Thomas F Lang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight
    Thomas F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 21:1224-30. 2006
  2. ncbi request reprint What do we know about fracture risk in long-duration spaceflight?
    T F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Musculoskelet Neuronal Interact 6:319-21. 2006
  3. doi request reprint Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture
    T Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    Bone 42:798-805. 2008
  4. doi request reprint Quantitative computed tomography
    Thomas F Lang
    Joint Bioengineering Graduate Group, and Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0946, USA
    Radiol Clin North Am 48:589-600. 2010
  5. pmc Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study
    Thomas Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 25:513-9. 2010
  6. pmc Sarcopenia: etiology, clinical consequences, intervention, and assessment
    T Lang
    Department of Radiology and Biomedical Imaging, University of California, UCSF, San Francisco, CA 94143 0946, USA
    Osteoporos Int 21:543-59. 2010
  7. ncbi request reprint One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
    N Engl J Med 353:555-65. 2005
  8. pmc Structural patterns of the proximal femur in relation to age and hip fracture risk in women
    Julio Carballido-Gamio
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 57:290-9. 2013
  9. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
  10. doi request reprint Quantitative computed tomography reveals the effects of race and sex on bone size and trabecular and cortical bone density
    Isra Saeed
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0946, USA
    J Clin Densitom 12:330-6. 2009

