Langholz B, Skolnik J, Barrett J, Renbarger J, Seibel N, Zajicek A, et al. Dactinomycin and vincristine toxicity in the treatment of childhood cancer: a retrospective study from the Children's Oncology Group. Pediatr Blood Cancer. 2011;57:252-7 pubmed publisher
..Current dosing practices result in a fairly uniform toxicity profile within age group. However, PK/PD studies should be done to provide further provide further information on best dosing guidelines. ..