Research Topics
Genomes and Genes
| Lewis L LanierSummaryAffiliation: University of California Country: USA Publications
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Publications
On guard--activating NK cell receptorsL L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, CA 94143 0414, USA
Nat Immunol 2:23-7. 2001..Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies...- NKG2DL L Lanier
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, 94143-0414, USA
J Biol Regul Homeost Agents 17:338-40. 2003 - Natural killer cell receptor signalingLewis L Lanier
University of California at San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
Curr Opin Immunol 15:308-14. 2003..In addition, recent studies of gene-deficient animals, in particular Syk and ZAP70 double-deficient mice, suggest that NK cells possess a robust and potentially redundant receptor system to ensure their development and function... - Missing self, NK cells, and The White AlbumLewis L Lanier
Department of Microbiology and Immunology and Cancer Research Institute, University of California School of Medicine, San Francisco, 94143, USA
J Immunol 174:6565. 2005 - NK cell recognitionLewis L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
Annu Rev Immunol 23:225-74. 2005..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition... - NKG2D in innate and adaptive immunityLewis L Lanier
University of California San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Ave, Box 0414, HSE 1001G, San Francisco, California 94143-0414, USA
Adv Exp Med Biol 560:51-6. 2005 - Face off--the interplay between activating and inhibitory immune receptorsL L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, 94143 0414, San Francisco, CA, USA
Curr Opin Immunol 13:326-31. 2001..Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions... - The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell functionL L Lanier
Dept of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
Immunol Today 21:611-4. 2000..Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses... - Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cellsLauren I Richie Ehrlich
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 174:1922-31. 2005..It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors... - Inhibition of immune responses by ITAM-bearing receptorsJessica A Hamerman
Department of Microbiology and Immunology, Cancer Research Institute, University of California, Box 0414, HSE1001, San Francisco, CA 94143-0414, USA
Sci STKE 2006:re1. 2006..Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system... 
Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cellsDavid B Rosen
Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 180:6508-17. 2008..Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs...- Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12Jessica A Hamerman
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143, USA
Nat Immunol 6:579-86. 2005..These data suggest that one or more DAP12-pairing receptors negatively regulate signaling through TLRs... - Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow graftsKouetsu Ogasawara
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143 0414, USA
Nat Immunol 6:938-45. 2005..If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts... - DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2Laura L Koth
Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
J Immunol 184:6522-8. 2010..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema... - Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12Jessica A Hamerman
Department of Microbiology and Immunology, University of California San Francisco, 514 Parnassus Avenue, San Francisco, CA 94143, USA
J Immunol 177:2051-5. 2006..A TREM-2 Fc fusion protein bound to macrophages, indicating that macrophages express a TREM-2 ligand. Thus, the interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response... - Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2Brian R Long
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
Immunology 129:186-96. 2010..This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection... - Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinasesDavid G T Hesslein
Department of Microbiology and Immunology and the Cancer Research Institute, USA
Blood 117:3087-95. 2011..We show that Syk, but not Zap70, controls the remaining CD45-independent, ITAM-specific NK-cell functions, demonstrating a functional difference between these 2 Syk-kinase family members in primary NK cells... 
NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene moleculesMelissa Lodoen
Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 197:1245-53. 2003..These experiments demonstrate that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1-NKG2D interaction...- TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and functionMary Beth Humphrey
Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
J Bone Miner Res 21:237-45. 2006..These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation... - Impairment of NK cell function by NKG2D modulation in NOD miceKouetsu Ogasawara
Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue HSE 420, Box 0414, San Francisco, CA 94143, USA
Immunity 18:41-51. 2003..Modulation of NKG2D was mostly dependent on the YxxM motif of DAP10, the NKG2D-associated adaptor that activates phosphoinositide 3 kinase. These results suggest that NK cells may be desensitized by exposure to NKG2D ligands... - Tolerance of NK cells encountering their viral ligand during developmentJoseph C Sun
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:1819-28. 2008..Thus, if immature NK cells encounter ligands for their activating receptors, regulatory mechanisms exist to keep these cells in an unresponsive state... - The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejectionJim Kim
Transplantation Research Laboratory, Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
J Immunol 179:6416-20. 2007..Notably, NKG2D blockade did not deplete CD8(+) T cells or NK1.1(+) cells nor affect their migration to the allografts. These results establish a functional role of NKG2D and its ligands in the rejection of solid organ transplants... - Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1Marine Champsaur
Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, University of California at San Francisco, San Francisco, CA 94143, USA
J Immunol 185:157-65. 2010..Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8(+) T cells in the context of viral infection... - CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subsetSandra Lopez-Verges
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Blood 116:3865-74. 2010.... - Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infectionMark T Orr
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143, USA
J Exp Med 206:807-17. 2009..Deletion of both DAP10 and DAP12 completely abrogates Ly49H surface expression and control of MCMV infection. Thus, optimal NK cell-mediated immunity to MCMV depends on Ly49H signaling through both DAP10 and DAP12... - IL-21 enhances tumor rejection through a NKG2D-dependent mechanismRayna Takaki
Department of Microbiology and Immunology, Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 175:2167-73. 2005..Collectively, these findings suggest that IL-21 therapy may work optimally against tumors that can elicit a NKG2D-mediated immune response... - Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4Jeffrey M Milush
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco
Blood 114:4823-31. 2009..Our data indicate that CD7 and CD56 coexpression discriminates NK cells from CD7(neg)CD56+ monocyte/DC-like cells, thereby improving our ability to study the intricacies of NK-cell subset phenotypes and functions in vivo... - Distinct requirements of microRNAs in NK cell activation, survival, and functionNatalie A Bezman
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
J Immunol 185:3835-46. 2010..Thus, our findings indicate a critical role for miRNAs in controlling NK cell homeostasis and effector function, with implications for miRNAs regulating diverse aspects of NK cell biology... - The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactionsMelissa B Lodoen
Department of Microbiology and Immunology, Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 200:1075-81. 2004..Thus, down-regulation of H60 by m155 is a powerful mechanism of inhibiting NKG2D-mediated antiviral function... - A Structural basis for the association of DAP12 with mouse, but not human, NKG2DDavid B Rosen
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 173:2470-8. 2004..Further, we show that human NKG2D is incapable of associating with DAP12 and provide evidence that structural differences in the transmembrane of mouse and human NKG2D account for the species-specific difference for this immune receptor... - Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infectionSandra Lopez-Verges
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 108:14725-32. 2011..Thus, we propose that CD57 might provide a marker of "memory" NK cells that have been expanded in response to infection... - Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptorJessica A Hamerman
Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 172:2001-5. 2004..RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection... - Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligandsChristian Naper
Veterans Affairs Medical Center, Northern California Institute for Research and Education, and University of California, San Francisco, CA 94121, USA
J Immunol 169:22-30. 2002..In conclusion, we have identified a novel Ly-49 receptor that triggers rat NK cell-mediated responses... - Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infectionBrian R Long
Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
J Virol 82:4785-92. 2008.... - NK cells are not required for spontaneous autoimmune diabetes in NOD miceJoshua N Beilke
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
PLoS ONE 7:e36011. 2012..NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4(+) T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice... - Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virusBrian R Long
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 941101, USA
Clin Vaccine Immunol 15:120-30. 2008..These results may form the basis for further investigations of the role of NK cells in immunity to influenza... - Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activationWilliam H Carr
Department of Microbiology and Immunology, Cancer Research Institute and Biomedical Sciences Graduate Program, University of California San Francisco, CA 94143, USA
