Research Topics
| Thomas F LangSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
What do we know about fracture risk in long-duration spaceflight?T F Lang
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
J Musculoskelet Neuronal Interact 6:319-21. 2006- Adaptation of the proximal femur to skeletal reloading after long-duration spaceflightThomas F Lang
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
J Bone Miner Res 21:1224-30. 2006..We observed that the readaptation of the proximal femur to Earth's gravity entailed an increase in bone size and an incomplete recovery of volumetric BMD... 
Pelvic body composition measurements by quantitative computed tomography: association with recent hip fractureT Lang
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
Bone 42:798-805. 2008....
Sarcopenia: etiology, clinical consequences, intervention, and assessmentT Lang
Department of Radiology and Biomedical Imaging, University of California, UCSF, San Francisco, CA 94143 0946, USA
Osteoporos Int 21:543-59. 2010..We also discuss the resulting long-term outcomes in terms of loss of function, which causes increased risk of musculoskeletal injuries and other morbidities, leading to frailty and loss of independence...- Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: the health, aging, and body composition studyThomas Lang
Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
J Bone Miner Res 25:513-9. 2010..This characteristic captures a physical characteristic of muscle tissue that may have importance in hip fracture etiology... - Quantitative computed tomographyThomas F Lang
Joint Bioengineering Graduate Group, and Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143 0946, USA
Radiol Clin North Am 48:589-600. 2010..This article focuses on the application of volumetric quantitative measures to studies of aging, disuse, and drug treatment as related to osteoporosis... - One year of alendronate after one year of parathyroid hormone (1-84) for osteoporosisDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94105, USA
N Engl J Med 353:555-65. 2005..In the continuation of this trial, we asked whether antiresorptive therapy is required to maintain gains in bone mineral density after one year of therapy with parathyroid hormone (1-84)... - Quantitative computed tomography reveals the effects of race and sex on bone size and trabecular and cortical bone densityIsra Saeed
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0946, USA
J Clin Densitom 12:330-6. 2009..Lower fracture rates in AA elderly compared with CA elderly are consistent with higher peak bone density, particularly in the trabecular compartment, and potentially lower rates of age-related bone loss rather than larger bone size... - Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCTDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
J Bone Miner Res 23:1326-33. 2008.... - Prediction of clinical non-spine fractures in older black and white men and women with volumetric BMD of the spine and areal BMD of the hip: the Health, Aging, and Body Composition Study*Dawn C Mackey
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
J Bone Miner Res 22:1862-8. 2007..4 yr), vertebral TrvBMD from QCT predicted non-spine fracture in black and white women and black men, but it was not a stronger predictor than total hip aBMD from DXA. Hip aBMD predicted non-spine fracture in black men... - Assessment of bone mineral at appendicular sites in females with fractures of the proximal femurP Augat
Department of Radiology, University of California San Francisco, USA
Bone 22:395-402. 1998..The risk assessment appears not to be improved by including information of cortical or geometric properties of the forearm... - Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal womenKuo-Chiang Lian
Department of Medicine and Radiology, University of California-San Francisco, San Francisco, CA 94143, USA
Osteoporos Int 16:642-50. 2005..In addition, GC treatment decreased bone strength as determined by FEM. The reduced cortical and trabecular bone mass in the hip may contribute to the disproportionately high hip fracture rates observed in GC-treated subjects... - Fat infiltration of muscle, diabetes, and clinical fracture risk in older adultsAnne L Schafer
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 95:E368-72. 2010..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture... - Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locationsP Augat
Department of Radiology, University of California, San Francisco 94143, USA
Med Eng Phys 20:124-31. 1998..The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant... - Comparison of DXA hip structural analysis with volumetric QCTSven Prevrhal
Department of Radiology, UCSF, San Francisco, CA 94107, USA
J Clin Densitom 11:232-6. 2008..5 for CSMI) and standard DXA at the neck (r2=0.82 for BMD). HSA and volumetric QCT compared favorably, which supports the validity of a projective technique such as DXA to derive geometrical properties of the proximal hip... - Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fracturesT F Lang
Department of Radiology, University of California, San Francisco, CA 94143 1250, USA
Bone 30:247-50. 2002.... - Image-based assessment of spinal trabecular bone structure from high-resolution CT imagesC L Gordon
Department of Radiology, University of California, San Francisco, USA
Osteoporos Int 8:317-25. 1998..These findings suggest that an assessment of vertebral trabecular structure from high-resolution CT images is useful in discriminating subjects with vertebral fractures and potentially useful for predicting future fractures... - Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosisQ Rehman
