrative Modeling Platform (IMP), MODELLER, and UCSF Chimera...
  2. pmc Integrative structure modeling of macromolecular assemblies from proteomics data
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA
    Mol Cell Proteomics 9:1689-702. 2010
    ..Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures...
  3. pmc UCSF Chimera, MODELLER, and IMP: an integrated modeling system
    Zheng Yang
    Resource for Biocomputing, Visualization, and Informatics, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    J Struct Biol 179:269-78. 2012
    ....
  4. pmc Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies
    Daniel Russel
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences QB3, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 10:e1001244. 2012
    ....
  5. doi request reprint Modeling of proteins and their assemblies with the integrative modeling platform
    Benjamin Webb
    Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, CA, USA
    Methods Mol Biol 781:377-97. 2011
    ..We also demonstrate the Integrative Modeling Platform (IMP) software, which provides the necessary computational framework to implement this protocol, and several applications for specific-use cases...
  6. pmc Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images
    Javier Velázquez-Muriel
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158 2552, USA
    Proc Natl Acad Sci U S A 109:18821-6. 2012
    ..Thus, integrative structural biology can now benefit from the relative ease with which the EM class averages are determined...
  7. doi request reprint Modeling of proteins and their assemblies with the Integrative Modeling Platform
    Benjamin Webb
    Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quanstitative Biosciences QB3, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 1091:277-95. 2014
    ..We also demonstrate the Integrative Modeling Platform (IMP) software, which provides the necessary computational framework to implement this protocol, and several applications for specific use cases. ..
  8. pmc The structural dynamics of macromolecular processes
    Daniel Russel
    Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, 1700 4th Street, San Francisco, CA 94158 2330, USA
    Curr Opin Cell Biol 21:97-108. 2009
    ..We review the relevant sources of information and introduce a framework for integrating the data to produce representations of dynamic processes...
  9. pmc MultiFit: a web server for fitting multiple protein structures into their electron microscopy density map
    Elina Tjioe
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA
    Nucleic Acids Res 39:W167-70. 2011
    ..The models can be viewed online or downloaded from the website. The service is available at; http://salilab.org/multifit/ and http://bioinfo3d.cs.tau.ac.il/...
  10. pmc Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
    Keren Lasker
    Department of Bioengineering and Therapeutic Sciences, California Institute of Quantitative Biosciences, 1700 4th Street, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:1380-7. 2012
    ..The modular structure of the 26S proteasome provides insights into the sequence of events prior to the degradation of ubiquitylated substrates...