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Genomes and Genes | Carol A LangeSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Integration of progesterone receptor action with rapid signaling events in breast cancer modelsCarol A Lange
University of Minnesota Cancer Center, Department of Medicine, Division of Hematology, Oncology, and Transplant, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Steroid Biochem Mol Biol 108:203-12. 2008..Cross-talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues, and is suspected to contribute to cancer biology...- Challenges to defining a role for progesterone in breast cancerCarol A Lange
University of Minnesota Cancer Center, Department of Medicine, 420 Delaware Street SE, MMC 806, Minneapolis, MN 55455, United States
Steroids 73:914-21. 2008..However, PR action in breast cancer remains controversial. Herein, we review existing evidence from in vitro and in vivo models, and discuss the challenges to defining a role for progesterone in breast cancer... 
Progesterone receptor action: translating studies in breast cancer models to clinical insightsCarol A Lange
Department of Medicine, Division of Hematology, Oncology and Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Adv Exp Med Biol 630:94-111. 2008....
Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancerCarol A Lange
Departments of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street South East, MMC 806, Minneapolis, Minnesota 55455, USA
Endocr Relat Cancer 18:C19-24. 2011..These studies provide renewed hope of effectively stabilizing endocrine-resistant breast cancers using available complementary (to endocrine-based therapies) cytostatic agents in the form of CDK4/6 inhibitors...- Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancerCarol A Lange
Department of Medicine Division of Hematology, Oncology, and Transplant, USA
Annu Rev Physiol 69:171-99. 2007.... - Progesterone and breast cancerCarol A Lange
University of Minnesota, Cancer Center, Department of Medicine Hematology, Oncology and Transplantation, 420 Delaware Street SE, MMC 806, MN 55455, USA
Womens Health (Lond Engl) 4:151-62. 2008..However, PR action in breast cancer is grossly understudied and remains controversial. Herein, we review existing evidence and discuss the challenges to defining a role for progesterone in breast cancer... - Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factorsEmily J Faivre
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 22:823-37. 2008..Our data demonstrate the therapeutic potential for PR-targeted breast cancer treatment by exploiting multiple nodes along the PR signaling pathway, including PR-B, EGFR, c-Src, MAPK, or Sp1... - Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cellsAndrea R Daniel
Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 106:14287-92. 2009..Our data explain why breast cancer models often remain insensitive to progestins, but are growth-inhibited by antiprogestins, and underscore the need to target PR-B and associated kinase activities as part of breast cancer therapy... - Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growthAndrea R Daniel
Department of Medicine, Division of Hematology, Oncology, and Transplantation and Pharmacology, University of Minnesota Cancer Center, Minneapolis, MN 55455, United States
Steroids 72:188-201. 2007..PR function likely contributes to breast cancer progression when EGFR family members or their ligands are overexpressed, a condition that predicts low abundance, but highly active and nuclear PR... - Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPKKristopher A Lofgren
Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware St SE, MMC 806, Minneapolis, MN 55455, USA
Breast Cancer Res 13:R89. 2011..The non-receptor PTK termed breast tumor kinase (Brk/PTK6) is overexpressed in approximately 86% of human breast tumors. The role of Brk in breast pathology is unclear... - Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinasesAndrew Skildum
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 19:327-39. 2005..Targeting the ability of steroid receptors to activate MAPKs may be beneficial for breast cancer patients... - Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cellsEmily J Faivre
Departments of Medicine and Pharmacology, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, MN 55455, USA
Mol Cell Biol 27:466-80. 2007..PR-B-induced sustained MAPK signaling may provide prosurvival or proliferative advantages to early breast cancer lesions... - Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progressionAlessia Locatelli
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, 55455, USA
Horm Cancer 3:14-25. 2012.... - Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cellsNancy E Castro
Department of Pharmacology, University of Minnesota, 321 Church Street S E, Minneapolis, MN 55455, USA
Breast Cancer Res 12:R60. 2010.... - Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2Lisa K Pierson-Mullany
University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Mol Cell Biol 24:10542-57. 2004.... - Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulatorsEmily Faivre
University of Minnesota Cancer Center and the Microbiology, Immunology, and Cancer Biology Graduate Program, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Steroids 70:418-26. 2005.... - Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cellsAndrea R Daniel
Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 21:2890-906. 2007..In the context of elevated protein kinase activities, such as during mammary gland development or breast cancer progression, phosphorylated PR-B may be undersumoylated, transcriptionally hyperactive, and unstable/undetectable... - Signaling inputs to progesterone receptor gene regulation and promoter selectivityAndrea R Daniel
Department of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
Mol Cell Endocrinol 308:47-52. 2009..e. EGF, heregulin). Herein, we discuss the actions of cytoplasmic signaling molecules such as c-Src and mitogen-activated protein kinases as key mediators of PR promoter selectivity... - Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cellsJulie Hanson Ostrander
