R C Lantz

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic
    R Clark Lantz
    Department of Cell Biology and Anatomy, and Southwest Environmental Health Science Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Environ Health Perspect 115:586-91. 2007
  2. ncbi request reprint Vinyl acetate decreases intracellular pH in rat nasal epithelial cells
    R Clark Lantz
    Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, The University of Arizona, P O Box 245044, Tucson, Arizona 85724, USA
    Toxicol Sci 75:423-31. 2003
  3. ncbi request reprint The effect of turmeric extracts on inflammatory mediator production
    R C Lantz
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ, USA
    Phytomedicine 12:445-52. 2005
  4. ncbi request reprint The effect of extracts from ginger rhizome on inflammatory mediator production
    R C Lantz
    Department of Cell Biology and Anatomy, University of Arizona, P O Box 245044, Tucson, AZ 85724, USA
    Phytomedicine 14:123-8. 2007
  5. pmc In utero and postnatal exposure to arsenic alters pulmonary structure and function
    R Clark Lantz
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Toxicol Appl Pharmacol 235:105-13. 2009
  6. ncbi request reprint Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanate
    R C Lantz
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
    Toxicol Sci 60:348-55. 2001
  7. ncbi request reprint Role of oxidative stress in arsenic-induced toxicity
    R Clark Lantz
    Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, University of Arizona, Tucson, Arizona 85724 5044, USA
    Drug Metab Rev 38:791-804. 2006
  8. ncbi request reprint Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment
    S Wang
    Department of Pediatrics, University of Arizona, Tucson 85724, USA
    Toxicol Pathol 27:334-41. 1999
  9. ncbi request reprint Arsenic and cigarette smoke synergistically increase DNA oxidation in the lung
    Allison Marie Hays
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724 5044, USA
    Toxicol Pathol 34:396-404. 2006
  10. ncbi request reprint Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters
    Jefferey L Burgess
    University of Arizona, Tucson, Arizona, USA
    J Occup Environ Med 46:1013-22. 2004

