Research Topics
| R C LantzSummaryAffiliation: University of Arizona Country: USA Publications
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Detail Information
Publications
Pulmonary biomarkers based on alterations in protein expression after exposure to arsenicR Clark Lantz
Department of Cell Biology and Anatomy, and Southwest Environmental Health Science Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
Environ Health Perspect 115:586-91. 2007..Our objective was to identify potential pulmonary protein biomarkers in the lung-lining fluid of mice chronically exposed to low-dose As and to validate these protein changes in human populations exposed to As...
Vinyl acetate decreases intracellular pH in rat nasal epithelial cellsR Clark Lantz
Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, The University of Arizona, P O Box 245044, Tucson, Arizona 85724, USA
Toxicol Sci 75:423-31. 2003..These results are consistent with the proposed mode of action for vinyl acetate and supply further data for developing appropriate risk assessments for vinyl acetate exposure...- The effect of turmeric extracts on inflammatory mediator productionR C Lantz
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ, USA
Phytomedicine 12:445-52. 2005..A combination of several of the fractions that contain the turmeric oils was more effective than the curcuminoids at inhibiting PGE2. While curcumin inhibited COX-2 expression, turmeric oils had no effect on levels of COX-2 mRNA... - The effect of extracts from ginger rhizome on inflammatory mediator productionR C Lantz
Department of Cell Biology and Anatomy, University of Arizona, P O Box 245044, Tucson, AZ 85724, USA
Phytomedicine 14:123-8. 2007..These data demonstrate that compounds found in ginger are capable of inhibiting PGE(2) production and that the compounds may act at several sites... - In utero and postnatal exposure to arsenic alters pulmonary structure and functionR Clark Lantz
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
Toxicol Appl Pharmacol 235:105-13. 2009..This model system demonstrates that in utero and postnatal exposure to environmentally relevant levels of arsenic can irreversibly alter pulmonary structure and function in the adults... - Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanateR C Lantz
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724, USA
Toxicol Sci 60:348-55. 2001..This rapid reaction suggests the importance of cellular thiols in TDI-induced pulmonary disease... - Role of oxidative stress in arsenic-induced toxicityR Clark Lantz
Department of Cell Biology and Anatomy, Southwest Environmental Health Science Center, University of Arizona, Tucson, Arizona 85724 5044, USA
Drug Metab Rev 38:791-804. 2006..Validation of the alterations seen in animal models of exposure is being carried out in humans... - Early alterations of lung injury following acute smoke exposure and 21-aminosteroid treatmentS Wang
Department of Pediatrics, University of Arizona, Tucson 85724, USA
Toxicol Pathol 27:334-41. 1999..These observations suggest that U75412E may exert its action through cooperative mechanisms, such as the modulation of arachidonic acid metabolism, in addition to its characterized antioxidative effects... - Arsenic and cigarette smoke synergistically increase DNA oxidation in the lungAllison Marie Hays
Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724-5044, USA
Toxicol Pathol 34:396-404. 2006..These results show that dual exposure of arsenic and cigarette smoke at environmentally relevant levels can act synergistically to cause DNA damage... - Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefightersJefferey L Burgess
University of Arizona, Tucson, Arizona, USA
J Occup Environ Med 46:1013-22. 2004..Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters... - Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritisJanet L Funk
Arizona Center for Phytomedicine Research, Department of Medicine, Department of Cell Biology and Anatomy, University of Arizona, Tucson, 85724, USA
J Nat Prod 69:351-5. 2006.... - Environmental Arsenic Exposure and Urinary 8-OHdG in Arizona and SonoraJefferey L Burgess
University of Arizona Tucson, Arizona, USA
Clin Toxicol (Phila) 45:490-8. 2007..At the exposure levels evaluated in this study, drinking water arsenic was not associated with increased DNA oxidation as measured by urinary 8-OHdG... - Substance P and neutral endopeptidase in development of acute respiratory distress syndrome following fire smoke inhalationSimon S Wong
Department of Pediatrics Critical Care Medicine, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
Am J Physiol Lung Cell Mol Physiol 287:L859-66. 2004.... - Arsenic-induced decreases in the vascular matrixAllison M Hays
Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona 85721 0207, USA
Toxicol Pathol 36:805-17. 2008..These AsIII-induced early pathological events may predispose humans to respiratory and cardiovascular diseases linked to chronic low-dose AsIII exposure... - Rapid decline in sputum IL-10 concentration following occupational smoke exposureJefferey L Burgess
Environmental and Occupational Health, University of Arizona College of Public Health, 1435 N Fremont, Box 210468, Tucson, AZ 85719 4197, USA
Inhal Toxicol 14:133-40. 2002..Reduced suppression of inflammation by IL-10 may be a mechanism by which low-level smoke exposure causes lung injury... - Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritisJanet L Funk
