Research Topics
| Peder E Z LarsonSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imagingPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
J Magn Reson 194:121-7. 2008..The metabolic products are observable for a longer window because the low pyruvate flip angle preserves magnetization, allowing for improved observation of spatially varying metabolic reactions...
Anisotropic field-of-view shapes for improved PROPELLER imagingPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
Magn Reson Imaging 27:470-9. 2009..Also presented are algorithms for further scan time reductions in PROPELLER echo-planar imaging (EPI) acquisitions by varying the sample spacing in two directions within each blade...- Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSIPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
Magn Reson Med 63:582-91. 2010..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization... - In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanineSimon Hu
Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
Magn Reson Imaging 29:1035-40. 2011..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected... - A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactateGalen D Reed
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
J Magn Reson 217:41-7. 2012..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed... - Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imagingKayvan R Keshari
Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:18606-11. 2011..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS... - Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studiesPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
Magn Reson Med 65:610-9. 2011..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution... - Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvateCornelius Von Morze
Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
J Magn Reson 211:109-13. 2011..The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized (13)C compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods... - A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substratesPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th St, San Francisco, CA 94158, USA
J Magn Reson 225:71-80. 2012..Generally, MAD-STEAM can be applied to any system in which spins undergo a frequency shift... - Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and ureaCornelius Von Morze
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
Magn Reson Imaging 30:305-11. 2012..A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism... - Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imagingPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
IEEE Trans Med Imaging 31:265-75. 2012.... - 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancerSimon Hu
Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
Magn Reson Med 63:312-21. 2010.... - 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regressionSimon Hu
Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
Cell Metab 14:131-42. 2011..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene... - Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer modelsCornelius Von Morze
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
J Magn Reson Imaging 33:692-7. 2011..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models... - Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imagingKayvan R Keshari
Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
J Am Chem Soc 131:17591-6. 2009..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies... - Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancerPeder E Z Larson
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA Electronic address
Magn Reson Imaging 31:635-42. 2013..This was shown in STEAM images that highlighted abnormal cancer cell metabolism and suppressed vascular (13)C metabolite signals... - Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumorsIlwoo Park
Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
Neuro Oncol 12:133-44. 2010..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors... - Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 TCornelius Von Morze
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
Magn Reson Imaging 31:163-70. 2013..1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer... - Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptorHagit Dafni
Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7400-10. 2010..Our results indicate that hyperpolarized (13)C MRSI could potentially detect the molecular effect of various cell signaling inhibitors, thus providing a radiation-free method to predict tumor response... - Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizerSimon Hu
Dept of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, 1700 4th St QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
Magn Reson Imaging 31:490-6. 2013..Dramatic increases in (13)C-bicarbonate were detected just 1min (as well as 6min) after DCA administration... - Diffusion MR of hyperpolarized 13C molecules in solutionBertram L Koelsch
Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
Analyst 138:1011-4. 2013..Potential applications include rapidly measuring molecular binding, cellular membrane transport, in vivo metabolite distribution and establishing a magnetic field independent hyperpolarized parameter...