Lewis L Lanier

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    Melissa Lodoen
    Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:1245-53. 2003
  2. pmc The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions
    Melissa B Lodoen
    Department of Microbiology and Immunology, Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 200:1075-81. 2004
  3. ncbi request reprint On guard--activating NK cell receptors
    L L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, CA 94143 0414, USA
    Nat Immunol 2:23-7. 2001
  4. ncbi request reprint Natural killer cell receptor signaling
    Lewis L Lanier
    University of California at San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
    Curr Opin Immunol 15:308-14. 2003
  5. ncbi request reprint NKG2D
    L L Lanier
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, 94143 0414, USA
    J Biol Regul Homeost Agents 17:338-40. 2003
  6. ncbi request reprint NKG2D in innate and adaptive immunity
    Lewis L Lanier
    University of California San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Ave, Box 0414, HSE 1001G, San Francisco, California 94143 0414, USA
    Adv Exp Med Biol 560:51-6. 2005
  7. ncbi request reprint NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
  8. ncbi request reprint Face off--the interplay between activating and inhibitory immune receptors
    L L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, 94143 0414, San Francisco, CA, USA
    Curr Opin Immunol 13:326-31. 2001
  9. ncbi request reprint The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
    L L Lanier
    Dept of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
    Immunol Today 21:611-4. 2000
  10. ncbi request reprint Missing self, NK cells, and The White Album
    Lewis L Lanier
    Department of Microbiology and Immunology and Cancer Research Institute, University of California School of Medicine, San Francisco, 94143, USA
    J Immunol 174:6565. 2005

Detail Information

Publications108 found, 100 shown here

  1. pmc NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    Melissa Lodoen
    Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:1245-53. 2003
    ..These experiments demonstrate that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1-NKG2D interaction...
  2. pmc The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions
    Melissa B Lodoen
    Department of Microbiology and Immunology, Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 200:1075-81. 2004
    ..Thus, down-regulation of H60 by m155 is a powerful mechanism of inhibiting NKG2D-mediated antiviral function...
  3. ncbi request reprint On guard--activating NK cell receptors
    L L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, CA 94143 0414, USA
    Nat Immunol 2:23-7. 2001
    ..Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies...
  4. ncbi request reprint Natural killer cell receptor signaling
    Lewis L Lanier
    University of California at San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
    Curr Opin Immunol 15:308-14. 2003
    ..In addition, recent studies of gene-deficient animals, in particular Syk and ZAP70 double-deficient mice, suggest that NK cells possess a robust and potentially redundant receptor system to ensure their development and function...
  5. ncbi request reprint NKG2D
    L L Lanier
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, 94143 0414, USA
    J Biol Regul Homeost Agents 17:338-40. 2003
  6. ncbi request reprint NKG2D in innate and adaptive immunity
    Lewis L Lanier
    University of California San Francisco, Department of Microbiology and Immunology and the Cancer Research Institute, 513 Parnassus Ave, Box 0414, HSE 1001G, San Francisco, California 94143 0414, USA
    Adv Exp Med Biol 560:51-6. 2005
  7. ncbi request reprint NK cell recognition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco School of Medicine, San Francisco, California 94143 0414, USA
    Annu Rev Immunol 23:225-74. 2005
    ..Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition...
  8. ncbi request reprint Face off--the interplay between activating and inhibitory immune receptors
    L L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, 94143 0414, San Francisco, CA, USA
    Curr Opin Immunol 13:326-31. 2001
    ..Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions...
  9. ncbi request reprint The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
    L L Lanier
    Dept of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
    Immunol Today 21:611-4. 2000
    ..Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses...
  10. ncbi request reprint Missing self, NK cells, and The White Album
    Lewis L Lanier
    Department of Microbiology and Immunology and Cancer Research Institute, University of California School of Medicine, San Francisco, 94143, USA
    J Immunol 174:6565. 2005
  11. ncbi request reprint Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells
    Lauren I Richie Ehrlich
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 174:1922-31. 2005
    ..It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors...
  12. ncbi request reprint Inhibition of immune responses by ITAM-bearing receptors
    Jessica A Hamerman
    Department of Microbiology and Immunology, Cancer Research Institute, University of California, Box 0414, HSE1001, San Francisco, CA 94143 0414, USA
    Sci STKE 2006:re1. 2006
    ..Here, we discuss these new negative roles for signaling by receptors that associate with ITAM-bearing adaptors in myeloid and other cell types within the immune system...
