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Genomes and Genes | Stephanie R LandSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Compliance with patient-reported outcomes in multicenter clinical trials: methodologic and practical approachesStephanie R Land
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA 15213, USA
J Clin Oncol 25:5113-20. 2007..We describe the effectiveness of several interventions and of observational factors...- Neurotoxicity from oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: NSABP C-07Stephanie R Land
National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, PA 15213, USA
J Clin Oncol 25:2205-11. 2007..Definitive analysis revealed an increase in 4-year disease-free survival from 67.0% to 73.2% in favor of FLOX. This study compares neurotoxicity between the treatments... 
Patient-reported outcomes in sentinel node-negative adjuvant breast cancer patients receiving sentinel-node biopsy or axillary dissection: National Surgical Adjuvant Breast and Bowel Project phase III protocol B-32Stephanie R Land
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistics Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Oncol 28:3929-36. 2010..We report the definitive patient-reported outcomes (PRO) comparisons...- Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trialStephanie R Land
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 295:2742-51. 2006..Tamoxifen has been approved for breast cancer risk reduction in high-risk women, but how raloxifene compares with tamoxifen is unknown... - Menstrual history and quality-of-life outcomes in women with node-positive breast cancer treated with adjuvant therapy on the NSABP B-30 trialPatricia A Ganz
National Surgical Adjuvant Breast and Bowel Project Operations Center NSABP, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
J Clin Oncol 29:1110-6. 2011..The National Surgical Adjuvant Breast and Bowel Project B-30 trial included menstrual history (MH) and quality-of-life (QOL) studies to compare treatments on these outcomes... 
Amenorrhea in premenopausal women on the doxorubicin-and-cyclophosphamide-followed-by-docetaxel arm of NSABP B-30 trialSandra M Swain
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
Breast Cancer Res Treat 113:315-20. 2009..These results can be used to inform premenopausal women about the risk and time course of amenorrhea associated with this common adjuvant therapy regimen, along with the effects on symptoms and QOL...- Quality of life in operable colon cancer patients receiving oral compared with intravenous chemotherapy: results from National Surgical Adjuvant Breast and Bowel Project Trial C-06Jacek A Kopec
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, PA, USA
J Clin Oncol 25:424-30. 2007.... - Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trialsReena S Cecchini
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Center, One Sterling Plaza, 201 N Craig St, Suite 350, Pittsburgh, PA 15213, USA
Cancer Prev Res (Phila) 5:583-92. 2012.... - Long-term results of a phase II trial of neoadjuvant chemotherapy followed by esophagectomy for locally advanced esophageal neoplasmArjun Pennathur
Heart, Lung, and Esophageal Surgery Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Ann Thorac Surg 85:1930-6; discussion 1936-7. 2008..We report the long-term results of our phase II study of neoadjuvant chemotherapy, followed by esophagectomy and adjuvant chemotherapy for potentially resectable esophageal carcinoma... - Is sentinel node biopsy necessary in conservatively treated DCIS?Thomas B Julian
National Surgical Adjuvant Breast and Bowel Project Operations Office and Biostatistical Center, Pittsburgh, Pennsylvania, USA
Ann Surg Oncol 14:2202-8. 2007..Its use in patients with DCIS versus local excision (LE), observation, and/or breast irradiation remains in question... - Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23Stephanie R Land
NSABP Biostatistical Center, Pittsburgh, USA Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
Breast Cancer Res Treat 86:153-64. 2004..QOL information was considered especially relevant given the possibility that the two chemotherapy regimens would prove equivalent in terms of clinical outcome... - Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcomeLaura P Stabile
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Clin Cancer Res 17:154-64. 2011..Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome... - Cigarette smoking, obesity, physical activity, and alcohol use as predictors of chemoprevention adherence in the National Surgical Adjuvant Breast and Bowel Project P-1 Breast Cancer Prevention TrialStephanie R Land
