Deborah Lang

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint PAX genes: roles in development, pathophysiology, and cancer
    Deborah Lang
    University of Chicago, Department of Medicine, Section of Dermatology, 5841 S Maryland Avenue, Chicago, IL 60637, United States
    Biochem Pharmacol 73:1-14. 2007
  2. pmc Melanocytes, melanocyte stem cells, and melanoma stem cells
    Deborah Lang
    Department of Medicine, Section of Dermatology, University of Chicago, Pritzker School of Medicine, MC 5067, Chicago, IL 60637, USA
    Clin Dermatol 31:166-78. 2013
  3. pmc PAX3 and SOX10 activate MET receptor expression in melanoma
    Joseph B Mascarenhas
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago IL, USA
    Pigment Cell Melanoma Res 23:225-37. 2010
  4. pmc PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene
    Joseph B Mascarenhas
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:27524-32. 2009
  5. pmc PAX3 expression in primary melanomas and nevi
    Rebecca S Plummer
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Mod Pathol 21:525-30. 2008
  6. pmc Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease
    Jennifer D Kubic
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Pigment Cell Melanoma Res 21:627-45. 2008
  7. pmc GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells
    Jennifer D Kubic
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Mol Cancer Res 10:1065-76. 2012
  8. ncbi request reprint PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation
    Deborah Lang
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Mol Carcinog 47:148-56. 2008
  9. ncbi request reprint Pax3 functions at a nodal point in melanocyte stem cell differentiation
    Deborah Lang
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 433:884-7. 2005
  10. pmc Alternative promoter and GATA5 transcripts in mouse
    Bohao Chen
    Departments of Medicine, Univ of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1214-22. 2009

Research Grants

  1. Pax3, Melanocyte Stem Cells and Melanoma
    Deborah Lang; Fiscal Year: 2010

Collaborators

  • Ravi Salgia
  • Pasi A Janne
  • Bruce A Ruggeri
  • Emily Y Chu
  • Aliya N Husain
  • Joe G N Garcia
  • Blanca Camoretti-Mercado
  • E E Vokes
  • Joseph B Mascarenhas
  • Jennifer D Kubic
  • Kacey P Young
  • Rebecca S Plummer
  • Erica L Littlejohn
  • Maria Nelson
  • Rajani Kanteti
  • Bohao Chen
  • Don Wolfgeher
  • Takumi Iizuka
  • Rebecca J Wolsky
  • Paul Kogut
  • Todd Kroll
  • Yong Huang
  • Eric C Svensson
  • Julian Solway
  • Lan Ma
  • Soundararajan Krishnaswamy
  • Jerrold R Turner
  • Maria Tretiakova
  • Leonardo Faoro
  • Peter J Gruber
  • Vidya Nallasura
  • Brian K Yoo
  • Yun Tao
  • Sivakumar Loganathan
  • Edward E Morrisey
  • Philip Cagle
  • Elena Yates
  • Anton E Ludvik
  • Christopher R Shea
  • Diane M Freeman
  • Sara K Powell
  • Colleen P Dan

Detail Information

Publications11

  1. ncbi request reprint PAX genes: roles in development, pathophysiology, and cancer
    Deborah Lang
    University of Chicago, Department of Medicine, Section of Dermatology, 5841 S Maryland Avenue, Chicago, IL 60637, United States
    Biochem Pharmacol 73:1-14. 2007
    ....
  2. pmc Melanocytes, melanocyte stem cells, and melanoma stem cells
    Deborah Lang
    Department of Medicine, Section of Dermatology, University of Chicago, Pritzker School of Medicine, MC 5067, Chicago, IL 60637, USA
    Clin Dermatol 31:166-78. 2013
    ....
  3. pmc PAX3 and SOX10 activate MET receptor expression in melanoma
    Joseph B Mascarenhas
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago IL, USA
    Pigment Cell Melanoma Res 23:225-37. 2010
    ..In consequence, MET promotes the melanoma cancer phenotype by promoting migration, invasion, resistance to apoptosis, and tumor cell growth...
  4. pmc PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene
    Joseph B Mascarenhas
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:27524-32. 2009
    ....
  5. pmc PAX3 expression in primary melanomas and nevi
    Rebecca S Plummer
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Mod Pathol 21:525-30. 2008
    ..Our data suggest that PAX3-expressing melanomas may be less environmentally dependent and more genetically linked...
  6. pmc Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease
    Jennifer D Kubic
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Pigment Cell Melanoma Res 21:627-45. 2008
    ..Due to its key task in melanocyte stem cells and tumors, the Pax3 pathway may provide an ideal target for either stem cell or cancer therapies...
  7. pmc GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells
    Jennifer D Kubic
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Mol Cancer Res 10:1065-76. 2012
    ..These data support a model wherein GSK-3 regulates proliferation and morphology of melanoma through phosphorylation and increased levels of PAX3...
  8. ncbi request reprint PAX6 is expressed in pancreatic adenocarcinoma and is downregulated during induction of terminal differentiation
    Deborah Lang
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Mol Carcinog 47:148-56. 2008
    ..This phenotype can be replicated by directly inhibiting PAX6 expression. These data support a model where PAX proteins are aberrantly expressed in tumors and downregulation leads to differentiation...
  9. ncbi request reprint Pax3 functions at a nodal point in melanocyte stem cell differentiation
    Deborah Lang
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 433:884-7. 2005
    ..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli...
  10. pmc Alternative promoter and GATA5 transcripts in mouse
    Bohao Chen
    Departments of Medicine, Univ of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1214-22. 2009
    ..These findings extend current understanding of the tissue distribution of GATA5 expression and suggests that GATA5 expression and function are more complex than previously appreciated...
  11. pmc PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription
    Rajani Kanteti
    Department of Hematology Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA
    Lab Invest 89:301-14. 2009
    ..Therefore, we propose that PAX5 could be an important regulator of c-Met transcription and a potential target for therapy in SCLC...

Research Grants2

  1. Pax3, Melanocyte Stem Cells and Melanoma
    Deborah Lang; Fiscal Year: 2010
    ..Our proposal seeks to determine normal molecular pathways of stem cells and to how they become subverted in the conversion into tumors. ..