  13. ncbi request reprint Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    Jessica A Hamerman
    Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 172:2001-5. 2004
    ..RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection...
  14. pmc Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts
    Kouetsu Ogasawara
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143 0414, USA
    Nat Immunol 6:938-45. 2005
    ..If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts...
  15. pmc Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells
    David B Rosen
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6508-17. 2008
    ..Expression of LLT1 on activated dendritic cells and B cells suggests that it might regulate the cross-talk between NK cells and APCs...
  16. pmc Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 6:579-86. 2005
    ..These data suggest that one or more DAP12-pairing receptors negatively regulate signaling through TLRs...
  17. ncbi request reprint Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    Hisashi Arase
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Science 296:1323-6. 2002
    ..These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen...
  18. ncbi request reprint Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    Jessica A Hamerman
    Department of Microbiology and Immunology, University of California San Francisco, 514 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 177:2051-5. 2006
    ..A TREM-2 Fc fusion protein bound to macrophages, indicating that macrophages express a TREM-2 ligand. Thus, the interaction of TREM-2 and its ligand results in an inhibitory signal that can reduce the inflammatory response...
  19. pmc DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
    ..These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema...
  20. pmc Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases
    David G T Hesslein
    Department of Microbiology and Immunology and the Cancer Research Institute, USA
    Blood 117:3087-95. 2011
    ..We show that Syk, but not Zap70, controls the remaining CD45-independent, ITAM-specific NK-cell functions, demonstrating a functional difference between these 2 Syk-kinase family members in primary NK cells...
  21. pmc Tolerance of NK cells encountering their viral ligand during development
    Joseph C Sun
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1819-28. 2008
    ..Thus, if immature NK cells encounter ligands for their activating receptors, regulatory mechanisms exist to keep these cells in an unresponsive state...
  22. ncbi request reprint Impairment of NK cell function by NKG2D modulation in NOD mice
    Kouetsu Ogasawara
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue HSE 420, Box 0414, San Francisco, CA 94143, USA
    Immunity 18:41-51. 2003
    ..Modulation of NKG2D was mostly dependent on the YxxM motif of DAP10, the NKG2D-associated adaptor that activates phosphoinositide 3 kinase. These results suggest that NK cells may be desensitized by exposure to NKG2D ligands...
  23. ncbi request reprint TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 21:237-45. 2006
    ..These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation...
  24. ncbi request reprint The activating immunoreceptor NKG2D and its ligands are involved in allograft transplant rejection
    Jim Kim
    Transplantation Research Laboratory, Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Immunol 179:6416-20. 2007
    ..Notably, NKG2D blockade did not deplete CD8(+) T cells or NK1.1(+) cells nor affect their migration to the allografts. These results establish a functional role of NKG2D and its ligands in the rejection of solid organ transplants...
  25. pmc Increased number and function of natural killer cells in human immunodeficiency virus 1-positive subjects co-infected with herpes simplex virus 2
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Immunology 129:186-96. 2010
    ..This suggests that HSV-2 infection mediates changes within the NK cell population that may affect immunity in HIV-1 infection...
  26. ncbi request reprint Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1
    Marine Champsaur
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 185:157-65. 2010
    ..Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8(+) T cells in the context of viral infection...
  27. ncbi request reprint IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
    Rayna Takaki
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 175:2167-73. 2005
    ..Collectively, these findings suggest that IL-21 therapy may work optimally against tumors that can elicit a NKG2D-mediated immune response...
  28. pmc Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection
    Mark T Orr
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143, USA
    J Exp Med 206:807-17. 2009
    ..Deletion of both DAP10 and DAP12 completely abrogates Ly49H surface expression and control of MCMV infection. Thus, optimal NK cell-mediated immunity to MCMV depends on Ly49H signaling through both DAP10 and DAP12...
  29. pmc CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset
    Sandra Lopez-Verges
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Blood 116:3865-74. 2010
    ....
  30. pmc Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4
    Jeffrey M Milush
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco
    Blood 114:4823-31. 2009
    ..Our data indicate that CD7 and CD56 coexpression discriminates NK cells from CD7(neg)CD56+ monocyte/DC-like cells, thereby improving our ability to study the intricacies of NK-cell subset phenotypes and functions in vivo...
