Research Topics
Genomes and Genes | Nicole LaRonde-LeBlancSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Defense systems up: structure of subtype I-C/Dvulg CRISPR/CasNicole A LaRonde-LeBlanc
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 4454, USA
Structure 20:1450-2. 2012..In this issue of Structure, Nam and colleagues provide new clues to deciphering these complex systems in the characterization of a subtype I-C CRISPR/Cas complex...
Tv-RIO1 - an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinusMin Hu
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
Parasit Vectors 1:34. 2008..abstract:..- Regulation of active site coupling in glutamine-dependent NAD(+) synthetaseNicole LaRonde-LeBlanc
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 2021, USA
Nat Struct Mol Biol 16:421-9. 2009.... - Structural basis for inhibition of translation by the tumor suppressor Pdcd4Nicole LaRonde-LeBlanc
Macromolecular Crystallography Laboratory, CCR, National Cancer Institute, Frederick, MD 21702, USA
Mol Cell Biol 27:147-56. 2007..Finally, our structural analysis reveals MA3 domains to be a novel subfamily of VHS domains... 
Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexesNicole LaRonde-LeBlanc
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
FEBS J 272:2800-10. 2005..These results give us further information about the nature of the active site of Rio2 kinase and suggest a mechanism of regulation of its enzymatic activity...- Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinasesNicole LaRonde-LeBlanc
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702, USA
Structure 12:1585-94. 2004..These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases... - Structure and activity of the atypical serine kinase Rio1Nicole LaRonde-LeBlanc
Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
FEBS J 272:3698-713. 2005..In addition, we show that a mutant enzyme that cannot be autophosphorylated can still phosphorylate an inactive form of Rio1, as well as a number of typical kinase substrates... - Pathological crystallography: case studies of several unusual macromolecular crystalsZbigniew Dauter
Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute and Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
Acta Crystallogr D Biol Crystallogr 61:967-75. 2005..Ways of identifying the observed phenomena and approaches to solving and refining macromolecular structures when only less than perfect crystals are available are discussed here... - Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GIHalina Zakowicz
Laboratory of Cancer Prevention, Bldg. 576, Rm. 101, National Cancer Institute, Frederick, MD 21702, USA
RNA 11:261-74. 2005..A competition experiment revealed that Pdcd4 competes with C-terminal eIF4G for binding to eIF4A. In summary, the Pdcd4-binding domains on eIF4A impact both binding to eIF4G and translation initiation in cells... - Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activityIrene N Kiburu
Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland, United States of America
PLoS ONE 7:e37371. 2012.... - Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycinJianting Zheng
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
J Mol Biol 387:1250-60. 2009.... - Structural and biochemical studies of the open state of Lys48-linked diubiquitinMing Yih Lai
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
Biochim Biophys Acta 1823:2046-56. 2012..This article is part of a Special Issue entitled: Ubiquitin Drug Discovery and Diagnostics... - Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glandsSeth R Thomas
Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland 20742, USA
J Biol Chem 284:19659-67. 2009..These structures now also provide a molecular basis for understanding thyroid disease based on mutations of IYD... - A family portrait of the RIO kinasesNicole LaRonde-LeBlanc
Protein Structure Section, Macromolecular Crystallography Laboratory, NCI Frederick, National Institutes of Health, MD 21702 1201, USA
J Biol Chem 280:37297-300. 2005..Although it has been shown that both Rio1 and Rio2 have the enzymatic activity of kinases and are capable of autophosphorylation, the biological substrates of RIO proteins and their full biological role still remain to be discovered... - The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progressionNicole LaRonde-LeBlanc
Protein Structure Section, Macromolecular Crystallography Laboratory, NCI Frederick, Bldg 536, Rm 5, Frederick, MD 21702 1201, USA
Biochim Biophys Acta 1754:14-24. 2005..cerevisiae and required for proper cell cycle progression and chromosome maintenance, the biological substrates of RIO proteins still remain to be identified... - Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuoleJennifer Smith
Department of Cell Biology and Molecular Genetics and Maryland Pathogens Research Institute, University of Maryland, College Park, Maryland 20742, USA
Infect Immun 76:5478-87. 2008..marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection...