Paul S Larson

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Minimally invasive surgery for movement disorders
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112
    Neurosurg Clin N Am 21:691-8, vii. 2010
  2. pmc Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Mol Ther 19:1048-57. 2011
  3. pmc An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:95-103; discussion 103. 2012
  4. pmc Clinical outcomes of PD patients having bilateral STN DBS using high-field interventional MR-imaging for lead placement
    Jill L Ostrem
    Department of Neurology, University of California, San Francisco, Surgical Movement Disorders, 1635 Divisadero Street, 5th Floor, Suites 520 530, San Francisco, CA 94115, USA
    Clin Neurol Neurosurg 115:708-12. 2013
  5. pmc Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
  6. doi request reprint Securing dual ipsilateral leads through a single burr hole in deep brain stimulation surgery: technical note
    Mathew B Potts
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 90:361-4. 2012
  7. doi request reprint Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 89:76-82. 2011
  8. pmc Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements
    Massimo S Fiandaca
    Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    J Neurosci Methods 196:124-30. 2011
  9. ncbi request reprint Implantation of deep brain stimulator electrodes using interventional MRI
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, 533 Parnassus Avenue Box 0445, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 20:193-203. 2009
  10. ncbi request reprint Software requirements for interventional MR in restorative and functional neurosurgery
    Alastair J Martin
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Box 0628, Room L 310, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 20:179-86. 2009

