Carol A Lange

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Molecular determinants of context-dependent progesterone receptor action in breast cancer
    Christy R Hagan
    Department of Medicine Hematology, Oncology, and Transplantation and the Department of Pharmacology, University of Minnesota, Masonic Cancer Center, 420 Delaware St SE, MMC 806, Minneapolis, MN 55455, USA
    BMC Med 12:32. 2014
  2. ncbi request reprint Progesterone receptor action: translating studies in breast cancer models to clinical insights
    Carol A Lange
    Department of Medicine, Division of Hematology, Oncology and Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Adv Exp Med Biol 630:94-111. 2008
  3. pmc Integration of progesterone receptor action with rapid signaling events in breast cancer models
    Carol A Lange
    University of Minnesota Cancer Center, Department of Medicine, Division of Hematology, Oncology, and Transplant, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Steroid Biochem Mol Biol 108:203-12. 2008
  4. doi request reprint Progesterone and breast cancer
    Carol A Lange
    University of Minnesota, Cancer Center, Department of Medicine Hematology, Oncology and Transplantation, 420 Delaware Street SE, MMC 806, MN 55455, USA
    Womens Health (Lond Engl) 4:151-62. 2008
  5. doi request reprint Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer
    Carol A Lange
    Departments of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street South East, MMC 806, Minneapolis, Minnesota 55455, USA
    Endocr Relat Cancer 18:C19-24. 2011
  6. ncbi request reprint Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    Carol A Lange
    Department of Medicine Division of Hematology, Oncology, and Transplant, USA
    Annu Rev Physiol 69:171-99. 2007
  7. pmc Challenges to defining a role for progesterone in breast cancer
    Carol A Lange
    University of Minnesota Cancer Center, Department of Medicine, 420 Delaware Street SE, MMC 806, Minneapolis, MN 55455, United States
    Steroids 73:914-21. 2008
  8. pmc Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    Emily J Faivre
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 22:823-37. 2008
  9. pmc Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells
    Andrea R Daniel
    Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:14287-92. 2009
  10. pmc Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth
    Andrea R Daniel
    Department of Medicine, Division of Hematology, Oncology, and Transplantation and Pharmacology, University of Minnesota Cancer Center, Minneapolis, MN 55455, United States
    Steroids 72:188-201. 2007

Collaborators

Detail Information

Publications45

  1. doi request reprint Molecular determinants of context-dependent progesterone receptor action in breast cancer
    Christy R Hagan
    Department of Medicine Hematology, Oncology, and Transplantation and the Department of Pharmacology, University of Minnesota, Masonic Cancer Center, 420 Delaware St SE, MMC 806, Minneapolis, MN 55455, USA
    BMC Med 12:32. 2014
    ....
  2. ncbi request reprint Progesterone receptor action: translating studies in breast cancer models to clinical insights
    Carol A Lange
    Department of Medicine, Division of Hematology, Oncology and Transplant, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Adv Exp Med Biol 630:94-111. 2008
    ....
  3. pmc Integration of progesterone receptor action with rapid signaling events in breast cancer models
    Carol A Lange
    University of Minnesota Cancer Center, Department of Medicine, Division of Hematology, Oncology, and Transplant, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Steroid Biochem Mol Biol 108:203-12. 2008
    ..Cross-talk between SR and membrane-initiated signaling events suggests a mechanism for coordinate regulation of gene subsets by mitogenic stimuli in hormonally responsive normal tissues, and is suspected to contribute to cancer biology...
  4. doi request reprint Progesterone and breast cancer
    Carol A Lange
    University of Minnesota, Cancer Center, Department of Medicine Hematology, Oncology and Transplantation, 420 Delaware Street SE, MMC 806, MN 55455, USA
    Womens Health (Lond Engl) 4:151-62. 2008
    ..However, PR action in breast cancer is grossly understudied and remains controversial. Herein, we review existing evidence and discuss the challenges to defining a role for progesterone in breast cancer...
  5. doi request reprint Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer
    Carol A Lange
    Departments of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street South East, MMC 806, Minneapolis, Minnesota 55455, USA
    Endocr Relat Cancer 18:C19-24. 2011
    ..These studies provide renewed hope of effectively stabilizing endocrine-resistant breast cancers using available complementary (to endocrine-based therapies) cytostatic agents in the form of CDK4/6 inhibitors...
