HELENE LANGEVIN

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. ncbi request reprint Evidence of connective tissue involvement in acupuncture
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington Vermont 05405, USA
    FASEB J 16:872-4. 2002
  2. ncbi request reprint Relationship of acupuncture points and meridians to connective tissue planes
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Anat Rec 269:257-65. 2002
  3. ncbi request reprint Connective tissue: a body-wide signaling network?
    Helene M Langevin
    Department of Neurology, University of Vermont, College of Medicine, Burlington, 05405, USA
    Med Hypotheses 66:1074-7. 2006
  4. ncbi request reprint Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts
    Kirsten N Storch
    Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 127:523-30. 2007
  5. pmc Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    BMC Syst Biol 1:25. 2007
  6. doi request reprint Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling
    Helene M Langevin
    Department of Neurological Sciences, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 228:1922-6. 2013
  7. pmc Cellular control of connective tissue matrix tension
    Helene M Langevin
    Department of Neurological Sciences, Vermont Cancer Center, University of Vermont, Burlington, Vermont, USA
    J Cell Biochem 114:1714-9. 2013
  8. pmc Electrical impedance along connective tissue planes associated with acupuncture meridians
    Andrew C Ahn
    Fletcher Allen Health Care, University of Vermont General Clinical Research Center, VT, USA
    BMC Complement Altern Med 5:10. 2005
  9. ncbi request reprint Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
    Med Hypotheses 68:74-80. 2007
  10. pmc Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotation
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    J Altern Complement Med 13:355-60. 2007