Collaborators

Detail Information

Publications25

  1. doi request reprint Minimally invasive surgery for movement disorders
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 0112
    Neurosurg Clin N Am 21:691-8, vii. 2010
    ..Finally, gene transfer eliminates the need for implanted hardware or batteries and simplifies postoperative care...
  2. pmc Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Mol Ther 19:1048-57. 2011
    ..The results elucidate the necessary parameters for achieving widespread GDNF expression in the putamenal motor area and afferent substantia nigra of PD patients...
  3. pmc An optimized system for interventional magnetic resonance imaging-guided stereotactic surgery: preliminary evaluation of targeting accuracy
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:95-103; discussion 103. 2012
    ..A novel system (SurgiVision ClearPoint) consisting of an aiming device (SMARTFrame) and software has been developed specifically for interventional MRI, including deep brain stimulation...
  4. pmc Clinical outcomes of PD patients having bilateral STN DBS using high-field interventional MR-imaging for lead placement
    Jill L Ostrem
    Department of Neurology, University of California, San Francisco, Surgical Movement Disorders, 1635 Divisadero Street, 5th Floor, Suites 520 530, San Francisco, CA 94115, USA
    Clin Neurol Neurosurg 115:708-12. 2013
    ..Recently, an iMRI-guided technique for implanting DBS electrodes without MER was developed at our center. Here we report the clinical outcomes of PD patients undergoing STN DBS surgery using this surgical approach...
  5. pmc Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Stereotact Funct Neurosurg 89:141-51. 2011
    ..The targeting accuracy of this delivery system and the performance of the infusion cannula were validated in nonhuman primates...
  6. doi request reprint Securing dual ipsilateral leads through a single burr hole in deep brain stimulation surgery: technical note
    Mathew B Potts
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 90:361-4. 2012
    ..This method has been used safely in 6 patients without detectable displacement of the first lead during implantation of the second lead...
  7. doi request reprint Incidence and management of venous air embolisms during awake deep brain stimulation surgery in a large clinical series
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 89:76-82. 2011
    ..The diagnosis and management of VAE in patients undergoing awake deep brain stimulation (DBS) lead implantation in the sitting position are underreported...
  8. pmc Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements
    Massimo S Fiandaca
    Movement Disorders Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, USA
    J Neurosci Methods 196:124-30. 2011
    ....
  9. ncbi request reprint Implantation of deep brain stimulator electrodes using interventional MRI
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, 533 Parnassus Avenue Box 0445, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 20:193-203. 2009
    ..With further technical refinement, the interventional MRI method should improve the accuracy, safety, and speed of deep brain stimulator electrode placement...
  10. ncbi request reprint Software requirements for interventional MR in restorative and functional neurosurgery
    Alastair J Martin
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Box 0628, Room L 310, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 20:179-86. 2009
    ..An optimal software interface for iMRI requires fusion of many of the capabilities offered by these individual devices and further requires the development of tools to handle the integration and presentation of dynamically updated data...
  11. doi request reprint Fluoroscopic, EMG-guided injection of botulinum toxin into the longus colli for the treatment of anterocollis
    Graham A Glass
    Department of Neurology, UCSF Medical Center, San Francisco, CA 94143, USA
    Parkinsonism Relat Disord 15:610-3. 2009
    ..Deep cervical muscles such as the longus colli likely play an important role in neck flexion but are not routinely injected...
  12. doi request reprint Interventional magnetic resonance guidance of deep brain stimulator implantation for Parkinson disease
    Alastair J Martin
    Departments of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA
    Top Magn Reson Imaging 19:213-21. 2009
    ..Preliminary evaluation of clinical outcomes indicates comparable results to that achieved with conventional implantation methods, and the technique holds promise for substantially reducing operative durations...
  13. doi request reprint Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models
    R Mark Richardson
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 63:629-442; dicussion 642-4. 2008
    ..The authors review data obtained from primate models that form the basis for ongoing clinical trials to consider how new preclinical models should be developed to answer questions that arise from experimental clinical data...
  14. doi request reprint Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
    William J Marks
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0138, USA
    Lancet Neurol 7:400-8. 2008
    ..The aim of this study was to assess the safety, tolerability, and potential efficacy of gene delivery of the neurotrophic factor neurturin...
  15. doi request reprint Minimally invasive precision brain access using prospective stereotaxy and a trajectory guide
    Alastair J Martin
    Department of Radiology, University of California, San Francisco, California 94143, USA
    J Magn Reson Imaging 27:737-43. 2008
    ..To evaluate the capabilities of MR-guided "prospective stereotaxy" methods for accessing brain structures for biopsy or electrode implantation...
  16. ncbi request reprint Placement of deep brain stimulator electrodes using real-time high-field interventional magnetic resonance imaging
    Alastair J Martin
    Department of Radiology, University of California, San Francisco, California 94143, USA
    Magn Reson Med 54:1107-14. 2005
    ..0 +/- 0.8 mm (range = 0.1-1.9 mm). All procedures were considered technical successes and there were no intraoperative complications; however, one patient did develop a postoperative infection...
  17. ncbi request reprint Magnetic resonance imaging of implanted deep brain stimulators: experience in a large series
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 86:92-100. 2008
    ..This series strongly suggests that the 0.1 W/kg recommendation for SAR may be unnecessarily low for the prevention of MRI-related adverse events...
  18. doi request reprint A stroke of silence: tinnitus suppression following placement of a deep brain stimulation electrode with infarction in area LC
    Paul S Larson
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 118:192-4. 2013
    ..Clinicians treating patients with DBS may wish to include auditory phantom assessment as part of the neurological evaluation...
  19. pmc Radially branched deployment for more efficient cell transplantation at the scale of the human brain
    Matthew T Silvestrini
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 91:92-103. 2013
    ..This technical deficiency may limit the successful clinical translation of cell transplantation...
  20. doi request reprint Intraoperative computed tomography for deep brain stimulation surgery: technique and accuracy assessment
    Kiarash Shahlaie
    Department of Neurological Surgery, University of California, San Francisco, and Parkinson s Disease Research, Education, and Care Center, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    Neurosurgery 68:114-24; discussion 124. 2011
    ..The efficacy of deep brain stimulation (DBS) is highly dependent on the accuracy of lead placement...
  21. doi request reprint Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease
    Francisco Valles
    Movement Disorder Research Program, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94103, USA
    Neurosurgery 67:1377-85. 2010
    ....
  22. pmc Subthalamic nucleus deep brain stimulator placement using high-field interventional magnetic resonance imaging and a skull-mounted aiming device: technique and application accuracy
    Philip A Starr
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 112:479-90. 2010
    ....
  23. doi request reprint Abnormal T2-weighted MRI signal surrounding leads in a subset of deep brain stimulation patients
    Dario J Englot
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Stereotact Funct Neurosurg 89:311-7. 2011
    ..Interestingly, we have observed several instances of abnormal T2-weighted signal hyperintensity surrounding DBS leads on postoperative MRI that are not associated with hemorrhage or infection...
  24. doi request reprint Deep brain stimulator hardware-related infections: incidence and management in a large series
    Karl A Sillay
    Department of Neurosurgery, University of California, San Francisco, California 94143 0445, USA
    Neurosurgery 62:360-6; discussion 366-7. 2008
    ..Device-related infection is a common complication of deep brain stimulator (DBS) implantation. We reviewed the incidence and management of early hardware-related infections in a large series...
  25. ncbi request reprint Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome
    Efstathios Papavassiliou
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    Neurosurgery 54:1120-29; discussion 1129-30. 2004
    ..We examined the relation of lead location to clinical outcome in a series of essential tremor patients treated by thalamic DBS...