ARTHUR LANDER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
  2. pmc Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome
    Akihiko Muto
    Department of Developmental and Cell Biology, University of California, Irvine, California, United States of America
    PLoS Biol 9:e1001181. 2011
  3. pmc Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization
    Wan Jong Kuo
    Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA
    Mol Biol Cell 21:4028-41. 2010
  4. pmc Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster
    Man Sun Kim
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    BMC Syst Biol 6:31. 2012
  5. pmc A reaction-diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of intestinal crypts
    Lei Zhang
    Department of Mathematics, University of California, Irvine, CA 92697, USA
    BMC Syst Biol 6:93. 2012
  6. pmc How cells know where they are
    Arthur D Lander
    Department of Developmental and Cell Biology, and Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA
    Science 339:923-7. 2013
  7. pmc Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
    Yi Huei Linda Jen
    Department of Developmental and Cell Biology, Developmental Biology Center and Center for Complex Biological Systems, University of California, Irvine, CA 92697 2300, USA
    Neural Dev 4:33. 2009
  8. pmc The elusive functions of proteoglycans: in vivo veritas
    A D Lander
    Department of Developmental Biology, University of California, Irvine, California 92697, USA
    J Cell Biol 148:227-32. 2000
  9. ncbi request reprint Do morphogen gradients arise by diffusion?
    Arthur D Lander
    Department of Developmental and Cell Biology, Developmental Biology Center, University of California, Irvine 92697, USA
    Dev Cell 2:785-96. 2002
  10. pmc A calculus of purpose
    Arthur D Lander
    Department of Developmental and Cell Biology, University of California, Irvine, USA
    PLoS Biol 2:e164. 2004

Research Grants

  1. Systems Biology of Morphogenesis and Spatial Information Flow
    ARTHUR LANDER; Fiscal Year: 2007
  2. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
  3. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
  4. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
  5. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2003
  6. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2002
  7. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
  8. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2001
  9. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2000
  10. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 1999

Collaborators

  • ANNE CALOF
  • Qing Nie
  • Yong Tao Zhang
  • Murray Korc
  • Michelle A Digman
  • S B Selleck
  • J Marsh
  • Ethan Bier
  • Martin Matzuk
  • Thomas Schilling
  • Yi Huei Linda Jen
  • Robin Lovell-Badge
  • Ian Krantz
  • Shimako Kawauchi
  • Joon Kim
  • Lei Zhang
  • Man Sun Kim
  • Akihiko Muto
  • Wan Jong Kuo
  • Steven G Potkin
  • Rosaysela Santos
  • Crestina L Beites
  • Wing Cheong Lo
  • Frederic Y M Wan
  • Hsiao Huei Wu
  • Richard J White
  • Claudia Mieko Mizutani
  • Kan Ding
  • Richard C Murray
  • Dongsan Kim
  • Kwang Hyun Cho
  • Jeong Rae Kim
  • Qi Wang
  • Xiaohui Xie
  • Marquis P Vawter
  • Anita Lakatos
  • Guia Guffanti
  • Jessica A Turner
  • James H Fallon
  • Fabio Macciardi
  • Michael F Miles
  • Abigail Chua
  • Taotao Lao
  • Leonard Kitzes
  • Andre Nussenzweig
  • Kyoko Yokomori
  • Mark S Lechner
  • Kimberly K Gokoffski
  • Ching Shan Chou
  • Benedikt Hallgrimsson
  • Piper L W Hollenbeck
  • Martha E Lopez-Burks
  • Michelle P Hoang
  • Clint M Young
  • Jeremy A Daniel
  • Rui Sousa-Neves
  • Martha Lopez-Burks
  • Karen M Lyons
  • José Antonio Sánchez-Duran
  • Peter Vilmos
  • John Fesenko
  • Daniel Navi

