Peder E Z Larson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
    J Magn Reson 194:121-7. 2008
  2. pmc Anisotropic field-of-view shapes for improved PROPELLER imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:470-9. 2009
  3. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
  4. pmc Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS
    Christine Leon Swisher
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA UC Berkeley UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA
    Magn Reson Med 71:1-11. 2014
  5. pmc Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates
    Yan Xing
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States
    J Magn Reson 234:75-81. 2013
  6. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
  7. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
  8. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
  9. pmc Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    J Magn Reson 211:109-13. 2011
  10. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011

Collaborators

Detail Information

Publications27

  1. pmc Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
    J Magn Reson 194:121-7. 2008
    ..The metabolic products are observable for a longer window because the low pyruvate flip angle preserves magnetization, allowing for improved observation of spatially varying metabolic reactions...
  2. pmc Anisotropic field-of-view shapes for improved PROPELLER imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:470-9. 2009
    ..Also presented are algorithms for further scan time reductions in PROPELLER echo-planar imaging (EPI) acquisitions by varying the sample spacing in two directions within each blade...
  3. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
    ..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization...
  4. pmc Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS
    Christine Leon Swisher
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA UC Berkeley UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA
    Magn Reson Med 71:1-11. 2014
    ..However, the accuracy of current methods to calculate kinetic parameters has been limited by T1 relaxation effects, extracellular signal contributions, and reduced precision at lower signal-to-noise ratio...
  5. pmc Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates
    Yan Xing
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States
    J Magn Reson 234:75-81. 2013
    ..This will allow for improved characterization of tissue perfusion and metabolic profiles in dynamic hyperpolarized MRI. ..
  6. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
    ..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected...
  7. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
    ..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed...
  8. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
    ..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS...
  9. pmc Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    J Magn Reson 211:109-13. 2011
    ..The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized (13)C compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods...
  10. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
    ..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution...
  11. pmc Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:635-42. 2013
    ..This was shown in STEAM images that highlighted abnormal cancer cell metabolism and suppressed vascular (13)C metabolite signals...
  12. pmc A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th St, San Francisco, CA 94158, USA
    J Magn Reson 225:71-80. 2012
    ..Generally, MAD-STEAM can be applied to any system in which spins undergo a frequency shift...
  13. pmc Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:305-11. 2012
    ..A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism...
  14. pmc Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:265-75. 2012
    ....
  15. pmc Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:163-70. 2013
    ..1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer...
  16. pmc 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
    Magn Reson Med 63:312-21. 2010
    ....
  17. pmc Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 71:19-25. 2014
    ..To investigate hyperpolarized (13) C metabolic imaging methods in the primate brain that can be translated into future clinical trials for patients with brain cancer...
  18. ncbi request reprint Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate
    Sarah J Nelson
    Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94158, USA
    Sci Transl Med 5:198ra108. 2013
    ..These findings will be valuable for noninvasive cancer diagnosis and treatment monitoring in future clinical trials...
  19. pmc 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
    ..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene...
  20. pmc Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI)
    Michael A Ohliger
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    J Magn Reson Imaging 38:701-13. 2013
    ..Human applications additionally require rapid imaging to permit breath-holding and to minimize the effects of physiologic motion...
  21. pmc Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer
    Simon Hu
    Dept of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, 1700 4th St QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 31:490-6. 2013
    ..Dramatic increases in (13)C-bicarbonate were detected just 1 min (as well as 6 min) after DCA administration...
  22. pmc Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
    J Am Chem Soc 131:17591-6. 2009
    ..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies...
  23. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
    ..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models...
  24. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
    ..In contrast, in cells that express mutant IDH1, hyperpolarized [1-(13)C] 2-hydroxyglutarate is also observed, both in cell lysates and in vivo in orthotopic tumours. ..
  25. pmc Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors
    Ilwoo Park
    Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
    Neuro Oncol 12:133-44. 2010
    ..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors...
  26. pmc Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor
    Hagit Dafni
    Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:7400-10. 2010
    ..Our results indicate that hyperpolarized (13)C MRSI could potentially detect the molecular effect of various cell signaling inhibitors, thus providing a radiation-free method to predict tumor response...
  27. pmc Diffusion MR of hyperpolarized 13C molecules in solution
    Bertram L Koelsch
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    Analyst 138:1011-4. 2013
    ..Potential applications include rapidly measuring molecular binding, cellular membrane transport, in vivo metabolite distribution and establishing a magnetic field independent hyperpolarized parameter...