Douglas R Langbehn

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Genetic and environmental risk factors for the onset of drug use and problems in adoptees
    Douglas R Langbehn
    Department of Psychiatry, University of Iowa, 5107 Westlawn Building, Iowa City, IA 52246, USA
    Drug Alcohol Depend 69:151-67. 2003
  2. ncbi request reprint Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality
    Douglas R Langbehn
    Department of Psychiatry, Psychiatry Research, Room 1 326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Drug Alcohol Depend 83:33-41. 2006
  3. pmc "Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness
    Kevin Duff
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    J Neuropsychiatry Clin Neurosci 22:196-207. 2010
  4. ncbi request reprint Hypochondriasis and fear of death
    Russell Noyes
    Department of Psychiatry, University of Iowa, College of Medicine, Psychiatry Research, Medical Education Building, Iowa City 52242 1000, USA
    J Nerv Ment Dis 190:503-9. 2002
  5. pmc Earliest functional declines in Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Psychiatry Res 178:414-8. 2010
  6. ncbi request reprint Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 62:1341-6. 2007
  7. ncbi request reprint Predictors of diagnosis in Huntington disease
    Douglas R Langbehn
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Neurology 68:1710-7. 2007
  8. pmc Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphology
    Aaron D Boes
    University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Behav Brain Res 181:224-31. 2007
  9. ncbi request reprint Abnormal brain structure in children with isolated clefts of the lip or palate
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Pediatr Adolesc Med 161:753-8. 2007
  10. doi request reprint Normative data on and psychometric properties of Verbal and Visual Indexes of the RBANS in older adults
    Kevin Duff
    University of Iowa, Department of Psychiatry, Iowa City, IA 52242 1000, USA
    Clin Neuropsychol 23:39-50. 2009