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Evidence of connective tissue involvement in acupuncture
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington Vermont 05405, USA
    FASEB J 16:872-4. 2002
    ..Winding may allow needle movements to deliver a mechanical signal into the tissue and may be key to acupuncture's therapeutic mechanism...
  2. ncbi request reprint Relationship of acupuncture points and meridians to connective tissue planes
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Anat Rec 269:257-65. 2002
    ....
  3. ncbi request reprint Connective tissue: a body-wide signaling network?
    Helene M Langevin
    Department of Neurology, University of Vermont, College of Medicine, Burlington, 05405, USA
    Med Hypotheses 66:1074-7. 2006
    ..Demonstrating the existence of a connective signaling network therefore may profoundly influence our understanding of health and disease...
  4. ncbi request reprint Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblasts
    Kirsten N Storch
    Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 127:523-30. 2007
    ..Although the function of these alpha-SMA-rich nuclear invaginations is at present unknown, the morphology of these structures suggests their possible involvement in cellular and nuclear mechanotransduction as well as nuclear transport...
  5. pmc Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasound
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    BMC Syst Biol 1:25. 2007
    ..In ten additional non-surgical subjects, we quantified changes in tissue spatial organization over time during needle rotation vs. no rotation using ultrasound and semi-variogram analyses...
  6. doi request reprint Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling
    Helene M Langevin
    Department of Neurological Sciences, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 228:1922-6. 2013
    ..Together, these results support a mechanism in which extracellular ATP signaling via connexin hemichannels mediate the active change in fibroblast shape that occurs in response to a static increase in tissue length...
  7. pmc Cellular control of connective tissue matrix tension
    Helene M Langevin
    Department of Neurological Sciences, Vermont Cancer Center, University of Vermont, Burlington, Vermont, USA
    J Cell Biochem 114:1714-9. 2013
    ..We also discuss fibroblast regulation of connective tissue tension with respect to lymphatic flow, immune function, and cancer...
  8. pmc Electrical impedance along connective tissue planes associated with acupuncture meridians
    Andrew C Ahn
    Fletcher Allen Health Care, University of Vermont General Clinical Research Center, VT, USA
    BMC Complement Altern Med 5:10. 2005
    ....
  9. ncbi request reprint Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanisms
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
    Med Hypotheses 68:74-80. 2007
    ....
  10. pmc Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotation
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT 05405, USA
    J Altern Complement Med 13:355-60. 2007
    ..Bidirectional (back-and-forth) rotation is one of the most common forms of needle manipulation used in acupuncture practice...
  11. pmc Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
    Helene M Langevin
    Department of Neurology, Given Building, University of Vermont, Burlington, VT 05405, USA
    BMC Musculoskelet Disord 10:151. 2009
    ....
  12. pmc Tissue stretch induces nuclear remodeling in connective tissue fibroblasts
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT, 05405, USA
    Histochem Cell Biol 133:405-15. 2010
    ..005) indicating an increase in nuclear convexity. The stretch-induced loss of invaginations may have important influences on gene expression, RNA trafficking and/or cell differentiation...
  13. pmc Fibroblast cytoskeletal remodeling contributes to connective tissue tension
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
    J Cell Physiol 226:1166-75. 2011
    ....
  14. pmc Reduced thoracolumbar fascia shear strain in human chronic low back pain
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington VT, USA
    BMC Musculoskelet Disord 12:203. 2011
    ..The goal of this study was to quantify shear plane motion within the thoracolumbar fascia using ultrasound elasticity imaging in human subjects with and without chronic low back pain (LBP)...
  15. ncbi request reprint Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanism
    Helene M Langevin
    Department of Neurology, Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 207:767-74. 2006
    ....
  16. ncbi request reprint Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actin
    Helene M Langevin
    Department of Neurology, Given C423, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
    Histochem Cell Biol 125:487-95. 2006
    ..This dual response pattern of alpha- and beta-actin may be an important component of cellular mechanotransduction mechanisms relevant to physiologic and therapeutic mechanical forces applied to connective tissue...
  17. ncbi request reprint Tissue displacements during acupuncture using ultrasound elastography techniques
    Helene M Langevin
    Department of Neurology, University of Vermont, Burlington, VT, USA
    Ultrasound Med Biol 30:1173-83. 2004
    ..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies...
  18. ncbi request reprint Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo
    Helene M Langevin
    Department of Neurology, Vermont Cancer Center, University of Vermont College of Medicine, Given C423, 89 Beaumont Ave, Burlington, VT 05405, USA
    Am J Physiol Cell Physiol 288:C747-56. 2005
    ....
  19. ncbi request reprint Fibroblasts form a body-wide cellular network
    Helene M Langevin
    Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Histochem Cell Biol 122:7-15. 2004
    ..Our findings indicate that soft tissue fibroblasts form an extensively interconnected cellular network, suggesting they may have important and so far unsuspected integrative functions at the level of the whole body...
  20. ncbi request reprint Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension
    James C Iatridis
    Department of Mechanical Engineering, University of Vermont, Burlington, Vermont 05405 0156, USA
    Connect Tissue Res 44:208-17. 2003
    ....
  21. pmc Tissue stretch decreases soluble TGF-beta1 and type-1 procollagen in mouse subcutaneous connective tissue: evidence from ex vivo and in vivo models
    Nicole A Bouffard
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Physiol 214:389-95. 2008
    ..These results have potential relevance to the mechanisms of treatments applying brief mechanical stretch to tissues (e.g., physical therapy, respiratory therapy, mechanical ventilation, massage, yoga, acupuncture)...
  22. ncbi request reprint Yin scores and yang scores: A new method for quantitative diagnostic evaluation in traditional Chinese medicine research
    Helene M Langevin
    University of Vermont General Clinical Research Center at Fletcher Allen Health Care, USA Helene Langevin uvm edu
    J Altern Complement Med 10:389-95; discussion 387. 2004
    ..This method aims to classify subjects into groups allowing future quantitative testing of key research questions such as: do different groups of patients respond differently to acupuncture treatments or Chinese herb formulas?..
  23. ncbi request reprint Using ultrasound to understand acupuncture. Acupuncture needle manipulation and its effect on connective tissue
    Elisa E Konofagou
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    IEEE Eng Med Biol Mag 24:41-6. 2005
  24. ncbi request reprint A new partnership: the Society for Acupuncture Research and the Journal of Alternative and Complementary Medicine
    Richard Hammerschlag
    J Altern Complement Med 9:807-8. 2003
  25. doi request reprint Electrical properties of acupuncture points and meridians: a systematic review
    Andrew C Ahn
    Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts 02215, USA
    Bioelectromagnetics 29:245-56. 2008
    ..However, the preliminary findings are suggestive and offer future directions for research based on in-depth interpretation of the data...

Research Grants16

  1. Connective Tissue Mechanotransduction
    Helene M Langevin; Fiscal Year: 2010
    ....
  2. Acupuncture Mechanism: Mechanotransduction Model
    HELENE LANGEVIN; Fiscal Year: 2006
    ..Understanding these mechanisms will permit improved clinical trials and expand clinical applications of acupuncture. ..
  3. Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain
    HELENE LANGEVIN; Fiscal Year: 2007
    ....
  4. BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLING
    HELENE LANGEVIN; Fiscal Year: 2001
    ..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
  5. Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain
    Helene M Langevin; Fiscal Year: 2010
    ....