Research Topics
| Li-xing LaoSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
[Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials]MING T TAN
Division of Biostatistics and Bioinformatics, University of Maryland School of Medicine, Baltimore, Maryland 21021, USA
Zhong Xi Yi Jie He Xue Bao 10:847-52. 2012..The purpose of this paper is to inspire further discussion of such special issues in clinical research design and thus contribute to the increased scientific rigor of TCM research...
Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: application to a randomized controlled acupuncture trialLixing Lao
Center for Integrative Medicine, University of Maryland, School of Medicine, East Hall, 520 W Lombard Street, Baltimore, MD 21201, USA
Stat Med 31:619-27. 2012..TCM study design entails all the challenges encountered in trials of drugs, devices, and surgical procedures in the Western medicine. We present possible solutions to some but leave many issues unresolved...- Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of ratsMing Yi
Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100191, China
Mol Pain 7:61. 2011..Overall, these results demonstrated distinct anti-nociceptive effects and mechanisms between different stimulating sides and implied the necessity of finding the best stimulating protocols for different pain states... - Perception of Deqi by Chinese and American acupuncturists: a pilot surveyKathleen Kks Hui
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA
Chin Med 6:2. 2011..abstract:.. - Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammationAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
BMC Complement Altern Med 8:20. 2008..This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia... 
Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammationAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
BMC Complement Altern Med 7:27. 2007..However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model...- The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferretsLixing Lao
Complementary Medicine Program, Department of Family Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 74:691-9. 2003..05). The present study suggests that acupuncture may be useful as an adjunctive therapy in the treatment of chemotherapy-induced emesis... - Acupuncture practice, past and present: is it safe and effective?Lixing Lao
Center for Integrative Medicine, University of Maryland School of Medicine, Kernan Hospital, Baltimore, MD 21207, USA
J Soc Integr Oncol 4:13-5. 2006..However, basic scientific studies on the mechanisms of acupuncture and well-designed randomized clinical trials that permit objective evaluation of this ancient science are urgently needed... - Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in ratsLixing Lao
Center for Integrative Medicine, School of Medicine, Department of Family Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, 3rd Floor, Baltimore, MD 21207, USA
Am J Chin Med 34:833-44. 2006..The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord... - [Evaluating the effects of acupuncture on knee osteoarthritis: a stepwise approach to research, University of Maryland experience]Lixing Lao
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21207, USA
Zhong Xi Yi Jie He Xue Bao 3:421-5. 2005..Their successful experience may be a useful model for future acupuncture and TCM research... - [Recommendations for enhancing the quality of traditional Chinese medicine clinical research reporting]Lixing Lao
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Zhong Xi Yi Jie He Xue Bao 2:402-6. 2004..TCM journal editors, who serve as gatekeepers of quality, must encourage higher quality clinical research reporting by setting and upholding publication standards... - Commentary on Sood et al.: "Cochrane systematic reviews in acupuncture: methodological diversity in database searching"Lixing Lao
Center for Integrative Medicine, University of Maryland, Baltimore, MD 21207, USA
J Altern Complement Med 11:723-4. 2005 - [Acupuncture clinical studies and evidence-based medicine--an update]Li Xing Lao
Center for Integrative Medicine, Department of Family Medicine, University of Maryland, Baltimore, MD 21207, USA
Zhen Ci Yan Jiu 33:53-61. 2008.... - A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in ratsLixing Lao
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
Brain Res 1020:18-29. 2004..The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain... - Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammationRui-Xin Zhang
Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1020:12-7. 2004..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain... - Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammationRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1048:235-40. 2005..These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia... - Variability in the traditional Chinese medicine (TCM) diagnoses and herbal prescriptions provided by three TCM practitioners for 40 patients with rheumatoid arthritisGrant G Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
J Altern Complement Med 11:415-21. 2005.... - The variability of TCM pattern diagnosis and herbal prescription on rheumatoid arthritis patientsGrant G Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, USA
Altern Ther Health Med 10:58-63. 2004.... - IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pain 135:232-9. 2008..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain... - Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat modelRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
Eur J Pain 12:870-8. 2008..These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain... - Involvement of peripheral opioid mechanisms in electroacupuncture analgesiaGrant G Zhang
Complementary Medicine Program, University of Maryland School of Medicine, Baltimore, USA
Explore (NY) 1:365-71. 2005..These data strongly suggest that peripheral opioids are released by EA at the inflammatory site... 