Detail Information

Publications30

  1. pmc Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
    Kan Ding
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697
    J Cell Biol 171:729-38. 2005
    ..These results support a specific role for shed syndecan-1 or MMP7-syndecan-1 complexes in tumor progression and add to accumulating evidence that syndecans and glypicans have nonequivalent functions in vivo...
  2. pmc Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome
    Akihiko Muto
    Department of Developmental and Cell Biology, University of California, Irvine, California, United States of America
    PLoS Biol 9:e1001181. 2011
    ....
  3. pmc Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization
    Wan Jong Kuo
    Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA
    Mol Biol Cell 21:4028-41. 2010
    ..This suggests a view of HS as a catalyst of the formation of signaling complexes, rather than as a stabilizer of growth factor binding...
  4. pmc Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster
    Man Sun Kim
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    BMC Syst Biol 6:31. 2012
    ..To overcome this limitation, we proposed the concept of a "spatiotemporal network motif," a spatiotemporal sequence of network motifs of sub-networks which are active only at specific time points and body parts...
  5. pmc A reaction-diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of intestinal crypts
    Lei Zhang
    Department of Mathematics, University of California, Irvine, CA 92697, USA
    BMC Syst Biol 6:93. 2012
    ....
  6. pmc How cells know where they are
    Arthur D Lander
    Department of Developmental and Cell Biology, and Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697, USA
    Science 339:923-7. 2013
    ....
  7. pmc Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis
    Yi Huei Linda Jen
    Department of Developmental and Cell Biology, Developmental Biology Center and Center for Complex Biological Systems, University of California, Irvine, CA 92697 2300, USA
    Neural Dev 4:33. 2009
    ..Here we investigate the developmental role played by one particular HSPG, glypican-1 (Gpc1), which is especially abundant on neuronal cell membranes, and is the major HSPG of the adult rodent brain...
  8. pmc The elusive functions of proteoglycans: in vivo veritas
    A D Lander
    Department of Developmental Biology, University of California, Irvine, California 92697, USA
    J Cell Biol 148:227-32. 2000
  9. ncbi request reprint Do morphogen gradients arise by diffusion?
    Arthur D Lander
    Department of Developmental and Cell Biology, Developmental Biology Center, University of California, Irvine 92697, USA
    Dev Cell 2:785-96. 2002
    ..Moreover, we show that a class of experiments, endocytic blockade, thought to effectively distinguish between diffusive and nondiffusive transport models actually fails to draw useful distinctions...
  10. pmc A calculus of purpose
    Arthur D Lander
    Department of Developmental and Cell Biology, University of California, Irvine, USA
    PLoS Biol 2:e164. 2004
  11. pmc Pattern, growth, and control
    Arthur D Lander
    Department of Developmental and Cell Biology, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697 2300, USA
    Cell 144:955-69. 2011
    ..By illuminating such principles, systems biology is helping to create a functional framework within which to make sense of the mechanistic complexity of organismal development...
  12. pmc The edges of understanding
    Arthur D Lander
    Center for Complex Biological Systems, Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    BMC Biol 8:40. 2010
    ..In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball...
  13. ncbi request reprint Spatially distributed morphogen production and morphogen gradient formation
    Arthur D Lander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 3875
    Math Biosci Eng 2:239-62. 2005
    ..System A will be analyzed in considerable detail in [6], and the limitation of System R as an approximation of System F will also be delineated there...
  14. pmc The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterning
    Arthur D Lander
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    Cold Spring Harb Perspect Biol 1:a002022. 2009
    ..This work also provides new insights into the longstanding question of why morphogen gradients show a maximum range in vivo...
  15. pmc The 'stem cell' concept: is it holding us back?
    Arthur D Lander
    Center for Complex Biological Systems, Department of Developmental and Cell Biology, and Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697 2300, USA
    J Biol 8:70. 2009
    ..Yet recent work adds to a growing body of literature suggesting that 'stemness' cannot be reduced to the molecular features of cell types, and is instead an emergent property of cell lineages under feedback control...
  16. ncbi request reprint Morpheus unbound: reimagining the morphogen gradient
    Arthur D Lander
    Department of Developmental and Cell Biology, Developmental Biology Center and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA
    Cell 128:245-56. 2007
    ..On close inspection, every morphogen gradient seems to use a rich array of regulatory mechanisms, suggesting that the tasks carried out by such systems are far more extensive than previously thought...
  17. pmc Cell lineages and the logic of proliferative control
    Arthur D Lander
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA
    PLoS Biol 7:e15. 2009
    ....
  18. pmc Identifying gene regulatory networks in schizophrenia
    Steven G Potkin
    Department of Psychiatry and Human Behavior, 5251 California Avenue, Suite 240, University of California, Irvine, CA 92617, USA
    Neuroimage 53:839-47. 2010
    ..The model demonstrates epistatic interactions between FGF and glypican on brain development and may be a useful model of negative symptom schizophrenia...
  19. ncbi request reprint Computational analysis of BMP gradients in dorsal-ventral patterning of the zebrafish embryo
    Yong Tao Zhang
    Department of Mathematics, University of California, Irvine, CA 92697, USA
    J Theor Biol 248:579-89. 2007
    ....
  20. pmc Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue
    Crestina L Beites
    Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA
    Development 136:2187-97. 2009
    ....
  21. ncbi request reprint GDF11 controls the timing of progenitor cell competence in developing retina
    Joon Kim
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Science 308:1927-30. 2005
    ..Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny...
  22. pmc Formation of the BMP activity gradient in the Drosophila embryo
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Dev Cell 8:915-24. 2005
    ....
  23. ncbi request reprint Widespread defects in the primary olfactory pathway caused by loss of Mash1 function
    Richard C Murray
    Department of Anatomy and Neurobiology, Developmental Biology Center, University of California, Irvine, Irvine, California 92697 2300, USA
    J Neurosci 23:1769-80. 2003
    ....
  24. pmc Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo
    Richard J White
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, United States of America
    PLoS Biol 5:e304. 2007
    ..Such control also provides an explanation for the fact that loss of an endogenous RA gradient can be compensated for by RA that is provided in a spatially uniform manner...
  25. pmc Feedback regulation in multistage cell lineages
    Wing Cheong Lo
    Departments of Mathematics, University of California, Irvine, CA, United States
    Math Biosci Eng 6:59-82. 2009
    ..Our results suggest that two factors -- autoregulation of the proliferation of transit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system...
  26. pmc Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11
    Shimako Kawauchi
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Development 136:1453-64. 2009
    ..Thus, the pro-neurogenic effects of Foxg1 are likely to be mediated through different signaling pathways in different parts of the nervous system...
  27. pmc Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome
    Shimako Kawauchi
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
    PLoS Genet 5:e1000650. 2009
    ..In addition, evidence is presented that reduced expression of genes involved in adipogenic differentiation may underlie the low amounts of body fat observed both in Nipbl+/- mice and in individuals with CdLS...
  28. ncbi request reprint Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B
    Ian D Krantz
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 36:631-5. 2004
    ..The fly homolog of NIPBL, Nipped-B, facilitates enhancer-promoter communication and regulates Notch signaling and other developmental pathways in Drosophila melanogaster...

Research Grants15

  1. Systems Biology of Morphogenesis and Spatial Information Flow
    ARTHUR LANDER; Fiscal Year: 2007
    ..Such insights will have a broad impact on a variety of health-related areas including human development and birth defects, stem cells and regeneration, normal and tumor cell growth, and basic physiology. ..
  2. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
    ..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
  3. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  4. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  5. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2003
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  6. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2002
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  7. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  8. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2001
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  9. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2000
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  10. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 1999
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..