R Landick

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Structure of RNA and DNA chains in paused transcription complexes containing Escherichia coli RNA polymerase
    D N Lee
    Department of Biology, Washington University, St Louis, MO 63130
    J Mol Biol 228:759-77. 1992
  2. ncbi request reprint GreA-induced transcript cleavage is accompanied by reverse translocation to a different transcription complex conformation
    D N Lee
    Department of Biology, Washington University, St Louis, Missouri 63130
    J Biol Chem 269:22295-303. 1994
  3. ncbi request reprint Dissection of the his leader pause site by base substitution reveals a multipartite signal that includes a pause RNA hairpin
    C L Chan
    Department of Biology, Washington University, St Louis, MO 63130
    J Mol Biol 233:25-42. 1993
  4. pmc Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:3110-22. 1998
  5. ncbi request reprint Force and velocity measured for single molecules of RNA polymerase
    M D Wang
    Department of Molecular Biology and Princeton Materials Institute, Princeton University, Princeton, NJ 08544, USA
    Science 282:902-7. 1998
  6. ncbi request reprint Single-molecule study of transcriptional pausing and arrest by E. coli RNA polymerase
    R J Davenport
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 287:2497-500. 2000
  7. pmc Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 97:7090-5. 2000
  8. pmc RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Bacteriol 182:6027-35. 2000
  9. ncbi request reprint Allosteric control of RNA polymerase by a site that contacts nascent RNA hairpins
    I Toulokhonov
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    Science 292:730-3. 2001
  10. ncbi request reprint GreA-induced transcript cleavage in transcription complexes containing Escherichia coli RNA polymerase is controlled by multiple factors, including nascent transcript location and structure
    G H Feng
    Department of Biology, Washington University, St Louis, Missouri 63130
    J Biol Chem 269:22282-94. 1994

Collaborators

  • C Yanofsky
  • I Artsimovitch
  • Seth Darst
  • Valley J Stewart
  • R R Burgess
  • H Yin
  • T M Gruber
  • M Palangat
  • I Toulokhonov
  • D N Lee
  • R J Davenport
  • M D Wang
  • C L Chan
  • D Wang
  • K Severinov
  • T M Arthur
  • D Markov
  • K M Geszvain
  • C Z Lu
  • B A Young
  • M M Sharp
  • H J Zhong
  • C A Gross
  • C Bustamante
  • G J Wuite
  • G Feng
  • J Gelles
  • M J Schnitzer
  • S M Block
  • G H Feng
  • D L Oxender
  • T I Meier
  • C J Daniels
  • G Zurawski
  • T K Antonucci
  • J J Anderson
  • R P Gunsalus
  • M D Adams
  • P M Nazos
  • A L Gibson
  • E Selker
  • T J Graddis
  • L M Wagner