Detail Information

Publications29

  1. ncbi request reprint Genetic and environmental risk factors for the onset of drug use and problems in adoptees
    Douglas R Langbehn
    Department of Psychiatry, University of Iowa, 5107 Westlawn Building, Iowa City, IA 52246, USA
    Drug Alcohol Depend 69:151-67. 2003
    ..We argue that the observed biological associations are broadly consistent with generalization to other substances of an alcoholism phenotype similar to Cloninger's Type II or Babor's Type B...
  2. ncbi request reprint Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality
    Douglas R Langbehn
    Department of Psychiatry, Psychiatry Research, Room 1 326, Medical Education Building, University of Iowa, Iowa City, IA 52242, USA
    Drug Alcohol Depend 83:33-41. 2006
    ..We note that, in combination with additional liabilities towards depression in women and alcoholism/sociopathy in men, the 124-bp allele may provide a basis for the phenomenon of depressive spectrum illness proposed by Winokur...
  3. pmc "Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness
    Kevin Duff
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    J Neuropsychiatry Clin Neurosci 22:196-207. 2010
    ..Participant/companion discrepancies, especially closest to Huntington's disease diagnosis, might suggest early lack of awareness in these individuals...
  4. ncbi request reprint Hypochondriasis and fear of death
    Russell Noyes
    Department of Psychiatry, University of Iowa, College of Medicine, Psychiatry Research, Medical Education Building, Iowa City 52242 1000, USA
    J Nerv Ment Dis 190:503-9. 2002
    ..Fear of death appears to be an integral part of hypochondriasis. Its presence lends support to three models of hypochondriasis-the perceptual, existential, and interpersonal-that correspond to the dimensions of fear of death...
  5. pmc Earliest functional declines in Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Psychiatry Res 178:414-8. 2010
    ..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis...
  6. ncbi request reprint Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 62:1341-6. 2007
    ..Psychiatric disturbances are relatively common in manifest Huntington's disease (HD), but less is known about these symptoms in the earliest phase of the illness...
  7. ncbi request reprint Predictors of diagnosis in Huntington disease
    Douglas R Langbehn
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Neurology 68:1710-7. 2007
    ..The objective is to examine the prognostic significance of these early clinical signs and symptoms regarding time until unequivocal clinical HD diagnosis...
  8. pmc Social function in boys with cleft lip and palate: relationship to ventral frontal cortex morphology
    Aaron D Boes
    University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Behav Brain Res 181:224-31. 2007
    ..These results are consistent with the possibility that aberrant VFC development may partially underlie social dysfunction in boys with ICLP...
  9. ncbi request reprint Abnormal brain structure in children with isolated clefts of the lip or palate
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Arch Pediatr Adolesc Med 161:753-8. 2007
    ..To evaluate brain structure in a sample of children with isolated clefts of the lip and/or palate (ICLP)...
  10. doi request reprint Normative data on and psychometric properties of Verbal and Visual Indexes of the RBANS in older adults
    Kevin Duff
    University of Iowa, Department of Psychiatry, Iowa City, IA 52242 1000, USA
    Clin Neuropsychol 23:39-50. 2009
    ..These data might allow clinicians and researchers to better assess laterality effects of brain dysfunction when using the RBANS, although clinical validation is needed...
  11. pmc Obsessive and compulsive symptoms in prediagnosed Huntington's disease
    Leigh J Beglinger
    University of Iowa, Department of Psychiatry, MEB 1 321, Iowa City, IA 52242 1000, USA
    J Clin Psychiatry 69:1758-65. 2008
    ..Although psychiatric symptoms have been reported in individuals with the HD gene expansion prior to clinical diagnosis (pre-HD), little is known about OCS in this phase of disease...
  12. pmc Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242 1000, USA
    J Clin Psychopharmacol 29:484-7. 2009
    ..Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder...
  13. doi request reprint Hypochondriacal symptoms associated with a less therapeutic physician-patient relationship
    Russell Noyes
    Department of Psychiatry, College of Medicine, College of Public Health at the University of Iowa, Iowa City, IA 52242 1000, USA
    Psychiatry 73:57-69. 2010
    ..Hypochondriacal symptoms appear to be associated with a less therapeutic physician-patient relationship. Physicians must recognize symptoms of this kind in order to properly address the relationship needs of their patients...
  14. pmc Self-paced timing detects and tracks change in prodromal Huntington disease
    Kelly C Rowe
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Neuropsychology 24:435-42. 2010
    ..This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (pr-HD) and a comparison group of gene non-expanded participants from affected families (NC)...
  15. pmc Practice effects in the prediction of long-term cognitive outcome in three patient samples: a novel prognostic index
    Kevin Duff
    University of Iowa, Department of Psychiatry, MEB 1 308, Iowa City, IA 52242 1000, United States
    Arch Clin Neuropsychol 22:15-24. 2007
    ..Additionally, this prognostic index could be used to offer interventions to patients who are in the earliest stages of progressive neurodegenerative disorders...
  16. ncbi request reprint Test of an interpersonal model of hypochondriasis
    Russell Noyes
    Department of Biostatistics, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa, USA
    Psychosom Med 65:292-300. 2003
    ..Such behavior is associated with interpersonal difficulties and strained patient-physician relationships...
  17. ncbi request reprint Specific phobia of illness: search for a new subtype
    Russell Noyes
    Department of Biostatistics, The University of Iowa Roy J and Lucille A Carver Colleges of Medicine and Public Health, Iowa City, IA 52242 1000, USA
    J Anxiety Disord 18:531-45. 2004
    ..We outline a research agenda for demonstrating this separation...
  18. ncbi request reprint White matter volume and cognitive dysfunction in early Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cogn Behav Neurol 18:102-7. 2005
    ..Fewer studies have examined other cerebral structures in early HD and potential associations with cognition...
  19. ncbi request reprint Prevalence and correlates of illness worry in the general population
    Russell Noyes
    Department of Psychiatry, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242 1000, USA
    Psychosomatics 46:529-39. 2005
    ..Worry about serious illness was associated with functional impairment and health care utilization...
  20. ncbi request reprint Preparing for preventive clinical trials: the Predict-HD study
    Jane S Paulsen
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Arch Neurol 63:883-90. 2006
    ..The optimal design and outcome measures for preventive clinical trials in neurodegenerative diseases are unknown...
  21. ncbi request reprint Probability of obsessive and compulsive symptoms in Huntington's disease
    Leigh J Beglinger
    Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 61:415-8. 2007
    ..The purpose of this study was to examine the probability of obsessive and compulsive (OC) symptoms across stages of Huntington's disease (HD) with both cross sectional and longitudinal data...
  22. ncbi request reprint Distinguishing between hypochondriasis and somatization disorder: a review of the existing literature
    Russell Noyes
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Psychother Psychosom 75:270-81. 2006
    ..A review of the literature indicates those domains where differences are most likely to be found. Research assessing these may serve to refine and validate these key somatoform categories and/or dimensions...
  23. ncbi request reprint Examining the repeatable battery for the assessment of neuropsychological status: factor analytic studies in an elderly sample
    Kevin Duff
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Geriatr Psychiatry 14:976-9. 2006
    ....
  24. pmc Cerebral cortex structure in prodromal Huntington disease
    Peggy C Nopoulos
    Department of Psychiatry, University of Iowa Roy and Lucille Carver College of Medicine, Iowa City, IA 52242, USA
    Neurobiol Dis 40:544-54. 2010
    ..Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum...
  25. pmc CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches
    Douglas R Langbehn
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010
    ..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling...
  26. ncbi request reprint fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, USA
    AJNR Am J Neuroradiol 25:1715-21. 2004
    ..The current study was designed to examine the relative sensitivity of fMRI compared with that of behavioral testing and morphometric measurements in detecting early neurodegenerative changes related to Huntington's disease (HD)...
  27. ncbi request reprint Childhood antecedents of hypochondriasis
    Russell Noyes
    Department of Biostatics, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Psychosomatics 43:282-9. 2002
    ..These findings are consistent with a growing literature that links childhood adversity to adult hypochondriasis; they support the interpersonal model...
  28. ncbi request reprint Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease
    Shannon A Johnson
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
    Brain 130:1732-44. 2007
    ..In contrast to previous results, we found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition...
  29. pmc Verbal episodic memory declines prior to diagnosis in Huntington's disease
    Andrea C Solomon
    Department of Psychological and Brain Sciences, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, USA
    Neuropsychologia 45:1767-76. 2007
    ..These findings indicate that verbal episodic memory is affected in early pre-diagnostic HD and may decline as striatal volumes decrease and individuals approach the motor diagnostic threshold...