J Immunol 178:647-51. 2007..Soluble KIR3DS1-Ig fusion proteins did not bind to EBV-transformed B lymphoid cell lines transfected with HLA-Bw4 80I or 80T allotypes, suggesting that if KIR3DS1 does recognize HLA-Bw4 ligands, this may be peptide dependent... - Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptorDavid B Rosen
Department of Microbiology and Immunology, The Cancer Research Institute, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
J Immunol 175:7796-9. 2005..Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A... - NK cell regulation of T cell-mediated responsesAlessandra Zingoni
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, CA 94143, USA
Mol Immunol 42:451-4. 2005..These findings suggest a novel link between natural and adaptative immune responses... - Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactionsAlessandra Zingoni
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 173:3716-24. 2004..These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells... - Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine productionDavid G T Hesslein
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:7012-7. 2006..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity... - Role of ITAM-containing adapter proteins and their receptors in the immune system and boneMary Beth Humphrey
Department of Medicine, University of California, San Francisco, CA 94121, USA
Immunol Rev 208:50-65. 2005.... - The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinaseAttila Mocsai
Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:6158-63. 2004..These results provide new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling... - NKG2D blockade prevents autoimmune diabetes in NOD miceKouetsu Ogasawara
Department of Microbiology and Immunology and the Cancer Research Institute, HSE 1001, Box 0414, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Immunity 20:757-67. 2004..These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes... - Adaptive immune features of natural killer cellsJoseph C Sun
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
Nature 457:557-61. 2009..These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system... - Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiencyYalei Wu
Department of Medicine, VA Medical Center, University of California San Francisco, San Francisco, California, United States of America Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 2:e586. 2007.... - NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitisKevin B Walsh
Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
J Virol 82:3031-44. 2008..These findings demonstrate a functional role for NKG2D in host defense during acute viral encephalitis by selectively enhancing CTL activity by infiltrating virus-specific CD8(+) T cells... - DAP10- and DAP12-associated receptors in innate immunityLewis L Lanier
Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
Immunol Rev 227:150-60. 2009..DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses... - TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patientsCourtney A Crane
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA
Neuro Oncol 12:7-13. 2010.... - Effect of NKG2D ligand expression on host immune responsesMarine Champsaur
Department of Microbiology and Immunology, The Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Immunol Rev 235:267-85. 2010..We also discuss the host response to both membrane-bound and secreted NKG2D ligands and summarize the models proposed to explain the consequences of this differential expression... - Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver diseaseKevin B Walsh
Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
J Virol 82:3021-30. 2008.... - Cutting edge: viral infection breaks NK cell tolerance to "missing self"Joseph C Sun
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 181:7453-7. 2008..Thus, although NK cells can be held in check against "missing self," acute inflammation driven by infection can rapidly break established self-tolerance... - Experimental malaria infection triggers early expansion of natural killer cellsCharles C Kim
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
Infect Immun 76:5873-82. 2008..These data indicate that the early response to P. chabaudi infection of the blood is marked by a primary wave of interferon with a subsequent response by NK cells... - Viral modulation of NK cell immunityMelissa B Lodoen
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 1001G, Box 0414, San Francisco, California 94143-0414, USA
Nat Rev Microbiol 3:59-69. 2005..Here, we review the unique relationship that exists between NK cells and viruses, with a focus on herpesviruses... - Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cellsKouetsu Ogasawara
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 169:3676-85. 2002..Furthermore, fewer metastases appeared in the liver and spleen of mice injected with the ICOS ligand-expressing tumor compared with mice bearing the parental tumor. These results indicate that NK cell functions are regulated by ICOS... - CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cellsDavid Voehringer
Department of Medicine, University of California San Francisco, CA 94143 0654, USA
J Biol Chem 279:54117-23. 2004.... - T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrowCraig N Jenne
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 206:2469-81. 2009..In summary, these findings identify S1P5 as a T-bet-induced gene that is required for NK cell egress from LNs and BM... - NK cells in innate immunityJessica A Hamerman
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 513 Parnassus Avenue HSE 1001, Box 0414, San Francisco, CA 94143-0414, USA
Curr Opin Immunol 17:29-35. 2005..These findings, as well as advances in understanding NK cell development and homeostasis, indicate that NK cell biology is more sophisticated than previously appreciated... - CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organsLawrence R Shiow
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
Nature 440:540-4. 2006..These observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream of IFN-alpha/beta, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs... - Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptorsHisashi Arase
