Leslie A Lange

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults
    L A Lange
    Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA
    J Thromb Haemost 6:654-9. 2008
  2. ncbi request reprint Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
  3. pmc Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults
    Ghenadie Curocichin
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    J Hum Genet 56:823-7. 2011
  4. pmc Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women
    Damien C Croteau-Chonka
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 19:1019-27. 2011
  5. pmc Population-specific coding variant underlies genome-wide association with adiponectin level
    Damien C Croteau-Chonka
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    Hum Mol Genet 21:463-71. 2012
  6. pmc Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Hum Mol Genet 19:4955-64. 2010
  7. pmc Family-based samples can play an important role in genetic association studies
    Ethan M Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 17:2208-14. 2008
  8. ncbi request reprint Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
    Ethan M Lange
    Department of Genetics, University of North Carolina, 4300D MBRB, CB 7264, 103 Mason Farm Road, Chapel Hill, NC 27599 7264, USA
    Hum Genet 119:400-7. 2006
  9. ncbi request reprint AKT1 and neurocognition in schizophrenia
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Aust N Z J Psychiatry 41:169-77. 2007
  10. pmc Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment
    Ying Wu
    Department of Genetics, University of North Carolina, 5112 Genetic Medicine Building, Chapel Hill, NC 27599 7264, USA
    Inflammation 35:574-83. 2012

Detail Information

Publications27

  1. doi request reprint Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults
    L A Lange
    Department of Genetics and the Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC, USA
    J Thromb Haemost 6:654-9. 2008
    ..We hypothesized that common coagulation gene variants contribute to differences in circulating D-dimer concentration...
  2. ncbi request reprint Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
    ..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
  3. pmc Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults
    Ghenadie Curocichin
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    J Hum Genet 56:823-7. 2011
    ..Our results demonstrated that variants in several loci are significantly associated with plasma CRP in Filipino young adults, suggesting shared genetic influences on circulating CRP across populations and age groups...
  4. pmc Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women
    Damien C Croteau-Chonka
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 19:1019-27. 2011
    ..Our results show that several genetic risk factors are associated with anthropometric traits in Filipinos and provide further insight into the effects of BDNF, FTO, and MC4R on BMI...
  5. pmc Population-specific coding variant underlies genome-wide association with adiponectin level
    Damien C Croteau-Chonka
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    Hum Mol Genet 21:463-71. 2012
    ....
  6. pmc Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Hum Mol Genet 19:4955-64. 2010
    ..Our findings provide the first genome-wide significant evidence of association with plasma adiponectin at the CDH13 locus and identify a novel uncommon KNG1-ADIPOQ haplotype strongly associated with adiponectin levels in Filipinos...
  7. pmc Family-based samples can play an important role in genetic association studies
    Ethan M Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 17:2208-14. 2008
    ....
  8. ncbi request reprint Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
    Ethan M Lange
    Department of Genetics, University of North Carolina, 4300D MBRB, CB 7264, 103 Mason Farm Road, Chapel Hill, NC 27599 7264, USA
    Hum Genet 119:400-7. 2006
    ....
  9. ncbi request reprint AKT1 and neurocognition in schizophrenia
    Andrea Poyastro Pinheiro
    Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
    Aust N Z J Psychiatry 41:169-77. 2007
    ..Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia...
  10. pmc Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment
    Ying Wu
    Department of Genetics, University of North Carolina, 5112 Genetic Medicine Building, Chapel Hill, NC 27599 7264, USA
    Inflammation 35:574-83. 2012
    ..1 loci on plasma CRP level...
  11. pmc Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
    Amanda F Marvelle
    Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:1987-91. 2008
    ..The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort...
  12. pmc Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol
    Leslie A Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Hum Genet 94:233-45. 2014
    ..In conclusion, this large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments. ..
  13. pmc Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Hum Mol Genet 19:2050-8. 2010
    ..55). These data confirm a recent finding that CPS1 is a locus influencing Hcy levels in women and suggest that genetic effects on Hcy may differ across developmental stages...
  14. pmc Genetic epidemiology of BMI and body mass change from adolescence to young adulthood
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Obesity (Silver Spring) 18:1474-6. 2010
    ..61 +/- 0.03) and young adulthood (rho(G) = 0.23 +/- 0.06). Our findings support a complex etiology of BMI and BMI change...
  15. ncbi request reprint Comparison of ENCODE region SNPs between Cebu Filipino and Asian HapMap samples
    Amanda F Marvelle
    Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Chapel Hill, NC 27599 7264, USA
    J Hum Genet 52:729-37. 2007
    ..These results suggest that the HapMap data will be an effective resource for future studies in Cebu Filipino samples...
  16. pmc Ultraconserved elements in the human genome: association and transmission analyses of highly constrained single-nucleotide polymorphisms
    Charleston W K Chiang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Genetics 192:253-66. 2012
    ..Our study also illustrated the importance of carefully modeling potential technical confounders when analyzing genotype data of rare variants...
  17. ncbi request reprint NCAM1 and neurocognition in schizophrenia
    Patrick F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Biol Psychiatry 61:902-10. 2007
    ..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings...
  18. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
    ..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
  19. pmc Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women
    Timothy D Howard
    The Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 36:1848-51. 2005
    ..Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility...
  20. ncbi request reprint Autosomal linkage analysis for the level of response to alcohol
    Marc A Schuckit
    Department of Genetics and Neurology, The Carolina Center for Genome Sciences, Chapel Hill, NC, USA
    Alcohol Clin Exp Res 29:1976-82. 2005
    ..4 and 0.6, and efforts are being made to find genes related to this phenotype. This paper presents data from a family-based genome with linkage analysis focusing on alcohol challenge determinants of LR...
  21. pmc A gene-centric association scan for Coagulation Factor VII levels in European and African Americans: the Candidate Gene Association Resource (CARe) Consortium
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC 27514, USA
    Hum Mol Genet 20:3525-34. 2011
    ....
  22. ncbi request reprint Impact of genotype-guided dosing on anticoagulation visits for adults starting warfarin: a randomized controlled trial
    Daniel E Jonas
    Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, 5034 Old Clinic Building, CB 7110, Chapel Hill, NC 27599, USA
    Pharmacogenomics 14:1593-603. 2013
    ..This study aimed to assess the effectiveness of genotype-guided warfarin dosing...
  23. ncbi request reprint Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 118:716-24. 2006
    ....
  24. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  25. doi request reprint Increased uptake of BRCA1/2 genetic testing among African American women with a recent diagnosis of breast cancer
    Lisa R Susswein
    Department of Genetics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
    J Clin Oncol 26:32-6. 2008
    ..Studies suggest that African American women are less likely to pursue BRCA1/2 genetic testing than white women. However, such studies are often confounded by unequal access to care...
  26. ncbi request reprint Dopamine transporter, gender, and number of sexual partners among young adults
    Guang Guo
    Department of Sociology, University of North Carolina, Chapel Hill, NC 27599 3210, USA
    Eur J Hum Genet 15:279-87. 2007
    ..Discussion is provided why this finding is absent among females...
  27. doi request reprint Sweet liking and high novelty seeking: independent phenotypes associated with alcohol-related problems
    Leslie A Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Alcohol Alcohol 45:431-6. 2010
    ....