  6. ncbi request reprint Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    Carol A Lange
    Department of Medicine Division of Hematology, Oncology, and Transplant, USA
    Annu Rev Physiol 69:171-99. 2007
    ....
  7. pmc Challenges to defining a role for progesterone in breast cancer
    Carol A Lange
    University of Minnesota Cancer Center, Department of Medicine, 420 Delaware Street SE, MMC 806, Minneapolis, MN 55455, United States
    Steroids 73:914-21. 2008
    ..However, PR action in breast cancer remains controversial. Herein, we review existing evidence from in vitro and in vivo models, and discuss the challenges to defining a role for progesterone in breast cancer...
  8. pmc Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors
    Emily J Faivre
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 22:823-37. 2008
    ..Our data demonstrate the therapeutic potential for PR-targeted breast cancer treatment by exploiting multiple nodes along the PR signaling pathway, including PR-B, EGFR, c-Src, MAPK, or Sp1...
  9. pmc Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells
    Andrea R Daniel
    Department of Medicine, Division of Hematology, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 106:14287-92. 2009
    ..Our data explain why breast cancer models often remain insensitive to progestins, but are growth-inhibited by antiprogestins, and underscore the need to target PR-B and associated kinase activities as part of breast cancer therapy...
  10. pmc Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth
    Andrea R Daniel
    Department of Medicine, Division of Hematology, Oncology, and Transplantation and Pharmacology, University of Minnesota Cancer Center, Minneapolis, MN 55455, United States
    Steroids 72:188-201. 2007
    ..PR function likely contributes to breast cancer progression when EGFR family members or their ligands are overexpressed, a condition that predicts low abundance, but highly active and nuclear PR...
  11. ncbi request reprint Progesterone receptors induce cell cycle progression via activation of mitogen-activated protein kinases
    Andrew Skildum
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 19:327-39. 2005
    ..Targeting the ability of steroid receptors to activate MAPKs may be beneficial for breast cancer patients...
  12. pmc Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK
    Kristopher A Lofgren
    Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware St SE, MMC 806, Minneapolis, MN 55455, USA
    Breast Cancer Res 13:R89. 2011
    ..The non-receptor PTK termed breast tumor kinase (Brk/PTK6) is overexpressed in approximately 86% of human breast tumors. The role of Brk in breast pathology is unclear...
  13. pmc Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells
    Emily J Faivre
    Departments of Medicine and Pharmacology, Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, MN 55455, USA
    Mol Cell Biol 27:466-80. 2007
    ..PR-B-induced sustained MAPK signaling may provide prosurvival or proliferative advantages to early breast cancer lesions...
  14. doi request reprint Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression
    Alessia Locatelli
    Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, 55455, USA
    Horm Cancer 3:14-25. 2012
    ....
  15. pmc Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2
    Lisa K Pierson-Mullany
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Mol Cell Biol 24:10542-57. 2004
    ....
  16. ncbi request reprint Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: role of mitogen-activated protein kinases and cell cycle regulators
    Emily Faivre
    University of Minnesota Cancer Center and the Microbiology, Immunology, and Cancer Biology Graduate Program, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Steroids 70:418-26. 2005
    ....
  17. pmc Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells
    Nancy E Castro
    Department of Pharmacology, University of Minnesota, 321 Church Street S E, Minneapolis, MN 55455, USA
    Breast Cancer Res 12:R60. 2010
    ....
  18. pmc Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression
    Tarah M Regan Anderson
    Authors Affiliations Division of Hematology, Oncology, and Transplantation, Department of Medicine and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota Center for Cancer Research, Department of Pathology and Laboratory Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee and Institute of Physiology and Z├╝rich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Cancer Res 73:5810-20. 2013
    ..Targeting Brk expression or activity may provide an effective means to block the progression of aggressive breast cancers...
  19. pmc A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells
    Christy R Hagan
    Departments of Medicine and Pharmacology, Cell Signaling Program Masonic Cancer Center, University of Minnesota, Cancer Cardiology Research Building, 2231 6th Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 41:8926-42. 2013
    ..Coregulation of select target genes by PR-B and STAT5 is likely a global mechanism required for growth promoting programs relevant to mammary stem cell biology and cancer. ..
