Li-xing Lao

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: application to a randomized controlled acupuncture trial
    Lixing Lao
    Center for Integrative Medicine, University of Maryland, School of Medicine, East Hall, 520 W Lombard Street, Baltimore, MD 21201, USA
    Stat Med 31:619-27. 2012
  2. ncbi [Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials]
    MING T TAN
    Division of Biostatistics and Bioinformatics, University of Maryland School of Medicine, Baltimore, Maryland 21021, USA
    Zhong Xi Yi Jie He Xue Bao 10:847-52. 2012
  3. pmc Adverse events of acupuncture: a systematic review of case reports
    Shifen Xu
    Acupuncture Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China Center for Integrative Medicine, School of Medicine, University of Maryland, East Hall, 520 W Lombard Street, Baltimore, MD 21201, USA
    Evid Based Complement Alternat Med 2013:581203. 2013
  4. pmc The efficacy and safety study of electro-acupuncture for severe chronic functional constipation: study protocol for a multicenter, randomized, controlled trial
    Zhishun Liu
    GuangAn Men Hospital, China Academy of Chinese Medical Sciences, No 5, Beixiange street, Xicheng District Beijing 100053, China
    Trials 14:176. 2013
  5. pmc Effectiveness Guidance Document (EGD) for acupuncture research - a consensus document for conducting trials
    Claudia M Witt
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    BMC Complement Altern Med 12:148. 2012
  6. pmc Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats
    Ming Yi
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, China
    Mol Pain 7:61. 2011
  7. pmc Perception of Deqi by Chinese and American acupuncturists: a pilot survey
    Kathleen Kks Hui
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Chin Med 6:2. 2011
  8. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
  9. pmc Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 7:27. 2007
  10. ncbi [Evaluating the effects of acupuncture on knee osteoarthritis: a stepwise approach to research, University of Maryland experience]
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21207, USA
    Zhong Xi Yi Jie He Xue Bao 3:421-5. 2005

