D F Larson

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Senescent ventricular dysfunction: issues related to cardiopulmonary bypass
    D F Larson
    Circulatory Sciences Graduate Perfusion Program, Sarver Heart Center, Tucson, Arizona, USA
    J Extra Corpor Technol 32:142-7. 2000
  2. ncbi request reprint TGF-beta1 overexpression: a mechanism of diastolic filling dysfunction in the aged population
    Douglas F Larson
    Circulatory Science Graduate Perfusion Program, Sarver Heart Center, The University of Arizona College of Medicine, Tucson, Arizona, USA
    J Extra Corpor Technol 36:69-74. 2004
  3. pmc Macrophage migration inhibitory factor: controller of systemic inflammation
    Douglas F Larson
    Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Crit Care 10:138. 2006
  4. ncbi request reprint Comparison of tumor necrosis factor-alpha effect on the expression of iNOS in macrophage and cardiac myocytes
    D B Sanders
    Circulatory Sciences Graduate Perfusion Program, Sarver Heart Center, University of Arizona, Tucson 85724, USA
    Perfusion 16:67-74. 2001
  5. ncbi request reprint Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice
    J Shi
    Arizona Prevention Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Alcohol 24:197-204. 2001
  6. ncbi request reprint A role for T lymphocytes in mediating cardiac diastolic function
    Qianli Yu
    Department of Medical Pharmacology, School of Medicine, Univ of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Physiol Heart Circ Physiol 289:H643-51. 2005
  7. ncbi request reprint Validation of conductance catheter system for quantification of murine pressure-volume loops
    B Yang
    Department of Surgery, College of Medicine, University of Arizona, Tucson 85724, USA
    J Invest Surg 14:341-55. 2001
  8. pmc Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome
    Sherma Zibadi
    Sarver Heart Center, College of Medicine, Mel and Enid Zuckerman Arizona College of Public Health, The University of Arizona, Tucson, Arizona 85724, USA
    Am J Physiol Heart Circ Physiol 297:H976-82. 2009
  9. pmc Myocardial cytokine IL-8 and nitric oxide synthase activity during and after resuscitation: preliminary observations in regards to post-resuscitation myocardial dysfunction
    Karl B Kern
    Sarver Heart Center, University of Arizona College of Medicine, 1501 N Campbell, Tucson, AZ 85724, USA
    Resuscitation 77:401-9. 2008
  10. doi request reprint T lymphocyte regulation of lysyl oxidase in diet-induced cardiac fibrosis
    Sherma Zibadi
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Cardiovasc Toxicol 10:190-8. 2010

Research Grants

Collaborators

  • RONALD WATSON
  • B Yang
  • J J Marchalonis
  • K B Kern
  • Robert Allen Berg
  • Qianli Yu
  • Sherma Zibadi
  • Randy Vazquez
  • T Swyers
  • Katherine Horak
  • S G Hall
  • D Redford
  • E Hirleman
  • Yingying Liu
  • Emily D Hirleman
  • Jin Zhang
  • S Gentry-Smetana
  • Jonathan R Triana
  • Laura Buford Stacy
  • Stacy Dunaway
  • K Hunter
  • Cory M Alwardt
  • Victoria Dotson
  • Julie Beischel
  • Ramón Tomás Sepúlveda
  • Sergio Montes
  • J Garcia
  • M Gorman
  • R Smith
  • D B Sanders
  • D Bradford Sanders
  • J Shi
  • Chirag Patel
  • Raj Venkataramani
  • Derek Moore
  • Elham Vali Khojeini
  • D Moore
  • Mark Yanagihashi
  • Peter J Rohdewald
  • Heddwen L Brooks
  • Matthew R McReynolds
  • Jeffrey H Baxter
  • Tara Kelley
  • Tamara F Lundeen
  • Denise Slayback
  • Cory Alwardt
  • Dongqin Zhang
  • Jiaqi Shi
  • J Beischel
  • Y Wu
  • C Jablonowski
  • J J Bahl
  • S Montes

Detail Information

Publications31

  1. ncbi request reprint Senescent ventricular dysfunction: issues related to cardiopulmonary bypass
    D F Larson
    Circulatory Sciences Graduate Perfusion Program, Sarver Heart Center, Tucson, Arizona, USA
    J Extra Corpor Technol 32:142-7. 2000
    ....
  2. ncbi request reprint TGF-beta1 overexpression: a mechanism of diastolic filling dysfunction in the aged population
    Douglas F Larson
    Circulatory Science Graduate Perfusion Program, Sarver Heart Center, The University of Arizona College of Medicine, Tucson, Arizona, USA
    J Extra Corpor Technol 36:69-74. 2004
    ..These data provide a potential contributory mechanism for diastolic dysfunction that may be vital in caring for the aged open-heart surgical patient...
  3. pmc Macrophage migration inhibitory factor: controller of systemic inflammation
    Douglas F Larson
    Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Crit Care 10:138. 2006
    ..The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function...
  4. ncbi request reprint Comparison of tumor necrosis factor-alpha effect on the expression of iNOS in macrophage and cardiac myocytes
    D B Sanders
    Circulatory Sciences Graduate Perfusion Program, Sarver Heart Center, University of Arizona, Tucson 85724, USA
    Perfusion 16:67-74. 2001
    ..This study suggests that HL-1 myocyte iNOS cannot be induced by TNF-alpha, unlike macrophage iNOS. Furthermore, the resultant cardiac dysfunction, secondary to proinflammatory cytokines effects, is regulated via diverse pathways...
  5. ncbi request reprint Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice
    J Shi
    Arizona Prevention Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Alcohol 24:197-204. 2001
    ..05) and a 23% decrease in preload recruitable stroke work (P<.01). It was concluded that the differential cardiovascular function and response to acute ethanol..
  6. ncbi request reprint A role for T lymphocytes in mediating cardiac diastolic function
    Qianli Yu
    Department of Medical Pharmacology, School of Medicine, Univ of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Am J Physiol Heart Circ Physiol 289:H643-51. 2005
    ..Thus modulation of TH lymphocyte function could promote adaptive remodeling in heart failure and postmyocardial infarction...
  7. ncbi request reprint Validation of conductance catheter system for quantification of murine pressure-volume loops
    B Yang
    Department of Surgery, College of Medicine, University of Arizona, Tucson 85724, USA
    J Invest Surg 14:341-55. 2001
    ..0 +/- 0.5 mL/min, respectively. We validated the relationship between measured volume by conductance catheter and the true volume and demonstrated the accuracy of the volume-conductance line for conversion of conductance to volume...
  8. pmc Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome
    Sherma Zibadi
    Sarver Heart Center, College of Medicine, Mel and Enid Zuckerman Arizona College of Public Health, The University of Arizona, Tucson, Arizona 85724, USA
    Am J Physiol Heart Circ Physiol 297:H976-82. 2009
    ..Our data signify that diet-induced MetS alters the remodeling enzymes, mainly LOX, thereby altering ECM structure by increasing the amount of cross-linking and inducing diastolic dysfunction...
  9. pmc Myocardial cytokine IL-8 and nitric oxide synthase activity during and after resuscitation: preliminary observations in regards to post-resuscitation myocardial dysfunction
    Karl B Kern
    Sarver Heart Center, University of Arizona College of Medicine, 1501 N Campbell, Tucson, AZ 85724, USA
    Resuscitation 77:401-9. 2008
    ....
  10. doi request reprint T lymphocyte regulation of lysyl oxidase in diet-induced cardiac fibrosis
    Sherma Zibadi
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Cardiovasc Toxicol 10:190-8. 2010
    ..Our results suggest a role for T lymphocytes in this dietary induction of diastolic dysfunction through modulation of LOX-dependent collagen maturation...
  11. ncbi request reprint Impact of Pycnogenol on cardiac extracellular matrix remodeling induced by L-NAME administration to old mice
    Sherma Zibadi
    Nutritional Sciences Department, The University of Arizona, Tucson, AZ, USA
    Cardiovasc Toxicol 7:10-8. 2007
    ..These data indicate that Pycnogenol can prevent adverse myocardial remodeling induced by L-NAME, through modulating TIMP and MMPs gene expression, MMPs activity, and further reduction in myocardial collagen degradation rate...
  12. ncbi request reprint Direct effects of volatile anesthetics on cardiac function
    S Gentry-Smetana
    Circulatory Sciences Graduate Perfusion Program, The University of Arizona, Tucson, AZ 85724, USA
    Perfusion 23:43-7. 2008
