Research Topics
| H M LangevinSummaryAffiliation: University of Vermont Country: USA Publications
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Detail Information
Publications
Evidence of connective tissue involvement in acupunctureHelene M Langevin
Department of Neurology, University of Vermont College of Medicine, Burlington Vermont 05405, USA
FASEB J 16:872-4. 2002..Winding may allow needle movements to deliver a mechanical signal into the tissue and may be key to acupuncture's therapeutic mechanism...- Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupunctureH M Langevin
Department of Neurology, University of Vermont, Burlington, Vermont 05405, USA
FASEB J 15:2275-82. 2001..Such a mechanism may explain local and remote, as well as long-term effects of acupuncture... - Biomechanical response to acupuncture needling in humansH M Langevin
Department of Neurology, Given C423, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Appl Physiol 91:2471-8. 2001..001). Pullout force was on average 18% greater at acupuncture points than at control points (P < 0.001). Needle grasp is therefore a measurable biomechanical phenomenon associated with acupuncture needle manipulation... - Relationship of acupuncture points and meridians to connective tissue planesHelene M Langevin
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Anat Rec 269:257-65. 2002.... - Connective tissue: a body-wide signaling network?Helene M Langevin
Department of Neurology, University of Vermont, College of Medicine, Burlington, 05405, USA
Med Hypotheses 66:1074-7. 2006..Demonstrating the existence of a connective signaling network therefore may profoundly influence our understanding of health and disease... - Subcutaneous tissue fibroblast cytoskeletal remodeling induced by acupuncture: evidence for a mechanotransduction-based mechanismHelene M Langevin
Department of Neurology, Vermont Cancer Center, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Cell Physiol 207:767-74. 2006.... - Pathophysiological model for chronic low back pain integrating connective tissue and nervous system mechanismsHelene M Langevin
Department of Neurology, Given C423, University of Vermont, Burlington, VT 05405, United States
Med Hypotheses 68:74-80. 2007.... - Alpha smooth muscle actin distribution in cytoplasm and nuclear invaginations of connective tissue fibroblastsKirsten N Storch
Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Histochem Cell Biol 127:523-30. 2007..Although the function of these alpha-SMA-rich nuclear invaginations is at present unknown, the morphology of these structures suggests their possible involvement in cellular and nuclear mechanotransduction as well as nuclear transport... 
Connective tissue fibroblast response to acupuncture: dose-dependent effect of bidirectional needle rotationHelene M Langevin
Department of Neurology, University of Vermont, Burlington, VT 05405, USA
J Altern Complement Med 13:355-60. 2007..Bidirectional (back-and-forth) rotation is one of the most common forms of needle manipulation used in acupuncture practice...- Dynamic morphometric characterization of local connective tissue network structure in humans using ultrasoundHelene M Langevin
Department of Neurology, University of Vermont, Burlington, VT, USA
BMC Syst Biol 1:25. 2007..In ten additional non-surgical subjects, we quantified changes in tissue spatial organization over time during needle rotation vs. no rotation using ultrasound and semi-variogram analyses... - Tissue stretch decreases soluble TGF-beta1 and type-1 procollagen in mouse subcutaneous connective tissue: evidence from ex vivo and in vivo modelsNicole A Bouffard
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Cell Physiol 214:389-95. 2008..These results have potential relevance to the mechanisms of treatments applying brief mechanical stretch to tissues (e.g., physical therapy, respiratory therapy, mechanical ventilation, massage, yoga, acupuncture)... - Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of alpha- and beta-actinHelene M Langevin
Department of Neurology, Given C423, University of Vermont College of Medicine, 89 Beaumont Ave, Burlington, VT 05405, USA
Histochem Cell Biol 125:487-95. 2006..This dual response pattern of alpha- and beta-actin may be an important component of cellular mechanotransduction mechanisms relevant to physiologic and therapeutic mechanical forces applied to connective tissue... - Using ultrasound to understand acupuncture. Acupuncture needle manipulation and its effect on connective tissueElisa E Konofagou
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
IEEE Eng Med Biol Mag 24:41-6. 2005 - Tissue displacements during acupuncture using ultrasound elastography techniquesHelene M Langevin
Department of Neurology, University of Vermont, Burlington, VT, USA
Ultrasound Med Biol 30:1173-83. 2004..In addition to being a valuable tool for studies of acupuncture's mechanism of action, this technique may have applications to other types of needling including biopsies... - Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivoHelene M Langevin
Department of Neurology, Vermont Cancer Center, University of Vermont College of Medicine, Given C423, 89 Beaumont Ave, Burlington, VT 05405, USA
Am J Physiol Cell Physiol 288:C747-56. 2005.... - Fibroblasts form a body-wide cellular networkHelene M Langevin
Department of Neurology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
Histochem Cell Biol 122:7-15. 2004..Our findings indicate that soft tissue fibroblasts form an extensively interconnected cellular network, suggesting they may have important and so far unsuspected integrative functions at the level of the whole body... - Yin scores and yang scores: A new method for quantitative diagnostic evaluation in traditional Chinese medicine researchHelene M Langevin
University of Vermont General Clinical Research Center at Fletcher Allen Health Care, USA Helene Langevin uvm edu
J Altern Complement Med 10:389-95; discussion 387. 2004..This method aims to classify subjects into groups allowing future quantitative testing of key research questions such as: do different groups of patients respond differently to acupuncture treatments or Chinese herb formulas?.. - Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tensionJames C Iatridis
Department of Mechanical Engineering, University of Vermont, Burlington, Vermont 05405 0156, USA
Connect Tissue Res 44:208-17. 2003.... - Electrical impedance along connective tissue planes associated with acupuncture meridiansAndrew C Ahn
Fletcher Allen Health Care, University of Vermont General Clinical Research Center, VT, USA
BMC Complement Altern Med 5:10. 2005.... - A new partnership: the Society for Acupuncture Research and the Journal of Alternative and Complementary MedicineRichard Hammerschlag
J Altern Complement Med 9:807-8. 2003 
Electrical properties of acupuncture points and meridians: a systematic reviewAndrew C Ahn
Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts 02215, USA
Bioelectromagnetics 29:245-56. 2008..However, the preliminary findings are suggestive and offer future directions for research based on in-depth interpretation of the data...