Collaborators

Detail Information

Publications49

  1. pmc Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: application to a randomized controlled acupuncture trial
    Lixing Lao
    Center for Integrative Medicine, University of Maryland, School of Medicine, East Hall, 520 W Lombard Street, Baltimore, MD 21201, USA
    Stat Med 31:619-27. 2012
    ..TCM study design entails all the challenges encountered in trials of drugs, devices, and surgical procedures in the Western medicine. We present possible solutions to some but leave many issues unresolved...
  2. ncbi [Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials]
    MING T TAN
    Division of Biostatistics and Bioinformatics, University of Maryland School of Medicine, Baltimore, Maryland 21021, USA
    Zhong Xi Yi Jie He Xue Bao 10:847-52. 2012
    ..The purpose of this paper is to inspire further discussion of such special issues in clinical research design and thus contribute to the increased scientific rigor of TCM research...
  3. pmc Adverse events of acupuncture: a systematic review of case reports
    Shifen Xu
    Acupuncture Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China Center for Integrative Medicine, School of Medicine, University of Maryland, East Hall, 520 W Lombard Street, Baltimore, MD 21201, USA
    Evid Based Complement Alternat Med 2013:581203. 2013
    ..Although the route of infection had changed, infections were still the major complication of acupuncture. Clearly, guidelines such as Clean Needle Technique must be followed in order to minimize acupuncture AEs...
  4. pmc The efficacy and safety study of electro-acupuncture for severe chronic functional constipation: study protocol for a multicenter, randomized, controlled trial
    Zhishun Liu
    GuangAn Men Hospital, China Academy of Chinese Medical Sciences, No 5, Beixiange street, Xicheng District Beijing 100053, China
    Trials 14:176. 2013
    ..We report a protocol for a randomized controlled trial using EA to confirm the efficacy and safety for severe chronic functional constipation...
  5. pmc Effectiveness Guidance Document (EGD) for acupuncture research - a consensus document for conducting trials
    Claudia M Witt
    Institute for Social Medicine, Epidemiology and Health Economics, Charite University Medical Center, Berlin, Germany
    BMC Complement Altern Med 12:148. 2012
    ..The aim of this EGD is to provide specific recommendations for the design of prospective acupuncture studies to support optimal use of resources for generating evidence that will inform stakeholder decision-making...
  6. pmc Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats
    Ming Yi
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, China
    Mol Pain 7:61. 2011
    ..Overall, these results demonstrated distinct anti-nociceptive effects and mechanisms between different stimulating sides and implied the necessity of finding the best stimulating protocols for different pain states...
  7. pmc Perception of Deqi by Chinese and American acupuncturists: a pilot survey
    Kathleen Kks Hui
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Chin Med 6:2. 2011
    ..abstract:..
  8. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
    ..This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia...
  9. pmc Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 7:27. 2007
    ..However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model...
  10. ncbi [Evaluating the effects of acupuncture on knee osteoarthritis: a stepwise approach to research, University of Maryland experience]
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21207, USA
    Zhong Xi Yi Jie He Xue Bao 3:421-5. 2005
    ..Their successful experience may be a useful model for future acupuncture and TCM research...
  11. ncbi Acupuncture practice, past and present: is it safe and effective?
    Lixing Lao
    Center for Integrative Medicine, University of Maryland School of Medicine, Kernan Hospital, Baltimore, MD 21207, USA
    J Soc Integr Oncol 4:13-5. 2006
    ..However, basic scientific studies on the mechanisms of acupuncture and well-designed randomized clinical trials that permit objective evaluation of this ancient science are urgently needed...
  12. ncbi Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, Department of Family Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, 3rd Floor, Baltimore, MD 21207, USA
    Am J Chin Med 34:833-44. 2006
    ..The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord...
  13. ncbi Commentary on Sood et al.: "Cochrane systematic reviews in acupuncture: methodological diversity in database searching"
    Lixing Lao
    Center for Integrative Medicine, University of Maryland, Baltimore, MD 21207, USA
    J Altern Complement Med 11:723-4. 2005
  14. ncbi The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets
    Lixing Lao
    Complementary Medicine Program, Department of Family Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 74:691-9. 2003
    ..05). The present study suggests that acupuncture may be useful as an adjunctive therapy in the treatment of chemotherapy-induced emesis...
  15. ncbi [Acupuncture clinical studies and evidence-based medicine--an update]
    Li Xing Lao
    Center for Integrative Medicine, Department of Family Medicine, University of Maryland, Baltimore, MD 21207, USA
    Zhen Ci Yan Jiu 33:53-61. 2008
    ....
  16. ncbi [Recommendations for enhancing the quality of traditional Chinese medicine clinical research reporting]
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Zhong Xi Yi Jie He Xue Bao 2:402-6. 2004
    ..TCM journal editors, who serve as gatekeepers of quality, must encourage higher quality clinical research reporting by setting and upholding publication standards...
  17. ncbi A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
    Brain Res 1020:18-29. 2004
    ..The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain...
  18. ncbi Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1020:12-7. 2004
    ..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain...
  19. ncbi Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1048:235-40. 2005
    ..These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia...
  20. ncbi Variability in the traditional Chinese medicine (TCM) diagnoses and herbal prescriptions provided by three TCM practitioners for 40 patients with rheumatoid arthritis
    Grant G Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    J Altern Complement Med 11:415-21. 2005
    ....
  21. ncbi The variability of TCM pattern diagnosis and herbal prescription on rheumatoid arthritis patients
    Grant G Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA
    Altern Ther Health Med 10:58-63. 2004
