Joseph Larner

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Fasting decreases the content of D-chiroinositol in human skeletal muscle
    Pavel N Shashkin
    Department of Internal Medicine, University of Virginia Charlottesville, Charlottesville, Virginia, USA
    Int J Exp Diabetes Res 3:163-9. 2002
  2. ncbi request reprint Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0735, USA
    J Med Chem 46:3283-91. 2003
  3. pmc D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Int J Exp Diabetes Res 3:47-60. 2002
  4. ncbi request reprint Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls
    Tie Hua Sun
    Insmed Incorporated, 4851 Lake Brooke Dr, Glen Allen, VA 23060, USA
    Biochem Biophys Res Commun 293:1092-8. 2002
  5. ncbi request reprint How I became a biochemical pharmacologist
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    IUBMB Life 55:111-3. 2003
  6. pmc D-chiro-inositol glycans in insulin signaling and insulin resistance
    Joseph Larner
    Allomed Pharmaceuticals, Charlottesville, Virginia, United States of America
    Mol Med 16:543-52. 2010
  7. ncbi request reprint Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls
    Douglas Heimark
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22903 USA
    Endocr J 61:111-7. 2014

Collaborators

Detail Information

Publications7

  1. pmc Fasting decreases the content of D-chiroinositol in human skeletal muscle
    Pavel N Shashkin
    Department of Internal Medicine, University of Virginia Charlottesville, Charlottesville, Virginia, USA
    Int J Exp Diabetes Res 3:163-9. 2002
    ....
  2. ncbi request reprint Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0735, USA
    J Med Chem 46:3283-91. 2003
    ..To our knowledge, this is the first example of a beta-1,4-linked inositol glycan consisting of D-chiro-inositol and galactosamine isolated from animal tissues with insulin mimetic actions...
  3. pmc D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    Int J Exp Diabetes Res 3:47-60. 2002
    ..Thus, administered D-chiro-inositol may act to bypass a defective normal epimerization of myo-inositol to D-chiro-inositol associated with insulin resistance and act to at least partially restore insulin sensitivity and glucose disposal...
  4. ncbi request reprint Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls
    Tie Hua Sun
    Insmed Incorporated, 4851 Lake Brooke Dr, Glen Allen, VA 23060, USA
    Biochem Biophys Res Commun 293:1092-8. 2002
    ..Further it may also possibly play a role in the underlying insulin resistance...
  5. ncbi request reprint How I became a biochemical pharmacologist
    Joseph Larner
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA
    IUBMB Life 55:111-3. 2003
  6. pmc D-chiro-inositol glycans in insulin signaling and insulin resistance
    Joseph Larner
    Allomed Pharmaceuticals, Charlottesville, Virginia, United States of America
    Mol Med 16:543-52. 2010
    ..The metabolism of DCI is associated with insulin sensitivity and resistance, supporting the concept that second messengers have a role in responses to and resistance to insulin...
  7. ncbi request reprint Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls
    Douglas Heimark
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22903 USA
    Endocr J 61:111-7. 2014
    ..Further biochemical and genetic studies will probe the mechanisms involved. ..