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, University of Pittsburgh, PA, USA
Cancer Prev Res (Phila) 4:1393-400. 2011..001; OR = 1.5 high vs. low) predicted adequate adherence at 36 months. There were no significant associations with obesity or physical activity. Alcohol use and smoking might indicate a need for greater adherence support... - Impact of IFNalpha2b upon pSTAT3 and the MEK/ERK MAPK pathway in melanomaWenjun Wang
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, Hillman Cancer Center, Research Pavilion, Suite 1 32, 5117 Centre Avenue, Pittsburgh, PA 15213 2584, USA
Cancer Immunol Immunother 57:1315-21. 2008..We have therefore evaluated STAT3 and MEK/ERK MAP kinases in patients with regional lymph node metastasis (stage IIIB) of melanoma in the context of a prospective neoadjuvant trial of HDI (UPCI 00-008)... - Modulation of signal transducers and activators of transcription 1 and 3 signaling in melanoma by high-dose IFNalpha2bWenjun Wang
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute Pittsburgh, PA, USA
Clin Cancer Res 13:1523-31. 2007..The goal of this study was to understand the effects of high-dose IFNalpha2b (HDI) in relation to the balance of pSTAT1 and pSTAT3... - Prevention of tobacco carcinogen-induced lung cancer in female mice using antiestrogensLaura P Stabile
Department of Pharmacology and Chemical Biology, University of Pittsburgh and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Carcinogenesis 33:2181-9. 2012..ERĪ² expressed by inflammatory and neoplastic epithelial cells in the lung may signal in response to local estrogen production... - Long-term neurotoxicity effects of oxaliplatin added to fluorouracil and leucovorin as adjuvant therapy for colon cancer: results from National Surgical Adjuvant Breast and Bowel Project trials C-07 and LTS-01Kelley M Kidwell
National Surgical Adjuvant Breast and Bowel Project Operations and Biostatistical Centers, Pittsburgh, Pennsylvania 15213, USA
Cancer 118:5614-22. 2012.... - Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patientsJulien Fourcade
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
J Immunother 31:781-91. 2008..They also suggest that the presence of tumor-induced NY-ESO-1-specific T cells of well-defined clonotypes is critical for the expansion of tumor-reactive NY-ESO-1-specific CD8+ T cells after peptide-based vaccine strategies... - Pathologic variables predictive of breast events in patients with ductal carcinoma in situEdwin R Fisher
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
Am J Clin Pathol 128:86-91. 2007..The similar predictive role of comedo necrosis in this study and that reported previously from NSABP B-17 (total of 2,079 patients) strongly supports its role as a simple high-risk predictor for ipsilateral breast tumor recurrences... - Association of cigarette smoking and media literacy about smoking among adolescentsBrian A Primack
Division of General Internal Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Adolesc Health 39:465-72. 2006..To determine whether media literacy concerning tobacco use is independently associated with two clinically relevant outcome measures in adolescents: current smoking and susceptibility to smoking... - Symptom measurement in the Breast Cancer Prevention Trial (BCPT) (P-1): psychometric properties of a new measure of symptoms for midlife womenDavid Cella
National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, PA, USA
Breast Cancer Res Treat 109:515-26. 2008..To evaluate scalability of a symptom scale administered to women enrolled in the Breast Cancer Prevention Trial (BCPT) (P-1) conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP)... - Adolescents' experiences using the contraceptive patch versus pillsGina S Sucato
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Pediatr Adolesc Gynecol 24:197-203. 2011..To compare use of the weekly transdermal contraceptive patch (patch) with daily combined hormonal contraceptive pills (pills) in adolescents... - Smoking behavior 1 year after computed tomography screening for lung cancer: Effect of physician referral for abnormal CT findingsMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, PA, USA
Cancer Epidemiol Biomarkers Prev 18:3484-9. 2009..Focusing on outcomes related to the reporting of CT abnormality, we examined the natural history of smoking in the Pittsburgh Lung Screening Study... - Association between media use in adolescence and depression in young adulthood: a longitudinal studyBrian A Primack
