Daudi K Langat

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi Differential expression of human leukocyte antigen-G (HLA-G) messenger RNAs and proteins in normal human prostate and prostatic adenocarcinoma
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 71:75-86. 2006
  2. ncbi Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    Immunogenetics 59:359-66. 2007
  3. pmc The role of HLA-G in human pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Reprod Biol Endocrinol 4:S10. 2006
  4. ncbi Potential regulatory sequences in the untranslated regions of the baboon MHC class Ib gene, Paan-AG, more closely resemble those in the human MHC class Ia genes than those in the class Ib gene, HLA-G
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 7400, USA
    Immunogenetics 56:657-66. 2004
  5. ncbi Baboon placentas express soluble and membrane-bound Paan-AG proteins encoded by alternatively spliced transcripts of the class Ib major histocompatibility complex gene, Paan-AG
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, 66160 7400, USA
    Immunogenetics 54:164-73. 2002
  6. pmc Synthesis of beta(2)-microglobulin-free, disulphide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells
    Pedro J Morales
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 7400, USA
    Immunology 122:179-88. 2007
  7. ncbi Methods for evaluating histocompatibility antigen gene expression in the baboon
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
    Methods Mol Med 122:165-80. 2006
  8. ncbi Do nonhuman primates comprise appropriate experimental models for studying the function of human leukocyte antigen-G?
    Daudi K Langat
    Institute of Primate Research, Karen, Nairobi, Kenya
    Biol Reprod 67:1367-74. 2002
  9. ncbi Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon
    Jason M Mwenda
    Institute of Primate Research, P O Box 24481, Karen, Nairobi, Kenya
    J Ethnopharmacol 103:379-84. 2006

Research Grants

Collaborators

Detail Information

Publications9

  1. ncbi Differential expression of human leukocyte antigen-G (HLA-G) messenger RNAs and proteins in normal human prostate and prostatic adenocarcinoma
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    J Reprod Immunol 71:75-86. 2006
    ..The results are consistent with this molecule may influencing female immune receptivity to sperm and suggest that such immunosuppression could be disturbed in men with prostatic adenocarcinomas...
  2. ncbi Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7400, USA
    Immunogenetics 59:359-66. 2007
    ..Overall, these results show that in vitro variations in the promoter region may influence transcription of Paan-AG...
  3. pmc The role of HLA-G in human pregnancy
    Joan S Hunt
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Reprod Biol Endocrinol 4:S10. 2006
    ..Both the monkey and the baboon express molecules that are similar but not identical to HLA-G, and may comprise suitable animal models for establishing a central role for these proteins in pregnancy...
  4. ncbi Potential regulatory sequences in the untranslated regions of the baboon MHC class Ib gene, Paan-AG, more closely resemble those in the human MHC class Ia genes than those in the class Ib gene, HLA-G
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 7400, USA
    Immunogenetics 56:657-66. 2004
    ....
  5. ncbi Baboon placentas express soluble and membrane-bound Paan-AG proteins encoded by alternatively spliced transcripts of the class Ib major histocompatibility complex gene, Paan-AG
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, 66160 7400, USA
    Immunogenetics 54:164-73. 2002
    ..Because of the structural similarities and common features of organ-specific expression and splicing of the message, studies on Paan-AG may be of value in dissecting the functions of the class Ib proteins in human pregnancy...
  6. pmc Synthesis of beta(2)-microglobulin-free, disulphide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells
    Pedro J Morales
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160 7400, USA
    Immunology 122:179-88. 2007
    ..Thus, our findings are consistent with the postulate that the natural beta2m-free homodimeric form of HLA-G5 synthesized in primary vCTB cells could comprise a particularly effective tolerogenic molecule at the maternal-fetal interface...
  7. ncbi Methods for evaluating histocompatibility antigen gene expression in the baboon
    Daudi K Langat
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, USA
    Methods Mol Med 122:165-80. 2006
    ..We used Paan-AG-specific primers to amplify Paan-AG transcripts from baboon placenta, and generated Paan-AG isoform-specific polyclonal antibodies for use in immunohistochemistry...
  8. ncbi Do nonhuman primates comprise appropriate experimental models for studying the function of human leukocyte antigen-G?
    Daudi K Langat
    Institute of Primate Research, Karen, Nairobi, Kenya
    Biol Reprod 67:1367-74. 2002
    ..Thus, this molecule may be the functional homologue of HLA-G, and these two species may comprise appropriate models for elucidating the function of HLA-G...
  9. ncbi Khat (Catha edulis) up-regulates testosterone and decreases prolactin and cortisol levels in the baboon
    Jason M Mwenda
    Institute of Primate Research, P O Box 24481, Karen, Nairobi, Kenya
    J Ethnopharmacol 103:379-84. 2006
    ..These effects were also evident 1 month post treatment and indicate khat may exert a transient effect on male fertility by interfering with the hormonal profiles...

Research Grants2

  1. Regulation of the baboon HLA-G-like class Ib MHC gene, Paan-AG
    DAUDI LANGAT; Fiscal Year: 2007
    ..Thus the baboon is clearly an excellent model for HLA-G functional experiments, and testing the therapeutic applications of HLA-G in human pregnancy and transplantation. ..