Department of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
Osteoporos Int 14:77-81. 2003.... - Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strengthT F Lang
Department of Radiology, University of California, San Francisco 94143 1250, USA
Bone 21:101-8. 1997..Thus, trabecular BMD measurements were reproducible and highly correlated to biomechanical strength measurements. These results support further exploration of quantitative CT for assessment of osteoporosis at the proximal femur... - Effects of age and sex on the strength and cortical thickness of the femoral neckR D Carpenter
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143 0946, USA
Bone 48:741-7. 2011..The higher bending strength of the male femoral neck may partly explain why elderly men have a lower risk of hip fracture than elderly women... - Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT)P Augat
Department of Radiology, University of California San Francisco, USA
Phys Med Biol 43:2873-83. 1998.... - Reduction in proximal femoral strength due to long-duration spaceflightJ H Keyak
Department of Orthopaedic Surgery, University of California, Irvine, CA, USA
Bone 44:449-53. 2009..If proximal femoral strength is not recovered, some crew members may be at increased risk for age-related hip fractures decades after their missions... - The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
N Engl J Med 349:1207-15. 2003..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone... - Sex- and race-related differences in cross-sectional geometry and bone density of the femoral mid-shaft in older adultsD R Taaffe
Department of Radiology, University of California, San Francisco, California, USA
Ann Hum Biol 30:329-46. 2003..Femoral shaft fracture incidence increases in older adults and is associated with low-energy trauma. Apart from bone density, the distribution and size of bone contributes to its strength... - Poor correlation of mid-femoral measurements by CT and hip measurements by DXA in the elderlyDennis R Taaffe
Epidemiology, Demography and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA
Aging Clin Exp Res 15:131-5. 2003..Therefore, we examined if it was possible to predict hip bone density using mid-femoral bone density... - Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. menLynn M Marshall
Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Bone Miner Res 21:1197-206. 2006..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct... - Association between bone mineral density and the use of nonsteroidal anti-inflammatory drugs and aspirin: impact of cyclooxygenase selectivityLaura D Carbone
Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USA
J Bone Miner Res 18:1795-802. 2003..Significantly higher BMD was found in users of relative COX-2 selective NSAIDs with aspirin (COX-2/ASA) compared with nonusers. This suggests a role for COX-2/ASA in osteoporosis... - New QCT analysis approach shows the importance of fall orientation on femoral neck strengthR Dana Carpenter
Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, California, USA
J Bone Miner Res 20:1533-42. 2005..A new image analysis technique showed that the strength of the femoral neck in 37 males varied significantly along the neck axis and that bending strength varied by a factor of up to 2.8 for different loading directions... - Race and ethnic variation in proximal femur structure and BMD among older menLynn M Marshall
Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
J Bone Miner Res 23:121-30. 2008..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength... - Increasing sex difference in bone strength in old age: The Age, Gene/Environment Susceptibility-Reykjavik study (AGES-REYKJAVIK)Gunnar Sigurdsson
Icelandic Heart Association, Kopavogur, Iceland Landspitali University Hospital, Reykjavik, Iceland
Bone 39:644-51. 2006.... - Quantitative computed tomographyGiuseppe Guglielmi
Department of Radiology, Scientific Institute Hospital Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy
Semin Musculoskelet Radiol 6:219-27. 2002..This article reviews the current capabilities of QCT at different skeletal sites and the recent technical developments, including volumetric acquisition...
Research Grants
- Age-related changes in proximal femoral strength in men and womenThomas Lang; Fiscal Year: 2009..In this study, we expect to derive clinically relevant information regarding the effect regarding how the structural characteristics of the proximal femur and its strength change with age and how they contribute to fracture risk. ..
- Age-related changes in proximal femoral strength in men and womenThomas Lang; Fiscal Year: 2007..In this study, we expect to derive clinically relevant information regarding the effect regarding how the structural characteristics of the proximal femur and its strength change with age and how they contribute to fracture risk. ..
- Race differences in hip strength, density and geometryThomas Lang; Fiscal Year: 2004....
- Precise 3D QCT to Monitor Osteoporosis TherapyThomas Lang; Fiscal Year: 2003..Moreover, the high reproducibility of our technique will permit CT centers to offer a method for monitoring therapy effects which will be superior to DXA. ..
- The Proximal Femoral Musculature: A new Risk Factor for Hip FractureThomas Lang; Fiscal Year: 2009..This quantitative measurement is modifiable and could become a treatment endpoint for specific exercise or drug therapies. ..