Research Grants

Detail Information

Publications38

  1. ncbi request reprint Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight
    Thomas F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 21:1224-30. 2006
    ..We observed that the readaptation of the proximal femur to Earth's gravity entailed an increase in bone size and an incomplete recovery of volumetric BMD...
  2. ncbi request reprint What do we know about fracture risk in long-duration spaceflight?
    T F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Musculoskelet Neuronal Interact 6:319-21. 2006
  3. doi request reprint Pelvic body composition measurements by quantitative computed tomography: association with recent hip fracture
    T Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    Bone 42:798-805. 2008
    ....
  4. doi request reprint Quantitative computed tomography
    Thomas F Lang
    Joint Bioengineering Graduate Group, and Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0946, USA
    Radiol Clin North Am 48:589-600. 2010
    ..This article focuses on the application of volumetric quantitative measures to studies of aging, disuse, and drug treatment as related to osteoporosis...
  5. pmc Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition study
    Thomas Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 25:513-9. 2010
    ..This characteristic captures a physical characteristic of muscle tissue that may have importance in hip fracture etiology...
  6. pmc Sarcopenia: etiology, clinical consequences, intervention, and assessment
    T Lang
    Department of Radiology and Biomedical Imaging, University of California, UCSF, San Francisco, CA 94143 0946, USA
    Osteoporos Int 21:543-59. 2010
    ..We also discuss the resulting long-term outcomes in terms of loss of function, which causes increased risk of musculoskeletal injuries and other morbidities, leading to frailty and loss of independence...
  7. ncbi request reprint One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
    N Engl J Med 353:555-65. 2005
    ..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)...
  8. pmc Structural patterns of the proximal femur in relation to age and hip fracture risk in women
    Julio Carballido-Gamio
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    Bone 57:290-9. 2013
    ..In women, the identification by TBM of fracture-specific morphometric alterations of the proximal femur, in conjunction with vBMD and clinical risk factors, may improve hip fracture prediction. ..
  9. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  10. doi request reprint Quantitative computed tomography reveals the effects of race and sex on bone size and trabecular and cortical bone density
    Isra Saeed
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0946, USA
    J Clin Densitom 12:330-6. 2009
    ..Lower fracture rates in AA elderly compared with CA elderly are consistent with higher peak bone density, particularly in the trabecular compartment, and potentially lower rates of age-related bone loss rather than larger bone size...
  11. pmc Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults
    Ann V Schwartz
    University of California, San Francisco, San Francisco, California 94107, USA
    J Clin Endocrinol Metab 98:2294-300. 2013
    ..However, little is known about the association of BMF with fracture or with separate trabecular and cortical bone compartments...
  12. ncbi request reprint Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*
    Dawn C Mackey
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
    J Bone Miner Res 22:1862-8. 2007
    ..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men...
  13. ncbi request reprint Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Bone 22:395-402. 1998
    ..The risk assessment appears not to be improved by including information of cortical or geometric properties of the forearm...
  14. pmc Circulating sclerostin associated with vertebral bone marrow fat in older men but not women
    Yu Heng Vivian Ma
    University of California, San Francisco Y H V M, A V S, T F H, T F L, e V, L P, X L, San Francisco, California 94107 Icelandic Heart Association S S, G E, A M H, K S, D O, V G, IS 201 Kopavogur, Iceland Laboratory of Epidemiology, Demography, and Biometry T B H, Intramural Research Program, National Institute on Aging, Bethesda, Maryland 20892 Maine Medical Center Research Institute C J R, Scarborough, Maine 04074 Faculty of Medicine G S, D O, V G, University of Iceland, IS 101 Reykjavik, Iceland Department of Endocrinology and Metabolism G S, Landspitali University Hospital, IS 101 Reykjavik, Iceland and Universita Campus Bio Medico N N, 00128 Rome, Italy
    J Clin Endocrinol Metab 99:E2584-90. 2014
    ..Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationship between osteocyte activity and MF...
  15. ncbi request reprint Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women
    Kuo Chiang Lian
    Department of Medicine and Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    Osteoporos Int 16:642-50. 2005
    ..The purpose of this investigation was to determine if there are differences in the quantities of trabecular and cortical bone and bone strength of the hip between GC-treated osteoporotic patients and controls...
  16. pmc Plasma phospholipid fatty acids and fish-oil consumption in relation to osteoporotic fracture risk in older adults: the Age, Gene/Environment Susceptibility Study
    Tamara B Harris
    From the Laboratory of Epidemiology, and Population Sciences, National Institute on Aging, Bethesda, MD TBH, IR, MEG, and RAM the Biomarker Laboratory, Fred Hutchinson Cancer Research Center, Seattle, WA XS the Department of Health Sciences and the EMGO Institute for Health and Care Research, VU University, Amsterdam, The Netherlands IR and IAB the Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA TFL the Icelandic Heart Association, Kopavogur, Iceland KS, SS, VG, GE, gs, and TA and the University of Iceland, Reykjavik, Iceland VG, gs, and LS
    Am J Clin Nutr 101:947-55. 2015
    ..Polyunsaturated fatty acids (PUFAs) may play a role in fracture, but studies have been largely confined to estimates of dietary intake...
  17. pmc Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults
    Anne L Schafer
    Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Clin Endocrinol Metab 95:E368-72. 2010
    ..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture...
  18. ncbi request reprint Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
    P Augat
    Department of Radiology, University of California, San Francisco 94143, USA
    Med Eng Phys 20:124-31. 1998
    ..The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant...