  20. pmc Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression
    Todd P Knutson
    Departments of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 USA
    Breast Cancer Res 14:R95. 2012
    ..As a broad range of PR protein expression is observed clinically, a PR gene signature would provide a valuable marker of PR contribution to early breast cancer progression...
  21. ncbi request reprint Phosphorylation-dependent antagonism of sumoylation derepresses progesterone receptor action in breast cancer cells
    Andrea R Daniel
    Department of Medicine Division of Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 21:2890-906. 2007
    ..In the context of elevated protein kinase activities, such as during mammary gland development or breast cancer progression, phosphorylated PR-B may be undersumoylated, transcriptionally hyperactive, and unstable/undetectable...
  22. doi request reprint Signaling inputs to progesterone receptor gene regulation and promoter selectivity
    Andrea R Daniel
    Department of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Cell Endocrinol 308:47-52. 2009
    ..e. EGF, heregulin). Herein, we discuss the actions of cytoplasmic signaling molecules such as c-Src and mitogen-activated protein kinases as key mediators of PR promoter selectivity...
  23. ncbi request reprint Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells
    Julie Hanson Ostrander
    Department of Medicine, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Res 67:4199-209. 2007
    ..These results place Brk in a novel signaling pathway downstream of ErbB receptors and upstream of Rac, p38 MAPK, and ERK5 and establish the ErbB-Brk-Rac-p38 MAPK pathway as a critical mediator of breast cancer cell migration...
  24. pmc Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells
    Caroline H Diep
    Department of Medicine, Hematology, Oncology, and Transplantation Division, University of Minnesota, Minneapolis, MN, USA
    Cell Cycle 12:1433-49. 2013
    ....
  25. pmc The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention
    Andrea R Daniel
    University of Minnesota Cancer Center, 420 Delaware Street SE, MMC 806, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 24:2126-38. 2010
    ..In sum, the PR hinge region is multifunctional. Understanding the ability of this region to couple acetylation, phosphorylation, and nuclear entry may provide clues to mechanisms of altered hormone responsiveness...
  26. pmc Brk/PTK6 signaling in normal and cancer cell models
    JULIE H OSTRANDER
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Pharmacol 10:662-9. 2010
    ....
  27. ncbi request reprint Making sense of cross-talk between steroid hormone receptors and intracellular signaling pathways: who will have the last word?
    Carol A Lange
    University of Minnesota Cancer Center, Department of Medicine, Division of Hematology, Oncology, and Transplant, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 18:269-78. 2004
    ....
  28. pmc ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells
    Christy R Hagan
    Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, Minnesota, USA
    Mol Cell Biol 31:2439-52. 2011
    ....
  29. ncbi request reprint MAP kinases couple multiple functions of human progesterone receptors: degradation, transcriptional synergy, and nuclear association
    Ming Qiu
    Department of Medicine, University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Steroid Biochem Mol Biol 85:147-57. 2003
    ..The uncoupling of these events during breast cancer progression is predicted to profoundly influence hormone responsiveness, as PR with altered stability may be driven primarily by upregulated growth factors...
  30. doi request reprint Progesterone receptor-cyclin d1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells
    Gwen E Dressing
    Departments of Medicine and Pharmacology G E D, T P K, A R D, C R H, C H D, C A L, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455 and Departments of Cancer Biology, Urology, and Radiation Oncology M J S, K E K, Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Mol Endocrinol 28:442-57. 2014
    ....
  31. doi request reprint Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models
    Gwen E Dressing
    Department of Medicine Division of Hematology, Oncology, and Transplantation and Pharmacology, Masonic Cancer Center, University of Minnesota, MMC 806, Minneapolis, Minnesota 55455, USA
    Endocr Relat Cancer 16:351-61. 2009
    ..Here, we review interactions between PR and mitogenic protein kinases and discuss the consequences of specific post-translational modifications on PR action in breast cancer cell-line models...
  32. ncbi request reprint Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors
    Ming Qiu
    Department of Medicine, University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Mol Endocrinol 17:628-42. 2003
    ..These results support a regulatory role for MAPK in nuclear steroid hormone receptor subcellular localization and coupling to multiple PR functions...