Improvement of agreement in TCM diagnosis among TCM practitioners for persons with the conventional diagnosis of rheumatoid arthritis: effect of trainingGrant G Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
J Altern Complement Med 14:381-6. 2008..To investigate whether a training process that focused on consensus on Traditional Chinese Medicine (TCM) diagnostic criteria will improve the agreement of TCM diagnosis on patients with rheumatoid arthritis (RA)...- Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibiaRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Pain 118:125-36. 2005..Further, bone cancer activates spinal glial cells, which may release IL-1beta and other cytokines and contribute to hyperalgesia... - Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trialBrian M Berman
University of Maryland School of Medicine, Baltimore, Maryland 21207, USA
Ann Intern Med 141:901-10. 2004..CONCLUSIONS: Acupuncture seems to provide improvement in function and pain relief as an adjunctive therapy for osteoarthritis of the knee when compared with credible sham acupuncture and education control groups... - Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory ratsRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 78:793-7. 2004..The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain... - Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed ratsBing Liu
Center for Integrative Medicine, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1044:87-92. 2005..The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways... - Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital, 2200 Kernan Drive, Baltimore, MD 21207, USA
Neurosci Lett 384:339-43. 2005..This suggests that EA-induced suppression of hyperalgesia is involved, at least partly, in the suppression of the spinal NK-1 receptors induced by sustained peripheral nociceptive input... - Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammationArthur Yin Fan
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
J Altern Complement Med 11:323-31. 2005..CONCLUSIONS: The data suggest that BC produces significant antihyperalgesia and anti-inflammation effects and that the antihyperalgesia may be mediated by suppressed inflammation-induced Fos expression in the spinal dorsal horn neurons... - Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammationRui Xin Zhang
Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
Brain Res 999:135-41. 2004..These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain... - Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory systemAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
Brain Res 1186:171-9. 2007..The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord... - Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat modelRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Anesth Analg 105:1482-8, table of contents. 2007.... - Electroacupuncture attenuates inflammation in a rat modelRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
J Altern Complement Med 11:135-42. 2005..CONCLUSION: At 10 Hz but not 100 Hz, EA suppresses inflammation by activating the hypothalamus-pituitary-adrenal axis (HPA) and the nervous system... - Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammationRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 81:146-51. 2005..These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management... - Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Man, 2200 Kernan Drive, Baltimore, MD 21207, USA
J Ethnopharmacol 121:366-71. 2009..The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation... - Assessing the consistency of traditional Chinese medical diagnosis: an integrative approachGrant G Zhang
Division of Rheumatology, Clinical Immunology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, USA
Altern Ther Health Med 9:66-71. 2003.... - Is acupuncture safe? A systematic review of case reportsLixing Lao
University of Maryland School of Medicine, Complementary Medicine Program, Baltimore, USA
Altern Ther Health Med 9:72-83. 2003..This paper, therefore, addresses the following question: What is the frequency and severity of adverse complications and events in acupuncture treatment?.. - Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Neurosci Lett 359:85-8. 2004..The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia... - Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammationRajesh Rajaiah
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Ethnopharmacol 123:40-4. 2009..However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined... - Meta-analysis: acupuncture for osteoarthritis of the kneeEric Manheimer
Center for Integrative Medicine, University of Maryland School of Medicine, Kernan Hospital Mansion, Baltimore, Maryland 21207, USA
Ann Intern Med 146:868-77. 2007..Knee osteoarthritis is a major cause of pain and functional limitation... - Interleukin-1ra inhibits Fos expression and hyperalgesia in ratsAihui Li
Center for Integrative Medicine, School of Medicine, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA
Neuroreport 18:495-8. 2007.... - Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Brain Res 1038:238-42. 2005..These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations... - Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Neurosci Lett 353:213-6. 2003..These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception... - Acupuncture-point stimulation for chemotherapy-induced nausea and vomitingJeanette Ezzo
JPS Enterprises, Baltimore, MD 21209, USA
J Clin Oncol 23:7188-98. 2005..Assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients. Materials and.. - Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathwaysYoung Beob Yu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, United States of America
PLoS ONE 5:e9339. 2010..This issue may be addressed through the use of contemporary methodology and validated animal models... - Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferationHongyan Wang
University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA
Altern Ther Health Med 9:62-6. 2003..These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability of preventing cell proliferation and inducing apoptosis...
Research Grants
- The Status and Future of Acupuncture Research: 10 Years Post-NIH Consensus ConferLixing Lao; Fiscal Year: 2007..The proposed conference will do so. ..