  31. pmc Distinct requirements of microRNAs in NK cell activation, survival, and function
    Natalie A Bezman
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Immunol 185:3835-46. 2010
    ..Thus, our findings indicate a critical role for miRNAs in controlling NK cell homeostasis and effector function, with implications for miRNAs regulating diverse aspects of NK cell biology...
  32. ncbi request reprint Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands
    Christian Naper
    Veterans Affairs Medical Center, Northern California Institute for Research and Education, and University of California, San Francisco, CA 94121, USA
    J Immunol 169:22-30. 2002
    ..In conclusion, we have identified a novel Ly-49 receptor that triggers rat NK cell-mediated responses...
  33. pmc Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    J Virol 82:4785-92. 2008
    ....
  34. ncbi request reprint A Structural basis for the association of DAP12 with mouse, but not human, NKG2D
    David B Rosen
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 173:2470-8. 2004
    ..Further, we show that human NKG2D is incapable of associating with DAP12 and provide evidence that structural differences in the transmembrane of mouse and human NKG2D account for the species-specific difference for this immune receptor...
  35. pmc Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection
    Sandra Lopez-Verges
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:14725-32. 2011
    ..During acute CMV infection, the NKG2C(+) NK cells proliferated, became NKG2C(hi), and finally acquired CD57. Thus, we propose that CD57 might provide a marker of "memory" NK cells that have been expanded in response to infection...
  36. pmc NK cells are not required for spontaneous autoimmune diabetes in NOD mice
    Joshua N Beilke
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e36011. 2012
    ..NK cells were also not required to promote disease induced by adoptively transferred pathogenic CD4(+) T cells. Thus, NK cells are not required for spontaneous autoimmune diabetes in NOD mice...
  37. ncbi request reprint Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor
    David B Rosen
    Department of Microbiology and Immunology, The Cancer Research Institute, and Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA
    J Immunol 175:7796-9. 2005
    ..Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A...
  38. pmc Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation
    William H Carr
    Department of Microbiology and Immunology, Cancer Research Institute and Biomedical Sciences Graduate Program, University of California San Francisco, CA 94143, USA
    J Immunol 178:647-51. 2007
    ..Soluble KIR3DS1-Ig fusion proteins did not bind to EBV-transformed B lymphoid cell lines transfected with HLA-Bw4 80I or 80T allotypes, suggesting that if KIR3DS1 does recognize HLA-Bw4 ligands, this may be peptide dependent...
  39. ncbi request reprint NK cell regulation of T cell-mediated responses
    Alessandra Zingoni
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, CA 94143, USA
    Mol Immunol 42:451-4. 2005
    ..These findings suggest a novel link between natural and adaptative immune responses...
  40. ncbi request reprint Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions
    Alessandra Zingoni
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 173:3716-24. 2004
    ..These findings suggest a novel and unexpected link between the natural and specific immune responses, providing direct evidence for cross-talk between human CD4+ T cells and NK receptor-activated NK cells...
  41. ncbi request reprint Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells
    Kouetsu Ogasawara
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 169:3676-85. 2002
    ..Furthermore, fewer metastases appeared in the liver and spleen of mice injected with the ICOS ligand-expressing tumor compared with mice bearing the parental tumor. These results indicate that NK cell functions are regulated by ICOS...
  42. pmc Natural killer cells: walking three paths down memory lane
    Gundula Min-Oo
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    Trends Immunol 34:251-8. 2013
    ....
  43. pmc Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 941101, USA
    Clin Vaccine Immunol 15:120-30. 2008
    ..These results may form the basis for further investigations of the role of NK cells in immunity to influenza...
  44. pmc Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency
    Yalei Wu
    Department of Medicine, VA Medical Center, University of California San Francisco, San Francisco, California, United States of America Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e586. 2007
    ....
  45. ncbi request reprint Role of ITAM-containing adapter proteins and their receptors in the immune system and bone
    Mary Beth Humphrey
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Immunol Rev 208:50-65. 2005
    ....
  46. pmc Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    David G T Hesslein
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:7012-7. 2006
    ..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity...
  47. pmc The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    Attila Mocsai
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:6158-63. 2004
    ..These results provide new insight into the biology of osteoclasts and suggest novel therapeutic targets in diseases of bony remodeling...
  48. ncbi request reprint NKG2D blockade prevents autoimmune diabetes in NOD mice
    Kouetsu Ogasawara
    Department of Microbiology and Immunology and the Cancer Research Institute, HSE 1001, Box 0414, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Immunity 20:757-67. 2004
    ..These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes...