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 66:181-8. 2009..Although certain media exposures have been linked to the presence of psychiatric conditions, few studies have investigated the association between media exposure and depression... - Adolescent smoking and volume of exposure to various forms of mediaBrian A Primack
Center for Research on Health Care, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Public Health 122:379-89. 2008..To assess the association between adolescent smoking and volume of exposure to various forms of media after controlling for multiple relevant covariates... - An association between postoperative radiotherapy for primary breast cancer in 11 National Surgical Adjuvant Breast and Bowel Project (NSABP) studies and the subsequent appearance of pleural mesotheliomaMelvin Deutsch
UPMC Presbyterian Department of Radiation Oncology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Am J Clin Oncol 30:294-6. 2007.... - The incidence of lung carcinoma after surgery for breast carcinoma with and without postoperative radiotherapy. Results of National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials B-04 and B-06Melvin Deutsch
Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Cancer 98:1362-8. 2003.... - Chemoimmunotherapy with low-dose fludarabine and cyclophosphamide and high dose rituximab in previously untreated patients with chronic lymphocytic leukemiaKenneth A Foon
Department of Medicine and Biostatistics, University of Pittsburgh School of Medicine, Graduate School of Public Health, University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Center Cancer Centers, PA, USA
J Clin Oncol 27:498-503. 2009..However, grade 3/4 neutropenia was reported in 52% of cycles of treatment. The purpose of this trial was to maintain the high responses but reduce the toxicity of FCR by decreasing the fludarabine and cyclophosphamide (FCR-Lite)... - Phase II trial of short-course CHOP-R followed by 90Y-ibritumomab tiuxetan and extended rituximab in previously untreated follicular lymphomaSamuel A Jacobs
Department of Medicine, University of Pittsburgh Medical Center Cancer Centers, Pittsburgh, Pennsylvania 15232, USA
Clin Cancer Res 14:7088-94. 2008.... - Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cellsGuangfeng Zhang
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA
Mol Endocrinol 23:146-56. 2009..In conclusion, our results suggest that that proliferative effects of estrogen in lung cancer cells is mediated primarily, if not exclusively, by the nongenomic action of ERbeta... - Elevated hepatocyte growth factor level correlates with poor outcome in early-stage and late-stage adenocarcinoma of the lungJill M Siegfried
Department of Pharmacology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213-1863, USA
Chest 125:116S-9S. 2004 - Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesisLaura P Stabile
Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Mol Cancer Ther 7:1913-22. 2008..These preclinical results show that blocking the HGF/c-Met interaction with a single monoclonal antibody delivered systemically can have profound inhibitory effects on development of lung tumors... - PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patientsJulien Fourcade
Department of Medicine and Division of Hematology Oncology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
J Immunol 182:5240-9. 2009..They further support the use of PD-1/PD-L1 pathway blockade in cancer patients to partially restore NY-ESO-1-specific CD8(+) T cell numbers and functions, increasing the likelihood of tumor regression... - The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening studyMindi A Styn
Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 150:254-61. 2009..The association between DRD2 TaqIA and smoking cessation supports the hypothesis that genetic variation in the dopamine pathway influences smoking cessation... - Association of the EGFR intron 1 CA repeat length with lung cancer riskWeiping Zhang
Department of Pharmacology, University of Pittsburgh Cancer Institute, SPORE in Lung Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 1863, USA
Mol Carcinog 46:372-80. 2007..Our study, which is preliminary, demonstrates for the first time that shorter EGFR-CA repeats associate with lung cancer risk. The number of EGFR-CA repeats identifies a possible susceptible population to lung cancer... - What do patients want from their radiation oncologist? Initial results from a prospective trialAjay K Bhatnagar
