Yu Lan

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development
    Yu Lan
    Center for Oral Biology, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genesis 45:618-24. 2007
  2. pmc The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice
    Wenjin Liu
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 135:3959-68. 2008
  3. pmc Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation
    Jin A Baek
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 350:520-31. 2011
  4. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
  5. pmc Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field
    Jing Zhou
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 353:344-53. 2011
  6. pmc Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development
    Yang Gao
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 328:200-9. 2009
  7. ncbi request reprint Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, Aab Institute of Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 131:3207-16. 2004
  8. pmc The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation
    Yang Gao
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 352:83-91. 2011
  9. pmc Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row
    Zunyi Zhang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 323:1232-4. 2009
  10. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009

Collaborators

Detail Information

Publications23

  1. pmc A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development
    Yu Lan
    Center for Oral Biology, Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genesis 45:618-24. 2007
    ..These data indicate that the Osr2(IresCre) knockin mice provide a unique tool for tissue-specific studies of the molecular mechanisms regulating palate and kidney development...
  2. pmc The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice
    Wenjin Liu
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 135:3959-68. 2008
    ..Overexpression of Mn1 in NIH3T3 cells also increased endogenous Tbx22 mRNA expression in a dose-dependent manner. These data indicate that Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development...
  3. pmc Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation
    Jin A Baek
    Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 350:520-31. 2011
    ..Our data indicate that Bmp signaling plays critical roles in the regulation of palatal mesenchyme condensation and osteoblast differentiation during palatal bone formation...
  4. pmc Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
    Jianquan Chen
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Biol 334:174-85. 2009
    ..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
  5. pmc Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field
    Jing Zhou
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 353:344-53. 2011
    ..These data indicate that Osr2 acts downstream of Pax9 and patterns the mesenchymal odontogenic field through protein-protein interactions with Msx1 and Pax9 during early tooth development...
  6. pmc Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development
    Yang Gao
    Department of Biomedical Genetics and Center for Oral Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 328:200-9. 2009
    ..These results indicate that the distinct functions of Osr1 and Osr2 during mouse development result from evolutionary divergence of their cis regulatory sequences rather than distinct biochemical activities of their protein products...
  7. ncbi request reprint Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, Aab Institute of Biomedical Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 131:3207-16. 2004
    ..These data identify Osr2 as a key intrinsic regulator of palatal growth and patterning...
  8. pmc The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation
    Yang Gao
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Dev Biol 352:83-91. 2011
    ..In addition, joint cells in the double mutants failed to upregulate expression of the articular cartilage marker gene Prg4. These data indicate that Osr1 and Osr2 function redundantly to control synovial joint formation...
  9. pmc Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row
    Zunyi Zhang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 323:1232-4. 2009
    ..These findings suggest that the Bmp4-Msx1 pathway propagates mesenchymal activation for sequential tooth induction and that spatial modulation of this pathway provides a mechanism for patterning vertebrate dentition...
  10. pmc Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Development 136:1387-96. 2009
    ....
  11. pmc The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis
    Wenjin Liu
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mol Cell Biol 30:4797-807. 2010
    ..In addition to defects in tendon collagen fibrillogenesis, Mkx(-/-) mutant mice exhibited abnormal tendon sheaths. These results identify Mkx as an important regulator of tendon development...
  12. pmc Generation of Osr1 conditional mutant mice
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Genesis 49:419-22. 2011
    ..The Osr1( fneo) conditional mice will be valuable for tissue-specific analysis of the roles of Osr1 in embryonic and postnatal developmental processes. genesis 49:419-422, 2011...
  13. pmc Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development
    Qingru Wang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 611, Rochester, NY 14642, USA
    Dev Biol 288:582-94. 2005
    ..These data provide new insights into the molecular mechanisms underlying heart morphogenesis and urogenital development...
  14. pmc Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development
    Liam M Casey
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1830-44. 2006
    ....
  15. pmc Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1448-54. 2006
    ..These data, together with the CLP lip phenotype in WNT3-/- humans and Wnt9b-/- mutant mice, indicate that Wnt3 and Wnt9b signal through the canonical Wnt signaling pathway to regulate midfacial development and lip fusion...
  16. pmc Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation
    Han Liu
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Gene Expr Patterns 6:632-6. 2006
    ..The developmental expression pattern indicates that Irxl1 is a good candidate gene for the Twirler gene...
  17. pmc The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene
    Jeffrey O Bush
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 101:7022-7. 2004
    ..These results identify gain of function of a T-box transcription factor gene as a mechanism underlying CL/P pathogenesis...
  18. ncbi request reprint Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene
    Jeffrey O Bush
    Department of Biology, University of Rochester, Rochester, New York 14642, USA
    Dev Dyn 225:322-6. 2002
    ..Together with the mutant phenotypes in human patients, our data indicate a primary role for Tbx22 in both palate and tongue development...
  19. pmc The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival
    Jianquan Chen
    Genesis 45:482-6. 2007
    ..Surprisingly, mice homozygous for the deleted allele were viable, fertile and did not exhibit any discernible developmental defect. Our data exclude an essential role for Bambi in mouse embryonic development and postnatal survival...
  20. pmc Smad4 is required for maintaining normal murine postnatal bone homeostasis
    Xiaohong Tan
    Genetic Laboratory of Development and Disease, Institute of Biotechnology, Beijing 100071, PR China
    J Cell Sci 120:2162-70. 2007
    ..These studies demonstrate essential roles of Smad4-mediated TGFbeta signaling in coupling bone formation and bone resorption and maintaining normal postnatal bone homeostasis...
  21. ncbi request reprint Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A
    Bao Feng Jin
    Institute of Basic Medical Sciences, National Center of Biomedical Analysis, 27 Tai Ping Road, Beijing 100850, China
    Oncogene 22:4819-30. 2003
    ..Our data pave the way to a better understanding of the mechanisms by which UP system has been linked to apoptosis...
  22. pmc Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genes Dev 17:1207-12. 2003
    ..Our results demonstrate that Dll1-mediated Notch signaling is essential for generation of left-right asymmetry, and that the Notch pathway acts upstream of Nodal expression during left-right asymmetry determination in mice...
  23. pmc Essential role of endothelial Smad4 in vascular remodeling and integrity
    Yu Lan
    Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, People s Republic of China
    Mol Cell Biol 27:7683-92. 2007
    ..Collectively, we have provided direct functional evidence that Smad4 activity in the developing ECs is essential for blood vessel remodeling, maturation, and integrity...