  49. pmc Adaptive immune features of natural killer cells
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California 94143, USA
    Nature 457:557-61. 2009
    ..These findings reveal properties of NK cells that were previously attributed only to cells of the adaptive immune system...
  50. pmc Cutting edge: viral infection breaks NK cell tolerance to "missing self"
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 181:7453-7. 2008
    ..Thus, although NK cells can be held in check against "missing self," acute inflammation driven by infection can rapidly break established self-tolerance...
  51. pmc Effect of NKG2D ligand expression on host immune responses
    Marine Champsaur
    Department of Microbiology and Immunology, The Biomedical Sciences Graduate Program and The Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 235:267-85. 2010
    ..We also discuss the host response to both membrane-bound and secreted NKG2D ligands and summarize the models proposed to explain the consequences of this differential expression...
  52. pmc Experimental malaria infection triggers early expansion of natural killer cells
    Charles C Kim
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA
    Infect Immun 76:5873-82. 2008
    ..These data indicate that the early response to P. chabaudi infection of the blood is marked by a primary wave of interferon with a subsequent response by NK cells...
  53. pmc Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease
    Kevin B Walsh
    Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
    J Virol 82:3021-30. 2008
    ....
  54. pmc NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis
    Kevin B Walsh
    Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, Irvine, CA 92697 3900, USA
    J Virol 82:3031-44. 2008
    ..These findings demonstrate a functional role for NKG2D in host defense during acute viral encephalitis by selectively enhancing CTL activity by infiltrating virus-specific CD8(+) T cells...
  55. pmc DAP10- and DAP12-associated receptors in innate immunity
    Lewis L Lanier
    Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Immunol Rev 227:150-60. 2009
    ..DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses...
  56. ncbi request reprint Viral modulation of NK cell immunity
    Melissa B Lodoen
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 1001G, Box 0414, San Francisco, California 94143 0414, USA
    Nat Rev Microbiol 3:59-69. 2005
    ..Here, we review the unique relationship that exists between NK cells and viruses, with a focus on herpesviruses...
  57. ncbi request reprint CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells
    David Voehringer
    Department of Medicine, University of California San Francisco, CA 94143 0654, USA
    J Biol Chem 279:54117-23. 2004
    ....
  58. pmc TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
    Courtney A Crane
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Neuro Oncol 12:7-13. 2010
    ....
  59. ncbi request reprint DAP12: an adapter protein with dual functionality
    Rayna Takaki
    The Biomedical Sciences Graduate Program, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 214:118-29. 2006
    ..Here we review the dual functionality of DAP12 and present evidence that DAP12 can suppress as well as activate NK cells...
  60. pmc T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
    Craig N Jenne
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:2469-81. 2009
    ..In summary, these findings identify S1P5 as a T-bet-induced gene that is required for NK cell egress from LNs and BM...
  61. ncbi request reprint NK cells in innate immunity
    Jessica A Hamerman
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 513 Parnassus Avenue HSE 1001, Box 0414, San Francisco, CA 94143 0414, USA
    Curr Opin Immunol 17:29-35. 2005
    ..These findings, as well as advances in understanding NK cell development and homeostasis, indicate that NK cell biology is more sophisticated than previously appreciated...
  62. ncbi request reprint CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs
    Lawrence R Shiow
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 440:540-4. 2006
    ..These observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream of IFN-alpha/beta, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs...
  63. pmc miR-150 regulates the development of NK and iNKT cells
    Natalie A Bezman
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 208:2717-31. 2011
    ..Our finding of increased NK cell and decreased iNKT cell frequencies in Myb heterozygous bone marrow chimeras suggests that miR-150 differentially controls the development of NK and iNKT cell lineages by targeting c-Myb...
  64. pmc Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus
    Mark T Orr
    Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Proc Natl Acad Sci U S A 107:15844-9. 2010
    ..g7 NK cells, even in the absence of T cells and B cells. Thus, the impaired cytotoxic function of NK cells in NOD mice is alleviated by viral infection, which enables NOD NK cells to efficiently control MCMV infection...
  65. doi request reprint Inhibitory Ly49 receptors on mouse natural killer cells
    Mark T Orr
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA, 94143, USA
    Curr Top Microbiol Immunol 350:67-87. 2011
    ..Here, we review the polymorphism, ligand specificity, and signaling capacity of the inhibitory Ly49 receptors and discuss how these molecules regulate NK cell development and function...