Detail Information

Publications23

  1. ncbi request reprint Structure of RNA and DNA chains in paused transcription complexes containing Escherichia coli RNA polymerase
    D N Lee
    Department of Biology, Washington University, St Louis, MO 63130
    J Mol Biol 228:759-77. 1992
    ..Rather, pausing may result from distinct interactions between RNA polymerase and both the pause RNA hairpin and the downstream DNA sequence...
  2. ncbi request reprint GreA-induced transcript cleavage is accompanied by reverse translocation to a different transcription complex conformation
    D N Lee
    Department of Biology, Washington University, St Louis, Missouri 63130
    J Biol Chem 269:22295-303. 1994
    ..coli RNA polymerase are similar to a recently postulated model for discontinuous translocation during transcription, but differ from those reported for arrested RNA polymerase II transcription complexes...
  3. ncbi request reprint Dissection of the his leader pause site by base substitution reveals a multipartite signal that includes a pause RNA hairpin
    C L Chan
    Department of Biology, Washington University, St Louis, MO 63130
    J Mol Biol 233:25-42. 1993
    ..We suggest that electrostatic interaction between the pause hairpin and RNA polymerase, rather than disruption of an RNA:DNA heteroduplex, delays elongation at the his leader pause site...
  4. pmc Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:3110-22. 1998
    ..Resistance of the paused complex to pyrophosphorolysis and its reversal by antisense oligonucleotides further suggest that interaction of the pause hairpin with RNA polymerase disengages the RNA 3' end from the active site...
  5. ncbi request reprint Force and velocity measured for single molecules of RNA polymerase
    M D Wang
    Department of Molecular Biology and Princeton Materials Institute, Princeton University, Princeton, NJ 08544, USA
    Science 282:902-7. 1998
    ..This contrasts with previous models that assumed force acts directly upon a single-base translocation step...
  6. ncbi request reprint Single-molecule study of transcriptional pausing and arrest by E. coli RNA polymerase
    R J Davenport
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 287:2497-500. 2000
    ..The conformational metastability of RNA polymerase revealed by this single-molecule study of transcription has direct implications for the mechanisms of gene regulation in both bacteria and eukaryotes...
  7. pmc Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 97:7090-5. 2000
    ..We propose that both pause classes, as well as arrest and termination, arise from a common intermediate that itself binds NTP substrate weakly...
  8. pmc RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro
    I Artsimovitch
    Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Bacteriol 182:6027-35. 2000
    ..We hypothesize that differences in signal recognition are due to the changes in contacts made between the beta and beta' subunits and the downstream DNA duplex...
  9. ncbi request reprint Allosteric control of RNA polymerase by a site that contacts nascent RNA hairpins
    I Toulokhonov
    Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA
    Science 292:730-3. 2001
    ..These findings favor an allosteric model for regulation of transcript elongation...
  10. ncbi request reprint GreA-induced transcript cleavage in transcription complexes containing Escherichia coli RNA polymerase is controlled by multiple factors, including nascent transcript location and structure
    G H Feng
    Department of Biology, Washington University, St Louis, Missouri 63130
    J Biol Chem 269:22282-94. 1994
    ..We propose that transcript cleavage and reverse translocation are controlled in part by backsliding of the nascent transcript through an RNA-binding site...
  11. ncbi request reprint Crystallization of GreA, a transcript cleavage factor from Escherichia coli
    S A Darst
    Rockefeller University, New York, NY 10021
    J Mol Biol 242:582-5. 1994
    ..The crystals diffract beyond 2 A resolution and belong to the orthorhombic space group P2(1)2(1)2(1), with cell dimensions a = 101.7 A, b = 42.22 A, c = 40.05 A and with one molecule in the asymmetric unit...
  12. ncbi request reprint Discontinuous movements of DNA and RNA in RNA polymerase accompany formation of a paused transcription complex
    D Wang
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Cell 81:341-50. 1995
    ..We suggest pausing and termination could be alternative outcomes of a similar isomerization that depend on the strength of contacts to 3'-proximal RNA remaining after the jump...
  13. ncbi request reprint Amino acid changes in conserved regions of the beta-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination
    R Landick
    Department of Biology, Washington University, St Louis, Missouri 63130
    Genes Dev 4:1623-36. 1990
    ....
  14. pmc Rho-dependent transcription termination in the tryptophanase operon leader region of Escherichia coli K-12
    V Stewart
    J Bacteriol 166:217-23. 1986
    ..In vivo termination appeared to occur at the rho-dependent termination sites identified in vitro. Transcription pausing analyses correlated sites of pausing in tnaL with sites of rho-dependent termination...
  15. ncbi request reprint The regulatory roles and mechanism of transcriptional pausing
    R Landick
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53705, USA
    Biochem Soc Trans 34:1062-6. 2006
    ..Recent findings from biochemical and single-molecule transcription experiments, coupled with the invaluable availability of RNAP crystal structures, have produced attractive hypotheses to explain the fundamental mechanism of pausing...
  16. ncbi request reprint Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein product may be a transcription factor
    R Landick
    Cell 38:175-82. 1984
    ..In addition, two regions of the predicted htpR product resemble protein-DNA contact points conserved in known DNA-binding proteins...
  17. ncbi request reprint The complete nucleotide sequences of the Escherichia coli LIV-BP and LS-BP genes. Implications for the mechanism of high-affinity branched-chain amino acid transport
    R Landick
    J Biol Chem 260:8257-61. 1985
    ..0-A crystal structure of the LIV-BP, have found regions of the BPs that may be involved in membrane protein interaction. We also analyzed the translational efficiency of the two BP mRNAs as determined by their nucleotide sequences...
  18. pmc Cloning and characterization of livH, the structural gene encoding a component of the leucine transport system in Escherichia coli
    P M Nazos
    J Bacteriol 166:565-73. 1986
    ..Expression of livH-containing plasmids in minicells suggested that a poorly expressed protein with an Mr of 30,000 could be the livH gene product...
  19. pmc Structural and functional analysis of cloned DNA containing genes responsible for branched-chain amino acid transport in Escherichia coli
    D L Oxender
    Proc Natl Acad Sci U S A 77:1412-6. 1980
    ..A minicell-producing strain transformed with plasmid pOX1 produced the binding proteins in the processed form...
  20. pmc Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and the mature form
    D L Oxender
    Proc Natl Acad Sci U S A 77:2005-9. 1980
    ..This suggests a possible role for the signal sequence in determining the conformation of the binding protein precursor that is recognized by the membrane...
  21. ncbi request reprint Nucleotide sequence and genetic characterization reveal six essential genes for the LIV-I and LS transport systems of Escherichia coli
    M D Adams
    Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
    J Biol Chem 265:11436-43. 1990
    ..This strain was used to show that each of the membrane component genes is required for high affinity leucine transport, including two genes, livM and livF, for which no previous genetic evidence had been obtained...
  22. ncbi request reprint Roles of RNA:DNA hybrid stability, RNA structure, and active site conformation in pausing by human RNA polymerase II
    M Palangat
    Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Dr, Madison, WI 53706, USA
    J Mol Biol 311:265-82. 2001
    ....
  23. ncbi request reprint Binding of the initiation factor sigma(70) to core RNA polymerase is a multistep process
    T M Gruber
    Departments of Stomatology and Microbiology and Immunology, University of California, San Francisco 94143, USA
    Mol Cell 8:21-31. 2001
    ..We propose that a cycle of changes in the interface of sigma(70) with core RNA polymerase is associated with progression through the process of transcription initiation...