Nichole E LaPointe

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro
    Nichole E LaPointe
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA
    Biochemistry 48:12290-7. 2009
  2. pmc Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    Nicholas M Kanaan
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:9858-68. 2011
  3. pmc The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity
    Nichole E LaPointe
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Neurosci Res 87:440-51. 2009

Collaborators

Detail Information

Publications3

  1. pmc Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro
    Nichole E LaPointe
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, 60611, USA
    Biochemistry 48:12290-7. 2009
    ..Taken together, these results indicate that the 6P/6D isoforms are potential endogenous inhibitors of tau filament formation and suggest a mechanism by which this ability may be disrupted in disease...
  2. pmc Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    Nicholas M Kanaan
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:9858-68. 2011
    ..Results from these studies reveal a novel role for tau in modulating axonal phosphotransferases and provide a molecular basis for a toxic gain-of-function associated with pathogenic forms of tau...
  3. pmc The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity
    Nichole E LaPointe
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Neurosci Res 87:440-51. 2009
    ..Our results suggest that pathological tau aggregation contributes to neurodegeneration by altering a regulatory pathway for FAT...