  66. pmc Up on the tightrope: natural killer cell activation and inhibition
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Immunol 9:495-502. 2008
    ....
  67. ncbi request reprint DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
    A B Bakker
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 13:345-53. 2000
    ..These data suggest that DAP12 signaling may be required for optimal antigen-presenting cell (APC) function or inflammation...
  68. ncbi request reprint Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    S G Tangye
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, USA
    J Immunol 162:6981-5. 1999
    ..These results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM, but also other cell surface molecules that utilize SAP as a signaling adaptor protein...
  69. ncbi request reprint The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
    Mary Beth Humphrey
    Department of Medicine, VA Medical Center and University of California, San Francisco, California 94121, USA
    J Bone Miner Res 19:224-34. 2004
    ..These data show a new role for DAP12 signaling in regulating formation of multinucleated osteoclasts...
  70. ncbi request reprint Back to the future--defining NK cells and T cells
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Eur J Immunol 37:1424-6. 2007
    ..These findings and other recent studies highlight the similarities of NK cells and T cells and the problems in discriminating between these two lineages...
  71. ncbi request reprint Virus-driven evolution of natural killer cell receptors
    Hisashi Arase
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143 0414, USA
    Microbes Infect 4:1505-12. 2002
    ..However, viruses have devised strategies to avoid immune detection. Here, we discuss NK cell recognition of viruses and propose that viruses may provide the evolutionary pressure causing the diversification of the NK cell receptors...
  72. pmc 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection
    Mark T Orr
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, California, USA
    Nat Immunol 11:321-7. 2010
    ..Signaling by the tyrosine phosphatase SHP-1 limited the proliferation of licensed NK cells but not that of unlicensed NK cells during infection. Thus, unlicensed NK cells are critical for protection against viral infection...
  73. pmc Evolutionary struggles between NK cells and viruses
    Lewis L Lanier
    Department of Microbiology and Immunology, and the Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0414, USA
    Nat Rev Immunol 8:259-68. 2008
    ..In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens...
  74. ncbi request reprint Natural killer cells: roundup
    Lewis L Lanier
    Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunol Rev 214:5-8. 2006
  75. ncbi request reprint Viral immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling in cell transformation and cancer
    Lewis L Lanier
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 1001G, San Francisco, CA 94143 00414, USA
    Trends Cell Biol 16:388-90. 2006
    ..These ITAM-bearing viral proteins have been implicated in cellular transformation in virus-infected hematopoietic cells, typically B cells, but also in non-hematopoietic tissues--including endothelial and epithelial cells...
  76. pmc DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells
    J Wu
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    J Exp Med 192:1059-68. 2000
    ....
  77. ncbi request reprint Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 12:721-7. 2000
    ..These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity...
  78. ncbi request reprint Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12
    D Yim
    Department of Microbiology and Immunology, Finch University of Health Sciences The Chicago Medical School, North Chicago, IL 60064, USA
    Immunogenetics 51:436-42. 2000
    ..In Northern blot analysis, DAP12 transcripts were detected in spleen, liver, thymus, and lymph node. DAP12 transcripts are expressed not only in PBLs, but also in granulocytes, macrophages, and monocytes...
  79. ncbi request reprint Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family
    M R Daws
    Department of Immunology, VA Medical Center San Francisco, San Francisco, USA
    Eur J Immunol 31:783-91. 2001
    ..Our studies define TREM-2 as a receptor family in mouse macrophages and demonstrate the capacity of these receptors to activate macrophage function through DAP12...
  80. ncbi request reprint Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D
    Adelheid Cerwenka
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 168:3131-4. 2002
    ..Ligands of the human NKG2D receptor are remarkably polymorphic, suggesting that these may also serve as minor histocompatibility Ags...
  81. pmc Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?
    Joseph C Sun
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Eur J Immunol 39:2059-64. 2009
    ..In light of new findings showing how NK cells possess nearly all of the features of adaptive immunity including memory, we propose the placement of NK cells as an "evolutionary bridge" between innate and adaptive immunity...
  82. ncbi request reprint Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)
    H Arase
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 167:1141-4. 2001
    ..Cytotoxicity mediated by the DX5(+) NK cells was dramatically higher as compared with DX5(-) NK cells. Therefore, DX5 mAb recognizes CD49b and can be used to define functionally distinct subsets of NK cells...