Department of Radiation Oncology, University of Pittsburgh Cancer Institute University of Pittsburgh Medical Center Cancer Centers, Pittsburgh, PA 15232, USA
Int J Radiat Oncol Biol Phys 69:1527-33. 2007..To assess patients' initial physician preferences using a newly developed instrument... - Development and validation of a smoking media literacy scale for adolescentsBrian A Primack
Center for Research on Health Care, Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 230 McKee Place, Ste 600, Pittsburgh, PA 15213, USA
Arch Pediatr Adolesc Med 160:369-74. 2006..To develop a smoking media literacy (SML) scale by using empiric survey data from a large sample of high school students and to assess reliability and criterion validity of the scale... - Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: twelve-year observations concerning lobular carcinoma in situEdwin R Fisher
Pathology Center, National Surgical Adjuvant Breast and Bowel Project Pathology Center, Pittsburgh, Pennsylvania, USA
Cancer 100:238-44. 2004..The current report represents a 12-year clinicopathologic update of an earlier 5-year analysis of 180 patients with lobular carcinoma in situ (LCIS) who were treated with local excision and subsequent surveillance only... - Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growthA McGarry Houghton
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Nat Med 16:219-23. 2010..Additionally, to our knowledge, this is the first description of a secreted proteinase gaining access to the inside of a cell and altering intracellular signaling... - Thoracic epidural versus intercostal nerve catheter plus patient-controlled analgesia: a randomized studyJames D Luketich
Division of Thoracic and Foregut Surgery, Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Ann Thorac Surg 79:1845-9; discussion 1849-50. 2005..Debate exists over the optimal pain control method. This randomized trial was designed to compare epidural (EPI) and intercostal nerve catheter with patient-controlled analgesia (ICN-PCA) for pain control after thoracotomy... - Volume of tobacco advertising in African American markets: systematic review and meta-analysisBrian A Primack
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Public Health Rep 122:607-15. 2007..This study compared the concentration (proportion of media messages that are for tobacco) and density (pro-tobacco media messages per person) of pro-tobacco media messages between African American and Caucasian markets... - Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responsesStergios J Moschos
Melanoma and Skin Cancer Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Oncol 24:3164-71. 2006..CONCLUSION: Neoadjuvant HDI is highly effective for the treatment of palpable stage IIIB-C melanoma, and the findings of this study implicate an indirect immunomodulatory mechanism rather than a direct antitumor mechanism... - Evaluation of anticyclin B1 serum antibody as a diagnostic and prognostic biomarker for lung cancerAnn Marie Egloff
University of Pittsburgh School of Medicine, E1040 Biomedical Science Tower, Pittsburgh, PA 15261, USA
Ann N Y Acad Sci 1062:29-40. 2005.... - Missing patient-reported outcome data in an adjuvant lung cancer studyStephanie R Land
J Clin Oncol 26:5018-9. 2008 - Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trialEleftherios P Mamounas
Aultman Health Foundation, 2600 6th St, SW Canton, OH 44710, USA
J Clin Oncol 26:1965-71. 2008.... - Funding patient-reported outcomes in cancer clinical trialsCarol M Moinpour
Southwest Oncology Group Statistical Center Fred Hutchinson Cancer Research Center, Seattle, WA 98104 1024, USA
J Clin Oncol 25:5100-5. 2007.... - Endostatin plus interferon-alpha2b therapy for metastatic melanoma: a novel combination of antiangiogenic and immunomodulatory agentsStergios J Moschos
Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, PA 15213 2584, USA
Melanoma Res 17:193-200. 2007..Better laboratory correlates of antiangiogenic response are needed, and the predictive value of circulating endothelial cells warrants further evaluation... - Mammographic density and breast cancer after ductal carcinoma in situLaurel A Habel
Division of Research, Kaiser Permanente Medical Care Program, Oakland, CA 94612, USA
J Natl Cancer Inst 96:1467-72. 2004..Our results provide initial evidence that the risk of second breast cancers may be increased among DCIS patients with highly dense breasts... - Statistics in oncologyStephanie R Land
J Clin Oncol 26:3668. 2008