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Science 296:1323-6. 2002..These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen... - miR-150 regulates the development of NK and iNKT cellsNatalie A Bezman
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 208:2717-31. 2011..Our finding of increased NK cell and decreased iNKT cell frequencies in Myb heterozygous bone marrow chimeras suggests that miR-150 differentially controls the development of NK and iNKT cell lineages by targeting c-Myb... - Up on the tightrope: natural killer cell activation and inhibitionLewis L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
Nat Immunol 9:495-502. 2008.... - Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirusMark T Orr
Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
Proc Natl Acad Sci U S A 107:15844-9. 2010..g7 NK cells, even in the absence of T cells and B cells. Thus, the impaired cytotoxic function of NK cells in NOD mice is alleviated by viral infection, which enables NOD NK cells to efficiently control MCMV infection... - Inhibitory Ly49 receptors on mouse natural killer cellsMark T Orr
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA, 94143, USA
Curr Top Microbiol Immunol 350:67-87. 2011..Here, we review the polymorphism, ligand specificity, and signaling capacity of the inhibitory Ly49 receptors and discuss how these molecules regulate NK cell development and function... - DAP12: an adapter protein with dual functionalityRayna Takaki
The Biomedical Sciences Graduate Program, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
Immunol Rev 214:118-29. 2006..Here we review the dual functionality of DAP12 and present evidence that DAP12 can suppress as well as activate NK cells... - DAP12-deficient mice fail to develop autoimmunity due to impaired antigen primingA B Bakker
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco 94143, USA
Immunity 13:345-53. 2000..These data suggest that DAP12 signaling may be required for optimal antigen-presenting cell (APC) function or inflammation... - Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAPS G Tangye
Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, USA
J Immunol 162:6981-5. 1999..These results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM, but also other cell surface molecules that utilize SAP as a signaling adaptor protein... - The signaling adapter protein DAP12 regulates multinucleation during osteoclast developmentMary Beth Humphrey
Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
J Bone Miner Res 19:224-34. 2004..These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts... - Viral immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling in cell transformation and cancerLewis L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 1001G, San Francisco, CA 94143 00414, USA
Trends Cell Biol 16:388-90. 2006..These ITAM-bearing viral proteins have been implicated in cellular transformation in virus-infected hematopoietic cells, typically B cells, but also in non-hematopoietic tissues--including endothelial and epithelial cells... - Evolutionary struggles between NK cells and virusesLewis L Lanier
Department of Microbiology and Immunology, and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
Nat Rev Immunol 8:259-68. 2008..In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens... - 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infectionMark T Orr
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California, USA
Nat Immunol 11:321-7. 2010..Signaling by the tyrosine phosphatase SHP-1 limited the proliferation of licensed NK cells but not that of unlicensed NK cells during infection. Thus, unlicensed NK cells are critical for protection against viral infection... - Virus-driven evolution of natural killer cell receptorsHisashi Arase
Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-0414, USA
Microbes Infect 4:1505-12. 2002..However, viruses have devised strategies to avoid immune detection. Here, we discuss NK cell recognition of viruses and propose that viruses may provide the evolutionary pressure causing the diversification of the NK cell receptors... - Back to the future--defining NK cells and T cellsLewis L Lanier
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
Eur J Immunol 37:1424-6. 2007..These findings and other recent studies highlight the similarities of NK cells and T cells and the problems in discriminating between these two lineages... - Natural killer cells: roundupLewis L Lanier
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
Immunol Rev 214:5-8. 2006 - Cloning and characterization of a novel mouse myeloid DAP12-associated receptor familyM R Daws
Department of Immunology, VA Medical Center San Francisco, San Francisco, USA
Eur J Immunol 31:783-91. 2001..Our studies define TREM-2 as a receptor family in mouse macrophages and demonstrate the capacity of these receptors to activate macrophage function through DAP12... - Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12D Yim
Department of Microbiology and Immunology, Finch University of Health Sciences The Chicago Medical School, North Chicago, IL 60064, USA
Immunogenetics 51:436-42. 2000..In Northern blot analysis, DAP12 transcripts were detected in spleen, liver, thymus, and lymph node. DAP12 transcripts are expressed not only in PBLs, but also in granulocytes, macrophages, and monocytes... - Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in miceA Cerwenka
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco 94143, USA
Immunity 12:721-7. 2000..These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity... - DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cellsJ Wu
Department of Microbiology and Immunology and the Cancer Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
J Exp Med 192:1059-68. 2000.... - Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?Joseph C Sun
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
Eur J Immunol 39:2059-64. 2009..In light of new findings showing how NK cells possess nearly all of the features of adaptive immunity including memory, we propose the placement of NK cells as an "evolutionary bridge" between innate and adaptive immunity... - Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2DAdelheid Cerwenka