    ..These data underscore the importance of using lower concentrations of volatile anesthetics during CPB especially during periods of cardiac recovery after aortic cross-clamp removal...
  13. ncbi request reprint Dilated cardiomyopathy in retrovirally infected mice: a novel model for silent viral DCM?
    Julie Beischel
    Sarver Heart Center, Tucson, AZ 85724, USA
    Cardiovasc Toxicol 4:317-25. 2004
    ..These findings support MAIDS retroviral infection as a new model of idiopathic DCM in which myo-carditis does not occur...
  14. pmc IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice
    Qianli Yu
    Surgery Department and Sarver Heart Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Heart Circ Physiol 297:H76-85. 2009
    ..These results provide direct evidence that the induction of IL-18 regulates OPN-mediated cardiac fibrosis and diastolic dysfunction...
  15. ncbi request reprint Comparative effects of dehydroepiandrosterone sulfate on ventricular diastolic function with young and aged female mice
    Cory M Alwardt
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Am J Physiol Regul Integr Comp Physiol 290:R251-6. 2006
    ..We conclude that exogenous DHEA(S) supplementation is capable of reversing the left ventricular stiffness and fibrosis that accompanies aging, with a paradoxical increased ventricular stiffness in young mice...
  16. ncbi request reprint Immunomodulation by immunopeptides and autoantibodies in aging, autoimmunity, and infection
    J J Marchalonis
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, 1501 N Campbell Avenue, Tucson, Arizona 85724, USA
    Ann N Y Acad Sci 1057:247-59. 2005
    ..An unexpected finding was an adaptive role of the T cells from peptide-treated mice in remodeling damaged hearts by increasing net collagen synthesis by cardiac fibroblasts...
  17. ncbi request reprint Modulation of the inflammatory response in the cardiomyocyte and macrophage
    D Bradford Sanders
    Circulatory Sciences Graduate Perfusion Program, Sarver Heart Center, University Medical Center, University of Arizona, Tucson 85724, USA
    J Extra Corpor Technol 33:167-74. 2001
    ..Likewise, therapeutic glucocorticoid administration could improve outcomes for patients with inflammatory cardiovascular disease states related to elevated NO production...
  18. ncbi request reprint Relationship of aging and cardiac IL-10
    Victoria Dotson
    The Circulatory Science Graduate Perfusion Program, Department of Surgery, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    J Extra Corpor Technol 36:197-201. 2004
    ..The use of therapeutics to modulate IL-10 and, thereby, optimizing regenerative processes in the injured myocardium may provide a unique means for the cardiac patient...
  19. ncbi request reprint Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodeling
    Qianli Yu
    Sarver Heart Center and Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Hypertension 48:98-104. 2006
    ..These data support the concept that the T lymphocytes may play a fundamental regulatory role in cardiac ECM composition through modulation of collagen synthesis, degradation, and cross-linking...
  20. ncbi request reprint Modulation of iNOS activity in age-related cardiac dysfunction
    Bo Yang
    University Heart Center and Department of Surgery, The University of Arizona, Room 4402, Tucson, AZ 85724, USA
    Life Sci 75:655-67. 2004
    ..In conclusion, these results suggested that the iNOS/NO/cGMP pathway may contribute to ventricular dysfunction during the aging process and that inhibition of iNOS activity significantly improved heart function in aged mice...
  21. ncbi request reprint Characterization of high-salt and high-fat diets on cardiac and vascular function in mice
    Qianli Yu
    College of Public Health, School of Medicine, Health Promotion Science Division, University of Arizona, Tucson, AZ 85724, USA
    Cardiovasc Toxicol 4:37-46. 2004
    ..These data suggest that the HFHSC diet causes dilated cardio-myopathy, whereas the HS diet produces arterial hypertension and the HFHS diet causes a vascular dysfunctional state that was highly responsive to alpha-adrenergic stimulation...
  22. doi request reprint Volatile anesthetic-induced preconditioning
    T Swyers
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ, USA
    Perfusion 29:10-5. 2014
    ..This report will, therefore, discuss the mechanism, safety and efficacy of volatile anesthetics as inducers of cardiac preconditioning. ..
  23. doi request reprint Cardiac power index: staging heart failure for mechanical circulatory support
    S G Hall
    Circulatory Sciences Graduate Perfusion Program, The University of Arizona, Tucson, Arizona, USA
    Perfusion 27:456-61. 2012
    ..05) in this patient population. These results showed that a cardiac power index at or below 0.34 Watts/m(2) resulted in increased mortality rate, ninety days post-implantation...