University of Arizona, Tucson, USA
Arthritis Rheum 54:3452-64. 2006..Therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (RA)... - Sodium arsenite enhances AP-1 and NFkappaB DNA binding and induces stress protein expression in precision-cut rat lung slicesJ B Wijeweera
Department of Cell Biology and Anatomy and College of Pharmacy, The University of Arizona, Tucson, Arizona 85724-5044, USA
Toxicol Sci 61:283-94. 2001..HSP 60 and HSP 90 were not changed by arsenite. These studies indicate that noncytotoxic concentrations of arsenite are capable of affecting signal transduction pathways and gene expression in the lung... - Tissue-specific patterns of neurokinin-1 receptor (NK-1R) gene expression in mice exposed to sidestream cigarette smokeSimon S Wong
Department of Pediatrics, Southwest Environmental Health Sciences Center, University of Arizona, P.O. Box 245073, 1501 N. Campbell Avenue, Tucson, AZ 85724-5073, USA
Toxicol Ind Health 18:435-44. 2002..The tissue-specific patterns by which SSCS affect NK-1R gene expression in these organs may partially explain dissimilarity of NK-1R activation and the associated toxicity caused by environmental tobacco smoke... - Inflammatory responses in mice sequentially exposed to JP-8 jet fuel and influenza virusSimon S Wong
Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona College of Medicine, Room 3354, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA
Toxicology 197:139-47. 2004..Taken together, most of the data did not provide supporting evidence that JP-8 inhalation synergizes influenza virus-induced inflammatory responses... - Nedocromil sodium inhibits canine adenovirus bronchiolitis in beagle puppiesK A Anderson
Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
Toxicol Pathol 28:317-25. 2000..We concluded that pretreatment with nedocromil sodium aerosols attenuated CAV2-induced airway inflammation in these beagle puppies... - In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limitSimon S Wong
Department of Pediatrics, Southwest Environmental Health Sciences Center, The University of Arizona, Tucson, AZ 85274, USA
Toxicology 254:106-11. 2008..Collectively, our data suggest that both fuels may have partially different deposition patterns, which may possibly contribute to specific different adverse effects in lung ventilatory function... - Pulmonary evaluation of permissible exposure limit of syntroleum S-8 synthetic jet fuel in miceSimon S Wong
Department of Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
Toxicol Sci 109:312-20. 2009.... - Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 productionShivanand D Jolad
Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
Phytochemistry 65:1937-54. 2004..Most of the fractions containing gingerols and/or gingerol derivatives showed excellent inhibition of LPS-induced PGE2 production... - Adverse respiratory effects following overhaul in firefightersJ L Burgess
Environmental and Occupational Health, University of Arizona College of Public Health, 1435 North Fremont, Box 210468, Tucson, AZ 85719 4197, USA
J Occup Environ Med 43:467-73. 2001..Firefighter exposures during overhaul have the potential to cause changes in spirometric measurements and lung permeability, and self-contained breathing apparatus should be worn during overhaul to prevent lung injury... - A reevaluation of the threshold exposure level of inhaled JP-8 in miceBradley R Herrin
Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona College of Medicine, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA
J Toxicol Sci 31:219-28. 2006.... - Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cellsColin E Olsen
Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, AZ 85724 5030, USA
Am J Physiol Lung Cell Mol Physiol 295:L293-302. 2008..We propose that arsenic in the airway can alter the airway epithelial barrier by restricting proper wound repair in part through the upregulation of MMP-9 by lung epithelial cells... - Enhanced activity of human IL-10 after nitration in reducing human IL-1 production by stimulated peripheral blood mononuclear cellsJon L Freels
Research Service, Southern Arizona Veterans Health Care System, Arizona Respiratory Sciences, University of Arizona, 3601 South 6th Avenue, Tucson, AZ 85723, USA
J Immunol 169:4568-71. 2002..This finding demonstrates that although peroxynitrite inhibits proinflammatory cytokines, it may augment anti-inflammatory cytokines and further point to an important role for peroxynitrite in the regulation of inflammation... - Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 productionShivanand D Jolad
Arizona Center for Phytomedicine Research, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
Phytochemistry 66:1614-35. 2005..The concentrations of gingerols, the major constituents of fresh ginger, were reduced slightly in dry ginger, while the concentrations of shogaols, the major gingerol dehydration products, increased... - Correlation between in vivo and in vitro pulmonary responses to jet propulsion fuel-8 using precision-cut lung slices and a dynamic organ culture systemAllison M Hays
Department of Cell Biology and Anatomy, The University of Arizona, Tucson, Arizona 85724-5044, USA
Toxicol Pathol 31:200-7. 2003..Thus, the lung tissue slice model appears to mimic in vivo effects of JP-8 and therefore is a useful model system for studying the mechanisms of lunginjury following JP-8 exposure...