  83. ncbi request reprint Molecular cloning and characterization of pig immunoreceptor DAP10 and NKG2D
    D Yim
    Department of Microbiology and Immunology, Finch University of Health Sciences, The Chicago Medical School, IL 60064, USA
    Immunogenetics 53:243-9. 2001
    ..RT-PCR analysis reveals that pig NKG2D transcripts are expressed in PBLs, NK cells, macrophages, and monocytes. When transiently transfected into COS-7 cells, pig NKG2D requires DAP10 for cell surface expression...
  84. ncbi request reprint Ligands for natural killer cell receptors: redundancy or specificity
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Immunol Rev 181:158-69. 2001
    ..A better understanding about how targets signal their distress, which renders them susceptible to natural killer (NK)-cell attack, will help to define the role of NK cells in antimicrobial and antitumor immunity and transplantation...
  85. ncbi request reprint Natural killer cells, viruses and cancer
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, 94143-0414, USA
    Nat Rev Immunol 1:41-9. 2001
    ..Here, we review the emerging evidence that natural killer cells have an important role in vivo in immune defence...
  86. pmc Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143-0414, USA
    Proc Natl Acad Sci U S A 98:11521-6. 2001
    ..Therefore, NK cells are able to reject a tumor expressing RAE-1 molecules, despite expression of self MHC class I on the tumor, demonstrating the potential for NK cells to participate in immunity against class I-bearing malignancies...
  87. ncbi request reprint Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
    Attila Mocsai
    Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
    Nat Immunol 7:1326-33. 2006
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism...
  88. ncbi request reprint Natural killer cells and cancer
    Jun Wu
    Shanghai Gnomics, Inc, and Chinese National Genome Center, Shanghai, China
    Adv Cancer Res 90:127-56. 2003
    ..The underlining mechanism of discriminating tumor cells and normal cells by NK cells has provided new insights into tumor immunosurveillance and has suggested new strategies for the treatment of human cancer...
  89. ncbi request reprint Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein
    Agnieszka Kielczewska
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada
    J Immunol 178:369-77. 2007
    ..These results link Ly49 homodimerization variability to the direct recognition of pathogen products...
  90. pmc Reprogramming of CTLs into natural killer-like cells in celiac disease
    Bertrand Meresse
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 203:1343-55. 2006
    ....
  91. pmc Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRgamma
    Ching Liang Chu
    Immunology Research Center, National Health Research Institutes, Taiwan
    Eur J Immunol 38:166-73. 2008
    ....
  92. ncbi request reprint IFN-dependent down-regulation of the NKG2D ligand H60 on tumors
    Jack D Bui
    Center for Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63310, USA
    J Immunol 176:905-13. 2006
    ..This process most likely helps to specify the type of immune effector cell populations that participate in host-protective antitumor responses...
  93. ncbi request reprint Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
    Camie W Chan
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, CRB 440, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Med 12:207-13. 2006
    ..By virtue of their capacity to kill target cells, followed by antigen presentation, IKDCs provide a link between innate and adaptive immunity...
  94. ncbi request reprint Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)
    Satoko Tahara-Hanaoka
    Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305 0074, Japan
    Int Immunol 16:533-8. 2004
    ..We also demonstrate that ligation of CD226 and LFA-1 with their respective ligands cooperates in triggering cytotoxicity and cytokine secretion by T and NK cells...
  95. pmc A role for NKG2D in NK cell-mediated resistance to poxvirus disease
    Min Fang
    Program of Viral Pathogenesis, Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 4:e30. 2008
    ..Together, our results have important implication towards the understanding of natural resistance to pathogenic viral infections...
  96. pmc Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor
    Ikuo Shiratori
    Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuoku, 260 8670, Japan
    J Exp Med 199:525-33. 2004
    ..Cells expressing the PILR ligand specifically activated NK cells and dendritic cells that express the activating PILRbeta. Our findings reveal a new regulatory mechanism of innate immunity by PILR and its CD99-like ligand...
  97. ncbi request reprint Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    Bertrand Meresse
    Department of Pathology, University of Chicago, IL 60637, USA
    Immunity 21:357-66. 2004
    ....
  98. pmc PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B
    Takeshi Satoh
    Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Cell 132:935-44. 2008
    ..These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection...
  99. pmc BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells
    Wei Cao
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS Biol 5:e248. 2007
    ..Therefore, by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of pDCs...
  100. pmc The role of innate immunity in autoimmunity
    Jean Francois Bach
    INSERM U580, Hopital Necker, Paris, France
    J Exp Med 200:1527-31. 2004
    ....