  33. doi request reprint Dynamic regulation of steroid hormone receptor transcriptional activity by reversible SUMOylation
    Todd P Knutson
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Vitam Horm 93:227-61. 2013
    ..e., SUMOylation) have on the transcriptional regulation of SR target genes. ..
  34. pmc Met receptors induce Sam68-dependent cell migration by activation of alternate extracellular signal-regulated kinase family members
    Alessia Locatelli
    Department of Medicine Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:21062-72. 2011
    ..These results suggest that Sam68 acts as a convergence point for ERK signaling to cell migration; blockade of phospho-Sam68 may provide a new avenue for therapeutic inhibition of metastatic cancers...
  35. doi request reprint Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events
    Nathan J Charles
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Masonic Cancer Center, Minneapolis, MN 55455, USA
    Horm Cancer 1:167-76. 2010
    ....
  36. doi request reprint Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation
    Gwen E Dressing
    Department of Medicine, Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States
    Steroids 74:573-6. 2009
    ..A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers...
  37. pmc Role of phosphorylation in progesterone receptor signaling and specificity
    Christy R Hagan
    University of Minnesota, Departments of Medicine and Pharmacology, Division of Hematology, Oncology, and Transplantation, Women s Cancer Program, Masonic Cancer Center, Minneapolis, MN 55455, United States
    Mol Cell Endocrinol 357:43-9. 2012
    ..e. lung, uterine and ovarian) in the clinic. This review focuses on PR phosphorylation by mitogenic protein kinases and mechanisms of PR-target gene selection that lead to increased cell proliferation...
  38. doi request reprint Scaffolding actions of membrane-associated progesterone receptors
    Christy R Hagan
    Department of Medicine and Women s Cancer Program, University of Minnesota, Minneapolis, MN, United States
    Steroids 74:568-72. 2009
    ..This review details the extra nuclear scaffolding actions of PR with c-Src and MEK1, the upstream components of MAP kinase modules...
  39. doi request reprint Roles of the EZH2 histone methyltransferase in cancer epigenetics
    Jeffrey A Simon
    Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Mutat Res 647:21-9. 2008
    ..Finally, we review recent findings that link EZH2 roles in stem cells and cancer, and we consider prospects for integrating EZH2 blockade into strategies for developing epigenetic therapies...
  40. pmc PELP1: a review of PELP1 interactions, signaling, and biology
    Brian J Girard
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States
    Mol Cell Endocrinol 382:642-51. 2014
    ..Here we will review (1) the cloning and characterization of PELP1 expression, (2) interacting proteins, (3) PELP1 signaling, and (4) PELP1-mediated biology. ..
  41. ncbi request reprint Regulated association of protein kinase B/Akt with breast tumor kinase
    Ping Zhang
    University of Minnesota Cancer Center and the Department of Medicine, Division of Hematology, Oncology, and Transplantation, and Pharmacology, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:1982-91. 2005
    ..Together these data provide clues to the possible proto-oncogenic and oncogenic functions of Brk...
  42. pmc Membrane progesterone receptor expression in mammalian tissues: a review of regulation and physiological implications
    Gwen E Dressing
    Department of Medicine, University of Minnesota, Masonic Cancer Center, Minneapolis, MN 55455, USA
    Steroids 76:11-7. 2011
    ..We also provide new data demonstrating mPR expression in the RAW 264.7 immune cell line and bone marrow-derived macrophages as well as mPR expression and downstream gene regulation in ovarian cancer cells...
  43. ncbi request reprint Breast cancer and pregnancy
    Kimberly K Leslie
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, 2211 Lomas Boulevard NE, ACC 4, Albuquerque, NM 87131, USA
    Obstet Gynecol Clin North Am 32:547-58. 2005
    ..The risks associated with pregnancy after breast cancer treatment and the effect of pregnancy on lifetime risk for breast cancer in the general population and for women with mutations in BRCA1 and BRCA2 are also discussed...
  44. pmc Steadying the boat: integrating mechanisms of membrane and nuclear-steroid-receptor signalling
    Cheryl S Watson
    Human Biological Chemistry and Genetics Department and Center for Interdisciplinary Research in Women s Health, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    EMBO Rep 6:116-9. 2005
  45. ncbi request reprint Editorial: membrane and nuclear steroid hormone receptors: two integrated arms of the same signaling pathway?
    Carol A Lange
    Steroids 72:105-6. 2007