Nicole LaRonde-LeBlanc

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity
    Irene N Kiburu
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e37371. 2012
  2. pmc Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis
    Seth R Thomas
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 39:2445-57. 2011
  3. ncbi request reprint Defense systems up: structure of subtype I-C/Dvulg CRISPR/Cas
    Nicole A LaRonde-LeBlanc
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 4454, USA
    Structure 20:1450-2. 2012
  4. pmc Tv-RIO1 - an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
    Min Hu
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Parasit Vectors 1:34. 2008
  5. pmc Structural basis for inhibition of translation by the tumor suppressor Pdcd4
    Nicole LaRonde-LeBlanc
    Macromolecular Crystallography Laboratory, CCR, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell Biol 27:147-56. 2007
  6. doi request reprint Regulation of active site coupling in glutamine-dependent NAD(+) synthetase
    Nicole LaRonde-LeBlanc
    Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 2021, USA
    Nat Struct Mol Biol 16:421-9. 2009
  7. ncbi request reprint Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
    FEBS J 272:2800-10. 2005
  8. ncbi request reprint Structure and activity of the atypical serine kinase Rio1
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
    FEBS J 272:3698-713. 2005
  9. ncbi request reprint Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702, USA
    Structure 12:1585-94. 2004
  10. ncbi request reprint Pathological crystallography: case studies of several unusual macromolecular crystals
    Zbigniew Dauter
    Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute and Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
    Acta Crystallogr D Biol Crystallogr 61:967-75. 2005

Collaborators

Detail Information

Publications18

  1. pmc Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity
    Irene N Kiburu
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland, United States of America
    PLoS ONE 7:e37371. 2012
    ....
  2. pmc Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis
    Seth R Thomas
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA
    Nucleic Acids Res 39:2445-57. 2011
    ..Finally, a uridine base is bound in the active site of Nep1, positioned for a methyltransfer at the C5 position, supporting its role as an N1-specific pseudouridine methyltransferase...
  3. ncbi request reprint Defense systems up: structure of subtype I-C/Dvulg CRISPR/Cas
    Nicole A LaRonde-LeBlanc
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 4454, USA
    Structure 20:1450-2. 2012
    ..In this issue of Structure, Nam and colleagues provide new clues to deciphering these complex systems in the characterization of a subtype I-C CRISPR/Cas complex...
  4. pmc Tv-RIO1 - an atypical protein kinase from the parasitic nematode Trichostrongylus vitrinus
    Min Hu
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Parasit Vectors 1:34. 2008
    ..While there is some information about RIO kinases and their roles in animals, nothing is known about them in parasites. This is the first study to characterise a RIO1 kinase from any parasite...
  5. pmc Structural basis for inhibition of translation by the tumor suppressor Pdcd4
    Nicole LaRonde-LeBlanc
    Macromolecular Crystallography Laboratory, CCR, National Cancer Institute, Frederick, MD 21702, USA
    Mol Cell Biol 27:147-56. 2007
    ..Finally, our structural analysis reveals MA3 domains to be a novel subfamily of VHS domains...
  6. doi request reprint Regulation of active site coupling in glutamine-dependent NAD(+) synthetase
    Nicole LaRonde-LeBlanc
    Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 2021, USA
    Nat Struct Mol Biol 16:421-9. 2009
    ....
  7. ncbi request reprint Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
    FEBS J 272:2800-10. 2005
    ..These results give us further information about the nature of the active site of Rio2 kinase and suggest a mechanism of regulation of its enzymatic activity...
  8. ncbi request reprint Structure and activity of the atypical serine kinase Rio1
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702 1201, USA
    FEBS J 272:3698-713. 2005
    ..In addition, we show that a mutant enzyme that cannot be autophosphorylated can still phosphorylate an inactive form of Rio1, as well as a number of typical kinase substrates...
  9. ncbi request reprint Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI Frederick, MD 21702, USA
    Structure 12:1585-94. 2004
    ..These discoveries have implications in determining the target and function of RIO proteins and define a distinct new family of protein kinases...
  10. ncbi request reprint Pathological crystallography: case studies of several unusual macromolecular crystals
    Zbigniew Dauter
    Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute and Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
    Acta Crystallogr D Biol Crystallogr 61:967-75. 2005
    ..Ways of identifying the observed phenomena and approaches to solving and refining macromolecular structures when only less than perfect crystals are available are discussed here...
  11. pmc Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI
    Halina Zakowicz
    Laboratory of Cancer Prevention, Bldg 576, Rm 101, National Cancer Institute, Frederick, MD 21702, USA
    RNA 11:261-74. 2005
    ..A competition experiment revealed that Pdcd4 competes with C-terminal eIF4G for binding to eIF4A. In summary, the Pdcd4-binding domains on eIF4A impact both binding to eIF4G and translation initiation in cells...
  12. doi request reprint Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin
    Jianting Zheng
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    J Mol Biol 387:1250-60. 2009
    ....
  13. pmc Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 Å resolution
    Xue Fei
    Center for Biological Structure and Organization, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 110:E2958-66. 2013
    ..Here, however, these conformational states are shown to exist as a structurally heterogeneous ensemble within a single ring. ..
  14. pmc Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands
    Seth R Thomas
    Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland 20742, USA
    J Biol Chem 284:19659-67. 2009
    ..These structures now also provide a molecular basis for understanding thyroid disease based on mutations of IYD...
  15. pmc Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole
    Jennifer Smith
    Department of Cell Biology and Molecular Genetics and Maryland Pathogens Research Institute, University of Maryland, College Park, Maryland 20742, USA
    Infect Immun 76:5478-87. 2008
    ..marinum escape from the vacuole and cell-to-cell spread. Our study provides new insight into the mechanism by which ESX-1 secretion and ESAT-6 enhance the virulence of mycobacterial infection...
  16. pmc Structural and biochemical studies of the open state of Lys48-linked diubiquitin
    Ming Yih Lai
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Biochim Biophys Acta 1823:2046-56. 2012
    ..This article is part of a Special Issue entitled: Ubiquitin Drug Discovery and Diagnostics...
  17. ncbi request reprint A family portrait of the RIO kinases
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, NCI Frederick, National Institutes of Health, MD 21702 1201, USA
    J Biol Chem 280:37297-300. 2005
    ..Although it has been shown that both Rio1 and Rio2 have the enzymatic activity of kinases and are capable of autophosphorylation, the biological substrates of RIO proteins and their full biological role still remain to be discovered...
  18. ncbi request reprint The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression
    Nicole LaRonde-LeBlanc
    Protein Structure Section, Macromolecular Crystallography Laboratory, NCI Frederick, Bldg 536, Rm 5, Frederick, MD 21702 1201, USA
    Biochim Biophys Acta 1754:14-24. 2005
    ..cerevisiae and required for proper cell cycle progression and chromosome maintenance, the biological substrates of RIO proteins still remain to be identified...