Department of Medicine, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Cancer Res 67:4199-209. 2007..These results place Brk in a novel signaling pathway downstream of ErbB receptors and upstream of Rac, p38 MAPK, and ERK5 and establish the ErbB-Brk-Rac-p38 MAPK pathway as a critical mediator of breast cancer cell migration... - Brk/PTK6 signaling in normal and cancer cell modelsJULIE H OSTRANDER
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Pharmacol 10:662-9. 2010.... - The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retentionAndrea R Daniel
University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 24:2126-38. 2010..In sum, the PR hinge region is multifunctional. Understanding the ability of this region to couple acetylation, phosphorylation, and nuclear entry may provide clues to mechanisms of altered hormone responsiveness... - ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cellsChristy R Hagan
Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, Minnesota, USA
Mol Cell Biol 31:2439-52. 2011.... - Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?Carol A Lange
University of Minnesota Cancer Center, Department of Medicine, Division of Hematology, Oncology, and Transplant, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 18:269-78. 2004.... - MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear associationMing Qiu
Department of Medicine, University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Steroid Biochem Mol Biol 85:147-57. 2003..The uncoupling of these events during breast cancer progression is predicted to profoundly influence hormone responsiveness, as PR with altered stability may be driven primarily by upregulated growth factors... - Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family membersAlessia Locatelli
Department of Medicine Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 286:21062-72. 2011..These results suggest that Sam68 acts as a convergence point for ERK signaling to cell migration; blockade of phospho-Sam68 may provide a new avenue for therapeutic inhibition of metastatic cancers... - Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferationGwen E Dressing
Department of Medicine, Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States
Steroids 74:573-6. 2009..A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers... - Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling eventsNathan J Charles
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
Horm Cancer 1:167-76. 2010.... - Mitogen-activated protein kinase regulates nuclear association of human progesterone receptorsMing Qiu
Department of Medicine, University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
Mol Endocrinol 17:628-42. 2003..These results support a regulatory role for MAPK in nuclear steroid hormone receptor subcellular localization and coupling to multiple PR functions... - Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer modelsGwen E Dressing
Department of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, MMC 806, Minneapolis, Minnesota 55455, USA
Endocr Relat Cancer 16:351-61. 2009..Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models... - Role of phosphorylation in progesterone receptor signaling and specificityChristy R Hagan
University of Minnesota, Departments of Medicine and Pharmacology, Division of Hematology, Oncology, and Transplantation, Women s Cancer Program, Masonic Cancer Center, Minneapolis, MN 55455, United States
Mol Cell Endocrinol 357:43-9. 2012..e. lung, uterine and ovarian) in the clinic. This review focuses on PR phosphorylation by mitogenic protein kinases and mechanisms of PR-target gene selection that lead to increased cell proliferation... - Scaffolding actions of membrane-associated progesterone receptorsChristy R Hagan
Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, MN, United States
Steroids 74:568-72. 2009..This review details the extra nuclear scaffolding actions of PR with c-Src and MEK1, the upstream components of MAP kinase modules... - Roles of the EZH2 histone methyltransferase in cancer epigeneticsJeffrey A Simon
Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
Mutat Res 647:21-9. 2008..Finally, we review recent findings that link EZH2 roles in stem cells and cancer, and we consider prospects for integrating EZH2 blockade into strategies for developing epigenetic therapies... - Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implicationsGwen E Dressing
Department of Medicine, University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA
Steroids 76:11-7. 2011..We also provide new data demonstrating mPR expression in the RAW 264.7 immune cell line and bone marrow-derived macrophages as well as mPR expression and downstream gene regulation in ovarian cancer cells... - Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progressionTodd P Knutson
Departments of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 USA
Breast Cancer Res 14:R95. 2012..As a broad range of PR protein expression is observed clinically, a PR gene signature would provide a valuable marker of PR contribution to early breast cancer progression... - Regulated association of protein kinase B/Akt with breast tumor kinasePing Zhang
University of Minnesota Cancer Center and the Department of Medicine, Division of Hematology, Oncology, and Transplantation, and Pharmacology, Minneapolis, Minnesota 55455, USA
J Biol Chem 280:1982-91. 2005..Together these data provide clues to the possible proto-oncogenic and oncogenic functions of Brk... - Editorial: membrane and nuclear steroid hormone receptors: two integrated arms of the same signaling pathway?Carol A Lange
Steroids 72:105-6. 2007 - Breast cancer and pregnancyKimberly K Leslie
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, 2211 Lomas Boulevard NE, ACC-4, Albuquerque, NM 87131, USA
Obstet Gynecol Clin North Am 32:547-58. 2005..The risks associated with pregnancy after breast cancer treatment and the effect of pregnancy on lifetime risk for breast cancer in the general population and for women with mutations in BRCA1 and BRCA2 are also discussed... - Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signallingCheryl S Watson
Human Biological Chemistry and Genetics Department and Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, Texas 77555-0645, USA
EMBO Rep 6:116-9. 2005