Research Topics
Species | Janine LaSalleSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylationDamina Balmer
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
J Mol Med (Berl) 81:61-8. 2003..Acquired elevated MeCP2 expression in neurons beginning in infancy and progressing through childhood may explain the delayed onset and developmental arrest of Rett syndrome..
Evolving role of MeCP2 in Rett syndrome and autismJanine M LaSalle
Medical Microbiology and Immunology and Rowe Program in Human Genetics, University of California Davis School of Medicine, Davis, CA 95616, USA
Epigenomics 1:119-30. 2009....- Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samplesHaley A Scoles
Medical Microbiology and Immunology, Genome Center, and Medical Institute of Neurodevelopmental Disorders, One Shields Avenue, University of California, Davis, Davis, CA 95616, USA
Mol Autism 2:19. 2011..abstract:.. - The role of MeCP2 in brain development and neurodevelopmental disordersMichael L Gonzales
School of Medicine, Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Curr Psychiatry Rep 12:127-34. 2010..As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies... 
Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patientsIvan J Delgado
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA
BMC Med Genet 7:61. 2006....- A genomic point-of-view on environmental factors influencing the human brain methylomeJanine M LaSalle
Medical Microbiology and Immunology, UC Davis School of Medicine, University of California, Davis, CA, USA
Epigenetics 6:862-9. 2011.... - The Odyssey of MeCP2 and parental imprintingJanine M LaSalle
Medical Microbiology and Immunology, One Shields Avenue, Davis, California 95616, USA
Epigenetics 2:5-10. 2007..The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process... - The odyssey of MeCP2 and parental imprintingJanine M LaSalle
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, One Shields Ave, University of California, Davis, CA 95616, USA
Epigenetics 2:5-10. 2007..The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process... - Quantitative localization of heterogeneous methyl-CpG-binding protein 2 (MeCP2) expression phenotypes in normal and Rett syndrome brain by laser scanning cytometryJ M LaSalle
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, 1 Shields Avenue, University of California, Davis, CA 95616, USA
Hum Mol Genet 10:1729-40. 2001..In addition, our results demonstrate the power of laser scanning cytometry in examining complex cellular phenotypes in disease pathogenesis... - MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brainDamina Balmer
Medical Microbiology and Immunology and Rowe Program in Human Genetics, School of Medicine, University of California, Davis, California, USA
Hum Genet 110:545-52. 2002..In conclusion, our results do not support an essential role for either MeCP2 or HDAC in the silencing of several imprinted genes... - Does HER2/neu expression provide prognostic information in patients with advanced urothelial carcinoma?Regina Gandour-Edwards
Department of Pathology, School of Medicine, University of California Davis, 95817, USA
Cancer 95:1009-15. 2002..Thus, the authors evaluated a possible correlation between HER2 expression in patients with high-grade, muscle-invasive urothelial carcinoma of the bladder and outcome in patients who received paclitaxel-based chemotherapy... - Gender influences monoallelic expression of ATP10A in human brainAmber Hogart
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, One Shields Ave, Davis, CA 95616, USA
Hum Genet 124:235-42. 2008..Our results show that monoallelic expression of human ATP10A is variable in the population and is influenced by both gender and common genetic variation... - 15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disordersAmber Hogart
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
Hum Mol Genet 16:691-703. 2007..Combined, these results suggest that MeCP2 acts as a chromatin organizer for optimal expression of both alleles of GABRB3 in neurons... - Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autismSusan E Swanberg
Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
Hum Mol Genet 18:525-34. 2009..In contrast to age-matched Controls, RTT and autism postmortem cortex samples showed significant reduction in EGR2. Together, these data support a role of dysregulation of an activity-dependent EGR2/MeCP2 pathway in RTT and autism... - Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3Rodney C Samaco
Microbiology and Immunology and Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
Hum Mol Genet 14:483-92. 2005..These results suggest an overlapping pathway of gene dysregulation within 15q11-q13 in Rett, Angelman and autism and implicate MeCP2 in the regulation of UBE3A and GABRB3 expressions in the postnatal mammalian brain... - Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genesDag H Yasui
Department of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, 1 Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 104:19416-21. 2007..These results indicate that the primary function of MeCP2 is not the silencing of methylated promoters... - The comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13Amber Hogart
Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, USA
Neurobiol Dis 38:181-91. 2010..This review provides an overview of the phenotypes of these disorders and their relationships with ASD and outlines the regional genes that may contribute to the autism susceptibility imparted by copy number variation of the region... - Rett syndrome: a Rosetta stone for understanding the molecular pathogenesis of autismJanine M LaSalle
Medical Microbiology and Immunology and Rowe Program in Human Genetics, School of Medicine, University of California, Davis 95616, USA
Int Rev Neurobiol 71:131-65. 2005 - Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylationRaman P Nagarajan
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, One Shields Ave, University of California, Davis, CA 95616, USA
Epigenetics 1:e1-11. 2006..These results suggest that both genetic and epigenetic defects lead to reduced MeCP2 expression and may be important in the complex etiology of autism... - Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samplesKaren N Thatcher
Medical Microbiology and Immunology and Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
Hum Mol Genet 14:785-97. 2005..These combined results suggest a role for MeCP2 in chromosome organization in the developing brain and provide a potential mechanistic association between several related neurodevelopmental disorders... - Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disordersRodney C Samaco
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis 95616, USA
Hum Mol Genet 13:629-39. 2004..These results suggest that multiple pathways regulate the complex developmental expression of MeCP2 and are defective in autism-spectrum disorders in addition to RTT... - Immunologic and neurodevelopmental susceptibilities of autismIsaac N Pessah
School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Neurotoxicology 29:532-45. 2008.... - Dynamic changes in Histone H3 lysine 9 acetylation localization patterns during neuronal maturation require MeCP2Karen N Thatcher
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, One Shields Ave, University of California, Davis, CA 95616, USA
Epigenetics 1:24-31. 2006..These results have implications for understanding the molecular pathogenesis of RTT and autism in which MECP2 mutation or deficiency corresponds with arrested neurodevelopment... - Imprinting regulates mammalian snoRNA-encoding chromatin decondensation and neuronal nucleolar sizeKaren N Leung
Microbiology and Immunology and Rowe Program in Human Genetics, UC Davis School of Medicine, Davis, CA 95616, USA
Hum Mol Genet 18:4227-38. 2009..These results are relevant to understanding the molecular pathogenesis of multiple human neurodevelopmental disorders, including PWS and some causes of autism... - Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndromeSailaja Peddada
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, CA 95616, USA
Hum Mol Genet 15:2003-14. 2006..Because of their involvement in cell differentiation and neural development, ID genes are ideal primary targets for MeCP2 regulation of neuronal maturation that may explain the molecular pathogenesis of RTT... - MECP2 promoter methylation and X chromosome inactivation in autismRaman P Nagarajan
Medical Microbiology and Immunology and Rowe Program in Human Genetics, University of California, Davis, CA 95616, USA
Autism Res 1:169-78. 2008..These results suggest that the aberrant MECP2 methylation in autism brain DNA samples is due to locus-specific rather than global X chromosome methylation changes... - Paradoxical role of methyl-CpG-binding protein 2 in Rett syndromeJanine M LaSalle
Medical Microbiology and Immunology and Rowe Program in Human Genetics, School of Medicine, University of California, Davis, California 95616, USA
Curr Top Dev Biol 59:61-86. 2004 - X-Chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2-/+ mouse brainDaniel Braunschweig
Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis 95616, USA
Hum Mol Genet 13:1275-86. 2004..These results help in explaining the role of XCI in the pathogenesis of RTT and have important implications in designing therapies for female RTT patients... - Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylationRaman P Nagarajan
Epigenetics 1:e1-11. 2006..These results suggest that both genetic and epigenetic defects lead to reduced MeCP2 expression and may be important in the complex etiology of autism... - Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivoAsmita Kumar
Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
J Cell Sci 121:1128-37. 2008..Some common RTT missense and nonsense mutations significantly affect binding kinetics, suggesting that alterations in chromatin binding can result in protein dysfunction and hence a disease phenotype... - Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15Nicholas J Wang
Nemours Biomedical Research, Alfred I, duPont Hospital for Children, Wilmington, Delaware, 19803, USA
BMC Genet 9:2. 2008..Five recurrent breakpoints have been described in most cases of segmental aneuploidy of chromosome 15q11-q13 and previous studies have shown that most idic(15) chromosomes arise through BP3:BP3 or BP4:BP5 recombination events...
Research Grants
- The Role of MeCP2 in Rett SyndromeJanine M LaSalle; Fiscal Year: 2010..These results are expected to be significant in understanding and designing future therapies for Rett syndrome, autism, and mental retardation. ..
- Epigenetic Etiologies of Autism-Spectrum DisordersJanine LaSalle; Fiscal Year: 2009..The successful completion of these studies should yield findings to help develop better diagnostic and treatment modalities for autism-spectrum disorders. ..
- Epigenetic Interaction of MECP2 and Organic Pollutants in NeurodevelopmentJanine LaSalle; Fiscal Year: 2009..factors in the etiology of autism and mental retardation? Can specific epigenetic changes be diagnostic for autism and mental retardation of unknown genetic etiology? Are epigenetic changes affecting neurodevelopment heritable? ..
- Epigenetic Interaction of MECP2 and Organic Pollutants in NeurodevelopmentJanine LaSalle; Fiscal Year: 2009..factors in the etiology of autism and mental retardation? Can specific epigenetic changes be diagnostic for autism and mental retardation of unknown genetic etiology? Are epigenetic changes affecting neurodevelopment heritable? ..
- The Role of MeCP2 in Rett SyndromeJanine LaSalle; Fiscal Year: 2006..These results from these studies are expected to be of significance in understanding the role of MeCP2 in normal human brain development and in understanding the pathogenesis of Rett syndrome. ..
- The Role of MeCP2 in Rett SyndromeJanine LaSalle; Fiscal Year: 2009..These results are expected to be significant in understanding and designing future therapies for Rett syndrome, autism, and mental retardation. ..