Research Topics
Species | JOHN R LARSONSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Automated study of simultaneous-cue olfactory discrimination learning in adult miceJohn Larson
Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Behav Neurosci 116:588-99. 2002..Good retention of olfactory cues was seen even at the longest memory delay. Automated testing of olfactory discriminations should be useful for assessing learning and memory abilities in genetically modified mice...- Olfactory discrimination learning deficit in heterozygous reeler miceJohn Larson
Department of Psychiatry, College of Medicine, University of Illinois, 1601 W Taylor St, Chicago, IL 60612, USA
Brain Res 971:40-6. 2003..Whether or not the olfactory learning deficit observed in HR mice is related to the low dendritic spine density or GAD67 reduction observed in hippocampus and cortex are currently under investigation... 
Extreme hypoxia tolerance of naked mole-rat brainJohn Larson
Department of Psychiatry, Psychiatric Institute, University of Illinois, Chicago, Illinois 60612, USA
Neuroreport 20:1634-7. 2009..We suggest that brain tolerance to hypoxia may result from slowed or arrested brain development in these extremely long-lived animals...- Age-dependent and selective impairment of long-term potentiation in the anterior piriform cortex of mice lacking the fragile X mental retardation proteinJohn Larson
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Neurosci 25:9460-9. 2005..No differences in hippocampal LTP were observed in WT and KO mice at any ages. The results indicate that FMRP deficiency is associated with an age-dependent and region-selective impairment in long-term synaptic plasticity... 
Olfactory discrimination learning in mice lacking the fragile X mental retardation proteinJohn Larson
Psychiatric Institute, Department of Psychiatry M C 912, College of Medicine, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
Neurobiol Learn Mem 90:90-102. 2008..Memory of these problems at two day delays did not differ between WT and KO mice. Tests using ethyl acetate demonstrated that WT and KO mice had similar odor detection thresholds...- Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampusNeil R Smalheiser
Department of Psychiatry and UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W Taylor Street, Chicago, IL 60612, USA
ASN Neuro 2:e00028. 2010..These in vivo results indicate that significant, dynamic and co-ordinated changes in miRNA expression accompany early stages of learning... - Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 miceYuan Shih Hu
Department of Anatomy and Cell Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
FASEB J 24:1667-81. 2010..This study suggests that environmental modulation can rescue the impaired phenotype of the Alzheimer's brain and that induction of brain plasticity may represent therapeutic and preventive avenues in AD... - Impaired olfactory discrimination learning and decreased olfactory sensitivity in aged C57Bl/6 miceRoseanne C Patel
Psychiatric Institute, Department of Psychiatry, College of Medicine, 1601 W Taylor St, M C 912, University of Illinois at Chicago, Chicago, IL 60612, USA
Neurobiol Aging 30:829-37. 2009..Old mice had significantly higher thresholds for discriminating ethyl acetate vapor from non-odorized air. The results suggest that mice may be a good model for study of olfactory dysfunction and cognitive deficits with aging... - Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient miceJohn Larson
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, 60612, USA
Neurosci Lett 393:23-6. 2006..These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes... - Immunocytochemical localization of reelin in the olfactory bulb of the heterozygous reeler mouse: an animal model for schizophreniaGeorge D Pappas
Department of Psychiatry, Psychiatric Institute, Department of Anatomy and Cell Biology, University of Illinois at Chicago, M C 912, 1601 W Taylor St, Chicago, IL 60612, USA
Neurol Res 25:819-30. 2003..Further studies of the HR mouse may provide a new basis for understanding the role of reelin in the adult CNS, especially as it may relate to schizophrenia... - Endogenous siRNAs and noncoding RNA-derived small RNAs are expressed in adult mouse hippocampus and are up-regulated in olfactory discrimination trainingNeil R Smalheiser
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
RNA 17:166-81. 2011..Further studies are warranted to characterize the role(s) played by endogenous siRNAs and noncoding RNA-derived small RNAs in learning and memory... - Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent mannerGiovanni Lugli
University of Illinois at Chicago, UIC Psychiatric Institute, Chicago, Illinois, USA
J Neurochem 94:896-905. 2005..This supports the hypothesis that dicer could be involved in synaptic plasticity... - Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrainGiovanni Lugli
Department of Psychiatry and Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois, USA
J Neurochem 106:650-61. 2008....
Research Grants
- Function of FMRP in the Mouse Olfactory SystemJohn Larson; Fiscal Year: 2007..Such new information would be vital for evaluating novel treatment strategies for a class of developmental disabilities. ..