  19. pmc Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens
    Thomas F Lang
    Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 29:1337-45. 2014
    ..This study supports VBM and volumetric QCT (vQCT) to quantify the spatially heterogeneous effects of types of muscle contractions on bone...
  20. doi request reprint Comparison of DXA hip structural analysis with volumetric QCT
    Sven Prevrhal
    Department of Radiology, UCSF, San Francisco, CA 94107, USA
    J Clin Densitom 11:232-6. 2008
    ..5 for CSMI) and standard DXA at the neck (r2=0.82 for BMD). HSA and volumetric QCT compared favorably, which supports the validity of a projective technique such as DXA to derive geometrical properties of the proximal hip...
  21. ncbi request reprint Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength
    T F Lang
    Department of Radiology, University of California, San Francisco 94143 1250, USA
    Bone 21:101-8. 1997
    ..Thus, trabecular BMD measurements were reproducible and highly correlated to biomechanical strength measurements. These results support further exploration of quantitative CT for assessment of osteoporosis at the proximal femur...
  22. ncbi request reprint Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures
    T F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 1250, USA
    Bone 30:247-50. 2002
    ....
  23. ncbi request reprint Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis
    Q Rehman
    Department of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Osteoporos Int 14:77-81. 2003
    ....
  24. ncbi request reprint Image-based assessment of spinal trabecular bone structure from high-resolution CT images
    C L Gordon
    Department of Radiology, University of California, San Francisco, USA
    Osteoporos Int 8:317-25. 1998
    ..These findings suggest that an assessment of vertebral trabecular structure from high-resolution CT images is useful in discriminating subjects with vertebral fractures and potentially useful for predicting future fractures...
  25. pmc Effects of age and sex on the strength and cortical thickness of the femoral neck
    R D Carpenter
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0946, USA
    Bone 48:741-7. 2011
    ..The higher bending strength of the male femoral neck may partly explain why elderly men have a lower risk of hip fracture than elderly women...
  26. pmc Proximal femoral density distribution and structure in relation to age and hip fracture risk in women
    Julio Carballido-Gamio
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 28:537-46. 2013
    ..The fracture-related cortical deficit noted in this study may provide a biomarker of increased hip fracture risk that may be translatable to dual-energy X-ray absorptiometry (DXA) and other clinical images...
  27. doi request reprint Reduction in proximal femoral strength due to long-duration spaceflight
    J H Keyak
    Department of Orthopaedic Surgery, University of California, Irvine, CA, USA
    Bone 44:449-53. 2009
    ..If proximal femoral strength is not recovered, some crew members may be at increased risk for age-related hip fractures decades after their missions...
  28. ncbi request reprint Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT)
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Phys Med Biol 43:2873-83. 1998
    ....
  29. pmc The effect of metal artefact reduction on CT-based attenuation correction for PET imaging in the vicinity of metallic hip implants: a phantom study
    Roy Harnish
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, Box 0946, San Francisco, CA, 94143 0946, USA
    Ann Nucl Med 28:540-50. 2014
    ....
  30. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  31. ncbi request reprint Sex- and race-related differences in cross-sectional geometry and bone density of the femoral mid-shaft in older adults
    D R Taaffe
    Department of Radiology, University of California, San Francisco, California, USA
    Ann Hum Biol 30:329-46. 2003
    ..Femoral shaft fracture incidence increases in older adults and is associated with low-energy trauma. Apart from bone density, the distribution and size of bone contributes to its strength...
  32. ncbi request reprint Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Bone Miner Res 21:1197-206. 2006
    ..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct...
  33. ncbi request reprint Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderly
    Dennis R Taaffe
    Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
    Aging Clin Exp Res 15:131-5. 2003
    ..Therefore, we examined if it was possible to predict hip bone density using mid-femoral bone density...
  34. pmc Race and ethnic variation in proximal femur structure and BMD among older men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
    J Bone Miner Res 23:121-30. 2008
    ..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength...
  35. ncbi request reprint Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivity
    Laura D Carbone
    Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
    J Bone Miner Res 18:1795-802. 2003
    ..Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers. This suggests a role for COX-2/ASA in osteoporosis...
  36. ncbi request reprint New QCT analysis approach shows the importance of fall orientation on femoral neck strength
    R Dana Carpenter
    Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Bone Miner Res 20:1533-42. 2005
    ..A new image analysis technique showed that the strength of the femoral neck in 37 males varied significantly along the neck axis and that bending strength varied by a factor of up to 2.8 for different loading directions...
  37. ncbi request reprint Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK)
    Gunnar Sigurdsson
    Icelandic Heart Association, Kopavogur, Iceland Landspitali University Hospital, Reykjavik, Iceland
    Bone 39:644-51. 2006
    ....
  38. ncbi request reprint Quantitative computed tomography
    Giuseppe Guglielmi
    Department of Radiology, Scientific Institute Hospital Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
    Semin Musculoskelet Radiol 6:219-27. 2002
    ..This article reviews the current capabilities of QCT at different skeletal sites and the recent technical developments, including volumetric acquisition...

Research Grants2

  1. Precise 3D QCT to Monitor Osteoporosis Therapy
    Thomas Lang; Fiscal Year: 2003
    ..Moreover, the high reproducibility of our technique will permit CT centers to offer a method for monitoring therapy effects which will be superior to DXA. ..
  2. Race differences in hip strength, density and geometry
    Thomas Lang; Fiscal Year: 2004
    ....