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 168:3131-4. 2002..Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags... - Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2DD Yim
Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, IL 60064, USA
Immunogenetics 53:243-9. 2001..RT-PCR analysis reveals that pig NKG2D transcripts are expressed in PBLs, NK cells, macrophages, and monocytes. When transiently transfected into COS-7 cells, pig NKG2D requires DAP10 for cell surface expression... - Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)H Arase
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 167:1141-4. 2001..Cytotoxicity mediated by the DX5(+) NK cells was dramatically higher as compared with DX5(-) NK cells. Therefore, DX5 mAb recognizes CD49b and can be used to define functionally distinct subsets of NK cells... - Ligands for natural killer cell receptors: redundancy or specificityA Cerwenka
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
Immunol Rev 181:158-69. 2001..A better understanding about how targets signal their distress, which renders them susceptible to natural killer (NK)-cell attack, will help to define the role of NK cells in antimicrobial and antitumor immunity and transplantation... - Natural killer cells, viruses and cancerA Cerwenka
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
Nat Rev Immunol 1:41-9. 2001..Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence... - Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivoA Cerwenka
Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143-0414, USA
Proc Natl Acad Sci U S A 98:11521-6. 2001..Therefore, NK cells are able to reject a tumor expressing RAE-1 molecules, despite expression of self MHC class I on the tumor, demonstrating the potential for NK cells to participate in immunity against class I-bearing malignancies... - Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptorsErin J Adams
Departments of Molecular and Cellular Physiology and Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:10128-33. 2007..Collectively, our results show that m157 represents a structurally divergent form of MHC class I-like proteins that directly engage Ly49 receptors with appreciable affinity in a noncanonical fashion... - IFN-dependent down-regulation of the NKG2D ligand H60 on tumorsJack D Bui
Center for Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63310, USA
J Immunol 176:905-13. 2006..This process most likely helps to specify the type of immune effector cell populations that participate in host-protective antitumor responses... - Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200Ikuo Shiratori
Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
J Immunol 175:4441-9. 2005..In addition, the presence of CD200 homologues on several viruses suggests a potentially unique relationship between basophil function and viral infection... - Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like proteinAgnieszka Kielczewska
Department of Human Genetics, McGill University, Montreal, Quebec, Canada
J Immunol 178:369-77. 2007..These results link Ly49 homodimerization variability to the direct recognition of pathogen products... - NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinasesSimona Zompi
Department of Immunology, Pasteur Institute, 25 28 rue Dr Roux, 75015 Paris, France
Nat Immunol 4:565-72. 2003.... - Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsAttila Mocsai
Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
Nat Immunol 7:1326-33. 2006..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism... - Reprogramming of CTLs into natural killer-like cells in celiac diseaseBertrand Meresse
Department of Pathology, University of Chicago, Chicago, IL 60637, USA
J Exp Med 203:1343-55. 2006.... - The role of innate immunity in autoimmunityJean Francois Bach
INSERM U580, Hopital Necker, Paris, France
J Exp Med 200:1527-31. 2004.... - Interferon-producing killer dendritic cells provide a link between innate and adaptive immunityCamie W Chan
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, CRB 440, 1650 Orleans Street, Baltimore, Maryland 21231, USA
Nat Med 12:207-13. 2006..By virtue of their capacity to kill target cells, followed by antigen presentation, IKDCs provide a link between innate and adaptive immunity... - Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac diseaseBertrand Meresse
Department of Pathology, University of Chicago, IL 60637, USA
Immunity 21:357-66. 2004.... - BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cellsWei Cao
Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
PLoS Biol 5:e248. 2007..Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs... - Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)Satoko Tahara-Hanaoka
Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305 0074, Japan
Int Immunol 16:533-8. 2004..We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells... - KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicityPer C Saether
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
J Immunol 181:3177-82. 2008.... - A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognitionJakob Michaelsson
Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
J Exp Med 196:1403-14. 2002..Such stress induced peptide interference would gradually uncouple CD94/NKG2A inhibitory recognition and provide a mechanism for NK cells to detect stressed cells in a peptide-dependent manner... - Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptorIkuo Shiratori
Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuoku, 260 8670, Japan
J Exp Med 199:525-33. 2004..Cells expressing the PILR ligand specifically activated NK cells and dendritic cells that express the activating PILRbeta. Our findings reveal a new regulatory mechanism of innate immunity by PILR and its CD99-like ligand... - Natural killer cells and cancerJun Wu
Shanghai Gnomics, Inc, and Chinese National Genome Center, Shanghai, China
Adv Cancer Res 90:127-56. 2003..The underlining mechanism of discriminating tumor cells and normal cells by NK cells has provided new insights into tumor immunosurveillance and has suggested new strategies for the treatment of human cancer...