    ..The consistency of diagnosis made among Traditional Chinese Medicine (TCM) practitioners and the relationship between TCM diagnosis and Chinese herbal prescription have not been adequately examined...
  22. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  23. ncbi Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats
    Bing Liu
    Center for Integrative Medicine, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1044:87-92. 2005
    ..The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways...
  24. ncbi Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Pain 118:125-36. 2005
    ..Further, bone cancer activates spinal glial cells, which may release IL-1beta and other cytokines and contribute to hyperalgesia...
  25. doi Improvement of agreement in TCM diagnosis among TCM practitioners for persons with the conventional diagnosis of rheumatoid arthritis: effect of training
    Grant G Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    J Altern Complement Med 14:381-6. 2008
    ..To investigate whether a training process that focused on consensus on Traditional Chinese Medicine (TCM) diagnostic criteria will improve the agreement of TCM diagnosis on patients with rheumatoid arthritis (RA)...
  26. ncbi Involvement of peripheral opioid mechanisms in electroacupuncture analgesia
    Grant G Zhang
    Complementary Medicine Program, University of Maryland School of Medicine, Baltimore, USA
    Explore (NY) 1:365-71. 2005
    ..These data strongly suggest that peripheral opioids are released by EA at the inflammatory site...
  27. ncbi Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
    Brian M Berman
    University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
    Ann Intern Med 141:901-10. 2004
    ..Evidence on the efficacy of acupuncture for reducing the pain and dysfunction of osteoarthritis is equivocal...
  28. ncbi Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 78:793-7. 2004
    ..The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain...
  29. pmc Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Pain 12:870-8. 2008
    ..These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain...
  30. ncbi Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Neurosci Lett 384:339-43. 2005
    ..This suggests that EA-induced suppression of hyperalgesia is involved, at least partly, in the suppression of the spinal NK-1 receptors induced by sustained peripheral nociceptive input...
  31. pmc Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Brain Res 1186:171-9. 2007
    ..The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord...
  32. ncbi Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Anesth Analg 105:1482-8, table of contents. 2007
    ....
  33. ncbi Electroacupuncture attenuates inflammation in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Altern Complement Med 11:135-42. 2005
    ..However, clinical trials investigating the effectiveness of the anti-inflammatory effects of acupuncture have yielded inconsistent results, and the underlying mechanisms of acupuncture-produced anti-inflammation are unclear...
  34. ncbi Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation
    Arthur Yin Fan
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    J Altern Complement Med 11:323-31. 2005
    ..The present study is an investigation of the effects of a BC extract on persistent hyperalgesia and edema in rats with peripheral inflammation...
  35. ncbi Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 81:146-51. 2005
    ..These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management...
  36. ncbi Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    Brain Res 999:135-41. 2004
    ..These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain...
  37. ncbi Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Neurosci Lett 359:85-8. 2004
    ..The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia...
  38. ncbi Is acupuncture safe? A systematic review of case reports
    Lixing Lao
    University of Maryland School of Medicine, Complementary Medicine Program, Baltimore, USA
    Altern Ther Health Med 9:72-83. 2003
    ..This paper, therefore, addresses the following question: What is the frequency and severity of adverse complications and events in acupuncture treatment?..
  39. pmc Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation
    Rajesh Rajaiah
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Ethnopharmacol 123:40-4. 2009
    ..However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined...
  40. pmc Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Man, 2200 Kernan Drive, Baltimore, MD 21207, USA
    J Ethnopharmacol 121:366-71. 2009
    ..The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation...
  41. ncbi Assessing the consistency of traditional Chinese medical diagnosis: an integrative approach
    Grant G Zhang
    Division of Rheumatology, Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA
    Altern Ther Health Med 9:66-71. 2003
    ....
  42. ncbi Meta-analysis: acupuncture for osteoarthritis of the knee
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, Kernan Hospital Mansion, Baltimore, Maryland 21207, USA
    Ann Intern Med 146:868-77. 2007
    ..Knee osteoarthritis is a major cause of pain and functional limitation...
  43. ncbi Interleukin-1ra inhibits Fos expression and hyperalgesia in rats
    Aihui Li
    Center for Integrative Medicine, School of Medicine, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Neuroreport 18:495-8. 2007
    ....
  44. ncbi Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Brain Res 1038:238-42. 2005
    ..These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations...
  45. ncbi Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Neurosci Lett 353:213-6. 2003
    ..These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception...
  46. ncbi Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting
    Jeanette Ezzo
    JPS Enterprises, Baltimore, MD 21209, USA
    J Clin Oncol 23:7188-98. 2005
    ..Assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients. Materials and..
  47. pmc Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways
    Young Beob Yu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 5:e9339. 2010
    ..This issue may be addressed through the use of contemporary methodology and validated animal models...
  48. ncbi Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation
    Hongyan Wang
    University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA
    Altern Ther Health Med 9:62-6. 2003
    ..These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability of preventing cell proliferation and inducing apoptosis...

Research Grants1

  1. The Status and Future of Acupuncture Research: 10 Years Post-NIH Consensus Confer
    Lixing Lao; Fiscal Year: 2007
    ..The proposed conference will do so. ..