Collaborators

Detail Information

Publications29

  1. pmc Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic
    R Clark Lantz
    Department of Cell Biology and Anatomy, and Southwest Environmental Health Science Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Environ Health Perspect 115:586-91. 2007
    ..Our objective was to identify potential pulmonary protein biomarkers in the lung-lining fluid of mice chronically exposed to low-dose As and to validate these protein changes in human populations exposed to As...
  2. ncbi request reprint Vinyl acetate decreases intracellular pH in rat nasal epithelial cells
    R Clark Lantz
    Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, The University of Arizona, P O Box 245044, Tucson, Arizona 85724, USA
    Toxicol Sci 75:423-31. 2003
    ..These results are consistent with the proposed mode of action for vinyl acetate and supply further data for developing appropriate risk assessments for vinyl acetate exposure...
  3. ncbi request reprint The effect of turmeric extracts on inflammatory mediator production
    R C Lantz
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ, USA
    Phytomedicine 12:445-52. 2005
    ..A combination of several of the fractions that contain the turmeric oils was more effective than the curcuminoids at inhibiting PGE2. While curcumin inhibited COX-2 expression, turmeric oils had no effect on levels of COX-2 mRNA...
  4. ncbi request reprint The effect of extracts from ginger rhizome on inflammatory mediator production
    R C Lantz
    Department of Cell Biology and Anatomy, University of Arizona, P O Box 245044, Tucson, AZ 85724, USA
    Phytomedicine 14:123-8. 2007
    ..These data demonstrate that compounds found in ginger are capable of inhibiting PGE(2) production and that the compounds may act at several sites...
  5. pmc In utero and postnatal exposure to arsenic alters pulmonary structure and function
    R Clark Lantz
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Toxicol Appl Pharmacol 235:105-13. 2009
    ..This model system demonstrates that in utero and postnatal exposure to environmentally relevant levels of arsenic can irreversibly alter pulmonary structure and function in the adults...
  6. ncbi request reprint Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanate
    R C Lantz
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
    Toxicol Sci 60:348-55. 2001
    ..This rapid reaction suggests the importance of cellular thiols in TDI-induced pulmonary disease...
  7. ncbi request reprint Role of oxidative stress in arsenic-induced toxicity
    R Clark Lantz
    Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, University of Arizona, Tucson, Arizona 85724 5044, USA
    Drug Metab Rev 38:791-804. 2006
    ..Validation of the alterations seen in animal models of exposure is being carried out in humans...
  8. ncbi request reprint Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatment
    S Wang
    Department of Pediatrics, University of Arizona, Tucson 85724, USA
    Toxicol Pathol 27:334-41. 1999
    ..These observations suggest that U75412E may exert its action through cooperative mechanisms, such as the modulation of arachidonic acid metabolism, in addition to its characterized antioxidative effects...
  9. ncbi request reprint Arsenic and cigarette smoke synergistically increase DNA oxidation in the lung
    Allison Marie Hays
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724 5044, USA
    Toxicol Pathol 34:396-404. 2006
    ..These results show that dual exposure of arsenic and cigarette smoke at environmentally relevant levels can act synergistically to cause DNA damage...
  10. ncbi request reprint Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters
    Jefferey L Burgess
    University of Arizona, Tucson, Arizona, USA
    J Occup Environ Med 46:1013-22. 2004
    ..Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters...
  11. pmc Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis
    Janet L Funk
    Arizona Center for Phytomedicine Research, Department of Medicine, Department of Cell Biology and Anatomy, University of Arizona, Tucson, 85724, USA
    J Nat Prod 69:351-5. 2006
    ....
  12. ncbi request reprint Environmental Arsenic Exposure and Urinary 8-OHdG in Arizona and Sonora
    Jefferey L Burgess
    University of Arizona Tucson, Arizona, USA
    Clin Toxicol (Phila) 45:490-8. 2007
    ..At the exposure levels evaluated in this study, drinking water arsenic was not associated with increased DNA oxidation as measured by urinary 8-OHdG...
  13. ncbi request reprint Substance P and neutral endopeptidase in development of acute respiratory distress syndrome following fire smoke inhalation
    Simon S Wong
    Department of Pediatrics Critical Care Medicine, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    Am J Physiol Lung Cell Mol Physiol 287:L859-66. 2004
    ....
  14. pmc Arsenic-induced decreases in the vascular matrix
    Allison M Hays
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721 0207, USA
    Toxicol Pathol 36:805-17. 2008
    ..These AsIII-induced early pathological events may predispose humans to respiratory and cardiovascular diseases linked to chronic low-dose AsIII exposure...
  15. ncbi request reprint Rapid decline in sputum IL-10 concentration following occupational smoke exposure
    Jefferey L Burgess
    Environmental and Occupational Health, University of Arizona College of Public Health, 1435 N Fremont, Box 210468, Tucson, AZ 85719 4197, USA
    Inhal Toxicol 14:133-40. 2002
    ..Reduced suppression of inflammation by IL-10 may be a mechanism by which low-level smoke exposure causes lung injury...
  16. ncbi request reprint Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis
