A A Larson

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Zinc in the extracellular area of the central nervous system is necessary for the development of kainic acid-induced persistent hyperalgesia in mice
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Pain 86:177-84. 2000
  2. ncbi request reprint Intrathecal Zn2+ attenuates morphine antinociception and the development of acute tolerance
    A A Larson
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 295 Animal Science Veterinary Medicine Building, Saint Paul, MN 55108, USA
    Eur J Pharmacol 407:267-72. 2000
  3. ncbi request reprint Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways
    A A Larson
    Graduate Program in Neuroscience, 295 Animal Science Veterinary Medicine Building, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Pain 87:201-11. 2000
  4. ncbi request reprint Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice
    A A Larson
    Graduate Program in Neuroscience, Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Pain 86:103-11. 2000
  5. ncbi request reprint Chelation of zinc in the extracellular area of the spinal cord, using ethylenediaminetetraacetic acid disodium-calcium salt or dipicolinic acid, inhibits the antinociceptive effect of capsaicin in adult mice
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    J Pharmacol Exp Ther 288:759-65. 1999
  6. ncbi request reprint Nociceptive aspects of fibromyalgia
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Curr Pain Headache Rep 5:338-46. 2001
  7. ncbi request reprint MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate
    X Sun
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuroscience 54:773-9. 1993
  8. ncbi request reprint Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuropharmacology 32:909-17. 1993
  9. ncbi request reprint Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite
    K J Kovacs
    Department of Veterinary Pathobiology, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, St Paul, MN 55108, USA
    Eur J Neurosci 14:577-84. 2001
  10. ncbi request reprint MK-801 inhibits the effects of capsaicin in the adult mouse by an action involving phencyclidine (PCP) sites not linked to NMDA activity
    X Sun
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuroreport 4:1147-50. 1993

Collaborators

  • Jon Russell
  • Y Cai
  • K J Kovacs
  • T M Laughlin
  • X Sun
  • G L Wilcox
  • S R Skilling
  • A J Beitz
  • D H Smullin

Detail Information

Publications12

  1. ncbi request reprint Zinc in the extracellular area of the central nervous system is necessary for the development of kainic acid-induced persistent hyperalgesia in mice
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Pain 86:177-84. 2000
    ..Together these data suggest that, while not translocated, zinc in the extracellular area is necessary but not sufficient for the development of kainic acid-induced hyperalgesia...
  2. ncbi request reprint Intrathecal Zn2+ attenuates morphine antinociception and the development of acute tolerance
    A A Larson
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, 295 Animal Science Veterinary Medicine Building, Saint Paul, MN 55108, USA
    Eur J Pharmacol 407:267-72. 2000
    ..These data suggest that the availability of Zn2+ is an important factor in opioid activity...
  3. ncbi request reprint Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways
    A A Larson
    Graduate Program in Neuroscience, 295 Animal Science Veterinary Medicine Building, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Pain 87:201-11. 2000
    ..Together these metabolic changes that covary with the intensity of pain in patients with FMS may reflect increased EAA release and a positive modulation of NMDA receptors by glycine, perhaps resulting in enhanced synthesis of NO...
  4. ncbi request reprint Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice
    A A Larson
    Graduate Program in Neuroscience, Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    Pain 86:103-11. 2000
    ..Together these data indicate that brief changes in the activity of nNOS induce both long- as well as short-term changes in nociception...
  5. ncbi request reprint Chelation of zinc in the extracellular area of the spinal cord, using ethylenediaminetetraacetic acid disodium-calcium salt or dipicolinic acid, inhibits the antinociceptive effect of capsaicin in adult mice
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108, USA
    J Pharmacol Exp Ther 288:759-65. 1999
    ..Thus, zinc appears to be necessary, but may not be sufficient, for the long-term antinociceptive effect of capsaicin, acting downstream from the action of substance P N-terminal metabolites...
  6. ncbi request reprint Nociceptive aspects of fibromyalgia
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, 1988 Fitch Avenue, St Paul, MN 55108, USA
    Curr Pain Headache Rep 5:338-46. 2001
    ..Based on this approach, examples are proposed of factors that fulfill some criteria and may, therefore, deserve further study for their possible role in pain associated with FMS...
  7. ncbi request reprint MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate
    X Sun
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuroscience 54:773-9. 1993
    ..Together, these data suggest that MK-801 and phencyclidine inhibit behavioral sensitization to kainate via phencyclidine receptors that are not linked to the N-methyl-D-aspartate receptor complex.(ABSTRACT TRUNCATED AT 250 WORDS)..
  8. ncbi request reprint Regulation of sigma activity by the amino-terminus of substance P in the mouse spinal cord: involvement of phencyclidine (PCP) sites not linked to N-methyl-D-aspartate (NMDA) activity
    A A Larson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuropharmacology 32:909-17. 1993
    ..5 pmol) or DTG (5 nmol), suggesting sensitization to the effects of these compounds.(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. ncbi request reprint Neuronal nitric oxide synthase (nNOS) mRNA is down-regulated, and constitutive NOS enzymatic activity decreased, in thoracic dorsal root ganglia and spinal cord of the rat by a substance P N-terminal metabolite
    K J Kovacs
    Department of Veterinary Pathobiology, University of Minnesota, 295 Animal Science/Veterinary Medicine Building, St Paul, MN 55108, USA
    Eur J Neurosci 14:577-84. 2001
    ..These data suggest that N-terminal SP fragments, which are known to cause long-term antinociception in the writhing assay, may do so by their ability to down-regulate NO synthesis along nociceptive pathways...
  10. ncbi request reprint MK-801 inhibits the effects of capsaicin in the adult mouse by an action involving phencyclidine (PCP) sites not linked to NMDA activity
    X Sun
    Department of Veterinary Pathobiology, University of Minnesota, St Paul 55108
    Neuroreport 4:1147-50. 1993
    ....
  11. ncbi request reprint Extracellular amino acid concentrations in the dorsal spinal cord of freely moving rats following veratridine and nociceptive stimulation
    S R Skilling
    Department of Veterinary Biology, University of Minnesota, St Paul 55108
    J Neurochem 51:127-32. 1988
    ..These data support the hypothesis that Glu and Asp are dorsal horn neurotransmitters involved in nociception...
  12. ncbi request reprint Mechanisms of induction of persistent nociception by dynorphin
    T M Laughlin
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    J Pharmacol Exp Ther 299:6-11. 2001
    ..Thus, it is hypothesized that dynorphin has both physiological and pathological roles in acute and chronic pain states...