  24. doi request reprint Cardiopulmonary bypass and edema: physiology and pathophysiology
    E Hirleman
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Perfusion 23:311-22. 2008
    ..Therefore, this review will focus on the physiology of fluid homeostasis and the pathologies of fluid shifts during CPB which lead to general edema as well as tissue-specific edema...
  25. ncbi request reprint Lusitropic effects of dobutamine in young and aged mice in vivo
    Emily D Hirleman
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, Arizona 85724, USA
    J Extra Corpor Technol 40:10-5. 2008
    ..Because the patient population requiring CPB is aging, these data suggest that the use of dobutamine at the terminal phase of CPB is warranted to increase systolic and diastolic function...
  26. ncbi request reprint Effects of chronic methamphetamine exposure on heart function in uninfected and retrovirus-infected mice
    Qianli Yu
    College of Public Health, School of Medicine, Health Promotion Science Division, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Life Sci 71:953-65. 2002
    ..These data suggest that MA induced myocardial cellular changes compensate for retrovirus induced DCM...
  27. ncbi request reprint Effect of acute alpha adrenergic stimulation on cardiac function
    Stacy Dunaway
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Perfusion 22:289-92. 2007
    ..It is important to identify the effect of PE, especially on cardiac function. This study was intended to show the effects of PE on cardiac function in the murine model via pressure-volume loops...
  28. ncbi request reprint Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities
    Laura Buford Stacy
    Sarver Heart Center, Circulatory Sciences Graduate Perfusion Program, College of Medicine, The University of Arizona, Tucson 85724, USA
    Perfusion 22:51-5. 2007
    ..Thus, Ang II and AT1-R and AT2-R differentially affect the collagenase and gelatinase MMPs activities released by cardiac fibroblasts...
  29. ncbi request reprint Mathematical modeling of buffers used in myocardial preservation
    Jonathan R Triana
    Sarver Heart Center, College of Medicine, The University of Arizona, Tucson, AZ 85724, USA
    Perfusion 22:353-62. 2007
    ..Our hypothesis is that mathematical modeling of three clinically used buffers will define their individual buffering capacities under simulated clinical conditions...
  30. ncbi request reprint Side-stream cigarette smoke induces dose-response in systemic inflammatory cytokine production and oxidative stress
    Jin Zhang
    Health Promotion Science Division, College of Public Health, and Sarver Heart Center, The University of Arizona Health Science Center, Tucson 85724, USA
    Exp Biol Med (Maywood) 227:823-9. 2002
    ..Exploring the mechanism of vascular dysfunction in mice is warranted. A more precise quantification of the smoking exposure dose in mice needs to be determined as well...
  31. ncbi request reprint Cocaethylene and heart disease during murine AIDS
    Yingying Liu
    Health Promotion Sciences, College of Public Health, University of Arizona, Tucson 85724, USA
    Int Immunopharmacol 2:139-50. 2002
    ..Both CMV and retrovirus infection suppressed the Th1 response. Our data suggest that cocaethylene treatment shifts the cytokine balance and suppresses Th1 response particularly, facilitating increased CVB3- or CMV-induced myocarditis...

Research Grants5

  1. Immunomodulation: Cardiovascular Structure and Function
    Douglas Larson; Fiscal Year: 2006
    ..The potential outcome of these studies will be a discovery of a new and novel pathway that will result in innovative therapeutic approaches for the treatment of hypertension, diastolic dysfunction, and heart failure. ..
  2. Immunomodulation: Cardiovascular Structure and Function
    Douglas Larson; Fiscal Year: 2007
    ..The potential outcome of these studies will be a discovery of a new and novel pathway that will result in innovative therapeutic approaches for the treatment of hypertension, diastolic dysfunction, and heart failure. ..
  3. Immunomodulation: Cardiovascular Structure and Function
    Douglas Larson; Fiscal Year: 2009
    ..The potential outcome of these studies will be a discovery of a new and novel pathway that will result in innovative therapeutic approaches for the treatment of hypertension, diastolic dysfunction, and heart failure. ..
  4. Blocking Hypertension by Regulatory T-lymphocytes
    Douglas F Larson; Fiscal Year: 2010
    ..The future of this research will be to develop selective antagonists to our proposed immune based pathogenesis of vascular remodeling to reduce the formation of cross-links and thereby reduce vascular stiffness. ..