    Janet L Funk
    University of Arizona, Tucson, USA
    Arthritis Rheum 54:3452-64. 2006
    ..Therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (RA)...
  17. ncbi request reprint Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slices
    J B Wijeweera
    Department of Cell Biology and Anatomy and College of Pharmacy, The University of Arizona, Tucson, Arizona 85724-5044, USA
    Toxicol Sci 61:283-94. 2001
    ..HSP 60 and HSP 90 were not changed by arsenite. These studies indicate that noncytotoxic concentrations of arsenite are capable of affecting signal transduction pathways and gene expression in the lung...
  18. ncbi request reprint Tissue-specific patterns of neurokinin-1 receptor (NK-1R) gene expression in mice exposed to sidestream cigarette smoke
    Simon S Wong
    Department of Pediatrics, Southwest Environmental Health Sciences Center, University of Arizona, P O Box 245073, 1501 N Campbell Avenue, Tucson, AZ 85724 5073, USA
    Toxicol Ind Health 18:435-44. 2002
    ..The tissue-specific patterns by which SSCS affect NK-1R gene expression in these organs may partially explain dissimilarity of NK-1R activation and the associated toxicity caused by environmental tobacco smoke...
  19. ncbi request reprint Inflammatory responses in mice sequentially exposed to JP-8 jet fuel and influenza virus
    Simon S Wong
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona College of Medicine, Room 3354, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Toxicology 197:139-47. 2004
    ..Taken together, most of the data did not provide supporting evidence that JP-8 inhalation synergizes influenza virus-induced inflammatory responses...
  20. ncbi request reprint Nedocromil sodium inhibits canine adenovirus bronchiolitis in beagle puppies
    K A Anderson
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
    Toxicol Pathol 28:317-25. 2000
    ..We concluded that pretreatment with nedocromil sodium aerosols attenuated CAV2-induced airway inflammation in these beagle puppies...
  21. pmc In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit
    Simon S Wong
    Department of Pediatrics, Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, AZ 85274, USA
    Toxicology 254:106-11. 2008
    ..Collectively, our data suggest that both fuels may have partially different deposition patterns, which may possibly contribute to specific different adverse effects in lung ventilatory function...
  22. pmc Pulmonary evaluation of permissible exposure limit of syntroleum S-8 synthetic jet fuel in mice
    Simon S Wong
    Department of Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    Toxicol Sci 109:312-20. 2009
    ....
  23. ncbi request reprint Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production
    Shivanand D Jolad
    Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Phytochemistry 65:1937-54. 2004
    ..Most of the fractions containing gingerols and/or gingerol derivatives showed excellent inhibition of LPS-induced PGE2 production...
  24. ncbi request reprint Adverse respiratory effects following overhaul in firefighters
    J L Burgess
    Environmental and Occupational Health, University of Arizona College of Public Health, 1435 North Fremont, Box 210468, Tucson, AZ 85719 4197, USA
    J Occup Environ Med 43:467-73. 2001
    ..Firefighter exposures during overhaul have the potential to cause changes in spirometric measurements and lung permeability, and self-contained breathing apparatus should be worn during overhaul to prevent lung injury...
  25. ncbi request reprint A reevaluation of the threshold exposure level of inhaled JP-8 in mice
    Bradley R Herrin
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona College of Medicine, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Toxicol Sci 31:219-28. 2006
    ....
  26. pmc Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cells
    Colin E Olsen
    Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 85724 5030, USA
    Am J Physiol Lung Cell Mol Physiol 295:L293-302. 2008
    ..We propose that arsenic in the airway can alter the airway epithelial barrier by restricting proper wound repair in part through the upregulation of MMP-9 by lung epithelial cells...
  27. ncbi request reprint Enhanced activity of human IL-10 after nitration in reducing human IL-1 production by stimulated peripheral blood mononuclear cells
    Jon L Freels
    Research Service, Southern Arizona Veterans Health Care System, Arizona Respiratory Sciences, University of Arizona, 3601 South 6th Avenue, Tucson, AZ 85723, USA
    J Immunol 169:4568-71. 2002
    ..This finding demonstrates that although peroxynitrite inhibits proinflammatory cytokines, it may augment anti-inflammatory cytokines and further point to an important role for peroxynitrite in the regulation of inflammation...
  28. ncbi request reprint Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production
    Shivanand D Jolad
    Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Phytochemistry 66:1614-35. 2005
    ..The concentrations of gingerols, the major constituents of fresh ginger, were reduced slightly in dry ginger, while the concentrations of shogaols, the major gingerol dehydration products, increased...
  29. ncbi request reprint Correlation between in vivo and in vitro pulmonary responses to jet propulsion fuel-8 using precision-cut lung slices and a dynamic organ culture system
    Allison M Hays
    Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724 5044, USA
    Toxicol Pathol 31:200-7. 2003
    ..Thus, the lung tissue slice model appears to mimic in vivo effects of JP-8 and therefore is a useful model system for studying the mechanisms of lunginjury following JP-8 exposure...